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BR0307033A - ácidos 3-(imidazolil)-2-aminopropanóicos para o uso como inibidores tafi-a para o tratamento de doenças trombóticas - Google Patents

ácidos 3-(imidazolil)-2-aminopropanóicos para o uso como inibidores tafi-a para o tratamento de doenças trombóticas

Info

Publication number
BR0307033A
BR0307033A BR0307033-6A BR0307033A BR0307033A BR 0307033 A BR0307033 A BR 0307033A BR 0307033 A BR0307033 A BR 0307033A BR 0307033 A BR0307033 A BR 0307033A
Authority
BR
Brazil
Prior art keywords
treatment
tafi
inhibitors
imidazolyl
thrombotic diseases
Prior art date
Application number
BR0307033-6A
Other languages
English (en)
Inventor
Charlotte Moira Norfo Allerton
Mark Edward Bunnage
John Steele
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0201387A external-priority patent/GB0201387D0/en
Priority claimed from GB0201911A external-priority patent/GB0201911D0/en
Application filed by Pfizer filed Critical Pfizer
Publication of BR0307033A publication Critical patent/BR0307033A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"áCIDOS 3-(IMIDAZOLIL)-2-AMINOPROPANóICOS PARA O USO COMO INIBIDORES TAFI-A PARA O TRATAMENTO DE DOENçAS TROMBóTICAS". A presente invenção refere-se a compostos de acordo com a fórmula geral (I), em que n é 1-4, R^ 1^ é alquilaC~ 1~-C~ 6~, alquenilaC~ 2~-C~ 6~ ou alcinilaC~ 2~-C~ 6~ opcionalmente substituída, heterociclo, heterociclo aromático, arila ou hidrogênio e cada um de R^ 2^, R^ 3^, R^ 4~, R^ 5^, R^ 6^, R^ 7^ e R^ 8^ é selecionado independentemente entre hidrogênio e alquilaC~ 1~-C~ 6~ opcionalmente substituída, são novos. São úteis para o tratamento de estados patológicos trombóticos e de outros estados patológicos associados à deposição de fibrina.
BR0307033-6A 2002-01-22 2003-01-13 ácidos 3-(imidazolil)-2-aminopropanóicos para o uso como inibidores tafi-a para o tratamento de doenças trombóticas BR0307033A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0201387A GB0201387D0 (en) 2002-01-22 2002-01-22 3-(imidazolyl)-2-aminopropanoic acids
GB0201911A GB0201911D0 (en) 2002-01-28 2002-01-28 3-(Imidazolyl)-2-Aminopropanoic acids
PCT/IB2003/000058 WO2003061653A1 (en) 2002-01-22 2003-01-13 3-(imidazolyl)-2-aminopropanoic acids for use as tafi-a inhibitors for the treatment of thrombotic diseases

Publications (1)

Publication Number Publication Date
BR0307033A true BR0307033A (pt) 2004-12-07

Family

ID=27614791

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0307033-6A BR0307033A (pt) 2002-01-22 2003-01-13 ácidos 3-(imidazolil)-2-aminopropanóicos para o uso como inibidores tafi-a para o tratamento de doenças trombóticas

Country Status (11)

Country Link
US (2) US6759426B2 (pt)
EP (1) EP1467732A1 (pt)
JP (1) JP2005516972A (pt)
BR (1) BR0307033A (pt)
CA (1) CA2472239A1 (pt)
HN (1) HN2003000040A (pt)
MX (1) MXPA04005940A (pt)
PA (1) PA8563601A1 (pt)
PE (1) PE20030858A1 (pt)
TW (1) TW200302093A (pt)
WO (1) WO2003061653A1 (pt)

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JP2005516972A (ja) * 2002-01-22 2005-06-09 ファイザー・インク 血栓疾患の治療のためのｔａｆｉ−ａ阻害剤として使用される３−（イミダゾリル）−２−アミノプロピオン酸
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US8710232B2 (en) 2004-04-22 2014-04-29 Sanofi-Aventis Deutschland Gmbh Imidazole derivatives used as TAFIa inhibitors
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JP2008536923A (ja) * 2005-04-18 2008-09-11 バイエル・シェーリング・ファルマ・アクチェンゲゼルシャフト 心筋の再灌流の増強およびｐｃｉの容易化のためのｔａｆｉ阻害剤の使用
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HUE035072T2 (en) * 2010-03-18 2018-05-02 Daiichi Sankyo Co Ltd Cycloalkyl substituted imidazole derivative
KR20130130737A (ko) 2010-11-11 2013-12-02 사노피 ３­（６­아미노­피리딘­３일）­２­아크릴산 유도체의 제조방법
US9834527B2 (en) 2013-06-10 2017-12-05 Sanofi Macrocyclic urea derivatives as inhibitors of TAFIa, their preparation and their use as pharmaceuticals
CN108883094A (zh) 2016-03-29 2018-11-23 第三共株式会社 炎症性肠病治疗剂

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Also Published As

Publication number Publication date
JP2005516972A (ja) 2005-06-09
CA2472239A1 (en) 2003-07-31
PE20030858A1 (es) 2003-10-21
US20040192668A1 (en) 2004-09-30
US20030191107A1 (en) 2003-10-09
US6919457B2 (en) 2005-07-19
WO2003061653A1 (en) 2003-07-31
PA8563601A1 (es) 2003-12-10
EP1467732A1 (en) 2004-10-20
US6759426B2 (en) 2004-07-06
WO2003061653A9 (en) 2003-12-24
HN2003000040A (es) 2003-08-01
TW200302093A (en) 2003-08-01
MXPA04005940A (es) 2004-09-13

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