BR0307278A - Formulação oral de liberação imediata, e, método para preparar uma formulação - Google Patents
Formulação oral de liberação imediata, e, método para preparar uma formulaçãoInfo
- Publication number
- BR0307278A BR0307278A BR0307278-9A BR0307278A BR0307278A BR 0307278 A BR0307278 A BR 0307278A BR 0307278 A BR0307278 A BR 0307278A BR 0307278 A BR0307278 A BR 0307278A
- Authority
- BR
- Brazil
- Prior art keywords
- formulation
- amount
- immediate release
- total weight
- preparing
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 9
- 238000009472 formulation Methods 0.000 title abstract 8
- 239000012729 immediate-release (IR) formulation Substances 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 239000013543 active substance Substances 0.000 abstract 2
- 239000007788 liquid Substances 0.000 abstract 2
- 229920000620 organic polymer Polymers 0.000 abstract 2
- 229940088623 biologically active substance Drugs 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 229920002959 polymer blend Polymers 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 239000004094 surface-active agent Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
"FORMULAçãO ORAL DE LIBERAçãO IMEDIATA, E, MéTODO PARA PREPARAR UMA FORMULAçãO". A presente invenção refere-se a uma formulação de liberação imediata com biodisponibilidade aumentada compreendendo uma solução homogênea e termoestável de uma substância biologicamente ativa deficientemente solúvel em água, em que a referida solução é composta de :a) a substância ativa em uma quantidade entre 10 e 50% do peso total da formulação, b) um tensoativo hidrofílico não iónico, que está na forma líquida entre 15 e 30<198>C, em uma quantidade entre 20% e 70% do peso total da formulação e c) um polimero orgânico ou mistura de polímeros orgânicos farmaceuticamente aceitável, sendo que o polímero ou mistura de polímeros está em forma líquida acima de 60<198>C e em forma sólida abaixo de 30<198>C, em uma quantidade entre 5% e 70% do peso total da formulação, e d) opcionalmente, um agente de desintegração em uma quantidade entre 1% e 10% do peso total da formulação. A invenção refere-se adicionalmente a substâncias ativas formuladas na forma acima e a métodos para produzir a formulação.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02075623 | 2002-02-14 | ||
| PCT/EP2003/050014 WO2003068266A1 (en) | 2002-02-14 | 2003-02-11 | Oral solid solution formulation of a poorly water-soluble active substance |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0307278A true BR0307278A (pt) | 2004-12-28 |
Family
ID=27619166
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0307278-9A BR0307278A (pt) | 2002-02-14 | 2003-02-11 | Formulação oral de liberação imediata, e, método para preparar uma formulação |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US20050008697A1 (pt) |
| EP (1) | EP1476196B1 (pt) |
| JP (1) | JP2005517041A (pt) |
| KR (1) | KR101014545B1 (pt) |
| CN (1) | CN1273194C (pt) |
| AR (1) | AR038681A1 (pt) |
| AT (1) | ATE345817T1 (pt) |
| AU (1) | AU2003208713B2 (pt) |
| BR (1) | BR0307278A (pt) |
| CA (1) | CA2472744A1 (pt) |
| DE (1) | DE60309839T2 (pt) |
| DK (1) | DK1476196T3 (pt) |
| ES (1) | ES2277635T3 (pt) |
| HR (1) | HRP20040613A2 (pt) |
| IL (2) | IL162883A0 (pt) |
| MX (1) | MXPA04007852A (pt) |
| NO (1) | NO20043832L (pt) |
| PL (1) | PL370452A1 (pt) |
| PT (1) | PT1476196E (pt) |
| RU (1) | RU2314811C2 (pt) |
| SI (1) | SI1476196T1 (pt) |
| UA (1) | UA79267C2 (pt) |
| WO (1) | WO2003068266A1 (pt) |
| ZA (1) | ZA200405608B (pt) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004062692A1 (en) * | 2003-01-13 | 2004-07-29 | Solvay Pharmaceuticals B.V. | Formulation of poorly water-soluble active substances |
| US8025899B2 (en) * | 2003-08-28 | 2011-09-27 | Abbott Laboratories | Solid pharmaceutical dosage form |
| US8377952B2 (en) * | 2003-08-28 | 2013-02-19 | Abbott Laboratories | Solid pharmaceutical dosage formulation |
| US20050267124A1 (en) * | 2004-05-14 | 2005-12-01 | Solvay Pharmaceuticals Gmbh | Pharmaceutical compositions comprising NEP-inhibitors, inhibitors of the endogenous producing system and PDEV inhibiitors |
| TW200633713A (en) * | 2004-12-23 | 2006-10-01 | Solvay Pharm Bv | Oral immediate release formulation of a poorly water-soluble active substance |
| US20060159748A1 (en) * | 2004-12-23 | 2006-07-20 | Rajesh Jain | Oral immediate release formulation of a poorly water-soluble active substance |
| WO2007054975A1 (en) * | 2005-11-08 | 2007-05-18 | Panacea Biotec Ltd | Pharmaceutical compositions for the treatment of cardiovascular and other associated disorders |
| US8497258B2 (en) | 2005-11-12 | 2013-07-30 | The Regents Of The University Of California | Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract |
| JP2007308479A (ja) | 2006-04-20 | 2007-11-29 | Shin Etsu Chem Co Ltd | 固体分散体製剤 |
| KR20090032085A (ko) * | 2006-06-16 | 2009-03-31 | 솔베이 파마슈티칼스 비. 브이 | 수용성이 불량한 활성 물질의 경구 투여용 약제학적 조성물 |
| JP2009541267A (ja) * | 2006-06-22 | 2009-11-26 | ソルベイ・フアーマシユーチカルズ・ベー・ブイ | 低い水溶性活性物質の経口製薬学的組成物 |
| WO2008003769A2 (en) * | 2006-07-06 | 2008-01-10 | Ares Trading S.A. | An oral pharmaceutical composition of an anilinopyrimidine, its preparation and use thereof |
| JP2010501642A (ja) * | 2006-09-01 | 2010-01-21 | テバ ファーマシューティカル インダストリーズ リミティド | カルシウム受容体−活性化合物の固体複合材料 |
| AR071375A1 (es) * | 2008-04-22 | 2010-06-16 | Solvay Pharm Gmbh | Formulaciones para ingredientes farmaceuticos activos de permeabilidad deficiente, proceso de preparacion y producto |
| WO2010144865A2 (en) | 2009-06-12 | 2010-12-16 | Meritage Pharma, Inc. | Methods for treating gastrointestinal disorders |
| SI2600850T1 (sl) | 2010-08-04 | 2018-12-31 | Gruenenthal Gmbh | Farmacevtska oblika odmerka, ki zajema 6'-fluoro-(N-metil- ali N,N- dimetil-)-4-fenil-4',9'-dihidro-3'H-spiro(cikloheksan-1,1'-pirano (3,4,B)indol)-4-amin, za zdravljenje nociceptivne bolečine |
| RU2582390C2 (ru) * | 2010-08-04 | 2016-04-27 | Грюненталь Гмбх | ЛЕКАРСТВЕННАЯ ДОЗИРОВАННАЯ ФОРМА, КОТОРАЯ СОДЕРЖИТ 6'-ФТОР-(N-МЕТИЛ-ИЛИ N,N-ДИМЕТИЛ-)-4-ФЕНИЛ-4', 9'-ДИГИДРО-3'Н-СПИРО[ЦИКЛОГЕКСАН-1,1'-ПИРАНО[3,4,b]ИНДОЛ]-4-АМИН |
| CN107735080B (zh) * | 2015-07-03 | 2020-10-23 | 浙江海正药业股份有限公司 | 一种人参皂苷c-k口服固体制剂及其制备方法 |
| PL424453A1 (pl) | 2018-01-31 | 2019-08-12 | Forty-Four Pharmaceuticals Spółka Z Ograniczoną Odpowiedzialnością | Sposoby zmniejszania szkodliwego działania niedoboru perfuzji narządów miąższowych przez inhibitory obojętnej endopeptydazy (NEP) i ludzkiej rozpuszczalnej endopeptydazy (hSEP) |
| PL424452A1 (pl) | 2018-01-31 | 2019-08-12 | Forty-Four Pharmaceuticals Spółka Z Ograniczoną Odpowiedzialnością | Inhibitory obojętnej endopeptydazy (NEP) i ludzkiej rozpuszczalnej endopeptydazy (hSEP) do profilaktyki i leczenia chorób oczu |
| FI3886820T3 (fi) | 2018-11-30 | 2023-05-25 | Chemocentryx Inc | Kapseliformulaatioita |
| CN121532170A (zh) * | 2023-07-18 | 2026-02-13 | 三亚制药株式会社 | 含普仑司特的药物组合物的制备方法以及通过所述制备方法制备的药物组合物 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3359167A (en) * | 1965-07-22 | 1967-12-19 | Pfizer & Co C | Vitamin a compositions |
| US4325970A (en) * | 1980-10-09 | 1982-04-20 | Hoffmann-La Roche Inc. | 15-Acetyl-prostaglandins |
| NZ224497A (en) * | 1987-05-18 | 1990-04-26 | Janssen Pharmaceutica Nv | Pharmaceutical composition comprising flunarizine |
| US5281420A (en) * | 1992-05-19 | 1994-01-25 | The Procter & Gamble Company | Solid dispersion compositions of tebufelone |
| DE19510566A1 (de) * | 1995-03-23 | 1996-09-26 | Kali Chemie Pharma Gmbh | Benzazepin-, Benzoxazepin- und Benzothiazepin-N-essigsäurederivate sowie Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
| DE19638020A1 (de) * | 1996-09-18 | 1998-03-19 | Solvay Pharm Gmbh | Die gastrointestinale Durchblutung fördernde Arzneimittel |
| TW426516B (en) * | 1996-12-06 | 2001-03-21 | Fujisawa Pharmaceutical Co | An oral pharmaceutical composition in solid dispersion containing water-insoluble tricyclic compounds |
| EP0988046B1 (en) * | 1997-01-30 | 2004-09-15 | Novartis AG | Oil-free pharmaceutical compositions containing cyclosporin a |
| US6008191A (en) * | 1997-09-08 | 1999-12-28 | Panacea Biotec Limited | Pharmaceutical compositions containing cyclosporin |
| KR100336090B1 (ko) * | 1998-06-27 | 2002-05-27 | 윤승원 | 오일, 지방산 또는 이들의 혼합물을 함유한 난용성 약물의 고형분산제제 |
| DE19906310A1 (de) * | 1999-02-16 | 2000-08-17 | Solvay Pharm Gmbh | Arzneimittel zur Behandlung von Bluthochdruck |
| DE19932555A1 (de) * | 1999-07-13 | 2001-01-18 | Solvay Pharm Gmbh | Arzneimittel mit protektiver Wirkung gegen oxidativ-toxische und insbesondere gegen kardiotoxische Substanzen |
| US20010036959A1 (en) * | 2000-04-03 | 2001-11-01 | Gabel Rolf Dieter | Carvedilol-hydrophilic solutions |
-
2003
- 2003-02-04 AR ARP030100341A patent/AR038681A1/es unknown
- 2003-02-11 ES ES03706620T patent/ES2277635T3/es not_active Expired - Lifetime
- 2003-02-11 DE DE60309839T patent/DE60309839T2/de not_active Expired - Lifetime
- 2003-02-11 AT AT03706620T patent/ATE345817T1/de active
- 2003-02-11 KR KR1020047012635A patent/KR101014545B1/ko not_active Expired - Fee Related
- 2003-02-11 AU AU2003208713A patent/AU2003208713B2/en not_active Ceased
- 2003-02-11 CA CA002472744A patent/CA2472744A1/en not_active Abandoned
- 2003-02-11 DK DK03706620T patent/DK1476196T3/da active
- 2003-02-11 HR HR20040613A patent/HRP20040613A2/hr not_active Application Discontinuation
- 2003-02-11 WO PCT/EP2003/050014 patent/WO2003068266A1/en not_active Ceased
- 2003-02-11 JP JP2003567446A patent/JP2005517041A/ja active Pending
- 2003-02-11 IL IL16288303A patent/IL162883A0/xx unknown
- 2003-02-11 PL PL03370452A patent/PL370452A1/xx not_active IP Right Cessation
- 2003-02-11 SI SI200330630T patent/SI1476196T1/sl unknown
- 2003-02-11 RU RU2004127457/15A patent/RU2314811C2/ru not_active IP Right Cessation
- 2003-02-11 MX MXPA04007852A patent/MXPA04007852A/es active IP Right Grant
- 2003-02-11 EP EP03706620A patent/EP1476196B1/en not_active Expired - Lifetime
- 2003-02-11 PT PT03706620T patent/PT1476196E/pt unknown
- 2003-02-11 BR BR0307278-9A patent/BR0307278A/pt not_active Application Discontinuation
- 2003-02-11 CN CNB038038978A patent/CN1273194C/zh not_active Expired - Fee Related
- 2003-11-02 UA UA20040907457A patent/UA79267C2/uk unknown
-
2004
- 2004-07-06 IL IL162883A patent/IL162883A/en not_active IP Right Cessation
- 2004-07-14 ZA ZA200405608A patent/ZA200405608B/en unknown
- 2004-08-11 US US10/915,560 patent/US20050008697A1/en not_active Abandoned
- 2004-09-13 NO NO20043832A patent/NO20043832L/no not_active Application Discontinuation
-
2010
- 2010-11-12 US US12/945,570 patent/US20110086844A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ES2277635T3 (es) | 2007-07-16 |
| RU2004127457A (ru) | 2005-04-20 |
| UA79267C2 (en) | 2007-06-11 |
| PT1476196E (pt) | 2007-02-28 |
| ATE345817T1 (de) | 2006-12-15 |
| CA2472744A1 (en) | 2003-08-21 |
| CN1633307A (zh) | 2005-06-29 |
| DK1476196T3 (da) | 2007-03-05 |
| PL370452A1 (en) | 2005-05-30 |
| EP1476196A1 (en) | 2004-11-17 |
| JP2005517041A (ja) | 2005-06-09 |
| EP1476196B1 (en) | 2006-11-22 |
| MXPA04007852A (es) | 2004-10-15 |
| DE60309839D1 (de) | 2007-01-04 |
| KR20040085193A (ko) | 2004-10-07 |
| ZA200405608B (en) | 2005-06-24 |
| KR101014545B1 (ko) | 2011-02-16 |
| AU2003208713B9 (en) | 2003-09-04 |
| NO20043832L (no) | 2004-09-13 |
| WO2003068266A1 (en) | 2003-08-21 |
| AU2003208713B2 (en) | 2007-10-18 |
| DE60309839T2 (de) | 2007-03-15 |
| HK1077218A1 (en) | 2006-02-10 |
| CN1273194C (zh) | 2006-09-06 |
| RU2314811C2 (ru) | 2008-01-20 |
| HRP20040613A2 (en) | 2005-04-30 |
| SI1476196T1 (sl) | 2007-04-30 |
| IL162883A0 (en) | 2005-11-20 |
| IL162883A (en) | 2009-05-04 |
| US20110086844A1 (en) | 2011-04-14 |
| AU2003208713A1 (en) | 2003-09-04 |
| AR038681A1 (es) | 2005-01-26 |
| US20050008697A1 (en) | 2005-01-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL. |