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BR0308243A - Composto, formulação farmacêutica, e, métodos de tratar diabetes, doença de alzheimer, e de inibir gsk-3 em um mamìfero - Google Patents

Composto, formulação farmacêutica, e, métodos de tratar diabetes, doença de alzheimer, e de inibir gsk-3 em um mamìfero

Info

Publication number
BR0308243A
BR0308243A BR0308243-1A BR0308243A BR0308243A BR 0308243 A BR0308243 A BR 0308243A BR 0308243 A BR0308243 A BR 0308243A BR 0308243 A BR0308243 A BR 0308243A
Authority
BR
Brazil
Prior art keywords
alzheimer
mammal
disease
compound
methods
Prior art date
Application number
BR0308243-1A
Other languages
English (en)
Other versions
BR0308243B1 (pt
Inventor
Joshua Ryan Clayton
Clive Gideon Diefenbacher
Thomas Albert Engler
Kelly Wayne Furness
James Robert Henry
Sushant Malhotra
Angela Lynn Marquart
Johnathan Alexander Mclean
David Mendel
Timothy Paul Burkholder
Yihong Li
Jon Kevin Reel
Brian Raymond Berridge
Charles Edward Ruegg
John Morris Sullivan
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of BR0308243A publication Critical patent/BR0308243A/pt
Publication of BR0308243B1 publication Critical patent/BR0308243B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

"COMPOSTO, FORMULAçãO FARMACêUTICA, E MéTODOS DE TRATAR DIABETES, DOENçA DE ALZHEIMER, E DE INIBIR GSK-3 EM UM MAMìFERO". A presente invenção proporciona inibidores de quinase de Fórmula I.
BRPI0308243-1A 2002-03-05 2003-03-04 Derivados de purina como inibidores de quinase, seu uso para tratar diabetes e doença de alzheimer, para estimular deposição óssea e inibir gsk-3, bem como formulação farmacêutica compreendendo os referidos derivados BR0308243B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US36224502P 2002-03-05 2002-03-05
US60/362245 2002-03-05
PCT/US2003/005050 WO2003076442A1 (en) 2002-03-05 2003-03-04 Purine derivatives as kinase inhibitors

Publications (2)

Publication Number Publication Date
BR0308243A true BR0308243A (pt) 2005-01-11
BR0308243B1 BR0308243B1 (pt) 2014-08-26

Family

ID=27805149

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0308243-1A BR0308243B1 (pt) 2002-03-05 2003-03-04 Derivados de purina como inibidores de quinase, seu uso para tratar diabetes e doença de alzheimer, para estimular deposição óssea e inibir gsk-3, bem como formulação farmacêutica compreendendo os referidos derivados

Country Status (16)

Country Link
US (4) US7491716B2 (pt)
EP (1) EP1483265B1 (pt)
JP (1) JP4414232B2 (pt)
KR (1) KR100974770B1 (pt)
CN (1) CN1312154C (pt)
AT (1) ATE346070T1 (pt)
AU (1) AU2003215325B8 (pt)
BR (1) BR0308243B1 (pt)
CA (1) CA2477967C (pt)
CY (1) CY1109006T1 (pt)
DE (1) DE60309848T2 (pt)
DK (1) DK1483265T3 (pt)
ES (1) ES2276048T3 (pt)
IL (2) IL163781A0 (pt)
PT (1) PT1483265E (pt)
WO (1) WO2003076442A1 (pt)

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Also Published As

Publication number Publication date
WO2003076442A1 (en) 2003-09-18
DE60309848T2 (de) 2007-05-16
CN1312154C (zh) 2007-04-25
CA2477967A1 (en) 2003-09-18
CY1109006T1 (el) 2014-07-02
AU2003215325A1 (en) 2003-09-22
KR100974770B1 (ko) 2010-08-06
IL163781A0 (en) 2005-12-18
CN1639165A (zh) 2005-07-13
IL163781A (en) 2010-04-15
US7491716B2 (en) 2009-02-17
US20110207721A1 (en) 2011-08-25
US20050090483A1 (en) 2005-04-28
AU2003215325B8 (en) 2008-10-09
US20090105229A1 (en) 2009-04-23
KR20040087338A (ko) 2004-10-13
CA2477967C (en) 2010-08-10
JP2005526072A (ja) 2005-09-02
EP1483265B1 (en) 2006-11-22
US8058425B2 (en) 2011-11-15
ATE346070T1 (de) 2006-12-15
US20110294792A1 (en) 2011-12-01
PT1483265E (pt) 2007-01-31
EP1483265A1 (en) 2004-12-08
AU2003215325B2 (en) 2008-09-18
DK1483265T3 (da) 2007-03-19
ES2276048T3 (es) 2007-06-16
BR0308243B1 (pt) 2014-08-26
US8022065B2 (en) 2011-09-20
JP4414232B2 (ja) 2010-02-10
DE60309848D1 (de) 2007-01-04

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Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 26/08/2014, OBSERVADAS AS CONDICOES LEGAIS.

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time
B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)