BR0111195A - Uso de b-l-2'-desoxi-nucleosìdeos no tratamento de infecção por vìrus de hepatite delta - Google Patents
Uso de b-l-2'-desoxi-nucleosìdeos no tratamento de infecção por vìrus de hepatite deltaInfo
- Publication number
- BR0111195A BR0111195A BR0111195-7A BR0111195A BR0111195A BR 0111195 A BR0111195 A BR 0111195A BR 0111195 A BR0111195 A BR 0111195A BR 0111195 A BR0111195 A BR 0111195A
- Authority
- BR
- Brazil
- Prior art keywords
- deoxy
- treatment
- nucleosides
- virus infection
- hepatitis delta
- Prior art date
Links
- 241000724709 Hepatitis delta virus Species 0.000 title 1
- 239000002777 nucleoside Substances 0.000 title 1
- 230000009385 viral infection Effects 0.000 title 1
- 208000005331 Hepatitis D Diseases 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
- A61K31/708—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid having oxo groups directly attached to the purine ring system, e.g. guanosine, guanylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
"USO DE <225>-L-2<39> -DESOXI-NUCLEOSìDEOS NO TRATAMENTO DE INFECçãO POR VìRUS DE HEPATITE DELTA". Um método e composição para o tratamento de um hospedeiro infectado com hepatite D, que compreende a administração de uma quantidade de tratamento eficaz para hepatite D de um 2<39>-desoxi-<225>-L-eritrofuranonucleosídeo descrito ou de um sal ou pró-droga farmaceuticamente aceitável desse.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20753800P | 2000-05-26 | 2000-05-26 | |
| PCT/US2001/017301 WO2001091737A2 (en) | 2000-05-26 | 2001-05-29 | Methods for treating hepatitis delta virus infection with beta-l-2' deoxy-nucleosides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0111195A true BR0111195A (pt) | 2004-07-20 |
Family
ID=22771005
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0111195-7A BR0111195A (pt) | 2000-05-26 | 2001-05-29 | Uso de b-l-2'-desoxi-nucleosìdeos no tratamento de infecção por vìrus de hepatite delta |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US6596700B2 (pt) |
| EP (1) | EP1292313B1 (pt) |
| JP (1) | JP2004513070A (pt) |
| KR (1) | KR100854398B1 (pt) |
| CN (1) | CN100490818C (pt) |
| AT (1) | ATE275406T1 (pt) |
| AU (3) | AU6348401A (pt) |
| BR (1) | BR0111195A (pt) |
| CA (1) | CA2410488C (pt) |
| DE (1) | DE60105424T2 (pt) |
| EA (1) | EA005890B1 (pt) |
| ES (1) | ES2227203T3 (pt) |
| IL (1) | IL153078A0 (pt) |
| MX (1) | MXPA02011641A (pt) |
| TR (1) | TR200402565T4 (pt) |
| WO (1) | WO2001091737A2 (pt) |
| ZA (2) | ZA200210100B (pt) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA986614B (en) * | 1997-07-25 | 1999-01-27 | Gilead Sciences | Nucleotide analog composition |
| US6444652B1 (en) * | 1998-08-10 | 2002-09-03 | Novirio Pharmaceuticals Limited | β-L-2'-deoxy-nucleosides for the treatment of hepatitis B |
| ES2579903T3 (es) * | 1998-08-10 | 2016-08-17 | Centre National De La Recherche Scientifique (Cnrs) | Beta-L-2'-desoxi-nucleósidos para el tratamiento de la hepatitis B |
| AU2001245575A1 (en) * | 2000-03-09 | 2001-09-17 | Videoshare, Inc. | Sharing a streaming video |
| ATE414520T1 (de) | 2000-04-13 | 2008-12-15 | Pharmasset Inc | 3 oder 2 hydroxymethyl substituierte nucleoside derivate und ihre verwendung zur behandlung von virusinfektionen |
| MY164523A (en) | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
| MXPA02011691A (es) | 2000-05-26 | 2004-05-17 | Idenix Cayman Ltd | Metodos y composiciones para el tratamiento de flavivirus y pestivirus. |
| US6787526B1 (en) * | 2000-05-26 | 2004-09-07 | Idenix Pharmaceuticals, Inc. | Methods of treating hepatitis delta virus infection with β-L-2′-deoxy-nucleosides |
| EP2251015B1 (en) | 2000-10-18 | 2013-02-20 | Gilead Pharmasset LLC | Modified nucleosides for the treatment of viral infections and abnormal cellular proliferation |
| EP1525209B1 (en) * | 2002-06-28 | 2017-11-15 | Idenix Pharmaceuticals LLC | 1'-, 2'- and 3' -modified nucleoside derivatives for treating flaviviridae infections |
| CN101172993A (zh) * | 2002-06-28 | 2008-05-07 | 埃迪尼克斯(开曼)有限公司 | 用于治疗黄病毒感染的2′-c-甲基-3′-o-l-缬氨酸酯核糖呋喃基胞苷 |
| US7608600B2 (en) | 2002-06-28 | 2009-10-27 | Idenix Pharmaceuticals, Inc. | Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections |
| JP2005533824A (ja) * | 2002-06-28 | 2005-11-10 | イデニクス(ケイマン)リミテツド | フラビウイルス科感染の治療のための2’−c−メチル−3’−o−l−バリンエステルリボフラノシルシチジン |
| MY140819A (en) * | 2002-06-28 | 2010-01-29 | Idenix Caymans Ltd | Modified 2' and 3'-nucleoside prodrugs for treating flaviviridae |
| US7186700B2 (en) * | 2002-09-13 | 2007-03-06 | Idenix Pharmaceuticals, Inc. | β-L-2′-deoxynucleosides for the treatment of resistant HBV strains and combination therapies |
| JP4689274B2 (ja) * | 2002-10-31 | 2011-05-25 | リガンド・ファーマシューティカルズ・インコーポレイテッド | 新規なシタラビン・モノホスフェートプロドラッグ |
| PL377342A1 (pl) * | 2002-11-15 | 2006-01-23 | Idenix (Cayman) Limited | Nukleozydy rozgałęzione w pozycji 2' oraz mutacja Flaviviridae |
| CN1303089C (zh) * | 2002-11-19 | 2007-03-07 | 天津药物研究院 | 阿德福韦酯结晶形态及其制备方法 |
| CN1330373C (zh) * | 2002-12-02 | 2007-08-08 | 美德(江西)生物科技有限公司 | 含alfa-干扰素,阿地福韦和二脱氧氟硫代胞嘧啶的药物组合物 |
| AU2003300901A1 (en) * | 2002-12-12 | 2004-06-30 | Idenix (Cayman) Limited | Process for the production of 2'-branched nucleosides |
| PL2604620T5 (pl) | 2003-05-30 | 2024-10-14 | Gilead Pharmasset Llc | Zmodyfikowane fluorowane analogi nukleozydu |
| CN101023094B (zh) | 2004-07-21 | 2011-05-18 | 法莫赛特股份有限公司 | 烷基取代的2-脱氧-2-氟代-d-呋喃核糖基嘧啶和嘌呤及其衍生物的制备 |
| NZ554442A (en) | 2004-09-14 | 2011-05-27 | Pharmasset Inc | Preparation of 2'fluoro-2'-alkyl-substituted or other optionally substituted ribofuranosyl pyrimidines and purines and their derivatives |
| AR054778A1 (es) | 2005-06-17 | 2007-07-18 | Novartis Ag | Uso de sangliferina en hcv |
| EP1976382B1 (en) * | 2005-12-23 | 2013-04-24 | IDENIX Pharmaceuticals, Inc. | Process for preparing a synthetic intermediate for preparation of branched nucleosides |
| GB0623493D0 (en) | 2006-11-24 | 2007-01-03 | Univ Cardiff | Chemical compounds |
| US7964580B2 (en) | 2007-03-30 | 2011-06-21 | Pharmasset, Inc. | Nucleoside phosphoramidate prodrugs |
| EA201100851A1 (ru) | 2008-12-23 | 2012-04-30 | Фармассет, Инк. | Аналоги нуклеозидов |
| EA019341B1 (ru) | 2008-12-23 | 2014-02-28 | Джилид Фармассет, Ллс. | Фосфорамидаты нуклеозидов |
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| TWI576352B (zh) | 2009-05-20 | 2017-04-01 | 基利法瑪席特有限責任公司 | 核苷磷醯胺 |
| US8618076B2 (en) | 2009-05-20 | 2013-12-31 | Gilead Pharmasset Llc | Nucleoside phosphoramidates |
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| BR112013001553B1 (pt) | 2010-07-22 | 2021-01-12 | Gilead Sciences, Inc. | compostos antivirais para o tratamento de infecções por paramyxoviridae e composições farmacêuticas que os compreendem |
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| JP6069215B2 (ja) | 2010-11-30 | 2017-02-01 | ギリアド ファーマセット エルエルシー | 化合物 |
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| US8916538B2 (en) | 2012-03-21 | 2014-12-23 | Vertex Pharmaceuticals Incorporated | Solid forms of a thiophosphoramidate nucleotide prodrug |
| HK1203356A1 (en) | 2012-03-22 | 2015-10-30 | 艾丽奥斯生物制药有限公司 | Pharmaceutical combinations comprising a thionucleotide analog |
| US20140212491A1 (en) | 2013-01-31 | 2014-07-31 | Gilead Pharmasset Llc | Combination formulation of two antiviral compounds |
| JP6423875B2 (ja) * | 2013-07-31 | 2018-11-14 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung | オキソキナゾリニル−ブタンアミド誘導体 |
| EP3038601B1 (en) | 2013-08-27 | 2020-04-08 | Gilead Pharmasset LLC | Combination formulation of two antiviral compounds |
| WO2015123352A1 (en) | 2014-02-13 | 2015-08-20 | Ligand Pharmaceuticals, Inc. | Prodrug compounds and their uses |
| CN106687118A (zh) | 2014-07-02 | 2017-05-17 | 配体药物公司 | 前药化合物及其用途 |
| MX389016B (es) * | 2015-06-17 | 2025-03-20 | Univ Columbia | Terapia con desoxinucleósidos para enfermedades generadas por grupos de nucleótidos desequilibrados, inclusive síndromes de agotamiento del adn mitocondrial. |
| MX2018002707A (es) * | 2015-09-02 | 2018-08-01 | Abbvie Inc | Derivados de tetrahidrofurano antivirales. |
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| CN111788196A (zh) | 2018-01-09 | 2020-10-16 | 配体药物公司 | 缩醛化合物及其治疗用途 |
| JP2023512656A (ja) | 2020-01-27 | 2023-03-28 | ギリアード サイエンシーズ, インコーポレイテッド | SARS CoV-2感染を治療するための方法 |
| AU2021234308C1 (en) | 2020-03-12 | 2024-02-22 | Gilead Sciences, Inc. | Methods of preparing 1'-cyano nucleosides |
| JP7482250B2 (ja) | 2020-04-06 | 2024-05-13 | ギリアード サイエンシーズ, インコーポレイテッド | 1’-シアノ置換カルバヌクレオシド類似体の吸入製剤 |
| PL4157272T3 (pl) | 2020-05-29 | 2025-10-20 | Gilead Sciences, Inc. | Remdesiwir do leczenia zakażeń wirusowych |
| TWI819321B (zh) | 2020-06-24 | 2023-10-21 | 美商基利科學股份有限公司 | 1'-氰基核苷類似物及其用途 |
| WO2022046631A1 (en) | 2020-08-24 | 2022-03-03 | Gilead Sciences, Inc. | Phospholipid compounds and uses thereof |
| WO2022047065A2 (en) | 2020-08-27 | 2022-03-03 | Gilead Sciences, Inc. | Compounds and methods for treatment of viral infections |
| TW202344257A (zh) | 2020-10-16 | 2023-11-16 | 美商基利科學股份有限公司 | 磷脂化合物及其用途 |
| TWI867455B (zh) | 2022-03-02 | 2024-12-21 | 美商基利科學股份有限公司 | 用於治療病毒感染的化合物及方法 |
| US12357577B1 (en) | 2024-02-02 | 2025-07-15 | Gilead Sciences, Inc. | Pharmaceutical formulations and uses thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE8802687D0 (sv) | 1988-07-20 | 1988-07-20 | Astra Ab | Nucleoside derivatives |
| JP3693357B2 (ja) * | 1993-04-09 | 2005-09-07 | 峯郎 実吉 | 逆転写酵素阻害剤 |
| WO1996011204A1 (de) | 1994-10-07 | 1996-04-18 | Max-Delbrück-Centrum für Molekulare Medizin | NEUE β-L-NUCLEOSIDE UND IHRE VERWENDUNG |
| ES2579903T3 (es) * | 1998-08-10 | 2016-08-17 | Centre National De La Recherche Scientifique (Cnrs) | Beta-L-2'-desoxi-nucleósidos para el tratamiento de la hepatitis B |
-
2001
- 2001-05-29 IL IL15307801A patent/IL153078A0/xx not_active IP Right Cessation
- 2001-05-29 EP EP01937785A patent/EP1292313B1/en not_active Expired - Lifetime
- 2001-05-29 EA EA200201263A patent/EA005890B1/ru not_active IP Right Cessation
- 2001-05-29 MX MXPA02011641A patent/MXPA02011641A/es active IP Right Grant
- 2001-05-29 TR TR2004/02565T patent/TR200402565T4/xx unknown
- 2001-05-29 JP JP2001587753A patent/JP2004513070A/ja active Pending
- 2001-05-29 DE DE60105424T patent/DE60105424T2/de not_active Expired - Fee Related
- 2001-05-29 BR BR0111195-7A patent/BR0111195A/pt not_active Application Discontinuation
- 2001-05-29 AU AU6348401A patent/AU6348401A/xx active Pending
- 2001-05-29 CA CA002410488A patent/CA2410488C/en not_active Expired - Fee Related
- 2001-05-29 ES ES01937785T patent/ES2227203T3/es not_active Expired - Lifetime
- 2001-05-29 AT AT01937785T patent/ATE275406T1/de not_active IP Right Cessation
- 2001-05-29 KR KR1020027015985A patent/KR100854398B1/ko not_active Expired - Fee Related
- 2001-05-29 CN CNB018134297A patent/CN100490818C/zh not_active Expired - Fee Related
- 2001-05-29 WO PCT/US2001/017301 patent/WO2001091737A2/en not_active Ceased
- 2001-05-29 US US09/867,110 patent/US6596700B2/en not_active Expired - Fee Related
- 2001-05-29 AU AU2001263484A patent/AU2001263484B2/en not_active Ceased
-
2002
- 2002-12-12 ZA ZA200210100A patent/ZA200210100B/en unknown
-
2004
- 2004-06-01 ZA ZA200404304A patent/ZA200404304B/xx unknown
-
2006
- 2006-12-21 AU AU2006252214A patent/AU2006252214A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA02011641A (es) | 2004-07-30 |
| EA005890B1 (ru) | 2005-06-30 |
| US6596700B2 (en) | 2003-07-22 |
| DE60105424T2 (de) | 2005-09-22 |
| IL153078A0 (en) | 2003-06-24 |
| CA2410488A1 (en) | 2001-12-06 |
| KR20030031487A (ko) | 2003-04-21 |
| ZA200404304B (en) | 2005-03-30 |
| AU2006252214A1 (en) | 2007-01-18 |
| ES2227203T3 (es) | 2005-04-01 |
| CA2410488C (en) | 2009-10-27 |
| WO2001091737A3 (en) | 2002-05-30 |
| TR200402565T4 (tr) | 2004-12-21 |
| EA200201263A1 (ru) | 2003-06-26 |
| ATE275406T1 (de) | 2004-09-15 |
| AU2001263484B2 (en) | 2006-12-14 |
| EP1292313A2 (en) | 2003-03-19 |
| WO2001091737A2 (en) | 2001-12-06 |
| EP1292313B1 (en) | 2004-09-08 |
| AU6348401A (en) | 2001-12-11 |
| JP2004513070A (ja) | 2004-04-30 |
| US20020035085A1 (en) | 2002-03-21 |
| ZA200210100B (en) | 2004-06-22 |
| CN100490818C (zh) | 2009-05-27 |
| HK1050999A1 (en) | 2003-07-18 |
| KR100854398B1 (ko) | 2008-08-26 |
| CN1444483A (zh) | 2003-09-24 |
| DE60105424D1 (de) | 2004-10-14 |
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