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BR0210060A - Heterobicycles fkbp ligands - Google Patents

Heterobicycles fkbp ligands

Info

Publication number
BR0210060A
BR0210060A BR0210060-6A BR0210060A BR0210060A BR 0210060 A BR0210060 A BR 0210060A BR 0210060 A BR0210060 A BR 0210060A BR 0210060 A BR0210060 A BR 0210060A
Authority
BR
Brazil
Prior art keywords
fkbp
heterobicycles
fkbp ligands
ligands
heterobicyc
Prior art date
Application number
BR0210060-6A
Other languages
Portuguese (pt)
Inventor
Xinjun Hou
Nancy Sue Barta
Raymond Andrew Hudack
Liming Dong
Chuangxing Guo
Judith Gail Deal
Steven Lee Bender
Christopher Franklin Bigge
Lorraine Kathleen Fay
Corinne E Augelli-Szafran
Bradley William Caprathe
Arindam Chatterjee
Original Assignee
Agouron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agouron Pharma filed Critical Agouron Pharma
Publication of BR0210060A publication Critical patent/BR0210060A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

"LIGANDOS DE FKBP DE HETEROBICICLOS". Derivados de diazabiciclo[3.3.1]nonano que inibem a atividade de enzima de isomerase de peptidil-prolila associada com as proteínas de ligação de FK-506 (FKBP) são descritos para tratar distúrbios neurológicos. São também descritos compostos úteis para a preparação de tais inibidores."HETEROBICYC FKBP LINKS". Diazabicyclo [3.3.1] nonane derivatives that inhibit peptidyl prolyl isomerase enzyme activity associated with FK-506 binding proteins (FKBP) are described to treat neurological disorders. Also useful compounds for the preparation of such inhibitors are described.

BR0210060-6A 2001-05-10 2002-05-10 Heterobicycles fkbp ligands BR0210060A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28982801P 2001-05-10 2001-05-10
PCT/US2002/014966 WO2002089806A1 (en) 2001-05-10 2002-05-10 Heterobicycles fkbp-ligands

Publications (1)

Publication Number Publication Date
BR0210060A true BR0210060A (en) 2004-08-17

Family

ID=23113278

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0210060-6A BR0210060A (en) 2001-05-10 2002-05-10 Heterobicycles fkbp ligands

Country Status (6)

Country Link
EP (1) EP1423119A4 (en)
JP (1) JP2004532854A (en)
BR (1) BR0210060A (en)
CA (1) CA2446795A1 (en)
MX (1) MXPA03010255A (en)
WO (1) WO2002089806A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009504773A (en) * 2005-08-19 2009-02-05 エラン ファーマシューティカルズ，インコーポレイテッド Bridged N-bicyclic sulfonamide inhibitors of gamma secretase
EP2690102A1 (en) * 2012-07-24 2014-01-29 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Bicyclic aza-amides for treatment of psychiatric disorders
US9914732B2 (en) * 2014-01-24 2018-03-13 Max-Planck-Gesellschaft Zur Forderung Der Wissensc Haften E.V. Diazabicyclo[4.3.1]decane derivatives for treatment of psychiatric disorders
EP2899192A1 (en) * 2014-01-24 2015-07-29 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Diazabicyclo[4.3.1]decane derivatives for treatment of psychiatric disorders
WO2016030306A1 (en) * 2014-08-27 2016-03-03 F. Hoffmann-La Roche Ag Substituted pyrazino[2,1-a]isoquinoline derivatives for the treatment of cns disorders
US10597378B2 (en) 2017-09-08 2020-03-24 National Health Research Institutes Tetrahydroisoquinolines for use as MOR/NOP dual agonists

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3880927A (en) * 1972-06-19 1975-04-29 Lilly Co Eli {62 -Phenyl-{62 ,{62 -difluoroethylamines
BR9912423A (en) * 1998-07-17 2001-06-05 Agouron Pharmaceticals Inc Pharmaceutically acceptable compounds and / or derivatives, pharmaceutical compositions, methods of treating neurological disorders in patients and processes for preparing pharmaceutically acceptable compounds or derivatives
US6818643B1 (en) * 1999-12-08 2004-11-16 Bristol-Myers Squibb Company Neurotrophic bicyclic diamides
CA2423789A1 (en) * 2000-10-19 2002-04-25 Pfizer Products Inc. Bridged piperazine derivatives
JP2004518688A (en) * 2001-01-30 2004-06-24 ブリストル−マイヤーズ　スクイブ　カンパニー Factor Xa inhibitor sulfonamide lactam and method thereof

Also Published As

Publication number Publication date
MXPA03010255A (en) 2005-03-07
CA2446795A1 (en) 2002-11-14
EP1423119A4 (en) 2005-04-13
EP1423119A1 (en) 2004-06-02
JP2004532854A (en) 2004-10-28
WO2002089806A1 (en) 2002-11-14

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Legal Events

Date Code Title Description
B08F Application fees: dismissal - article 86 of industrial property law

Free format text: REFERENTE 7A., E 8A., ANUIDADES.

B08K Lapse as no evidence of payment of the annual fee has been furnished to inpi (acc. art. 87)

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2060 DE 29/06/2010.