BR0209594A - Inibidores de protease de hiv de amplo espectro de 2-amino-benzoxazol sulfonamida - Google Patents
Inibidores de protease de hiv de amplo espectro de 2-amino-benzoxazol sulfonamidaInfo
- Publication number
- BR0209594A BR0209594A BR0209594-7A BR0209594A BR0209594A BR 0209594 A BR0209594 A BR 0209594A BR 0209594 A BR0209594 A BR 0209594A BR 0209594 A BR0209594 A BR 0209594A
- Authority
- BR
- Brazil
- Prior art keywords
- alkyl
- protease inhibitors
- cycloalkyl
- hiv protease
- amino
- Prior art date
Links
- 239000004030 hiv protease inhibitor Substances 0.000 title abstract 3
- SDCCPSGJFZFNPB-UHFFFAOYSA-N 2-amino-3h-1,3-benzoxazole-2-sulfonamide Chemical compound C1=CC=C2OC(N)(S(N)(=O)=O)NC2=C1 SDCCPSGJFZFNPB-UHFFFAOYSA-N 0.000 title abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 4
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 238000009007 Diagnostic Kit Methods 0.000 abstract 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 229940124522 antiretrovirals Drugs 0.000 abstract 1
- 239000003903 antiretrovirus agent Substances 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 239000002207 metabolite Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000001228 spectrum Methods 0.000 abstract 1
- 125000004426 substituted alkynyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Virology (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
"INIBIDORES DE PROTEASE DE HIV DE AMPLO ESPECTRO DE 2-AMINO-BENZOXAZOL SULFONAMIDA". A presente invenção refere-se a compostos tendo a fórmula (I), seus N-óxidos, sais, formas estereoisoméricas, misturas racêmicas, pró-drogas, ésteres e metabólitos, onde R1 e R8 são, cada um H, C~ 1-6~ alquila opcionalmente substituída, C~ 2-6~ alquenila, C~ 3-7~ cicloalquila, arila, Het^ 1^, Het^ 2^; R1 também pode ser um radical de fórmula (R11 aR11b)NC(R10aR10b)CR9-; t é 0,1 ou 2; R2 é H ou C~ 1-6~ alquila; L é -C(=O)-, -O-C(=O)-, -NR8-C(=O)-, -0-C1-6-alcanodiil-C(=O)-, -NR8-C1-6 alcanodiil-C(=O)-, -S(=0)2-, -OS(=0)2-, -NR8-S(=0)2; R3 é C1-6 alquila, arila, C3-7 cicloalquila, C3-7 ciclo-alquil C1-4 alquila, ou aril C1-4 alquila; R4 é H, C1-4 alquil OC(=O), carboxila, aminoC(=O), mono- ou di(Cl-4 alquil) aminoC(=O), C3-7 cicloalquila, C2-6 alquenila, C2-6 alquinila ou C1-6 alquila opcionalmente substituída; R5 e R6 são H ou C1-6 alquila. Ela ainda refere-se a seu uso como inibidores de protease de HIV de amplo espectro, processo para sua preparação assim como composições farmacêuticas e kits diagnósticos compreendendo os mesmos. Ela também refere-se a suas combinações com outros agentes anti-retrovirais, e a seu uso em ensaios como compostos de referência ou como reagentes.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01201732 | 2001-05-11 | ||
| PCT/EP2002/005212 WO2002092595A1 (en) | 2001-05-11 | 2002-05-10 | Broadspectrum 2-amino-benzoxazole sulfonamide hiv protease inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0209594A true BR0209594A (pt) | 2004-03-30 |
Family
ID=8180286
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0209594-7A BR0209594A (pt) | 2001-05-11 | 2002-05-10 | Inibidores de protease de hiv de amplo espectro de 2-amino-benzoxazol sulfonamida |
Country Status (31)
| Country | Link |
|---|---|
| US (2) | US7622490B2 (pt) |
| EP (1) | EP1387842B1 (pt) |
| JP (1) | JP4467889B2 (pt) |
| KR (1) | KR100878853B1 (pt) |
| CN (1) | CN100549007C (pt) |
| AP (1) | AP1652A (pt) |
| AR (1) | AR035970A1 (pt) |
| AT (1) | ATE429431T1 (pt) |
| AU (1) | AU2002310818B2 (pt) |
| BG (1) | BG66350B1 (pt) |
| BR (1) | BR0209594A (pt) |
| CA (1) | CA2444895C (pt) |
| CY (1) | CY1109247T1 (pt) |
| CZ (1) | CZ304524B6 (pt) |
| DE (1) | DE60232067D1 (pt) |
| DK (1) | DK1387842T3 (pt) |
| EA (1) | EA009590B1 (pt) |
| EE (1) | EE05307B1 (pt) |
| ES (1) | ES2325809T3 (pt) |
| HR (1) | HRP20031026B1 (pt) |
| HU (1) | HUP0400438A3 (pt) |
| IL (1) | IL158093A0 (pt) |
| MX (1) | MXPA03010258A (pt) |
| NO (1) | NO326883B1 (pt) |
| NZ (1) | NZ529250A (pt) |
| OA (1) | OA13134A (pt) |
| PL (1) | PL209029B1 (pt) |
| PT (1) | PT1387842E (pt) |
| SK (1) | SK287952B6 (pt) |
| WO (1) | WO2002092595A1 (pt) |
| ZA (1) | ZA200307799B (pt) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7364752B1 (en) | 1999-11-12 | 2008-04-29 | Abbott Laboratories | Solid dispersion pharamaceutical formulations |
| CA2359945C (en) | 1999-11-12 | 2011-04-26 | Abbott Laboratories | Inhibitors of crystallization in a solid dispersion |
| DE10026698A1 (de) | 2000-05-30 | 2001-12-06 | Basf Ag | Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung |
| CA2472580A1 (en) | 2002-01-07 | 2003-07-17 | Sequoia Pharmaceuticals | Broad spectrum inhibitors |
| US7157489B2 (en) | 2002-03-12 | 2007-01-02 | The Board Of Trustees Of The University Of Illinois | HIV protease inhibitors |
| US8025899B2 (en) | 2003-08-28 | 2011-09-27 | Abbott Laboratories | Solid pharmaceutical dosage form |
| US20070123574A1 (en) * | 2003-09-30 | 2007-05-31 | De Kock Herman A | Methods for the preparation of benzoxazole sulfonamide compounds and intermediates thereof |
| US20050131042A1 (en) * | 2003-12-11 | 2005-06-16 | Flentge Charles A. | HIV protease inhibiting compounds |
| US8193227B2 (en) | 2003-12-11 | 2012-06-05 | Abbott Laboratories | HIV protease inhibiting compounds |
| JP4818124B2 (ja) | 2003-12-23 | 2011-11-16 | テイボテク・フアーマシユーチカルズ・リミテツド | （３Ｒ，３ａＳ，６ａＲ）−ヘキサヒドロフロ〔２，３−ｂ〕フラン−３−イル（１Ｓ，１Ｒ）−３−〔〔（４−アミノフェニル）スルホニル〕（イソブチル）アミノ〕−１−ベンジル−２−ヒドロキシプロピルカルバマートの製造方法 |
| DE602004021640D1 (de) | 2003-12-23 | 2009-07-30 | Tibotec Pharm Ltd | Verfahren zur herstellung von (1s,2r)-3-ää(4-aminophenyl)sulfonylü(isobutyl)aminoü-1-benzyl-2-hydroxypropylcarbamidsäure-(3r,3as,6ar)-hexahydrofuroä2,3-büfuran-3-ylester |
| AU2005244121B2 (en) * | 2004-05-07 | 2012-01-19 | Sequoia Pharmaceuticals, Inc. | Resistance-repellent retroviral protease inhibitors |
| DK1856125T3 (da) | 2005-02-25 | 2009-12-07 | Tibotec Pharm Ltd | Syntese af proteasehæmmerforstadie |
| AR053845A1 (es) * | 2005-04-15 | 2007-05-23 | Tibotec Pharm Ltd | 5-tiazolilmetil[(1s,2r)-3-[[(2-amino-6-benzoxazolil)sulfonil)](2-metilpropil)amino]-2-hidroxi-1-(fenilmetil)propil]carbamato como mejorador de farmacos metabolizados por el citocromo p450 |
| US20120220520A1 (en) * | 2006-10-17 | 2012-08-30 | Van T Klooster Gerben Albert Eleutherius | Bioavailable combinations for hcv treatment |
| WO2014194519A1 (en) | 2013-06-07 | 2014-12-11 | Merck Sharp & Dohme Corp. | Imidazole derivatives and methods of use thereof for improving pharmacokinetics of drug |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE8204879D0 (sv) | 1982-08-26 | 1982-08-26 | Haessle Ab | Novel chemical intermediates |
| ES2093073T3 (es) | 1990-03-09 | 1996-12-16 | Milliken Res Corp | Materiales organicos que tienen restos poli(oxialquilenos) enlazados por un grupo sulfonamido y su preparacion. |
| US5145684A (en) | 1991-01-25 | 1992-09-08 | Sterling Drug Inc. | Surface modified drug nanoparticles |
| ES2103488T3 (es) * | 1992-08-25 | 1997-09-16 | Searle & Co | N-(alcanoilamino-2-hidroxipropil)sulfonamidas utiles como inhibidores de proteasas retrovirales. |
| PH30929A (en) | 1992-09-03 | 1997-12-23 | Janssen Pharmaceutica Nv | Beads having a core coated with an antifungal and a polymer. |
| DK0715618T3 (da) * | 1993-08-24 | 1999-08-23 | Searle & Co | Hydroxyethylaminosulfonamider til anvendelse som inhibitorer af retrovirale proteaser |
| CN1110300C (zh) | 1993-10-01 | 2003-06-04 | 阿斯特拉公司 | 工艺技术ⅰ |
| EP0804428B1 (en) | 1995-01-20 | 2007-12-26 | G.D. Searle LLC. | Bis-sulfonamide hydroxyethylamino retroviral protease inhibitors |
| US5756533A (en) * | 1995-03-10 | 1998-05-26 | G.D. Searle & Co. | Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors |
| US6150556A (en) * | 1995-03-10 | 2000-11-21 | G. D. Dearle & Co. | Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors |
| US5705500A (en) | 1995-03-10 | 1998-01-06 | G.D. Searle & Co. | Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors |
| WO1996028465A1 (en) | 1995-03-10 | 1996-09-19 | G.D. Searle & Co. | Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors |
| AU7722296A (en) * | 1995-11-15 | 1997-06-05 | G.D. Searle & Co. | Substituted sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors |
| ATE255883T1 (de) | 1996-05-20 | 2003-12-15 | Janssen Pharmaceutica Nv | Fungizide mittel mit verbesserter bioverfügbarkeit |
| AP1227A (en) | 1997-03-26 | 2003-11-24 | Janssen Pharmaceutica Nv | Pellets having a core coated with an antifungal and a polymer. |
| GB9717849D0 (en) | 1997-08-23 | 1997-10-29 | Seal Sands Chemicals Limited | Preparation of pyridene derivatives |
| WO1999033792A2 (en) | 1997-12-24 | 1999-07-08 | Vertex Pharmaceuticals Incorporated | Prodrugs os aspartyl protease inhibitors |
| US6436989B1 (en) | 1997-12-24 | 2002-08-20 | Vertex Pharmaceuticals, Incorporated | Prodrugs of aspartyl protease inhibitors |
| AU2012199A (en) | 1997-12-24 | 1999-07-19 | Vertex Pharmaceuticals Incorporated | Prodrugs of aspartyl protease inhibitors |
| AP2000001856A0 (en) | 1997-12-24 | 2000-09-30 | Vertex Pharma | Prodrugs of aspartyl protease inhibitors. |
| ES2362404T5 (es) | 1998-06-23 | 2015-11-25 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Ensayo de aptitud y métodos para reducir la resistencia del VIH a terapia |
| WO1999067254A2 (en) * | 1998-06-23 | 1999-12-29 | The United States Of America Represented By The Secretary, Department Of Health And Human Services | Multi-drug resistant retroviral protease inhibitors and use thereof |
| MXPA03009179A (es) * | 2001-04-09 | 2004-11-22 | Tibotec Pharm Ltd | 2-(amino sustituido)-benzoxazol sunfonamidas, inhibidores de amplio espectro de la vih proteasa. |
-
2002
- 2002-05-10 EA EA200301234A patent/EA009590B1/ru not_active IP Right Cessation
- 2002-05-10 PL PL366780A patent/PL209029B1/pl unknown
- 2002-05-10 BR BR0209594-7A patent/BR0209594A/pt not_active IP Right Cessation
- 2002-05-10 IL IL15809302A patent/IL158093A0/xx not_active IP Right Cessation
- 2002-05-10 WO PCT/EP2002/005212 patent/WO2002092595A1/en not_active Ceased
- 2002-05-10 NZ NZ529250A patent/NZ529250A/en not_active IP Right Cessation
- 2002-05-10 ES ES02735354T patent/ES2325809T3/es not_active Expired - Lifetime
- 2002-05-10 AR ARP020101722A patent/AR035970A1/es active IP Right Grant
- 2002-05-10 DE DE60232067T patent/DE60232067D1/de not_active Expired - Lifetime
- 2002-05-10 US US10/474,485 patent/US7622490B2/en not_active Expired - Fee Related
- 2002-05-10 MX MXPA03010258A patent/MXPA03010258A/es active IP Right Grant
- 2002-05-10 HU HU0400438A patent/HUP0400438A3/hu not_active IP Right Cessation
- 2002-05-10 AP APAP/P/2003/002904A patent/AP1652A/en active
- 2002-05-10 DK DK02735354T patent/DK1387842T3/da active
- 2002-05-10 CA CA2444895A patent/CA2444895C/en not_active Expired - Fee Related
- 2002-05-10 HR HRP20031026AA patent/HRP20031026B1/xx not_active IP Right Cessation
- 2002-05-10 EP EP02735354A patent/EP1387842B1/en not_active Expired - Lifetime
- 2002-05-10 KR KR1020037013145A patent/KR100878853B1/ko not_active Expired - Fee Related
- 2002-05-10 AT AT02735354T patent/ATE429431T1/de active
- 2002-05-10 CZ CZ2003-3290A patent/CZ304524B6/cs not_active IP Right Cessation
- 2002-05-10 JP JP2002589479A patent/JP4467889B2/ja not_active Expired - Fee Related
- 2002-05-10 CN CNB028097416A patent/CN100549007C/zh not_active Expired - Fee Related
- 2002-05-10 SK SK1490-2003A patent/SK287952B6/sk not_active IP Right Cessation
- 2002-05-10 PT PT02735354T patent/PT1387842E/pt unknown
- 2002-05-10 EE EEP200300547A patent/EE05307B1/xx not_active IP Right Cessation
- 2002-05-10 AU AU2002310818A patent/AU2002310818B2/en not_active Ceased
- 2002-05-10 OA OA1200300277A patent/OA13134A/en unknown
-
2003
- 2003-10-06 ZA ZA2003/07799A patent/ZA200307799B/en unknown
- 2003-11-03 BG BG108309A patent/BG66350B1/bg unknown
- 2003-11-10 NO NO20034988A patent/NO326883B1/no not_active IP Right Cessation
-
2009
- 2009-07-21 CY CY20091100774T patent/CY1109247T1/el unknown
- 2009-10-07 US US12/575,216 patent/US7863306B2/en not_active Expired - Fee Related
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR0209594A (pt) | Inibidores de protease de hiv de amplo espectro de 2-amino-benzoxazol sulfonamida | |
| BR0207862A (pt) | Inibidores de protease de hiv 2-(amino-substituìda)-benzotiazol-sulfonamida de amplo espectro | |
| BR9808513A (pt) | Composto, composição farmacêutica, método para tratamento de infecções por hiv e kit farmacêutico. | |
| AR064492A1 (es) | Derivados de isoquinolona sustituidos con cicloalquilamina | |
| BR112014013998A2 (pt) | misturas de ácidos dialquilfosfínicos e alquilfosfônicos, processo para produção das mesmas e uso das mesmas | |
| NO20063129L (no) | Substituerte 6-cykloheksylalkylsubstituerte 2-kinolinoner og 2-kinoksalinoner som poly(ADP-ribose) polymeraseinhibitorer | |
| CY1108409T1 (el) | Υβριδικα αντιβιοτικα οξαζολιδινονης-κινολονης | |
| MX382435B (es) | Compuestos de piperidina sustituidos y su uso. | |
| BR0309397A (pt) | Derivados de n-[fenil(piperidin-2-il)metil]benzamida, sua preparação e sua aplicação em terapia | |
| BRPI0514606A (pt) | sais de lercanidipina | |
| ES2189726T3 (es) | Isoxazolidinas sustituidas con heterociclo y su uso como fungicidas. | |
| BRPI0515121A (pt) | derivados da n-2 adamantil-2-fenóxi acetamida como inibidores da 11-beta hidroxiesteróide desidrogenase | |
| BRPI0512615A (pt) | compostos de sulfonamida | |
| PE20080611A1 (es) | Compuestos de azabenzofuranil y metodos de uso | |
| EA200300943A1 (ru) | Производные пиразола для лечения инфекции вируса иммунодефицита человека (вич) | |
| CY1112971T1 (el) | Σουλφοναμιδια 2-(υποκατεστημενο-αμινο)-βενζοθειαζολης ως αναστολεις της πρωτεασης ηiv | |
| BR0305771A (pt) | Inibidores de protease do hiv oxindol sulfonamida substituìdos de amplo espectro | |
| BR0108974A (pt) | 3-fenil-5-alcóxi-1,3,4-oxdiazol-2-onas substituìdas e seu uso para a inibição das lipases sensìveis a hormÈnios | |
| ATE511500T1 (de) | Sulfonamide als orexin-antagonisten | |
| BR0308588A (pt) | Inibidores de entrada de molécula pequena | |
| BR0208796A (pt) | Inibidores 2-(amino substituìdo)-benzoxazol sulfonamida hiv protease de amplo espectro | |
| SV2003000995A (es) | Nuevas arilsulfonamidas como agentes antivirales ref. lea35214-sv | |
| BR0310089A (pt) | Inibidores de protease de hiv de sulfonamida benzisoxazol substituìda de largo espectro | |
| EP1671957A4 (en) | THIADIAZOLINDERIVATE | |
| BRPI0515140A (pt) | derivados de benzamidina de 4-aminometila e seu emprego como inibidores do fator viia |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B25G | Requested change of headquarter approved |
Owner name: TIBOTEC PHARMACEUTICALS LTD. (IE) Free format text: SEDE ALTERADA CONFORME SOLICITADO NA PETICAO NO 020070001806/RJ DE 05/01/2007. |
|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B15K | Others concerning applications: alteration of classification |
Free format text: ALTERADA DA INT.CL: C07D 513/12, C07D 493/04, C07D 417/12, C07D 263/58, C07D 498/04, C07D 513/04, C07D 413/14, C07D 417/14, A61K 31/423, C07D 491/04 Ipc: C07D 413/12 (2011.01), C07D 493/04 (2011.01), C07D |
|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B07F | Notification of approval that there is no relation to art. 229 of lpi (pipeline patents) [chapter 7.6 patent gazette] |
Free format text: NOTIFICACAO DE NAO ANUENCIA RELACIONADA COM O ART. 229 DA LPI |
|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 14A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2385 DE 20-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |