[go: up one dir, main page]

BR0110735A - platelet function assay and reagent for the same - Google Patents

platelet function assay and reagent for the same

Info

Publication number
BR0110735A
BR0110735A BRPI0110735-6A BR0110735A BR0110735A BR 0110735 A BR0110735 A BR 0110735A BR 0110735 A BR0110735 A BR 0110735A BR 0110735 A BR0110735 A BR 0110735A
Authority
BR
Brazil
Prior art keywords
reagent
platelet function
same
assay
function assay
Prior art date
Application number
BRPI0110735-6A
Other languages
Portuguese (pt)
Inventor
Donald E Mahan
Michael W Stewart
Original Assignee
Pharmanetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmanetics Inc filed Critical Pharmanetics Inc
Publication of BR0110735A publication Critical patent/BR0110735A/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G01N33/54333—Modification of conditions of immunological binding reaction, e.g. use of more than one type of particle, use of chemical agents to improve binding, choice of incubation time or application of magnetic field during binding reaction

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

ENSAIO DE FUNçãO DE PLAQUETAS E REAGENTE PARA O MESMO. Um reagente de ensaio de função de plaquetas é fornecido para executar um ensaio de função de plaquetas em que o reagente contém uma mistura de particulas magnéticas e não-magneticas, em que as partículas magnéticas têm aderidas a uma superfície externa uma quantidade de um primeiro ligante que tem uma afinidade para interação direta com os receptores de GP-ib nas plaquetas de sangue e um que as partículas não-magnéticas têm aderidas a uma sua superfície externa uma quantidade de um segundo ligante que tem uma afunidade para interação direta com os receptores de GP-ib nas plaquetas de sangue,de tal modo que a interação de qualquer um do primeiro ou do segundo ligantes com o receptor de plaquetas de GP-ib ativará as plaquetas de sangue da direção da agregação em que o primeiro ligante e o segundo ligante podem ser o mesmo ou diferente, e o ensaio utilizando tal reagente, para fornecer uma avaliação de ponto de atentimento rápido, confíavel.Platelet function test and reagent for the same. A platelet function assay reagent is provided to perform a platelet function assay wherein the reagent contains a mixture of magnetic and nonmagnetic particles, wherein the magnetic particles have adhered to an outer surface an amount of a first binder. which has an affinity for direct interaction with GP-ib receptors on blood platelets and one that non-magnetic particles have adhered to their outer surface an amount of a second binder that has an affinity for direct interaction with blood receptors. GP-ib in blood platelets such that the interaction of either the first or second ligands with the GP-ib platelet receptor will activate the blood platelets in the direction of aggregation where the first ligand and the second ligand they may be the same or different, and the assay using such a reagent to provide a reliable, rapid watchpoint assessment.

BRPI0110735-6A 2000-05-09 2001-05-09 platelet function assay and reagent for the same BR0110735A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20263800P 2000-05-09 2000-05-09
PCT/US2001/011760 WO2001086248A2 (en) 2000-05-09 2001-05-09 Platelet function assay and reagent therefor

Publications (1)

Publication Number Publication Date
BR0110735A true BR0110735A (en) 2007-05-08

Family

ID=22750704

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0110735-6A BR0110735A (en) 2000-05-09 2001-05-09 platelet function assay and reagent for the same

Country Status (9)

Country Link
EP (1) EP1280931A4 (en)
JP (1) JP2003532891A (en)
KR (1) KR20030014219A (en)
AU (1) AU2001261020A1 (en)
BR (1) BR0110735A (en)
CA (1) CA2408850A1 (en)
MX (1) MXPA02011017A (en)
NO (1) NO20025300L (en)
WO (1) WO2001086248A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6680177B2 (en) * 2001-12-07 2004-01-20 Cardiovascular Diagnostics, Inc. Low molecular weight heparin assay, system and reagent therefor
JP4078247B2 (en) * 2003-05-02 2008-04-23 キヤノン株式会社 Magnetic substance-biological substance complex type structure, peptide fragment having amino acid sequence capable of binding to magnetic substance and gene thereof, and method for producing magnetic substance-biological substance complex type structure
WO2011135397A1 (en) * 2010-04-29 2011-11-03 University Of Calcutta Antiplatelet agent and methods of using the same
KR101276179B1 (en) * 2011-08-08 2013-06-18 고려대학교 산학협력단 Apparatus and method of platelet multi-function analysis, and micro stirring chip
US8772040B2 (en) 2012-08-31 2014-07-08 Korea University Research And Business Foundation Apparatus and method of platelet multi-function analysis, and micro stirring chip

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4849340A (en) * 1987-04-03 1989-07-18 Cardiovascular Diagnostics, Inc. Reaction system element and method for performing prothrombin time assay
US5110727A (en) * 1987-04-03 1992-05-05 Cardiovascular Diagnostics, Inc. Method for performing coagulation assays accurately, rapidly and simply, using dry chemical reagents and paramagnetic particles
TW221493B (en) * 1990-07-10 1994-03-01 Cardiovascular Diagnostics Inc
US5616311A (en) * 1991-01-15 1997-04-01 Hemosphere, Inc. Non-crosslinked protein particles for therapeutic and diagnostic use
US5446132A (en) * 1992-10-01 1995-08-29 The General Hospital Corporation Thrombin-activated platelet protein-2 (TAPP-2)
US5427913A (en) * 1992-12-03 1995-06-27 Alberta Cancer Board Methods for determining platelet function
AU689768B2 (en) * 1993-02-17 1998-04-09 Cardiovascular Diagnostics, Inc. Dry chemistry cascade immunoassay and affinity assay
US5686597A (en) * 1995-06-06 1997-11-11 Incyte Pharmaceuticals, Inc. Thrombin receptor homolog
US5922551A (en) * 1997-03-20 1999-07-13 Accumetrics, Inc. Agglutrimetric platelet binding assays in blood
US6046051A (en) * 1997-06-27 2000-04-04 Hemosense, Inc. Method and device for measuring blood coagulation or lysis by viscosity changes
US5932445A (en) * 1997-11-07 1999-08-03 Incyte Pharmaceuticals, Inc. Signal peptide-containing proteins

Also Published As

Publication number Publication date
EP1280931A4 (en) 2005-02-09
MXPA02011017A (en) 2004-08-19
JP2003532891A (en) 2003-11-05
NO20025300D0 (en) 2002-11-05
KR20030014219A (en) 2003-02-15
AU2001261020A1 (en) 2001-11-20
CA2408850A1 (en) 2001-11-15
WO2001086248A3 (en) 2002-02-28
WO2001086248A2 (en) 2001-11-15
EP1280931A2 (en) 2003-02-05
NO20025300L (en) 2003-01-07

Similar Documents

Publication Publication Date Title
WO2002039949A3 (en) Platelet/leukocyte interaction assay and reagent therefor
Behbehani et al. Transient partial permeabilization with saponin enables cellular barcoding prior to surface marker staining
ATE174122T1 (en) PLATELE BLOCKADE TEST
Connor et al. Detection of the procoagulant activity of microparticle-associated phosphatidylserine using XACT
EP0227173A3 (en) New method for the detection of specific binding agents and their corresponding bindable substances
IL57722A (en) Dispersed metal particle labelled assay method and kit and reagents for use therein
DE69816474D1 (en) Stabilized particles of their preparation and use
Devreese et al. Interference of C-reactive protein with clotting times
DE69230105D1 (en) DIFFERENTIAL BINDING SFFINITIES AND BASED DISSOCIATION TESTING PROCEDURES
KR890012165A (en) Ion-Capture Analysis Method and Apparatus
BRPI0720361A8 (en) METHOD FOR MEASURING AGGLUTINATION OF ONE OR MORE PARTICLES IN A TARGET-INDUCED AGGLUTINATION ASSAY PERFORMED IN A REACTION CHAMBER, AND, KIT AND DEVICE FOR MEASURING ONE OR MORE PARTICLES AGGLUTINATION ASSAY IN A TARGET-INDUCED AGGLUTINATION ASSAY
BR0215327A (en) internal calibration system for flow circulation tests
Föller et al. Temperature sensitivity of suicidal erythrocyte death
ATE479092T1 (en) CONFIGURABLE MULTIFUNCTION TESTS
DE60128794D1 (en) MULTIANALYT DIAGNOSTIC PROCEDURE FOR THYROID DISORDER
BR0110735A (en) platelet function assay and reagent for the same
KR890702039A (en) How to Analyze 1,25-Dihydroxy Vitamin D
Spurgeon et al. OMIP‐097: High‐parameter phenotyping of human platelets by spectral flow cytometry
WO2005106047A3 (en) Detection of molecular interactions using colloid dispersion
Beke Debreceni et al. L‐Selectin Expression is Influenced by Phosphatase Activity in Chronic Lymphocytic Leukemia
BR9913770A (en) Test procedure for determining cobalamin bound to transcobalamin ii (tcii) in a body sample, kit for use in a diagnostic assay, and use of holo-tc ii
DE69229960D1 (en) AGGLUTATION ASSAYS AND COLLOID DYES TESTS USING
ES8707342A1 (en) Method for measuring free ligands in biological fluids.
Edwards et al. Efficient use of monoclonal antibodies for immunofluorescence
BR9911677A (en) Immunoassay test kit and containers