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BR0213861A - Processo para a preparação de composições de ribavirina de carga elevada, de dissolução rápida - Google Patents

Processo para a preparação de composições de ribavirina de carga elevada, de dissolução rápida

Info

Publication number
BR0213861A
BR0213861A BR0213861-1A BR0213861A BR0213861A BR 0213861 A BR0213861 A BR 0213861A BR 0213861 A BR0213861 A BR 0213861A BR 0213861 A BR0213861 A BR 0213861A
Authority
BR
Brazil
Prior art keywords
ribavirin
composition
compositions
granulation
preparation
Prior art date
Application number
BR0213861-1A
Other languages
English (en)
Inventor
Amol Singh Matharu
Mahendra R Patel
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of BR0213861A publication Critical patent/BR0213861A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)

Abstract

"PROCESSO PARA A PREPARAçãO DE COMPOSIçõES DE RIBAVIRINA DE CARGA ELEVADA, DE DISSOLUçãO RáPIDA". A presente invenção refere-se a uma composição de ribavirina de carga elevada, de dissolução rápida a qual é essencialmente livre de formas polimórficas de ribavirina, a referida composição é preparada por um processo compreendendo: (a) misturar ribavirina, pelo menos um desintegrante e /ou pelo menos uma carga para formar uma mistura homogênea; (b) granular a mistura na presença de água para formar uma granulação; (c) secar a granulação; e (d) misturar pelo menos um desintegrante e /ou pelo menos um lubrificante com a granulação para produzir uma composição de ribavirina, onde a referida composição de ribavirina compreende pelo menos 80 por cento em peso de ribavirina, com base no peso total da composição. As composições de ribavirina preparadas pelo processo de granulação úmida da invenção são de fluxo livre e têm adequada densidade de carga para processamento em cápsulas. Além disso, as composições de ribavirina contêm pelo menos 80 por cento em peso de ribavirina. Além disso, as composições de ribavirina são substancialmente livres de formas polimórficas de ribavirina, isto é, não existe nenhum sinal de alteração polimórfica na ribavirina tal como determinado pela espectrofotometria de infravermelho.
BR0213861-1A 2001-11-02 2002-10-31 Processo para a preparação de composições de ribavirina de carga elevada, de dissolução rápida BR0213861A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33685301P 2001-11-02 2001-11-02
PCT/US2002/034899 WO2003039517A1 (en) 2001-11-02 2002-10-31 Process for preparing quick dissolving, high loading ribavirin compositions

Publications (1)

Publication Number Publication Date
BR0213861A true BR0213861A (pt) 2004-12-21

Family

ID=23317956

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0213861-1A BR0213861A (pt) 2001-11-02 2002-10-31 Processo para a preparação de composições de ribavirina de carga elevada, de dissolução rápida

Country Status (16)

Country Link
US (1) US20030104050A1 (pt)
EP (1) EP1443911A1 (pt)
JP (1) JP2005511587A (pt)
KR (1) KR20050042035A (pt)
CN (1) CN1585631A (pt)
AU (1) AU2002350082B9 (pt)
BR (1) BR0213861A (pt)
CA (1) CA2465159A1 (pt)
HR (1) HRP20040384A2 (pt)
HU (1) HUP0402364A2 (pt)
IL (1) IL161697A0 (pt)
MX (1) MXPA04004181A (pt)
NO (1) NO20042143L (pt)
PL (1) PL368550A1 (pt)
RU (1) RU2004116821A (pt)
WO (1) WO2003039517A1 (pt)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6720000B2 (en) 2001-03-19 2004-04-13 Three Rivers Pharmaceutical, Llc Process for producing wet ribavirin pellets
US7538094B2 (en) * 2002-09-19 2009-05-26 Three Rivers Pharmacueticals, Llc Composition containing ribavirin and use thereof
CZ298224B6 (cs) * 2003-04-29 2007-07-25 Pliva Istrazivanje I Razvoj D.O.O. Farmaceutická kompozice obsahující jako úcinnou látku ribavirin a zpusob její výroby
MY144631A (en) * 2004-05-24 2011-10-14 Nycomed Pharma As Particulate comprising a calcium-containing compound and a sugar alcohol
WO2006002365A2 (en) * 2004-06-24 2006-01-05 Angiotech International Ag Microparticles with high loadings of a bioactive agent
US7723310B2 (en) * 2004-10-18 2010-05-25 Three Rivers Pharmaceuticals, Llc Large dose ribavirin formulations
US20060110479A1 (en) * 2004-11-24 2006-05-25 Mitra Shankar K Natural composition for curing hepatitis-B, methods for making the same and pharmaceutical formulations thereof
US8202546B2 (en) 2005-08-04 2012-06-19 Vertical Pharmaceuticals, Inc. Nutritional supplement for use under physiologically stressful conditions
US8263137B2 (en) 2005-08-04 2012-09-11 Vertical Pharmaceuticals, Inc. Nutritional supplement for women
US7901710B2 (en) 2005-08-04 2011-03-08 Vertical Pharmaceuticals, Inc. Nutritional supplement for use under physiologically stressful conditions
AU2007338751A1 (en) * 2006-12-21 2008-07-03 Mallinckrodt Inc. Composition of and method for preparing orally disintegrating tablets containing a high dose of pharmaceutically active ingredients
US8202996B2 (en) * 2007-12-21 2012-06-19 Bristol-Myers Squibb Company Crystalline forms of N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-4-((7-chloro-4-methoxy-1-isoquinolinyl)oxy)-N- ((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)-L-prolinamide
WO2010062996A2 (en) * 2008-11-28 2010-06-03 Adamas Pharmaceuticals, Inc. Ribavirin composition
EP2295037A1 (en) 2009-09-11 2011-03-16 Ratiopharm GmbH Pharmaceutical formulation containing Ribavirin
WO2011154772A1 (es) * 2010-06-08 2011-12-15 Laboratorio De Diagnostico Gam, S.A. Composición veterinaria oral para salmónidos que comprende 1-beta-d-ribofuranosil-1h-1,2,4-triazol-3-carboxamida y el uso para el tratamiento de la anemia infecciosa del salmón (isa) en salmónidos
EP3307327A1 (en) * 2015-06-09 2018-04-18 Commonwealth Scientific and Industrial Research Organisation Antiviral conjugates of polyanionic polymer and antiviral drug
CN106806345B (zh) * 2015-11-27 2020-10-13 北京科信必成医药科技发展有限公司 一种利巴韦林掩味颗粒及其制备方法
CN108464972A (zh) * 2018-07-02 2018-08-31 福州大学 一种含有斯诺普利的抗肺动脉高压口服片剂及其制备方法
KR20230011359A (ko) 2020-06-18 2023-01-20 엑스더블유파마 리미티드 수용성 활성 약제 성분의 제어 방출 과립화물
JP7751638B2 (ja) 2020-10-05 2025-10-08 エックスダブリューファーマ リミテッド ガンマ－ヒドロキシ酪酸誘導体の調節放出組成物
CN113304114B (zh) * 2021-06-08 2022-06-10 药大制药有限公司 一种利巴韦林颗粒及其制备方法

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Also Published As

Publication number Publication date
KR20050042035A (ko) 2005-05-04
AU2002350082B9 (en) 2006-08-31
RU2004116821A (ru) 2005-04-20
MXPA04004181A (es) 2005-01-25
IL161697A0 (en) 2004-09-27
JP2005511587A (ja) 2005-04-28
AU2002350082B2 (en) 2006-07-20
CN1585631A (zh) 2005-02-23
NO20042143L (no) 2004-05-25
US20030104050A1 (en) 2003-06-05
EP1443911A1 (en) 2004-08-11
PL368550A1 (en) 2005-04-04
WO2003039517A1 (en) 2003-05-15
HUP0402364A2 (hu) 2005-02-28
CA2465159A1 (en) 2003-05-15
HRP20040384A2 (en) 2005-08-31

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A, 7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2099 DE 29/03/2011.