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BR0210026A - Dry Powder Inhalers Disintegration Method and Method - Google Patents

Dry Powder Inhalers Disintegration Method and Method

Info

Publication number
BR0210026A
BR0210026A BR0210026-6A BR0210026A BR0210026A BR 0210026 A BR0210026 A BR 0210026A BR 0210026 A BR0210026 A BR 0210026A BR 0210026 A BR0210026 A BR 0210026A
Authority
BR
Brazil
Prior art keywords
chamber
air
circulation
disintegration
passageway
Prior art date
Application number
BR0210026-6A
Other languages
Portuguese (pt)
Inventor
Anne Haaije De Boer
Henderik Willem Frijlink
Doetie GJALTEMA
Joachim Goede
Paul Hagedoorn
Original Assignee
Sofotec Gmbh & Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sofotec Gmbh & Co Kg filed Critical Sofotec Gmbh & Co Kg
Publication of BR0210026A publication Critical patent/BR0210026A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0086—Inhalation chambers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/001—Particle size control
    • A61M11/002—Particle size control by flow deviation causing inertial separation of transported particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2206/00—Characteristics of a physical parameter; associated device therefor
    • A61M2206/10—Flow characteristics
    • A61M2206/16—Rotating swirling helical flow, e.g. by tangential inflows

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Detergent Compositions (AREA)

Abstract

"SISTEMA E MéTODO DE DESINTEGRAçãO DE FORMULAçãO EM Pó PARA INALADORES DE Pó SECO". A presente invenção refere-se a um mecanismo de desintegração para inaladores de pó seco, cujo propósito é o aumento da eficácia da aplicação de formulações médias em pó. O referido mecanismo compreende uma câmara de circulação de ar substancialmente cilíndrica (3) com uma altura sendo menor do que o seu diâmetro e pelo menos dois canais de suprimento de ar (2, 9), que entram na câmara (3) como tangentes a sua parede cilíndrica (5) em lados geralmente opostos dessa parede (5), adequados para criar um padrão circular de fluxo de ar no interior da câmara (3), ambos os canais de ar (2, 9) tendo entradas diferentes ou, alternativamente, compartilhando a mesma entrada, que é dividida, de modo a ter uma passagem (2) para atravessar a região de medição de dose ou de fornecimento de dose do inalador, para permitir a quantidade de pó de uma dose única arrastada para a câmara de circulação (3) pela circulação de ar através dessa passagem (2) e a outra passagem para servir como um canal de desvio (9) em direção à câmara de circulação (3) adequada para acelerar as partículas e criar um padrão de fluxo mais simétrico no interior do referido conduto de ar (3) e um método."DUST FORMULATION DISINTEGRATION SYSTEM AND METHOD FOR DRY DUST INHALERS". The present invention relates to a disintegration mechanism for dry powder inhalers, the purpose of which is to increase the effectiveness of the application of medium powder formulations. Said mechanism comprises a substantially cylindrical air circulation chamber (3) with a height being less than its diameter and at least two air supply channels (2, 9), which enter the chamber (3) as tangents to its cylindrical wall (5) on generally opposite sides of that wall (5), suitable for creating a circular air flow pattern within the chamber (3), both air channels (2, 9) having different inlets or alternatively , sharing the same inlet, which is divided so as to have a passage (2) for traversing the dose metering or dose delivery region of the inhaler, to allow the amount of single dose powder to be drawn into the chamber. circulation (3) by air circulation through this passageway (2) and the other passageway to serve as a bypass channel (9) towards the circulation chamber (3) suitable for accelerating the particles and creating a more symmetrical flow pattern inside the meal fast air duct (3) is a method.

BR0210026-6A 2001-06-22 2002-06-15 Dry Powder Inhalers Disintegration Method and Method BR0210026A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10129703A DE10129703A1 (en) 2001-06-22 2001-06-22 Atomizing system for a powder mixture and method for dry powder inhalers
PCT/EP2002/006610 WO2003000325A1 (en) 2001-06-22 2002-06-15 Powder formulation disintegrating system and method for dry powder

Publications (1)

Publication Number Publication Date
BR0210026A true BR0210026A (en) 2004-04-13

Family

ID=7688810

Family Applications (2)

Application Number Title Priority Date Filing Date
BRPI0210026A BRPI0210026B8 (en) 2001-06-22 2002-06-15 powder formulation disintegration system for dry powder inhalers and inhaler
BR0210026-6A BR0210026A (en) 2001-06-22 2002-06-15 Dry Powder Inhalers Disintegration Method and Method

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BRPI0210026A BRPI0210026B8 (en) 2001-06-22 2002-06-15 powder formulation disintegration system for dry powder inhalers and inhaler

Country Status (30)

Country Link
EP (1) EP1397174B1 (en)
JP (1) JP4116537B2 (en)
KR (1) KR100904955B1 (en)
CN (1) CN100337699C (en)
AR (1) AR034616A1 (en)
AT (1) ATE477826T1 (en)
AU (1) AU2009200071B2 (en)
BG (1) BG66589B1 (en)
BR (2) BRPI0210026B8 (en)
CA (1) CA2445892C (en)
CY (1) CY1110924T1 (en)
CZ (1) CZ302528B6 (en)
DE (2) DE10129703A1 (en)
DK (1) DK1397174T3 (en)
ES (1) ES2350973T3 (en)
HR (1) HRP20040058B1 (en)
HU (1) HU227457B1 (en)
IL (3) IL158614A0 (en)
MX (1) MXPA03011550A (en)
NO (1) NO332992B1 (en)
NZ (1) NZ530308A (en)
PL (1) PL204900B1 (en)
PT (1) PT1397174E (en)
RU (1) RU2291717C2 (en)
SI (1) SI1397174T1 (en)
SK (1) SK288034B6 (en)
TW (1) TW567075B (en)
UA (1) UA74648C2 (en)
WO (1) WO2003000325A1 (en)
ZA (1) ZA200308555B (en)

Families Citing this family (111)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2165768B1 (en) 1999-07-14 2003-04-01 Almirall Prodesfarma Sa NEW DERIVATIVES OF QUINUCLIDINE AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM.
EP1488819A1 (en) 2003-06-16 2004-12-22 Rijksuniversiteit te Groningen Dry powder inhaler and method for pulmonary inhalation of dry powder
RU2258539C1 (en) * 2004-03-23 2005-08-20 Чучалин Александр Григорьевич Powder inhaler
ES2265276B1 (en) 2005-05-20 2008-02-01 Laboratorios Almirall S.A. DERIVATIVES OF 4- (2-AMINO-1-HYDROXYETHYL) Phenol as agonists of the BETA2 ADRENERGIC RECEIVER.
DE102005046645B3 (en) * 2005-09-29 2006-07-20 Braunform Gmbh Medical powder inhaler has at least two reservoir containers from which different powders can be separately forwarded into a metering unit so that they are mixed together when traveling along an inhalation tube
DE102005046644B3 (en) * 2005-09-29 2006-07-20 Braunform Gmbh Improved powder inhaler comprises spiral baffle mounted longitudinally in channel in its casing, over which air entering through the inlet flows, so that turbulence is produced
DE102006007495A1 (en) * 2006-02-17 2007-08-23 Siegfried Generics International Ag Dispersion unit e.g. for medical powder inhalator and aerosol dispersion, uses annular guide chamber to direct entering powder flow in mainly radial direction
EP2004258A1 (en) * 2006-04-13 2008-12-24 Boehringer Ingelheim Microparts Gmbh Dispensing device
ES2319596B1 (en) 2006-12-22 2010-02-08 Laboratorios Almirall S.A. NEW DERIVATIVES OF THE AMINO-NICOTINIC AND AMINO-ISONICOTINIC ACIDS.
ES2320955B1 (en) 2007-03-02 2010-03-16 Laboratorios Almirall S.A. NEW DERIVATIVES OF 3 - ((1,2,4) TRIAZOLO (4,3-A) PIRIDIN-7-IL) BENZAMIDA.
ES2569359T3 (en) * 2007-07-06 2016-05-10 Vectura Delivery Devices Limited Inhaler
EP2020249A1 (en) 2007-08-01 2009-02-04 Boehringer Ingelheim Pharma GmbH & Co. KG Inhalator
UY31272A1 (en) 2007-08-10 2009-01-30 Almirall Lab NEW DERIVATIVES OF AZABIFENILAMINOBENZOIC ACID
DE102007041720A1 (en) * 2007-09-04 2009-03-05 Alfred Von Schuckmann Device for administering a blister-packed medicament
US8439033B2 (en) * 2007-10-09 2013-05-14 Microdose Therapeutx, Inc. Inhalation device
CA2709071C (en) 2007-12-14 2016-11-15 Labogroup S.A.S. Delivering aerosolizable food products
EP2082764A1 (en) 2008-01-24 2009-07-29 Boehringer Ingelheim International GmbH Inhaler
EP2082769B1 (en) 2008-01-24 2015-06-03 Vectura Delivery Devices Limited Inhaler
EP2100598A1 (en) 2008-03-13 2009-09-16 Laboratorios Almirall, S.A. Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease
EP2100599A1 (en) 2008-03-13 2009-09-16 Laboratorios Almirall, S.A. Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease
EP2108641A1 (en) 2008-04-11 2009-10-14 Laboratorios Almirall, S.A. New substituted spiro[cycloalkyl-1,3'-indo]-2'(1'H)-one derivatives and their use as p38 mitogen-activated kinase inhibitors
EP2113503A1 (en) 2008-04-28 2009-11-04 Laboratorios Almirall, S.A. New substituted indolin-2-one derivatives and their use as p39 mitogen-activated kinase inhibitors
UA99656C2 (en) * 2008-05-23 2012-09-10 Оцука Фармасьютикал Ко., Лтд. Powder inhaler
EP2135610A1 (en) 2008-06-20 2009-12-23 Laboratorios Almirall, S.A. Combination comprising DHODH inhibitors and methotrexate
EP2177521A1 (en) 2008-10-14 2010-04-21 Almirall, S.A. New 2-Amidothiadiazole Derivatives
EP2196465A1 (en) 2008-12-15 2010-06-16 Almirall, S.A. (3-oxo)pyridazin-4-ylurea derivatives as PDE4 inhibitors
UY32297A (en) 2008-12-22 2010-05-31 Almirall Sa MESILATE SALT OF 5- (2 - {[6- (2,2-DIFLUORO-2-PHENYLITOXI) HEXIL] AMINO} -1-HYDROXYETHYL) -8-HYDROXYCHINOLIN-2 (1H) -ONA AS A RECEIVER AGONIST B (BETA ) 2 ACRENERGIC
EP2202232A1 (en) 2008-12-26 2010-06-30 Laboratorios Almirall, S.A. 1,2,4-oxadiazole derivatives and their therapeutic use
EP2210890A1 (en) 2009-01-19 2010-07-28 Almirall, S.A. Oxadiazole derivatives as S1P1 receptor agonists
EP2210615A1 (en) 2009-01-21 2010-07-28 Almirall, S.A. Combinations comprising methotrexate and DHODH inhibitors
EP2221055A1 (en) 2009-02-18 2010-08-25 Almirall, S.A. 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one for the treatment of lung function
EP2221297A1 (en) 2009-02-18 2010-08-25 Almirall, S.A. 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1-hydroxyethyl)-8-hydroxyquinolin-2(1h)-one and its use in the treatment of pulmonary diseases
EP2226323A1 (en) 2009-02-27 2010-09-08 Almirall, S.A. New tetrahydropyrazolo[3,4-c]isoquinolin-5-amine derivatives
AU2010221254B2 (en) * 2009-03-04 2014-04-03 Mannkind Corporation An improved dry powder drug delivery system
EP2228368A1 (en) 2009-03-12 2010-09-15 Almirall, S.A. Process for manufacturing 5-(2-{[6-(2,2-difluoro-2-phenylethoxy) hexyl]amino}-1-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one
EP2239256A1 (en) 2009-03-13 2010-10-13 Almirall, S.A. Sodium salt of 5-cyclopropyl-2-{[2-(2,6-difluorophenyl)pyrimidin-5-yl]amino}benzoic acid as DHODH inhibitor
EP2305660A1 (en) 2009-09-25 2011-04-06 Almirall, S.A. New thiadiazole derivatives
EP2314577A1 (en) 2009-10-16 2011-04-27 Almirall, S.A. Process for manufacturing 2-[(3,5-difluoro-3'-methoxy-1,1'-biphenyl-4-yl)amino]nicotinic acid
GB0919465D0 (en) * 2009-11-06 2009-12-23 Norton Healthcare Ltd Airflow adaptor for a breath-actuated dry powder inhaler
EP2322176A1 (en) 2009-11-11 2011-05-18 Almirall, S.A. New 7-phenyl-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one derivatives
WO2011059953A1 (en) * 2009-11-13 2011-05-19 Schering Corporation Drug products, dry powder inhalers and polyflux collider arrangements
EP2343287A1 (en) 2009-12-10 2011-07-13 Almirall, S.A. New 2-aminothiadiazole derivatives
EP2338888A1 (en) 2009-12-24 2011-06-29 Almirall, S.A. Imidazopyridine derivatives as JAK inhibitors
UY33213A (en) 2010-02-18 2011-09-30 Almirall Sa PIRAZOL DERIVATIVES AS JAK INHIBITORS
EP2360158A1 (en) 2010-02-18 2011-08-24 Almirall, S.A. Pyrazole derivatives as jak inhibitors
EP2366702A1 (en) 2010-03-18 2011-09-21 Almirall, S.A. New oxadiazole derivatives
EP2380890A1 (en) 2010-04-23 2011-10-26 Almirall, S.A. New 7,8-dihydro-1,6-naphthyridin-5(6h)-one-derivatives as PDE4 inhibitors
EP2386555A1 (en) 2010-05-13 2011-11-16 Almirall, S.A. New cyclohexylamine derivatives having beta2 adrenergic agonist and m3 muscarinic antagonist activities
EP2390252A1 (en) 2010-05-19 2011-11-30 Almirall, S.A. New pyrazole derivatives
EP2394998A1 (en) 2010-05-31 2011-12-14 Almirall, S.A. 3-(5-Amino-6-oxo-1,6-dihydropyridazin-3-yl)-biphenyl derivatives as PDE4 inhibitors
EP2397482A1 (en) 2010-06-15 2011-12-21 Almirall, S.A. Heteroaryl imidazolone derivatives as jak inhibitors
EP2441755A1 (en) 2010-09-30 2012-04-18 Almirall, S.A. Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors
EP2455080A1 (en) 2010-11-23 2012-05-23 Almirall, S.A. S1P1 receptor agonists for use in the treatment of multiple sclerosis
EP2455081A1 (en) 2010-11-23 2012-05-23 Almirall, S.A. S1P1 receptor agonists for use in the treatment of crohn's disease
EP2457900A1 (en) 2010-11-25 2012-05-30 Almirall, S.A. New pyrazole derivatives having CRTh2 antagonistic behaviour
EP2463289A1 (en) 2010-11-26 2012-06-13 Almirall, S.A. Imidazo[1,2-b]pyridazine derivatives as JAK inhibitors
US8974450B2 (en) 2011-02-03 2015-03-10 Covidien Lp System and method for ablation procedure monitoring using electrodes
EP2489663A1 (en) 2011-02-16 2012-08-22 Almirall, S.A. Compounds as syk kinase inhibitors
EP2510928A1 (en) 2011-04-15 2012-10-17 Almirall, S.A. Aclidinium for use in improving the quality of sleep in respiratory patients
EP2518070A1 (en) 2011-04-29 2012-10-31 Almirall, S.A. Pyrrolotriazinone derivatives as PI3K inhibitors
EP2518071A1 (en) 2011-04-29 2012-10-31 Almirall, S.A. Imidazopyridine derivatives as PI3K inhibitors
EP2527344A1 (en) 2011-05-25 2012-11-28 Almirall, S.A. Pyridin-2(1H)-one derivatives useful as medicaments for the treatment of myeloproliferative disorders, transplant rejection, immune-mediated and inflammatory diseases
EP2526945A1 (en) 2011-05-25 2012-11-28 Almirall, S.A. New CRTH2 Antagonists
EP2548863A1 (en) 2011-07-18 2013-01-23 Almirall, S.A. New CRTh2 antagonists.
EP2548876A1 (en) 2011-07-18 2013-01-23 Almirall, S.A. New CRTh2 antagonists
EP2554544A1 (en) 2011-08-01 2013-02-06 Almirall, S.A. Pyridin-2(1h)-one derivatives as jak inhibitors
WO2013036881A2 (en) 2011-09-07 2013-03-14 Syphase, Llc Dry powder inhalation device
EP2578570A1 (en) 2011-10-07 2013-04-10 Almirall, S.A. Novel process for preparing 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1(r)-hydroxyethyl)-8-hydroxyquinolin-2(1h)-one via novel intermediates of synthesis.
EP2592078A1 (en) 2011-11-11 2013-05-15 Almirall, S.A. New cyclohexylamine derivatives having beta2 adrenergic agonist and M3 muscarinic antagonist activities
EP2592077A1 (en) 2011-11-11 2013-05-15 Almirall, S.A. New cyclohexylamine derivatives having beta2 adrenergic agonist and M3 muscarinic antagonist activities
EP2617449A1 (en) 2012-01-20 2013-07-24 Almirall S.A. Inhalation device for powdered drugs
EP2617450A1 (en) 2012-01-20 2013-07-24 Almirall S.A. Inhaltion device for powdered drugs
EP2617448A1 (en) * 2012-01-20 2013-07-24 Almirall S.A. Inhalation device for powdered drugs
EP2641900A1 (en) 2012-03-20 2013-09-25 Almirall, S.A. Novel polymorphic Crystal forms of 5-(2-{[6-(2,2-difluoro-2-phenylethoxy) hexyl]amino}-1-(R)-hydroxyethyl)-8-hydroxyquinolin-2(1h)-one, heminapadisylate as agonist of the ß2 adrenergic receptor.
EP2647627A1 (en) 2012-04-02 2013-10-09 Almirall, S.A. Salts of 5-[(1r)-2-({2-[4-(2,2-difluoro-2-phenylethoxy)phenyl] ethyl}amino)-1-hydroxyethyl]-8-hydroxyquinolin-2(1h)-one.
EP2666465A1 (en) 2012-05-25 2013-11-27 Almirall, S.A. Novel dosage and formulation
EP2668941A1 (en) 2012-05-31 2013-12-04 Almirall, S.A. Novel dosage form and formulation of abediterol
WO2014060431A1 (en) 2012-10-16 2014-04-24 Almirall, S.A. Pyrrolotriazinone derivatives as pi3k inhibitors
EP2738172A1 (en) 2012-11-28 2014-06-04 Almirall, S.A. New bicyclic compounds as crac channel modulators
CN104869996A (en) 2012-12-17 2015-08-26 阿尔米雷尔有限公司 New use of aclidinium
CN105142673B8 (en) 2012-12-18 2018-02-16 阿尔米雷尔有限公司 Novel cyclohexyl and quininuclidinyl carbamate derivatives with beta 2-adrenergic activator and M3 muscarinic antagonists activity
UY35332A (en) 2013-02-15 2014-11-28 Almirall Sa PIRROLOTRIAZINE DERIVATIVES AS PI3K INHIBITORS
EP2848615A1 (en) 2013-07-03 2015-03-18 Almirall, S.A. New pyrazole derivatives as CRAC channel modulators
WO2015091285A1 (en) 2013-12-19 2015-06-25 Almirall S.A. Dosage formulation comprising salmeterol and fluticasone propionate
EP2944343A1 (en) 2014-05-15 2015-11-18 AstraZeneca AB Dry powder inhaler
JP6717756B2 (en) * 2014-06-06 2020-07-01 ライクスウニフェルシテイト フローニンゲン Breath-actuated dry powder inhaler
CA2966377C (en) 2014-11-26 2018-12-04 Vectura Delivery Devices Limited Dry powder inhaler
EP3244952A4 (en) 2015-01-14 2018-11-14 Respira Therapeutics, Inc. Powder dispersion methods and devices
MA41938A (en) 2015-04-21 2018-02-28 Almirall Sa AMINO-SUBSTITUTED HETEROCYCLIC DERIVATIVES USED AS SODIUM CHANNEL INHIBITORS
WO2016202800A1 (en) 2015-06-16 2016-12-22 Almirall, S.A. Pyrrolotriazinone derivatives as pi3k inhibitors
WO2017076990A1 (en) 2015-11-05 2017-05-11 Almirall, S.A. Addition salts of n-[4-(4-{[(1s)-1-(5-methyl-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl]amino}-7h-pyrrolo[2,3-d]pyrimidin-5-yl)-1h-indol-6-yl]sulfamide
RU2634258C1 (en) * 2016-11-08 2017-10-24 федеральное государственное автономное образовательное учреждение высшего образования "Российский университет дружбы народов" (РУДН) Filler for capsular inhaler
CN109922851B (en) * 2016-11-30 2022-05-27 菲利普莫里斯生产公司 Inhaler with sized cavity
WO2018183528A1 (en) 2017-03-28 2018-10-04 Concentrx Pharmaceuticals, Inc. Devices and methods for delivering dry powder medicaments
CN107123354B (en) * 2017-05-21 2019-03-19 谭淞文 Sort inhalator, respiratory tract and the lung model integration of equipments of flower-shape particulate carrier
TW201919682A (en) 2017-08-08 2019-06-01 西班牙商阿爾米雷爾有限公司 Novel compounds activating the Nrf2 pathway
EP3755167B1 (en) * 2018-02-19 2022-10-19 Philip Morris Products S.A. Dry powder inhaler
CN110201278B (en) * 2018-02-28 2021-07-30 张江 Medicine box for inhalation administration and inhalation administration combined structure
CN110201281B (en) * 2018-02-28 2021-08-06 张江 Inhalation administration device and inhalation administration combination structure
CN110201280B (en) * 2018-02-28 2021-07-30 张江 Suction nozzle for an inhalation device and inhalation device
CN110201279B (en) * 2018-02-28 2021-05-11 张江 Medicine box for inhalation administration and inhalation administration combined structure
CN111514418B (en) * 2019-06-12 2022-01-14 中南大学湘雅二医院 Self-suction nasal powder material feeding device
CN111359060A (en) * 2020-02-20 2020-07-03 深圳麦克韦尔科技有限公司 Atomizing suction nozzle and atomizing device
US12117379B2 (en) * 2020-05-15 2024-10-15 Horiba, Ltd. Sample dispersing device and sample dispersing method
CN112030136B (en) * 2020-09-01 2024-12-27 江苏微导纳米科技股份有限公司 Coating chamber and powder coating device
CN113750331B (en) * 2021-08-18 2022-08-16 华中科技大学 Dry powder inhaler
CN114632235B (en) * 2022-03-04 2023-04-25 华中科技大学 Dry powder inhaler
CN115006656A (en) * 2022-05-18 2022-09-06 苏州易合医药有限公司 A drug delivery device capable of continuously providing pulmonary active agent powder spray
CN117547693B (en) * 2023-12-20 2025-08-01 上海新黄河制药有限公司 Runner suitable for two storehouse powder aerosol devices
CN118575973B (en) * 2024-06-27 2025-11-21 黑龙江飞鹤乳业有限公司 Method for preparing compressed food powder and method for preparing compressed food
CN118592629B (en) * 2024-07-01 2026-01-02 广西瀛开科技有限公司 A nut shell separation device

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1478138A (en) * 1973-07-18 1977-06-29 Beecham Group Ltd Device for the administration of powders
IT7920688U1 (en) 1979-02-05 1980-08-05 Chiesi Paolo Inhaler for powdered medicinal substances, with combined dosing function
ATE23272T1 (en) 1981-07-08 1986-11-15 Draco Ab POWDER INHALER.
US4570630A (en) 1983-08-03 1986-02-18 Miles Laboratories, Inc. Medicament inhalation device
DE3927170A1 (en) 1989-08-17 1991-02-21 Boehringer Ingelheim Kg INHALATOR
IT1237118B (en) 1989-10-27 1993-05-18 Miat Spa MULTI-DOSE INHALER FOR POWDER DRUGS.
IL111254A (en) * 1990-06-14 1998-10-30 Rhone Poulenc Rorer Ltd Powder inhalers
WO1992003175A1 (en) 1990-08-11 1992-03-05 Fisons Plc Inhalation device
US5492112A (en) * 1991-05-20 1996-02-20 Dura Pharmaceuticals, Inc. Dry powder inhaler
DE4211475A1 (en) * 1991-12-14 1993-06-17 Asta Medica Ag POWDER INHALATOR
DE4239402A1 (en) * 1992-11-24 1994-05-26 Bayer Ag Multiple dosage powder inhaler - has acceleration channel and dwell chamber for uniformly high drug dispersion
WO1994014492A2 (en) 1992-12-18 1994-07-07 Schering Corporation Inhaler for powdered medications
EP0776253B1 (en) * 1994-10-04 2000-11-15 The Procter & Gamble Company Electrostatic spraying of particulate material
DE19522416C2 (en) * 1995-06-21 2003-11-20 Sofotec Gmbh & Co Kg Device for dispersing powder in an air stream for use with powder inhalers
ATE209518T1 (en) * 1995-06-21 2001-12-15 Asta Medica Ag MEDICINAL POWDER CARTRIDGE WITH INTEGRATED DOSING DEVICE AND POWDER INHALER
FR2738153B1 (en) * 1995-09-04 1998-01-02 Valois INHALATION APPARATUS FOR DELIVERING PRECISE AND REPRODUCIBLE DOSES OF POWDERY PRODUCT
EP1129705A1 (en) * 2000-02-17 2001-09-05 Rijksuniversiteit te Groningen Powder formulation for inhalation

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EP1397174B1 (en) 2010-08-18
IL158614A0 (en) 2004-05-12
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