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BR0113579A - Polymer Modified Synthetic Proteins - Google Patents

Polymer Modified Synthetic Proteins

Info

Publication number
BR0113579A
BR0113579A BR0113579-1A BR0113579A BR0113579A BR 0113579 A BR0113579 A BR 0113579A BR 0113579 A BR0113579 A BR 0113579A BR 0113579 A BR0113579 A BR 0113579A
Authority
BR
Brazil
Prior art keywords
proteins
polymer modified
modified synthetic
synthetic proteins
polypeptides
Prior art date
Application number
BR0113579-1A
Other languages
Portuguese (pt)
Inventor
Gerd Kochendoerfer
Paolo Botti
James A Bradburne
Shiah-Yun Chen
Sonya Cresman
Christie L Hunter
Stephen B H Kent
Donald W Low
Jil G Wilken
Kochendoerfer Gerd
Original Assignee
Gryphon Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gryphon Therapeutics Inc filed Critical Gryphon Therapeutics Inc
Priority claimed from PCT/US2001/021930 external-priority patent/WO2002020033A1/en
Publication of BR0113579A publication Critical patent/BR0113579A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/80—Cytochromes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06147—Dipeptides with the first amino acid being heterocyclic and His-amino acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)

Abstract

"PROTEìNAS SINTéTICAS MODIFICADAS POR POLìMERO". A presente invenção refere-se a métodos e composições para a modificação de peptídeos, polipeptídeos e proteínas utilizando polímeros, especialmente polímeros glicomiméticos, de modo a aperfeiçoar sua atividade biológica ou propriedades farmacocinéticas. A invenção provê ainda métodos e usos dos referidos peptídeos, polipeptídeos e proteínas. A invenção e particularmente adequada para uso na síntese de proteínas bioativas sintéticas modificadas por polímero e de composições farmacêuticas que contêm essas proteínas."POLYMER MODIFIED SYNTHETIC PROTEINS". The present invention relates to methods and compositions for modifying peptides, polypeptides and proteins using polymers, especially glycomimetic polymers, to enhance their biological activity or pharmacokinetic properties. The invention further provides methods and uses of said peptides, polypeptides and proteins. The invention is particularly suitable for use in the synthesis of polymer modified synthetic bioactive proteins and pharmaceutical compositions containing such proteins.

BR0113579-1A 2000-09-08 2001-07-12 Polymer Modified Synthetic Proteins BR0113579A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23133900P 2000-09-08 2000-09-08
PCT/US2001/021930 WO2002020033A1 (en) 2000-09-08 2001-07-12 Polymer-modified synthetic proteins

Publications (1)

Publication Number Publication Date
BR0113579A true BR0113579A (en) 2003-06-17

Family

ID=22868813

Family Applications (2)

Application Number Title Priority Date Filing Date
BR0113579-1A BR0113579A (en) 2000-09-08 2001-07-12 Polymer Modified Synthetic Proteins
BR0113623-2A BR0113623A (en) 2000-09-08 2001-07-12 Synthetic erythropoiesis stimulating proteins

Family Applications After (1)

Application Number Title Priority Date Filing Date
BR0113623-2A BR0113623A (en) 2000-09-08 2001-07-12 Synthetic erythropoiesis stimulating proteins

Country Status (12)

Country Link
EP (1) EP1315738A4 (en)
JP (2) JP2004508383A (en)
KR (1) KR20030061785A (en)
CN (1) CN1452632A (en)
AU (2) AU2001288937B2 (en)
BR (2) BR0113579A (en)
CA (1) CA2412298A1 (en)
ES (1) ES2360203T3 (en)
IL (1) IL154015A0 (en)
MX (1) MXPA03001450A (en)
WO (1) WO2002020557A1 (en)
ZA (3) ZA200300315B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60331437D1 (en) * 2002-06-10 2010-04-08 Amylin Pharmaceuticals Inc SUSPENDED SULPHIDE PROTECTION FOR CONVERGENT PROTEIN MANUFACTURE IN THE PROCESS OF CHEMICAL LIGATION
US8034900B2 (en) 2002-12-30 2011-10-11 Amylin Pharmaceuticals, Inc. Water-soluble thioester and selenoester compounds and methods for making and using the same
WO2007049635A1 (en) * 2005-10-25 2007-05-03 Riken Process for production of peptide thioester
US8859730B2 (en) 2009-08-12 2014-10-14 Xuechen Li Native chemical ligation at serine and threonine sites
FR2952058B1 (en) * 2009-10-29 2013-10-04 Centre Nat Rech Scient PROCESS FOR NATIVE LIGATION OF POLYPEPTIDES
CN115058426B (en) * 2022-05-16 2024-07-16 上海志药科技有限公司 Nucleic acid molecular probe for specifically recognizing SARS-CoV-19, screening method, detection product and application thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6184344B1 (en) * 1995-05-04 2001-02-06 The Scripps Research Institute Synthesis of proteins by native chemical ligation
JP4358307B2 (en) * 1996-12-24 2009-11-04 ザ スクリップス リサーチ インスティテュート General chemical bond
US6307018B1 (en) * 1996-12-24 2001-10-23 The Scripps Research Institute General chemical ligation

Also Published As

Publication number Publication date
MXPA03001450A (en) 2004-12-13
EP1315738A1 (en) 2003-06-04
ES2360203T3 (en) 2011-06-01
ZA200300315B (en) 2004-02-04
EP1315738A4 (en) 2006-06-07
WO2002020557A1 (en) 2002-03-14
CN1452632A (en) 2003-10-29
IL154015A0 (en) 2003-07-31
JP2008150393A (en) 2008-07-03
ZA200300314B (en) 2004-02-04
ZA200300659B (en) 2004-03-05
AU8893701A (en) 2002-03-22
JP2004508383A (en) 2004-03-18
BR0113623A (en) 2004-06-22
CA2412298A1 (en) 2002-03-14
AU2001288937B2 (en) 2005-04-28
KR20030061785A (en) 2003-07-22

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Legal Events

Date Code Title Description
B25C Requirement related to requested transfer of rights

Owner name: GRYPHON THERAPEUTICS, INC. (US)

Free format text: A FIM DE ATENDER O SOLICITADO NA PETICAO DE TRANSFERENCIA NO 020070035353/RJ DE 22/03/2007, QUEIRAREAPRESENTAR O DOCUMENTO DE CESSAO ASSINADO PELA CEDENTE, CESSIONARIA E DUAS TESTEMUNHAS E COM A DEVIDA NOTARIZACAO E LEGALIZACAO CONSULAR.

B25C Requirement related to requested transfer of rights

Owner name: GRYPHON THERAPEUTICS, INC. (US)

Free format text: A FIM DE ATENDER A TRANSFERENCIA REQUERIDA ATRAVES DA PETICAO NO 020080024974/RJ DE 20/02/2008, QUEIRA APRESENTAR A LEGALIZACAO CONSULAR.

B25A Requested transfer of rights approved

Owner name: AMYLIN PHARMACEUTICALS, INC. (US)

Free format text: TRANSFERIDO DE: GRYPHON THERAPEUTICS, INC.

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 8A ,9A,10A,11A E 12A ANUIDADES

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2206 DE 16/04/2013.