BR0209738A - Método para produzir microorganismos não virulentos a partir de microoganismos patogênicos através de modificação genética permanente de suas membranas biológicas para produção de vacinas - Google Patents
Método para produzir microorganismos não virulentos a partir de microoganismos patogênicos através de modificação genética permanente de suas membranas biológicas para produção de vacinasInfo
- Publication number
- BR0209738A BR0209738A BR0209738-9A BR0209738A BR0209738A BR 0209738 A BR0209738 A BR 0209738A BR 0209738 A BR0209738 A BR 0209738A BR 0209738 A BR0209738 A BR 0209738A
- Authority
- BR
- Brazil
- Prior art keywords
- microorganisms
- virulent
- genetic modification
- vaccine production
- permanent genetic
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 4
- 244000005700 microbiome Species 0.000 title abstract 4
- 238000012239 gene modification Methods 0.000 title abstract 3
- 230000005017 genetic modification Effects 0.000 title abstract 3
- 235000013617 genetically modified food Nutrition 0.000 title abstract 3
- 239000012528 membrane Substances 0.000 title abstract 3
- 244000000010 microbial pathogen Species 0.000 title abstract 3
- 229960005486 vaccine Drugs 0.000 title abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 5
- 238000000034 method Methods 0.000 abstract 3
- 102000004169 proteins and genes Human genes 0.000 abstract 3
- 230000033228 biological regulation Effects 0.000 abstract 2
- 208000015181 infectious disease Diseases 0.000 abstract 2
- 241000206602 Eukaryota Species 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 238000009825 accumulation Methods 0.000 abstract 1
- 230000002238 attenuated effect Effects 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 210000005260 human cell Anatomy 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 230000004048 modification Effects 0.000 abstract 1
- 238000012986 modification Methods 0.000 abstract 1
- 244000052769 pathogen Species 0.000 abstract 1
- 230000035939 shock Effects 0.000 abstract 1
- 230000019491 signal transduction Effects 0.000 abstract 1
- 241000894007 species Species 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
- C12N9/0083—Miscellaneous (1.14.99)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Veterinary Medicine (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
"MéTODO PARA GERAR MICROORGANISMOS NãO VIRULENTOS A PARTIR DE MICROORGANISMOS PATOGêNICOS ATRAVéS DE MODIFICAçãO GENéTICA PERMANENTE DE SUAS MEMBRANAS BIOLóGICAS PARA PRODUçãO DE VACINAS". Aqui nós descrevemos uma metodologia para gerar microorganismos não virulentos a partir de microorganismos patogênicos através de modificação genética permanente do estado físico de suas membranas (MPS) . Então, no início da infecção, nesses organismos transformados, como eles infectam um hospedeiro, por exemplo, uma célula alvo de um eucariote superior, particularmente mamíferos, e mais especificamente células humanas, ou injetando-os em um modelo de infecção animal, a expressão dos genes de choque térmico (estresse) e acúmulo das proteínas codificadas (proteínas estressadas ou HSPS) e de outros produtos genes espécie-específico, a regulagem é alterada como uma conseq³ência da modificação do MPS. Dentre outros, nós nos referimos também a genes cuja regulagem é mediada pelos meios de transdução de sinal. Portanto, como um resultado deste procedimento, patógenos tornaram-se não virulentos (atenuados, microorganismos vivos) que podem ser usados para produção de vacina.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2001RM000295A ITRM20010295A1 (it) | 2001-05-30 | 2001-05-30 | Metodo per ottenere microrganismi patogeni non virulenti attraverso una modificazione dello stato fisico e/o dinamico delle loro membrane bi |
| PCT/EP2002/005893 WO2002097081A2 (en) | 2001-05-30 | 2002-05-29 | Method to generate non virulent microorganisms from pathogenic ones trough permanent genetic modification of their biological membrane for vaccine production |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0209738A true BR0209738A (pt) | 2004-07-27 |
Family
ID=11455559
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0209738-9A BR0209738A (pt) | 2001-05-30 | 2002-05-29 | Método para produzir microorganismos não virulentos a partir de microoganismos patogênicos através de modificação genética permanente de suas membranas biológicas para produção de vacinas |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20050158277A1 (pt) |
| EP (1) | EP1409665A2 (pt) |
| JP (1) | JP2004535184A (pt) |
| CN (1) | CN1516735A (pt) |
| AP (1) | AP2003002944A0 (pt) |
| AU (1) | AU2002344183A1 (pt) |
| BR (1) | BR0209738A (pt) |
| CA (1) | CA2449014A1 (pt) |
| IT (1) | ITRM20010295A1 (pt) |
| MX (1) | MXPA03010910A (pt) |
| OA (1) | OA13301A (pt) |
| WO (1) | WO2002097081A2 (pt) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016118512A1 (en) | 2015-01-19 | 2016-07-28 | Kansas State University Research Foundation | Attenuated vaccines to protect against tick-borne ehrlichia species infections |
| CN110699312B (zh) * | 2019-11-28 | 2022-08-12 | 西北农林科技大学 | 一种猪种布鲁氏菌bi-1基因缺失菌株及其构建方法和应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9007194D0 (en) * | 1990-03-30 | 1990-05-30 | Wellcome Found | Live vaccines |
| EP1150711A1 (en) * | 1999-02-02 | 2001-11-07 | The Regents Of The University Of California | Compositions and methods for treating and preventing pathogenic bacterial infection based on the essential role of dna methylation in bacterial virulence |
| WO2001030384A1 (en) * | 1999-10-22 | 2001-05-03 | Advanced Microbial Solutions Corporation | Vaccine compositions |
-
2001
- 2001-05-30 IT IT2001RM000295A patent/ITRM20010295A1/it unknown
-
2002
- 2002-05-29 CN CNA028108647A patent/CN1516735A/zh active Pending
- 2002-05-29 OA OA1200400055A patent/OA13301A/en unknown
- 2002-05-29 US US10/479,653 patent/US20050158277A1/en not_active Abandoned
- 2002-05-29 AU AU2002344183A patent/AU2002344183A1/en not_active Abandoned
- 2002-05-29 WO PCT/EP2002/005893 patent/WO2002097081A2/en not_active Ceased
- 2002-05-29 CA CA002449014A patent/CA2449014A1/en not_active Abandoned
- 2002-05-29 AP APAP/P/2003/002944A patent/AP2003002944A0/en unknown
- 2002-05-29 BR BR0209738-9A patent/BR0209738A/pt not_active IP Right Cessation
- 2002-05-29 EP EP02743126A patent/EP1409665A2/en not_active Withdrawn
- 2002-05-29 JP JP2003500248A patent/JP2004535184A/ja active Pending
- 2002-05-29 MX MXPA03010910A patent/MXPA03010910A/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| ITRM20010295A0 (it) | 2001-05-30 |
| EP1409665A2 (en) | 2004-04-21 |
| MXPA03010910A (es) | 2004-11-22 |
| WO2002097081A3 (en) | 2003-09-25 |
| WO2002097081A2 (en) | 2002-12-05 |
| AU2002344183A1 (en) | 2002-12-09 |
| JP2004535184A (ja) | 2004-11-25 |
| ITRM20010295A1 (it) | 2002-12-02 |
| OA13301A (en) | 2007-04-13 |
| AP2003002944A0 (en) | 2003-11-29 |
| US20050158277A1 (en) | 2005-07-21 |
| CN1516735A (zh) | 2004-07-28 |
| CA2449014A1 (en) | 2002-12-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE 6A., 7A. E 8A. ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2060 DE 29/06/2010. |