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BR0212775A - 1,2,4-triazole compound - Google Patents

1,2,4-triazole compound

Info

Publication number
BR0212775A
BR0212775A BR0212775-0A BR0212775A BR0212775A BR 0212775 A BR0212775 A BR 0212775A BR 0212775 A BR0212775 A BR 0212775A BR 0212775 A BR0212775 A BR 0212775A
Authority
BR
Brazil
Prior art keywords
group
compound
hyperuricemia
therapeutic agent
pyridyl
Prior art date
Application number
BR0212775-0A
Other languages
Portuguese (pt)
Other versions
BRPI0212775B1 (en
BRPI0212775B8 (en
Inventor
Hiroshi Nakamura
Soichi Kaneda
Takahiro Sato
Naoki Ashizawa
Koji Matsumoto
Takashi Iwanaga
Tsutomu Inoue
Original Assignee
Fuji Yakuhin Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fuji Yakuhin Co Ltd filed Critical Fuji Yakuhin Co Ltd
Publication of BR0212775A publication Critical patent/BR0212775A/en
Publication of BRPI0212775B1 publication Critical patent/BRPI0212775B1/en
Publication of BRPI0212775B8 publication Critical patent/BRPI0212775B8/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/16—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"COMPOSTOS DE 1,2,4-TRIAZOL". é provido um novo composto de 1,2,4-triazol que é útil como um agente terapêutico para hiperuricemia e gota devido a hiperuricemia. Um composto é representado pela seguinte fórmula geral (1): [Substância química 6] em que R~ 2~ representa um grupo piridila não-substituído ou substituído, R~ 1~, representa um grupo piridila similar, um grupo piridina-N-óxido correspondente a estes grupos piridila, ou um grupo fenila, e R~ 3~ representa hidrogênio ou um grupo alquila inferior substituído por grupo pivaloilóxi e R~ 3~ se liga a um átomo de nitrogênio no anel. Também são promovidos um processo para a produção de um composto por reação de uma nitrila e uma hidrazida, e um agente terapêutico, particularmente um inibidor de oxidase de xantina."1,2,4-Triazole Compounds". A novel 1,2,4-triazole compound is provided which is useful as a therapeutic agent for hyperuricemia and gout due to hyperuricemia. A compound is represented by the following general formula (1): [Chemical 6] wherein R 2 - represents an unsubstituted or substituted pyridyl group, R 1 - represents a similar pyridyl group, a pyridine-N- group. oxide corresponding to these pyridyl groups, or a phenyl group, and R3 represents hydrogen or a lower alkyl group substituted by pivaloyloxy group and R3 bonds to a nitrogen atom in the ring. Also promoted is a process for the production of a compound by reaction of a nitrile and a hydrazide, and a therapeutic agent, particularly a xanthine oxidase inhibitor.

BRPI0212775A 2002-01-28 2002-12-03 composed of 1,2,4-triazole and drug BRPI0212775B8 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2002017825 2002-01-28
PCT/JP2002/012662 WO2003064410A1 (en) 2002-01-28 2002-12-03 Novel 1,2,4-triazole compound

Publications (3)

Publication Number Publication Date
BR0212775A true BR0212775A (en) 2004-10-13
BRPI0212775B1 BRPI0212775B1 (en) 2017-06-06
BRPI0212775B8 BRPI0212775B8 (en) 2021-05-25

Family

ID=27653386

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0212775A BRPI0212775B8 (en) 2002-01-28 2002-12-03 composed of 1,2,4-triazole and drug

Country Status (21)

Country Link
US (1) US7074816B2 (en)
EP (1) EP1471065B1 (en)
JP (1) JP3600832B2 (en)
CN (1) CN1561340B (en)
AR (1) AR042602A1 (en)
AT (1) ATE387438T1 (en)
AU (1) AU2002349754B2 (en)
BR (1) BRPI0212775B8 (en)
CA (1) CA2462132C (en)
DE (1) DE60225341T2 (en)
DK (1) DK1471065T3 (en)
ES (1) ES2300486T3 (en)
MX (1) MXPA04004037A (en)
NO (1) NO326941B1 (en)
NZ (1) NZ531673A (en)
PL (1) PL208260B1 (en)
PT (1) PT1471065E (en)
RU (1) RU2293733C2 (en)
TW (1) TWI257926B (en)
WO (1) WO2003064410A1 (en)
ZA (1) ZA200401777B (en)

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CN103724329B (en) * 2013-12-23 2015-02-18 济南百诺医药科技开发有限公司 Preparation method of 4-[5-(pyridyl-4-yl)-1H-[1,2,4]triazolyl-3-yl]pyridyl-2-formonitrile
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CN105315260A (en) * 2014-07-29 2016-02-10 北京海步医药科技股份有限公司 Topiroxostat monohydrate crystal form and preparation method thereof
CN105367490B (en) * 2014-08-18 2019-01-04 上海医药工业研究院 Synthesis support his new intermediate and preparation method thereof of pyrrole department
CN105348264B (en) * 2014-08-18 2018-01-16 上海医药工业研究院 A kind of his synthetic method of support pyrrole department
CN104151297B (en) * 2014-08-27 2016-03-16 王庆本 The preparation method of 4-[5-(pyridin-4-yl)-1H-[1,2,4] triazole-3-base] pyridine-2-formonitrile HCN
WO2016133069A1 (en) * 2015-02-17 2016-08-25 株式会社 三和化学研究所 Drug for preventing or treating cardiac failure
CN107427517B (en) 2015-02-24 2021-11-16 国立大学法人鸟取大学 Medicine for preventing and/or treating dementia
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CN105693699B (en) * 2015-03-30 2019-06-18 苏州晶云药物科技股份有限公司 Hold in the palm his crystal form and preparation method thereof of pyrrole department
CN104910068B (en) * 2015-04-24 2017-07-14 南京医科大学 A kind of synthetic method of the tosilate of 2 cyano group isonicotinic acid hydrazide 1.5
CN106279111A (en) * 2015-05-12 2017-01-04 北京济美堂医药研究有限公司 His new method of a kind of refined torr pyrrole department
CN104961730B (en) * 2015-06-18 2017-05-17 山东金城医药化工股份有限公司 Novel topiroxostat crystal form and method for preparing same
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CN105294656A (en) * 2015-10-10 2016-02-03 大道隆达（北京）医药科技发展有限公司 Preparation process and method for topiroxostat
CN106336399A (en) * 2015-11-03 2017-01-18 江苏悦兴药业有限公司 Preparation method of Topiroxostat process impurity
CN105294584A (en) * 2015-11-30 2016-02-03 中国医科大学 1-substituted phenyl-1H-1,2,3-triazole compound as well as preparation method and application thereof
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CN108250183A (en) * 2016-12-29 2018-07-06 北京诚济制药有限公司 A kind of preparation method of the Topiroxostat of high-purity
CN109721586B (en) * 2017-10-27 2021-03-02 中国医科大学 A kind of 5-benzyl-3-pyridyl-1H-1,2,4-triazole compound and its preparation method and use
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Also Published As

Publication number Publication date
NZ531673A (en) 2006-06-30
JP3600832B2 (en) 2004-12-15
ZA200401777B (en) 2005-08-31
BRPI0212775B1 (en) 2017-06-06
NO326941B1 (en) 2009-03-16
ATE387438T1 (en) 2008-03-15
DK1471065T3 (en) 2008-03-25
PL368672A1 (en) 2005-04-04
PL208260B1 (en) 2011-04-29
AR042602A1 (en) 2005-06-29
AU2002349754B2 (en) 2008-01-31
WO2003064410A1 (en) 2003-08-07
PT1471065E (en) 2008-03-13
DE60225341T2 (en) 2009-04-09
US7074816B2 (en) 2006-07-11
CA2462132A1 (en) 2003-08-07
JPWO2003064410A1 (en) 2005-05-26
CN1561340A (en) 2005-01-05
EP1471065A4 (en) 2005-06-15
CN1561340B (en) 2012-05-23
US20050004175A1 (en) 2005-01-06
BRPI0212775B8 (en) 2021-05-25
EP1471065B1 (en) 2008-02-27
TWI257926B (en) 2006-07-11
DE60225341D1 (en) 2008-04-10
ES2300486T3 (en) 2008-06-16
HK1067132A1 (en) 2005-04-01
RU2004106554A (en) 2005-07-27
TW200302222A (en) 2003-08-01
CA2462132C (en) 2010-08-10
NO20041075L (en) 2004-03-15
MXPA04004037A (en) 2004-07-23
RU2293733C2 (en) 2007-02-20
EP1471065A1 (en) 2004-10-27

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Legal Events

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B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B12B Appeal against refusal [chapter 12.2 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]
B16C Correction of notification of the grant [chapter 16.3 patent gazette]

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