BR0111764A - Indole derivatives useful for the treatment of central nervous system (snc) disorders; compound; pharmaceutical composition; compound use and treatment method - Google Patents
Indole derivatives useful for the treatment of central nervous system (snc) disorders; compound; pharmaceutical composition; compound use and treatment methodInfo
- Publication number
- BR0111764A BR0111764A BR0111764-5A BR0111764A BR0111764A BR 0111764 A BR0111764 A BR 0111764A BR 0111764 A BR0111764 A BR 0111764A BR 0111764 A BR0111764 A BR 0111764A
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- treatment
- disorders
- pharmaceutical composition
- nervous system
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 5
- 210000003169 central nervous system Anatomy 0.000 title abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 229940054051 antipsychotic indole derivative Drugs 0.000 title 1
- 150000002475 indoles Chemical class 0.000 title 1
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 abstract 2
- 102000040125 5-hydroxytryptamine receptor family Human genes 0.000 abstract 1
- 108091032151 5-hydroxytryptamine receptor family Proteins 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 abstract 1
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 abstract 1
- 102000015554 Dopamine receptor Human genes 0.000 abstract 1
- 108050004812 Dopamine receptor Proteins 0.000 abstract 1
- 208000019695 Migraine disease Diseases 0.000 abstract 1
- 208000012902 Nervous system disease Diseases 0.000 abstract 1
- 208000025966 Neurological disease Diseases 0.000 abstract 1
- 208000028017 Psychotic disease Diseases 0.000 abstract 1
- 208000010877 cognitive disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 206010027599 migraine Diseases 0.000 abstract 1
- 208000020016 psychiatric disease Diseases 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
- 229940076279 serotonin Drugs 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
"DERIVADOS DE INDOL úTEIS PARA O TRATAMENTO DE DISTúRBIOS DO SISTEMA NERVOSO CENTRAL (SNC); COMPOSTO; COMPOSIçãO FARMACêUTICA; UTILIZAçãO DE COMPOSTO E MéTODO DE TRATAMENTO". A presente invenção refere-se a ligandos de receptor de serotonina e dopamina possuindo a fórmula geral (I), onde um entre Y^ 1^ e Y^ 2^ é N, o qual é unido a Y^ 4^, Y^ 3^ é Z-CH~ 2~, CH~ 2~-Z ou CH~ 2~CH~ 2~ e os outros significados de Y^ 1^, Y^ 2^, Y^ 3^, Y^ 4^, Z, W, n, m, X, R^ 1^ a R^ 9^ e R^ 10^ são como o definido nas reivindicações e na descrição. Os compostos da invenção são úteis no tratamento de certos distúrbios psiquiátricos e neurológicos, ou seja, esquizofrenia, outras psicoses, distúrbios de ansiedade, depressão, enxaqueca, distúrbios cognitivos, ADHD e na melhora de sono."INDOLATED DERIVATIVES FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM (CNS) DISORDERS; COMPOUND; PHARMACEUTICAL COMPOSITION; USE OF COMPOUND AND METHOD OF TREATMENT". The present invention relates to serotonin and dopamine receptor ligands having the general formula (I), wherein one between Y4 1 ^ and Y ^ 2 ^ is N, which is attached to Y ^ 4 ^, Y ^ 3 ^ is Z-CH ~ 2 ~, CH ~ 2 ~ -Z or CH ~ 2 ~ CH ~ 2 ~ and the other meanings of Y ^ 1 ^, Y ^ 2 ^, Y ^ 3 ^, Y ^ 4 ^, Z , W, n, m, X, R 4 R 1 to R 9 9 and R 10 10 are as defined in the claims and the description. The compounds of the invention are useful in the treatment of certain psychiatric and neurological disorders, namely, schizophrenia, other psychoses, anxiety disorders, depression, migraine, cognitive disorders, ADHD, and sleep improvement.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200000919 | 2000-06-14 | ||
| PCT/DK2001/000406 WO2001096328A1 (en) | 2000-06-14 | 2001-06-13 | Indole derivatives useful for the treatment of cns disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0111764A true BR0111764A (en) | 2003-07-08 |
Family
ID=8159557
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0111764-5A BR0111764A (en) | 2000-06-14 | 2001-06-13 | Indole derivatives useful for the treatment of central nervous system (snc) disorders; compound; pharmaceutical composition; compound use and treatment method |
Country Status (9)
| Country | Link |
|---|---|
| CN (1) | CN100415737C (en) |
| BR (1) | BR0111764A (en) |
| EA (1) | EA006315B1 (en) |
| IL (2) | IL153234A0 (en) |
| IS (1) | IS6643A (en) |
| PL (1) | PL358967A1 (en) |
| SK (1) | SK402003A3 (en) |
| UA (1) | UA74830C2 (en) |
| ZA (1) | ZA200209958B (en) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA9711376B (en) * | 1996-12-20 | 1998-07-21 | Lundbeck & Co As H | Indole or dihydroindole derivatives |
| GB9825413D0 (en) * | 1998-11-19 | 1999-01-13 | Lilly Co Eli | Pharmaceutical compounds |
-
2001
- 2001-06-13 UA UA2002129625A patent/UA74830C2/en unknown
- 2001-06-13 IL IL15323401A patent/IL153234A0/en active IP Right Grant
- 2001-06-13 CN CNB018138101A patent/CN100415737C/en not_active Expired - Fee Related
- 2001-06-13 BR BR0111764-5A patent/BR0111764A/en not_active IP Right Cessation
- 2001-06-13 PL PL01358967A patent/PL358967A1/en not_active Application Discontinuation
- 2001-06-13 EA EA200300019A patent/EA006315B1/en not_active IP Right Cessation
- 2001-06-13 SK SK40-2003A patent/SK402003A3/en unknown
-
2002
- 2002-11-29 IS IS6643A patent/IS6643A/en unknown
- 2002-12-03 IL IL153234A patent/IL153234A/en not_active IP Right Cessation
- 2002-12-09 ZA ZA200209958A patent/ZA200209958B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN100415737C (en) | 2008-09-03 |
| UA74830C2 (en) | 2006-02-15 |
| CN1446211A (en) | 2003-10-01 |
| EA006315B1 (en) | 2005-10-27 |
| SK402003A3 (en) | 2003-07-01 |
| HK1059086A1 (en) | 2004-06-18 |
| PL358967A1 (en) | 2004-08-23 |
| ZA200209958B (en) | 2004-06-23 |
| IL153234A0 (en) | 2003-07-06 |
| IL153234A (en) | 2007-12-03 |
| IS6643A (en) | 2002-11-29 |
| EA200300019A1 (en) | 2003-04-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application fees: dismissal - article 86 of industrial property law |
Free format text: CONFORME ARTIGO 10O DA RESOLUCAO 124/06, CABE SER ARQUIVADO REFERENTE AO NAO RECOLHIMENTO DA 9A E 10A ANUIDADES. |
|
| B08K | Lapse as no evidence of payment of the annual fee has been furnished to inpi (acc. art. 87) |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2144 DE 07/02/2012. |