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BR0113036A - 2,5-dkg permeases - Google Patents

2,5-dkg permeases

Info

Publication number
BR0113036A
BR0113036A BRPI0113036-6A BR0113036A BR0113036A BR 0113036 A BR0113036 A BR 0113036A BR 0113036 A BR0113036 A BR 0113036A BR 0113036 A BR0113036 A BR 0113036A
Authority
BR
Brazil
Prior art keywords
host cell
dkg
klg
transport
produce
Prior art date
Application number
BRPI0113036-6A
Other languages
English (en)
Inventor
Veronique A Dartois
James A Hoch
Fernando Valle
Manoj Kumar
Original Assignee
Microgenomics Inc
Genencor Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microgenomics Inc, Genencor Int filed Critical Microgenomics Inc
Publication of BR0113036A publication Critical patent/BR0113036A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/58—Aldonic, ketoaldonic or saccharic acids
    • C12P7/60—2-Ketogulonic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/26—Klebsiella (G)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Laminated Bodies (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Production Of Multi-Layered Print Wiring Board (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

"2,5-DKG PERMEASES". A invenção refere-se a moléculas de ácido nucléico isoladas codificando polipeptídeos tendo atividade 2,5-DKG permease, e oligonucleotídeos a partir das mesmas. As moléculas de ácido nucléico isoladas podem ser expressas em células bacterianas apropriadas para melhorar a produção de 2-KLG, que podem ser subseqüentemente convertidas em ácido ascórbico. São ainda providos polipeptídeos isolados tendo atividade 2,5-DKG permease, peptídeos imunogênicos a partir dos mesmos e anticorpos específicos para os mesmos. A invenção também provê métodos de identificação de novas 2,5-DKG permeases.
BRPI0113036-6A 2000-08-04 2001-08-03 2,5-dkg permeases BR0113036A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US63329400A 2000-08-04 2000-08-04
US67703200A 2000-09-29 2000-09-29
PCT/US2001/024507 WO2002012468A2 (en) 2000-08-04 2001-08-03 2,5-dkg permeases

Publications (1)

Publication Number Publication Date
BR0113036A true BR0113036A (pt) 2006-02-21

Family

ID=27091840

Family Applications (3)

Application Number Title Priority Date Filing Date
BRPI0113032-3A BR0113032A (pt) 2000-08-04 2001-08-03 acentuação de produção industrial aumentando transporte de substrato
BRPI0113036-6A BR0113036A (pt) 2000-08-04 2001-08-03 2,5-dkg permeases
BRPI0113034-0A BR0113034B1 (pt) 2000-08-04 2001-08-03 Método para aumento da produção biossintética de ácido 2-ceto-L-gulônico (2-KLG) de uma célula hospedeira

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BRPI0113032-3A BR0113032A (pt) 2000-08-04 2001-08-03 acentuação de produção industrial aumentando transporte de substrato

Family Applications After (1)

Application Number Title Priority Date Filing Date
BRPI0113034-0A BR0113034B1 (pt) 2000-08-04 2001-08-03 Método para aumento da produção biossintética de ácido 2-ceto-L-gulônico (2-KLG) de uma célula hospedeira

Country Status (12)

Country Link
US (1) US20040029234A1 (pt)
EP (3) EP1305421B1 (pt)
JP (3) JP4975937B2 (pt)
CN (3) CN100378222C (pt)
AT (2) ATE318907T1 (pt)
AU (3) AU2001283132A1 (pt)
BR (3) BR0113032A (pt)
CA (4) CA2417969A1 (pt)
DE (1) DE60117566T2 (pt)
DK (1) DK1305421T3 (pt)
MX (3) MXPA03001030A (pt)
WO (3) WO2002012468A2 (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE318907T1 (de) * 2000-08-04 2006-03-15 Genencor Int Erhöhte herstellung von 2-keto-l-gulonsäure
US6720168B2 (en) 2000-08-04 2004-04-13 Genencor International, Inc. 2,5-DKG permeases
US7229811B2 (en) 2001-08-03 2007-06-12 Genencor International, Inc. 2,5-diketo-D-gluconic acid (2,5-DKG) permeases
JP2007525186A (ja) 2003-05-22 2007-09-06 ジェネンコー・インターナショナル・インク 非機能化された内因性グルコン酸トランスポーターを有する代謝を修飾したバクテリア系統
EP1484410B1 (en) * 2003-06-05 2011-11-02 Ajinomoto Co., Inc. Fermentation methods using modified bacteria with increased byproduct uptake.
JP4742521B2 (ja) * 2003-06-05 2011-08-10 味の素株式会社 目的物質の製造法
WO2006084725A1 (en) * 2005-02-11 2006-08-17 Dsm Ip Assets B.V. Novel gene sts 16
JP4980651B2 (ja) * 2006-06-09 2012-07-18 Ｊｘ日鉱日石エネルギー株式会社 菌体温度を制御する能力を有する細菌
EP3004362A4 (en) * 2013-06-05 2017-01-11 Lanzatech New Zealand Limited Recombinant microorganisms exhibiting increased flux through a fermentation pathway
CN114045243B (zh) * 2021-12-03 2023-12-26 山东天力药业有限公司 一种缩短生黑葡萄糖酸杆菌发酵周期的方法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4757012A (en) * 1983-06-28 1988-07-12 Genentech, Inc. Ascorbic acid intermediates and process enzymes
US5047340A (en) * 1985-06-05 1991-09-10 The University Of Kentucky Research Foundation LAC+ saccharomyces cerevisiae
US5032514A (en) * 1988-08-08 1991-07-16 Genentech, Inc. Metabolic pathway engineering to increase production of ascorbic acid intermediates
US5376544A (en) * 1992-09-08 1994-12-27 Rutgers The State University Of New Jersey Enzymes for the production of 2-keto-L-gulonic acid
HU220798B1 (hu) * 1993-10-08 2002-05-28 Lonza Ag. A butiro-betain/krotono-betain-L-karnitin-anyagcsere génjeit kódoló DNS-molekulák és alkalmazásuk L-karnitin mikrobiológiai előállítására
US5795716A (en) * 1994-10-21 1998-08-18 Chee; Mark S. Computer-aided visualization and analysis system for sequence evaluation
DE19523279A1 (de) * 1995-06-27 1997-01-09 Forschungszentrum Juelich Gmbh Verfahren zur mikrobiellen Herstellung von Aminosäuren mittels rekombinanter Mikroorganismen mit erhöhter Sekretionsrate
FR2736652B1 (fr) * 1995-07-13 1997-08-14 Univ Bourgogne Levures et bacteries transformees pour operer la fermentation malolactique dans les vins
US5958672A (en) * 1995-07-18 1999-09-28 Diversa Corporation Protein activity screening of clones having DNA from uncultivated microorganisms
US5795761A (en) * 1996-01-11 1998-08-18 Rutgers, The State University Of New Jersey Mutants of 2,5-diketo-D-gluconic acid (2,5-DKG) reductase A
US5783431A (en) * 1996-04-24 1998-07-21 Chromaxome Corporation Methods for generating and screening novel metabolic pathways
US5817490A (en) * 1996-05-17 1998-10-06 Eastman Chemical Company Enzymatic process for the manufacture of ascorbic acid 2-keto-L-gulonic acid and esters of 2-keto-L-gulonic acid
CN1180747A (zh) * 1996-10-18 1998-05-06 中国科学院上海生物工程研究中心 从葡萄糖发酵制备2－酮基－l－古龙酸的新方法
US5834231A (en) * 1996-10-24 1998-11-10 Archer Daniels Midland Co. Bacterial strains and use thereof in fermentation process for 2-keto-L-gulonic acid production
DE19644566A1 (de) * 1996-10-26 1998-04-30 Forschungszentrum Juelich Gmbh Mikrobielle Herstellung von Substanzen aus dem aromatischen Stoffwechsel / I
EP0839909A1 (en) * 1996-10-29 1998-05-06 Rijksuniversiteit te Groningen Nucleic acid sequences encoding citrate transporter proteins
CN1119414C (zh) * 1997-12-30 2003-08-27 中国科学院上海生物工程研究中心 突变的2,5二酮基－d－葡萄糖酸还原酶及其基因工程表达
US6368793B1 (en) * 1998-10-14 2002-04-09 Microgenomics, Inc. Metabolic selection methods
ATE318907T1 (de) * 2000-08-04 2006-03-15 Genencor Int Erhöhte herstellung von 2-keto-l-gulonsäure
US6720168B2 (en) * 2000-08-04 2004-04-13 Genencor International, Inc. 2,5-DKG permeases

Also Published As

Publication number Publication date
MXPA03001025A (es) 2003-11-25
ATE510017T1 (de) 2011-06-15
JP2004519214A (ja) 2004-07-02
JP4975938B2 (ja) 2012-07-11
JP2004514421A (ja) 2004-05-20
CA2417970A1 (en) 2002-02-14
US20040029234A1 (en) 2004-02-12
EP1305422B1 (en) 2011-05-18
CA2417970C (en) 2013-09-24
CN100378222C (zh) 2008-04-02
JP2004519213A (ja) 2004-07-02
AU2001283132A1 (en) 2002-02-18
CN1458976A (zh) 2003-11-26
CA2820132A1 (en) 2002-02-14
CN1527880A (zh) 2004-09-08
CN100547073C (zh) 2009-10-07
EP1305423A2 (en) 2003-05-02
BR0113034B1 (pt) 2014-09-16
AU2001281068A1 (en) 2002-02-18
CA2417871A1 (en) 2002-02-14
CA2417871C (en) 2011-11-15
CN1469927A (zh) 2004-01-21
WO2002012528A2 (en) 2002-02-14
EP1305422A2 (en) 2003-05-02
DK1305421T3 (da) 2006-07-10
MXPA03001030A (es) 2003-11-25
JP4975937B2 (ja) 2012-07-11
ATE318907T1 (de) 2006-03-15
MXPA03001026A (es) 2003-09-22
CA2417969A1 (en) 2002-02-14
DE60117566D1 (de) 2006-04-27
EP1305421B1 (en) 2006-03-01
WO2002012468A3 (en) 2002-12-05
WO2002012481A3 (en) 2002-10-10
WO2002012481A2 (en) 2002-02-14
WO2002012468A2 (en) 2002-02-14
BR0113034A (pt) 2005-08-16
WO2002012528A3 (en) 2003-02-06
BR0113032A (pt) 2006-02-21
EP1305421A2 (en) 2003-05-02
DE60117566T2 (de) 2007-01-11
AU2001281018A1 (en) 2002-02-18

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07G Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette]

Free format text: NOTIFICACAO DE DEVOLUCAO DO PEDIDO POR NAO SE ENQUADRAR NO ART. 229-C DA LPI.

B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B25D Requested change of name of applicant approved

Owner name: MICROGENOMICS, INC (US) , DANISCO US INC. (US)

B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements