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BR0209028A - Método de transferência nuclear - Google Patents

Método de transferência nuclear

Info

Publication number
BR0209028A
BR0209028A BR0209028-7A BR0209028A BR0209028A BR 0209028 A BR0209028 A BR 0209028A BR 0209028 A BR0209028 A BR 0209028A BR 0209028 A BR0209028 A BR 0209028A
Authority
BR
Brazil
Prior art keywords
nuclear transfer
transfer method
relates
present
somatic cell
Prior art date
Application number
BR0209028-7A
Other languages
English (en)
Inventor
Ian Lewis
Gabor Vajta
Tayfur Tecirlioglu
Original Assignee
Univ Monash
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Monash filed Critical Univ Monash
Publication of BR0209028A publication Critical patent/BR0209028A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/873—Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

"MéTODO DE TRANSFERêNCIA NUCLEAR". A presente invenção se refere a métodos de transferência nuclear e embriões desenvolvidos a partir dos mesmos. Em particular, a presente invenção se refere a métodos de transferência nuclear compreendendo a etapa de transferir uma célula somática ou núcleos de célula somática em um oócito enucleado livre de zona pellucida.
BR0209028-7A 2001-04-20 2002-04-19 Método de transferência nuclear BR0209028A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AUPR4514A AUPR451401A0 (en) 2001-04-20 2001-04-20 A method of nuclear transfer
PCT/AU2002/000491 WO2002086103A1 (en) 2001-04-20 2002-04-19 A method of nuclear transfer

Publications (1)

Publication Number Publication Date
BR0209028A true BR0209028A (pt) 2005-05-31

Family

ID=3828509

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0209028-7A BR0209028A (pt) 2001-04-20 2002-04-19 Método de transferência nuclear

Country Status (8)

Country Link
US (2) US20040177390A1 (pt)
JP (1) JP2004529648A (pt)
CN (1) CN1524121A (pt)
AU (1) AUPR451401A0 (pt)
BR (1) BR0209028A (pt)
CA (1) CA2444621A1 (pt)
NZ (1) NZ529007A (pt)
WO (1) WO2002086103A1 (pt)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1687421B1 (en) * 2003-09-30 2018-06-27 Sterrenbeld Biotechnologie North America, Inc. A process for producing exogenous protein in the milk of transgenic mammals and a process for purifying proteins therefrom
KR101383825B1 (ko) * 2005-09-08 2014-04-10 오르후스 우니베르시테트 세포 핵 이식
CN101580828B (zh) * 2009-05-06 2012-06-20 深圳华大基因科技有限公司 一种细胞核移植方法
CN101880690B (zh) * 2010-06-12 2012-12-19 中国科学院西北高原生物研究所 藏羚羊-山羊种间克隆胚胎构建与体外培养的方法
CN101880689B (zh) * 2010-06-12 2012-12-19 中国科学院西北高原生物研究所 藏羚羊-牛种间体细胞核移植胚胎的构建与体外发育方法
CN102766655A (zh) * 2012-06-20 2012-11-07 中国农业科学院北京畜牧兽医研究所 一种生产体细胞克隆牛囊胚的方法
HRP20181648T1 (hr) 2013-04-16 2019-01-25 Regeneron Pharmaceuticals, Inc. Ciljana modifikacija genoma štakora
MX388127B (es) 2013-12-11 2025-03-19 Regeneron Pharma Metodos y composiciones para la modificacion dirigida de un genoma.
RS58159B1 (sr) 2013-12-11 2019-03-29 Regeneron Pharma Postupci i kompozicije za ciljanu modifikaciju genoma
CA2950173C (en) 2014-06-06 2023-10-10 Regeneron Pharmaceuticals, Inc. Methods and compositions for modifying a targeted locus
KR102386101B1 (ko) 2014-06-26 2022-04-14 리제너론 파마슈티칼스 인코포레이티드 표적화된 유전자 변형을 위한 방법 및 그 조성물, 및 사용 방법
ES2731437T3 (es) 2014-11-21 2019-11-15 Regeneron Pharma Métodos y composiciones para la modificación genética dirigida mediante el uso de pares de ARN guías
CN107208113A (zh) 2014-12-19 2017-09-26 瑞泽恩制药公司 用于通过单步多重靶向进行靶向遗传修饰的方法和组合物
KR102616160B1 (ko) 2015-03-16 2023-12-22 리제너론 파마슈티칼스 인코포레이티드 저하된 상위 및 하위 운동 뉴런 기능 및 감각 지각을 나타내는 비-인간 동물
CN107920498A (zh) 2015-05-29 2018-04-17 瑞泽恩制药公司 具有c9orf72基因座破坏的非人类动物
CN108135155A (zh) 2015-10-13 2018-06-08 佛泰尔塞夫股份有限公司 制备用于低温程序的生物样品的装置及方法
US11617365B2 (en) * 2015-10-13 2023-04-04 Fertilesafe Ltd. Devices and methods for preparation of a biological sample for a cryoprocedure
KR20180110107A (ko) 2016-02-16 2018-10-08 리제너론 파마슈티칼스 인코포레이티드 돌연변이 키뉴레니나아제 유전자를 갖는 비인간 동물
CN113831407B (zh) 2016-05-20 2024-06-11 瑞泽恩制药公司 用于使用多个引导rna来破坏免疫耐受性的方法
MX2019001211A (es) 2016-07-29 2019-09-16 Regeneron Pharma Ratones que comprenden mutaciones que dan lugar a la expresión de la fibrilina-1 truncada en c.
MX381216B (es) 2016-09-30 2025-03-12 Regeneron Pharma Animales no humanos que tienen una expansion de repeticiones de hexanucleotidos en un locus c9orf72.
US11064685B2 (en) 2017-02-27 2021-07-20 Regeneron Pharmaceuticals, Inc. Non-human animal models of retinoschisis
KR102701443B1 (ko) 2017-06-27 2024-09-04 리제너론 파마슈티칼스 인코포레이티드 인간화 asgr1 유전자좌를 포함하는 비인간 동물
KR20200032117A (ko) 2017-07-31 2020-03-25 리제너론 파마슈티칼스 인코포레이티드 생체 내에서 외인성 공여체 핵산과의 CRISPR/Cas-유도된 재조합의 평가
KR20200033259A (ko) 2017-07-31 2020-03-27 리제너론 파마슈티칼스 인코포레이티드 생체내에서 CRISPR/Cas-매개된 파괴 또는 삭제 및 외인성 도너 핵산과의 CRISPR/Cas-유도된 재조합을 평가하기 위한 방법 및 조성물
US11130999B2 (en) 2017-07-31 2021-09-28 Regeneron Pharmaceuticals, Inc. Cas-ready mouse embryonic stem cells and mice and uses thereof
EP3585162B1 (en) 2017-09-29 2023-08-30 Regeneron Pharmaceuticals, Inc. Rodents comprising a humanized ttr locus and methods of use
AU2018366290B2 (en) 2017-11-10 2022-01-27 Regeneron Pharmaceuticals, Inc. Non-human animals comprising Slc30a8 mutation and methods of use
SG11202002456WA (en) 2017-11-30 2020-04-29 Regeneron Pharma Non-human animals comprising a humanized trkb locus
WO2019183123A1 (en) 2018-03-19 2019-09-26 Regeneron Pharmaceuticals, Inc. Transcription modulation in animals using crispr/cas systems
CN112969367B (zh) 2018-09-13 2023-04-07 瑞泽恩制药公司 作为c3肾小球病模型的补体因子h基因敲除大鼠
AU2019403015B2 (en) 2018-12-20 2024-01-18 Regeneron Pharmaceuticals, Inc. Nuclease-mediated repeat expansion
ES2966625T3 (es) 2019-04-04 2024-04-23 Regeneron Pharma Roedores que comprenden un locus del factor de coagulación 12 humanizado
JP7610339B2 (ja) 2019-06-04 2025-01-08 リジェネロン・ファーマシューティカルズ・インコーポレイテッド ベータスリップ変異を有するヒト化ｔｔｒ遺伝子座を含む非ヒト動物と使用方法
CA3137764A1 (en) 2019-06-07 2020-12-10 Regeneron Pharmaceuticals, Inc. Non-human animals comprising a humanized albumin locus
CA3217237A1 (en) 2019-06-27 2020-12-30 Regeneration Pharmaceuticals, Inc. Modeling tdp-43 proteinopathy
CN110904034A (zh) * 2019-11-15 2020-03-24 芜湖职业技术学院 一种去除卵细胞细胞核的方法
WO2021108363A1 (en) 2019-11-25 2021-06-03 Regeneron Pharmaceuticals, Inc. Crispr/cas-mediated upregulation of humanized ttr allele
CN111004775B (zh) * 2020-01-08 2023-05-02 中国医学科学院医学生物学研究所 一种物理性去除卵母细胞透明带的方法
AU2021212668A1 (en) 2020-01-28 2022-08-18 Regeneron Pharmaceuticals, Inc. Non-human animals comprising a humanized PNPLA3 locus and methods of use
EP4099821A1 (en) 2020-02-07 2022-12-14 Regeneron Pharmaceuticals, Inc. <smallcaps/>? ? ?klkb1? ? ? ? ?non-human animals comprising a humanizedlocus and methods of use
US20230102342A1 (en) 2020-03-23 2023-03-30 Regeneron Pharmaceuticals, Inc. Non-human animals comprising a humanized ttr locus comprising a v30m mutation and methods of use
EP4171215A2 (en) 2020-06-26 2023-05-03 Regeneron Pharmaceuticals, Inc. Non-human animals comprising a humanized ace2 locus
CN113061572A (zh) * 2021-04-21 2021-07-02 广西壮族自治区畜牧研究所 手工克隆程序中无透明带胚胎培养的微穴改进方法
CN118488784A (zh) 2021-11-04 2024-08-13 瑞泽恩制药公司 包含经修饰的cacng1基因座的非人动物
WO2023108047A1 (en) 2021-12-08 2023-06-15 Regeneron Pharmaceuticals, Inc. Mutant myocilin disease model and uses thereof
EP4451863A1 (en) 2021-12-20 2024-10-30 Regeneron Pharmaceuticals, Inc. Non-human animals comprising humanized ace2 and tmprss loci
CN114350600B (zh) * 2022-01-26 2023-08-18 中国农业大学 一种提高冷冻卵母细胞体外培育质量的培养液及其应用
US20250194571A1 (en) 2022-02-07 2025-06-19 Regeneron Pharmaceuticals, Inc. Compositions and methods for defining optimal treatment timeframes in lysosomal disease
IL314673A (en) 2022-02-11 2024-10-01 Regeneron Pharma Compositions and methods for screening 4r tau targeting agents
EP4531554A1 (en) 2022-05-31 2025-04-09 Regeneron Pharmaceuticals, Inc. Animal model of tdp-43 proteinopathy
EP4561348A2 (en) 2022-07-29 2025-06-04 Regeneron Pharmaceuticals, Inc. Non-human animals comprising a modified transferrin receptor locus
KR20250044256A (ko) 2022-08-05 2025-03-31 리제너론 파마슈티칼스 인코포레이티드 Tdp-43의 응집 저항성 변이체
EP4593590A1 (en) 2022-09-29 2025-08-06 Regeneron Pharmaceuticals, Inc. Correction of hepatosteatosis in humanized liver animals through restoration of il6/il6r/gp130 signaling in human hepatocytes
WO2024163650A1 (en) 2023-02-01 2024-08-08 Regeneron Pharmaceuticals, Inc. Animals comprising a modified klhdc7b locus
AU2024309884A1 (en) 2023-06-30 2025-12-18 Regeneron Pharmaceuticals, Inc. Methods and compositions for increasing homology-directed repair
WO2025122754A1 (en) 2023-12-07 2025-06-12 Regeneron Pharmaceuticals, Inc. Gaa knockout non-human animals
WO2025250495A1 (en) 2024-05-28 2025-12-04 Regeneron Pharmaceuticals, Inc. Acceleration of human hepatocyte engraftment in humanized liver animals by supplementing paracrine ligands or agonists that activate human liver regeneration signals

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ336493A (en) * 1997-01-02 2001-01-26 Univ Monash A method of oocyte enucleation and production of reconstituted embryos

Also Published As

Publication number Publication date
AUPR451401A0 (en) 2001-05-24
CN1524121A (zh) 2004-08-25
US20080092249A1 (en) 2008-04-17
NZ529007A (en) 2005-05-27
WO2002086103A1 (en) 2002-10-31
US20040177390A1 (en) 2004-09-09
JP2004529648A (ja) 2004-09-30
CA2444621A1 (en) 2002-10-31

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Legal Events

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B08E Application fees: payment of additional fee required [chapter 8.5 patent gazette]

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B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

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B15K Others concerning applications: alteration of classification

Ipc: C12N 15/873 (2010.01)