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BR0208154A - Inibidores de fosfodiesterase 3',5'-mono-fosfato guanosina cìclica - Google Patents

Inibidores de fosfodiesterase 3',5'-mono-fosfato guanosina cìclica

Info

Publication number
BR0208154A
BR0208154A BR0208154-7A BR0208154A BR0208154A BR 0208154 A BR0208154 A BR 0208154A BR 0208154 A BR0208154 A BR 0208154A BR 0208154 A BR0208154 A BR 0208154A
Authority
BR
Brazil
Prior art keywords
guanosine
cyclically
phosphodiesterase inhibitors
monophosphate phosphodiesterase
monophosphate
Prior art date
Application number
BR0208154-7A
Other languages
English (en)
Inventor
Stephen Martin Denton
Mary Ian Kemp
Sandra Dora Newman
David James Rawson
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of BR0208154A publication Critical patent/BR0208154A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

"INIBIDORES DE FOSFODIESTERASE 3',5'-MONOFOSFATO GUANOSINA CìCLICA". Composto de fórmula geral I: em que R^ 1^, R^ 2^,R^ 3^, R^ 4^ X e R^ 5^ possuem os significados dados aqui que são úteis no tratamento curativo e profilático de um estado clínico para o qual é desejada a inibição de uma fosfodiesterase de 3',5'-monofosfato de guanosina cíclica (por exemplo cGMP PDE5).
BR0208154-7A 2001-03-16 2002-03-04 Inibidores de fosfodiesterase 3',5'-mono-fosfato guanosina cìclica BR0208154A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0106661.2A GB0106661D0 (en) 2001-03-16 2001-03-16 Pharmaceutically active compounds
PCT/IB2002/000659 WO2002074774A1 (en) 2001-03-16 2002-03-04 Cyclic guanosine 3',5'-monophosphate phosphodiesterase inhibitors

Publications (1)

Publication Number Publication Date
BR0208154A true BR0208154A (pt) 2004-03-02

Family

ID=9910932

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0208154-7A BR0208154A (pt) 2001-03-16 2002-03-04 Inibidores de fosfodiesterase 3',5'-mono-fosfato guanosina cìclica

Country Status (10)

Country Link
EP (1) EP1368352B1 (pt)
JP (1) JP2004523585A (pt)
AT (1) ATE283856T1 (pt)
BR (1) BR0208154A (pt)
CA (1) CA2439528A1 (pt)
DE (1) DE60202134T2 (pt)
ES (1) ES2231667T3 (pt)
GB (1) GB0106661D0 (pt)
MX (1) MXPA03005937A (pt)
WO (1) WO2002074774A1 (pt)

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DE60237425D1 (de) * 2002-03-28 2010-10-07 Univerzita Palackeho V Olomouc PyrazoloÄ4,3-dÜpyrimidine, Verfahren zu ihrer Herstellung und therapeutische Anwendung
DE10238722A1 (de) 2002-08-23 2004-03-11 Bayer Ag Selektive Phosphodiesterase 9A-Inhibitoren als Arzneimittel zur Verbesserung kognitiver Prozesse
PT1572173E (pt) 2002-12-13 2010-05-10 Warner Lambert Co Ligando alfa-2-delta para tratar sintomas do tracto urinário inferior
CN100374441C (zh) * 2003-06-06 2008-03-12 天津倍方科技发展有限公司 二氢吡咯[2，3-d]嘧啶-4-酮衍生物，其制备方法及其制药用途
JP2006219374A (ja) 2003-06-13 2006-08-24 Daiichi Asubio Pharma Co Ltd Ｐｄｅ７阻害作用を有するイミダゾトリアジノン誘導体
WO2005012256A1 (en) 2003-07-22 2005-02-10 Astex Therapeutics Limited 3, 4-disubstituted 1h-pyrazole compounds and their use as cyclin dependent kinases (cdk) and glycogen synthase kinase-3 (gsk-3) modulators
WO2005028480A2 (en) * 2003-09-03 2005-03-31 Neurogen Corporation 5-aryl-pyrazolo[4,3-d]pyrimidines, pyridines, and pyrazines and related compounds
US7485637B2 (en) 2005-01-04 2009-02-03 Hoffmann-La Roche Inc. Benzoyl-tetrahydropiperidine derivatives
AR054425A1 (es) 2005-01-21 2007-06-27 Astex Therapeutics Ltd Sales de adicion de piperidin 4-il- amida de acido 4-(2,6-dicloro-benzoilamino) 1h-pirazol-3-carboxilico.
US8404718B2 (en) 2005-01-21 2013-03-26 Astex Therapeutics Limited Combinations of pyrazole kinase inhibitors
PT1848694E (pt) 2005-02-07 2010-02-02 Hoffmann La Roche Fenil-metanonas heterocíclicas substituídas, como inibidores do transportador de glicina 1
EA018668B1 (ru) * 2005-02-18 2013-09-30 Сурфейс Логикс Инк. Фармакокинетически улучшенные соединения
EP2514751A1 (en) 2005-11-15 2012-10-24 Vertex Pharmaceuticals, Inc. Azaindazoles useful as inhibitor of kinases
WO2007057316A2 (en) * 2005-11-16 2007-05-24 F. Hoffmann-La Roche Ag Novel process for the preparation of thoc
CN101563348B (zh) * 2006-12-21 2011-08-24 上海特化医药科技有限公司 西地那非的制备方法及其中间体
CN101678006A (zh) * 2007-05-11 2010-03-24 参天制药株式会社 含有非麦角类的选择性d2受体激动剂作为有效成分的后眼部疾病的预防或治疗剂
WO2009068617A1 (en) 2007-11-30 2009-06-04 Boehringer Ingelheim International Gmbh 1, 5-dihydro-pyrazolo (3, 4-d) pyrimidin-4-one derivatives and their use as pde9a modulators for the teatment of cns disorders
UA105362C2 (en) 2008-04-02 2014-05-12 Бьорингер Ингельхайм Интернациональ Гмбх 1-heterocyclyl-1, 5-dihydro-pyrazolo [3, 4-d] pyrimidin-4-one derivatives and their use as pde9a modulators
MX2011002340A (es) 2008-09-08 2011-04-04 Boehringer Ingelheim Int Pirazolopirimidinas y su uso para el tratamiento de trastornos del snc.
JP2012513464A (ja) 2008-12-23 2012-06-14 ザ トラスティーズ オブ コロンビア ユニヴァーシティ イン ザ シティ オブ ニューヨーク ホスホジエステラーゼ阻害剤及びその使用
BRPI1011533A2 (pt) 2009-03-31 2016-03-29 Boehringer Ingelheim Int derivados de 1-heterocicil-1 5- diidro-pirazolo [3,4--d] pirimidin-4-ona e seu uso como moduladores de pde9a.
TWI393578B (zh) 2009-07-07 2013-04-21 Shl Group Ab 注射裝置
AP2012006631A0 (en) 2010-08-12 2012-12-31 Boehringer Ingelheim Int 6-Cycloalkyl-1, 5-dihydro-pyrazolo[3,4-D] pyrimidin-4-one derivatives and their use as PDE9A inhibitors
US8809345B2 (en) 2011-02-15 2014-08-19 Boehringer Ingelheim International Gmbh 6-cycloalkyl-pyrazolopyrimidinones for the treatment of CNS disorders
BR112013026744B1 (pt) 2011-04-21 2022-05-17 Origenis Gmbh Compostos heterocíclicos, seus usos e seus intermediários, e composição farmacêutica
CN103492389B (zh) * 2011-04-21 2016-09-14 原真股份有限公司 用作激酶抑制剂的吡唑并[4,3-d]嘧啶
TW201341367A (zh) 2012-03-16 2013-10-16 Axikin Pharmaceuticals Inc ３，５－二胺基吡唑激酶抑制劑
US9637491B2 (en) 2012-10-19 2017-05-02 Origenis Gmbh Pyrazolo[4,3-D]pyrimidines as kinase inhibitors
US10000482B2 (en) 2012-10-19 2018-06-19 Origenis Gmbh Kinase inhibitors
NZ631142A (en) 2013-09-18 2016-03-31 Axikin Pharmaceuticals Inc Pharmaceutically acceptable salts of 3,5-diaminopyrazole kinase inhibitors
JP2017500333A (ja) * 2013-12-20 2017-01-05 バイエル・ファルマ・アクティエンゲゼルシャフト グルコース輸送阻害剤
SG11201705088VA (en) 2014-12-23 2017-07-28 Axikin Pharmaceuticals Inc 3,5-diaminopyrazole kinase inhibitors
AU2016355854B2 (en) 2015-11-16 2021-05-06 Topadur Pharma Ag 2-phenyl-3,4-dihydropyrrolo[2,1 -f] [1,2,4]triazinone derivatives as phosphodiesterase inhibitors and uses thereof
CN105669680B (zh) * 2016-03-24 2018-02-23 南京药捷安康生物科技有限公司 吡咯并[2,1‑f][1,2,4]三嗪‑4(1H)‑酮衍生物类PDE9A抑制剂
EP4511116A1 (en) 2022-04-22 2025-02-26 Vertex Pharmaceuticals Incorporated Heteroaryl compounds for the treatment of pain

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GB1493685A (en) * 1970-12-15 1977-11-30 May & Baker Ltd 8-azapurinones
GB8817651D0 (en) * 1988-07-25 1988-09-01 Smith Kline French Lab Chemical compounds
US6225315B1 (en) * 1998-11-30 2001-05-01 Pfizer Inc Method of treating nitrate-induced tolerance
EA200200240A1 (ru) * 1999-10-11 2002-10-31 Пфайзер Инк. 5-(2-ЗАМЕЩЕННЫЕ-5-ГЕТЕРОЦИКЛИЛСУЛЬФОНИЛПИРИД-3-ИЛ)-ДИГИДРОПИРАЗОЛО[4,3-d]ПИРИМИДИН-7-ОНЫ В КАЧЕСТВЕ ИНГИБИТОРОВ ФОСФОДИЭСТЕРАЗЫ

Also Published As

Publication number Publication date
ATE283856T1 (de) 2004-12-15
ES2231667T3 (es) 2005-05-16
JP2004523585A (ja) 2004-08-05
GB0106661D0 (en) 2001-05-09
DE60202134D1 (en) 2005-01-05
MXPA03005937A (es) 2003-09-10
EP1368352A1 (en) 2003-12-10
WO2002074774A1 (en) 2002-09-26
DE60202134T2 (de) 2005-11-24
CA2439528A1 (en) 2002-09-26
EP1368352B1 (en) 2004-12-01

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A, 7A, 8A E 9A ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2112 DE 28/06/2011.