BR0114058A - Prodrugs of a 7-Acylamino-3heteroarylthio-3-cephem carboxylic acid antibiotic - Google Patents
Prodrugs of a 7-Acylamino-3heteroarylthio-3-cephem carboxylic acid antibioticInfo
- Publication number
- BR0114058A BR0114058A BR0114058-2A BR0114058A BR0114058A BR 0114058 A BR0114058 A BR 0114058A BR 0114058 A BR0114058 A BR 0114058A BR 0114058 A BR0114058 A BR 0114058A
- Authority
- BR
- Brazil
- Prior art keywords
- prodrugs
- acylamino
- carboxylic acid
- acid antibiotic
- cephem carboxylic
- Prior art date
Links
- 229940002612 prodrug Drugs 0.000 title abstract 4
- 239000000651 prodrug Substances 0.000 title abstract 4
- 230000003115 biocidal effect Effects 0.000 title abstract 3
- 239000002253 acid Substances 0.000 title abstract 2
- -1 2-amino-5-chlorothiazol-4-yl Chemical group 0.000 abstract 2
- 125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 abstract 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000007935 neutral effect Effects 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
"PRó-DROGAS DE UM ANTIBIóTICO DE áCIDO 7-ACILAMINO-3-HETEROARILTIO-3-CEFEM CARBOXìLICO". A presente invenção refere-se a pró-drogas do composto antibiótico ácido (7R)-7-[(Z)-2-(2-amino-5-clorotiazol-4-il)-2-(hidroxilimino) acetamido]-3-[3-(2-aminoetiltiometil) pirid-4-iltio]-3-cefem-4-carboxílico, quando as pró-drogas são substancialmente mais solúveis em água a ou próximo do pH neutro do que o composto original."Prodrugs of a 7-acylamino-3-heteroaryltyl-3-CEFEM CARBOXYLIC ACID ANTIBIOTIC". The present invention relates to (7R) -7 - [(Z) -2- (2-amino-5-chlorothiazol-4-yl) -2- (hydroxylimino) acetamido] -3 acid antibiotic prodrugs - [3- (2-Aminoethylthiomethyl) pyrid-4-ylthio] -3-cephem-4-carboxylic, when prodrugs are substantially more soluble in water at or near neutral pH than the parent compound.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/668,722 US6723716B1 (en) | 1999-09-22 | 2000-09-21 | 7-acylamino-3-heteroarylthio-3-cephem carboxylic acid antibiotics and prodrugs thereof |
| PCT/US2001/008980 WO2002024708A1 (en) | 2000-09-21 | 2001-03-20 | Prodrugs of a 7-acylamino-3-heteroarylthio-3-cephem carboxylic acid antibiotic |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0114058A true BR0114058A (en) | 2003-07-22 |
Family
ID=24683471
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0114058-2A BR0114058A (en) | 2000-09-21 | 2001-03-20 | Prodrugs of a 7-Acylamino-3heteroarylthio-3-cephem carboxylic acid antibiotic |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP1320533A4 (en) |
| JP (1) | JP2004525862A (en) |
| CN (1) | CN1535275A (en) |
| AU (2) | AU4590201A (en) |
| BR (1) | BR0114058A (en) |
| CA (1) | CA2423334A1 (en) |
| IL (1) | IL154883A0 (en) |
| MX (1) | MXPA03002456A (en) |
| NO (1) | NO20031275L (en) |
| NZ (1) | NZ525401A (en) |
| RU (1) | RU2279435C2 (en) |
| WO (1) | WO2002024708A1 (en) |
| ZA (1) | ZA200302127B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1303086C (en) * | 2005-03-24 | 2007-03-07 | 朱晓茂 | Compound of dual functional esterified prodrug of Cefetamet, and oral preparation |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE65926B1 (en) * | 1990-07-19 | 1995-11-29 | Shionogi & Co | Thioalkylthio cephalosporin derivatives |
| MY127641A (en) * | 1995-10-12 | 2006-12-29 | Essential Therapeutics Inc | Cephalosporin antibiotics |
| US6025352A (en) * | 1997-09-29 | 2000-02-15 | Microcide Pharmaceuticals, Inc. | Cephalosporin antibiotics |
-
2001
- 2001-03-20 BR BR0114058-2A patent/BR0114058A/en not_active IP Right Cessation
- 2001-03-20 EP EP01918879A patent/EP1320533A4/en not_active Withdrawn
- 2001-03-20 NZ NZ525401A patent/NZ525401A/en unknown
- 2001-03-20 MX MXPA03002456A patent/MXPA03002456A/en not_active Application Discontinuation
- 2001-03-20 AU AU4590201A patent/AU4590201A/en active Pending
- 2001-03-20 IL IL15488301A patent/IL154883A0/en unknown
- 2001-03-20 WO PCT/US2001/008980 patent/WO2002024708A1/en not_active Ceased
- 2001-03-20 ZA ZA200302127A patent/ZA200302127B/en unknown
- 2001-03-20 JP JP2002529118A patent/JP2004525862A/en active Pending
- 2001-03-20 CN CNA018191274A patent/CN1535275A/en active Pending
- 2001-03-20 AU AU2001245902A patent/AU2001245902B2/en not_active Ceased
- 2001-03-20 RU RU2003111169/04A patent/RU2279435C2/en not_active IP Right Cessation
- 2001-03-20 CA CA002423334A patent/CA2423334A1/en not_active Abandoned
-
2003
- 2003-03-19 NO NO20031275A patent/NO20031275L/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA03002456A (en) | 2003-06-19 |
| EP1320533A4 (en) | 2004-12-15 |
| IL154883A0 (en) | 2003-10-31 |
| NZ525401A (en) | 2005-10-28 |
| NO20031275L (en) | 2003-05-21 |
| ZA200302127B (en) | 2007-07-25 |
| CN1535275A (en) | 2004-10-06 |
| AU2001245902B2 (en) | 2007-08-23 |
| EP1320533A1 (en) | 2003-06-25 |
| NO20031275D0 (en) | 2003-03-19 |
| WO2002024708A1 (en) | 2002-03-28 |
| JP2004525862A (en) | 2004-08-26 |
| CA2423334A1 (en) | 2002-03-28 |
| RU2279435C2 (en) | 2006-07-10 |
| AU4590201A (en) | 2002-04-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 9A E 10A ANUIDADE(S). |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2125 DE 27/09/2011. |