BR0110459A - Ciclipostinas, processos para sua produção e uso das mesmas - Google Patents
Ciclipostinas, processos para sua produção e uso das mesmasInfo
- Publication number
- BR0110459A BR0110459A BR0110459-4A BR0110459A BR0110459A BR 0110459 A BR0110459 A BR 0110459A BR 0110459 A BR0110459 A BR 0110459A BR 0110459 A BR0110459 A BR 0110459A
- Authority
- BR
- Brazil
- Prior art keywords
- cyclipostins
- physiologically compatible
- processes
- production
- dsm
- Prior art date
Links
- 229930183107 cyclipostin Natural products 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 abstract 3
- 239000000126 substance Substances 0.000 abstract 2
- 229940127470 Lipase Inhibitors Drugs 0.000 abstract 1
- 241000187747 Streptomyces Species 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/6574—Esters of oxyacids of phosphorus
- C07F9/65744—Esters of oxyacids of phosphorus condensed with carbocyclic or heterocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/6574—Esters of oxyacids of phosphorus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P9/00—Preparation of organic compounds containing a metal or atom other than H, N, C, O, S or halogen
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/465—Streptomyces
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Diabetes (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Genetics & Genomics (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Obesity (AREA)
- Molecular Biology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
"CICLIPOSTINAS, PROCESSOS PARA SUA PRODUçãO E USO DAS MESMAS". A invenção refere-se a compostos da fórmula geral (I), na qual R^ 1^, R^ 2^, E, X~ 1~, X~ 2~ e X~ 3~ têm o significado do presente, obteníveis por cultura de Streptomyces species HAG 004107 (DSM 13381) e seus sais fisiologicamente compatíveis e equivalentes químicos. A invenção refere-se, ainda, a um processo para produção das ciclipostinas, ao microorganismo HAG 004107 (DSM 13381), ao uso das ciclipostinas e de seus sais fisiologicamente compatíveis e equivalentes químicos como medicamento, particularmente como inibidores de lipases, bem como a preparações farmacêuticas com um conteúdo de ciclipostina ou um sal fisiologicamente compatível ou equivalente da mesma.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10021731A DE10021731B4 (de) | 2000-05-04 | 2000-05-04 | Cyclipostine, Verfahren zu ihrer Herstellung und pharmazeutische Zubereitung derselben |
| PCT/EP2001/004652 WO2001083497A1 (de) | 2000-05-04 | 2001-04-25 | Cyclipostine, verfahren zu ihrer herstellung und verwendung derselben |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0110459A true BR0110459A (pt) | 2003-03-11 |
Family
ID=7640768
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0110459-4A BR0110459A (pt) | 2000-05-04 | 2001-04-25 | Ciclipostinas, processos para sua produção e uso das mesmas |
Country Status (27)
| Country | Link |
|---|---|
| EP (1) | EP1280812B1 (pt) |
| JP (1) | JP5038572B2 (pt) |
| KR (1) | KR100779867B1 (pt) |
| CN (1) | CN1216890C (pt) |
| AR (1) | AR028398A1 (pt) |
| AT (1) | ATE288442T1 (pt) |
| AU (2) | AU2001262229B2 (pt) |
| BR (1) | BR0110459A (pt) |
| CA (1) | CA2407808C (pt) |
| CZ (1) | CZ20023547A3 (pt) |
| DE (2) | DE10021731B4 (pt) |
| DK (1) | DK1280812T3 (pt) |
| EE (1) | EE05090B1 (pt) |
| ES (1) | ES2236234T3 (pt) |
| HR (1) | HRP20020864A2 (pt) |
| HU (1) | HUP0300306A3 (pt) |
| IL (2) | IL152612A0 (pt) |
| MX (1) | MXPA02010297A (pt) |
| NO (1) | NO330438B1 (pt) |
| NZ (1) | NZ522352A (pt) |
| PL (1) | PL358328A1 (pt) |
| PT (1) | PT1280812E (pt) |
| RU (1) | RU2266911C2 (pt) |
| SK (1) | SK15602002A3 (pt) |
| WO (1) | WO2001083497A1 (pt) |
| YU (1) | YU81502A (pt) |
| ZA (1) | ZA200208928B (pt) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7737260B2 (en) | 2003-11-13 | 2010-06-15 | Hanmi Pharm. Co., Ltd | Protein complex using an immunoglobulin fragment and method for the preparation thereof |
| US8110665B2 (en) | 2003-11-13 | 2012-02-07 | Hanmi Holdings Co., Ltd. | Pharmaceutical composition comprising an immunoglobulin FC region as a carrier |
| KR100754667B1 (ko) | 2005-04-08 | 2007-09-03 | 한미약품 주식회사 | 비펩타이드성 중합체로 개질된 면역글로불린 Ｆｃ 단편 및이를 포함하는 약제학적 조성물 |
| EP1894601A1 (en) | 2006-08-29 | 2008-03-05 | sanofi-aventis | Treating mycobacterial infections with cyclipostins |
| KR200453850Y1 (ko) * | 2008-04-23 | 2011-05-30 | 주식회사 에이티티알앤디 | 수질 관리 센서 내장형 수도미터기 |
| KR102073748B1 (ko) | 2013-01-31 | 2020-02-05 | 한미약품 주식회사 | 재조합 효모 형질전환체 및 이를 이용하여 면역글로불린 단편을 생산하는 방법 |
| AR096891A1 (es) | 2013-07-12 | 2016-02-03 | Hanmi Pharm Ind Co Ltd | Conjugado de monómero polipéptido biológicamente activo y conjugado de fragmento fc de inmunoglobulina, que muestra aclaramiento mediado por receptor reducido, y el método para la preparación del mismo |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04145089A (ja) * | 1990-10-05 | 1992-05-19 | Nippon Kayaku Co Ltd | 抗生物質ｎｋ９０１０９３、その製造法及びそれを有効成分として含有する殺虫・殺ダニ剤 |
| AU649116B2 (en) * | 1991-03-27 | 1994-05-12 | Sankyo Company Limited | New compounds, named the "Leustroducins", their preparation and their therapeutic uses |
| JPH0656859A (ja) * | 1991-07-25 | 1994-03-01 | Nippon Kayaku Co Ltd | 抗生物質ｎｋ９０１０９３ａ、その製造法及びそれを有効成分として含有する殺虫・殺ダニ剤 |
| RU2077204C1 (ru) * | 1995-05-12 | 1997-04-20 | Третьяков Анатолий Петрович | Способ производства микробиологических препаратов |
-
2000
- 2000-05-04 DE DE10021731A patent/DE10021731B4/de not_active Expired - Fee Related
-
2001
- 2001-04-25 WO PCT/EP2001/004652 patent/WO2001083497A1/de not_active Ceased
- 2001-04-25 AT AT01936275T patent/ATE288442T1/de active
- 2001-04-25 SK SK1560-2002A patent/SK15602002A3/sk unknown
- 2001-04-25 DK DK01936275T patent/DK1280812T3/da active
- 2001-04-25 ES ES01936275T patent/ES2236234T3/es not_active Expired - Lifetime
- 2001-04-25 RU RU2002132558/04A patent/RU2266911C2/ru not_active IP Right Cessation
- 2001-04-25 HU HU0300306A patent/HUP0300306A3/hu unknown
- 2001-04-25 CN CN018088813A patent/CN1216890C/zh not_active Expired - Fee Related
- 2001-04-25 AU AU2001262229A patent/AU2001262229B2/en not_active Ceased
- 2001-04-25 MX MXPA02010297A patent/MXPA02010297A/es active IP Right Grant
- 2001-04-25 NZ NZ522352A patent/NZ522352A/en unknown
- 2001-04-25 IL IL15261201A patent/IL152612A0/xx unknown
- 2001-04-25 PL PL01358328A patent/PL358328A1/xx unknown
- 2001-04-25 EP EP01936275A patent/EP1280812B1/de not_active Expired - Lifetime
- 2001-04-25 HR HRP20020864 patent/HRP20020864A2/xx not_active Application Discontinuation
- 2001-04-25 BR BR0110459-4A patent/BR0110459A/pt not_active IP Right Cessation
- 2001-04-25 EE EEP200200599A patent/EE05090B1/xx not_active IP Right Cessation
- 2001-04-25 AU AU6222901A patent/AU6222901A/xx active Pending
- 2001-04-25 PT PT01936275T patent/PT1280812E/pt unknown
- 2001-04-25 KR KR1020027014691A patent/KR100779867B1/ko not_active Expired - Fee Related
- 2001-04-25 CA CA2407808A patent/CA2407808C/en not_active Expired - Fee Related
- 2001-04-25 YU YU81502A patent/YU81502A/sh unknown
- 2001-04-25 DE DE50105249T patent/DE50105249D1/de not_active Expired - Lifetime
- 2001-04-25 CZ CZ20023547A patent/CZ20023547A3/cs unknown
- 2001-04-25 JP JP2001580922A patent/JP5038572B2/ja not_active Expired - Fee Related
- 2001-05-02 AR ARP010102068A patent/AR028398A1/es not_active Application Discontinuation
-
2002
- 2002-10-30 NO NO20025209A patent/NO330438B1/no not_active IP Right Cessation
- 2002-11-03 IL IL152612A patent/IL152612A/en not_active IP Right Cessation
- 2002-11-04 ZA ZA200208928A patent/ZA200208928B/en unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B25D | Requested change of name of applicant approved |
Owner name: SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) Free format text: ALTERADO DE: AVENTIS PHARMA DEUTSCHLAND GMBH |
|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 15A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2385 DE 20-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |