[go: up one dir, main page]

BR0110184A - Derivado de piridina-1-óxido, e processo para a sua transformação em compostos farmaceuticamente eficazes - Google Patents

Derivado de piridina-1-óxido, e processo para a sua transformação em compostos farmaceuticamente eficazes

Info

Publication number
BR0110184A
BR0110184A BR0110184-6A BR0110184A BR0110184A BR 0110184 A BR0110184 A BR 0110184A BR 0110184 A BR0110184 A BR 0110184A BR 0110184 A BR0110184 A BR 0110184A
Authority
BR
Brazil
Prior art keywords
pyridine
oxide
transformation
piperidinyl
propoxy
Prior art date
Application number
BR0110184-6A
Other languages
English (en)
Other versions
BRPI0110184B1 (pt
BRPI0110184B8 (pt
Inventor
Laszlo Uroegi
Zita Jegesne Csakai
Lajos Gruber
Laszlo Itvoes
Jozsef Toth
Istvan Toemoeskoezi
Aniko Szakacsne Schmidt
Ferencne Reider
Maria Schneiderne Barlay
Original Assignee
Biorex Kutato Fejlesztoe Kft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biorex Kutato Fejlesztoe Kft filed Critical Biorex Kutato Fejlesztoe Kft
Publication of BR0110184A publication Critical patent/BR0110184A/pt
Publication of BRPI0110184B1 publication Critical patent/BRPI0110184B1/pt
Publication of BRPI0110184B8 publication Critical patent/BRPI0110184B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

"DERIVADO DE PIRIDINA-1-óXIDO, E PROCESSO PARA A SUA TRANSFORMAçãO EM COMPOSTOS FARMACEUTICAMENTE EFICAZES". A presente invenção refere-se a N-[2-hidróxi-3-(1-piperidinil)propóxi] piridina-1-óxido-3-carboxamidina e os enantiómeros oticamente ativos do mesmo. (R)-(-)-N-[2-hidróxi-3- (1-piperidinil) propóxi] piridina-1-óxido-3-carboxamidina e (S)-(+)-N- [2-hidróxi-3-(1-piperidinil) propóxi] piridina-1-óxido-3-carboxamidina. Ademais, a presente invenção refere-se à preparação de cloreto de N-[2-hidróxi-3-(1-piperidinil)propóxi] piridina-1-óxido-3-carboxamidina, que pode ser usado como um ingrediente ativo de medicamentos, e a preparação dos enantiómeros oticamente ativos do composto ao usar os compostos da presente invenção como substâncias intermediárias.
BRPI0110184A 2000-04-18 2001-04-17 derivado de piridina-1-óxido, e processo para a sua transformação em compostos farmaceuticamente eficazes BRPI0110184B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU0001583A HUP0001583A2 (hu) 2000-04-18 2000-04-18 Egy piridin-1-oxid-származék és eljárás annak átalakítására gyógyászati hatású vegyületekké
PCT/HU2001/000046 WO2001079174A1 (en) 2000-04-18 2001-04-17 A pyridine-1-oxide derivative, and process for its transformation into pharmaceutically effective compounds

Publications (3)

Publication Number Publication Date
BR0110184A true BR0110184A (pt) 2003-06-17
BRPI0110184B1 BRPI0110184B1 (pt) 2015-12-29
BRPI0110184B8 BRPI0110184B8 (pt) 2021-05-25

Family

ID=90001563

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0110184A BRPI0110184B8 (pt) 2000-04-18 2001-04-17 derivado de piridina-1-óxido, e processo para a sua transformação em compostos farmaceuticamente eficazes

Country Status (31)

Country Link
US (1) US7126002B2 (pt)
EP (1) EP1274685B1 (pt)
JP (1) JP5066638B2 (pt)
KR (1) KR100742482B1 (pt)
CN (1) CN1216868C (pt)
AT (1) ATE332894T1 (pt)
AU (2) AU2001254997B2 (pt)
BG (1) BG65889B1 (pt)
BR (1) BRPI0110184B8 (pt)
CA (1) CA2406266C (pt)
CY (1) CY1107473T1 (pt)
CZ (1) CZ301576B6 (pt)
DE (1) DE60121431T2 (pt)
DK (1) DK1274685T3 (pt)
EE (1) EE05085B1 (pt)
ES (1) ES2267758T3 (pt)
HR (1) HRP20020825A2 (pt)
HU (1) HUP0001583A2 (pt)
IL (2) IL152337A0 (pt)
MX (1) MXPA02010320A (pt)
NO (1) NO323535B1 (pt)
NZ (1) NZ522017A (pt)
PL (1) PL359826A1 (pt)
PT (1) PT1274685E (pt)
RS (1) RS51003B (pt)
RU (1) RU2281282C2 (pt)
SI (1) SI1274685T1 (pt)
SK (1) SK287606B6 (pt)
UA (1) UA75353C2 (pt)
WO (1) WO2001079174A1 (pt)
ZA (1) ZA200208460B (pt)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP9900475D0 (en) * 1999-02-26 1999-04-28 Biorex Kutato Fejlesztoe Kft O-(3-piperidino-2-hydroxy-1-propyl)-hiyroximic acid-halogenid derivative, it's use for treating insulin resistance, and pharmaceutical compositions containing them as active component
HU0103939D0 (en) * 2001-09-27 2001-11-28 Biorex Kutato Fejlesztoe Kft Pharmaceutical composition containing methformin and n-[2-hydroxy-3-(1-piperidinyl)-propoxy]-pyridine-1-oxide-3-carboximidoyl chloride
MXPA04006716A (es) * 2002-01-11 2004-11-10 Biorex Kutato Es Rejleszt Rt Derivados de carboxamidina y su uso en el tratamiento de enfermedades vasculares.
HUP0303584A3 (en) 2003-10-30 2009-12-28 Cytrx Corp Use of a hydroximic acid halide derivative in the treatment of neurodegenerative diseases
TW200831479A (en) * 2006-09-26 2008-08-01 Cytrx Corp Pharmaceutical compositions and methods for treating diseases
DK2318032T3 (da) 2008-06-26 2012-06-11 Orphazyme Aps Anvendelse af Hsp70 som regulator af enzymatisk aktivitet
US9662375B2 (en) 2010-11-30 2017-05-30 Orphazyme Aps Methods for increasing intracellular activity of Hsp70
HUP1100534A2 (en) 2011-09-26 2013-04-29 Balazs Dr Hazay Pharmaceutical composition for the treatment of muscle atrophy
HUP1100535A2 (en) 2011-09-26 2013-04-29 Bracelia Invest Ltd Pharmaceutical composition for enhancement of stem cell treatment
CN107106494B (zh) 2014-09-15 2021-12-21 奥菲泽米有限公司 阿瑞洛莫制剂
US10898476B2 (en) 2016-04-13 2021-01-26 Orphazyme A/S Heat shock proteins and cholesterol homeostasis
HRP20210047T1 (hr) 2016-04-29 2021-04-16 Orphazyme A/S, c/o COBIS A/S Arimoclomol za liječenje poremećaja povezanih s glukocerebrozidazom
BR112020005732A2 (pt) 2017-09-22 2020-10-27 The University Of Adelaide métodos e produtos para melhorar a qualidade de espermatozoides
HUP1800298A1 (hu) 2018-08-30 2020-05-28 N Gene Res Laboratories Inc Gyógyszerkombináció béta-receptor blokkolók hatásának módosítására és a mellékhatások csökkentésére
IL299250A (en) 2020-06-24 2023-02-01 Kempharm Denmark As Arimoclomol for the treatment of Gaucher disease
KR20230128462A (ko) * 2020-11-19 2023-09-05 제브라 덴마크 에이/에스 아리모클로몰 시트레이트 및 이의 중간체를 제조하기 위한 공정
CN116783164A (zh) * 2020-11-19 2023-09-19 泽维拉丹麦股份有限公司 制备柠檬酸阿瑞洛莫及其中间体的方法
MX2023007551A (es) 2020-12-24 2023-09-04 Zevra Denmark As Arimoclomol para el tratamiento de la enfermedad de niemann pick, tipo c, en pacientes con mutaciones de sentido erroneo de tipo reticulo endoplasmatico (er).
AU2023454616A1 (en) 2023-07-10 2026-01-22 N-Gene Research Laboratories, Inc. Increasing telomere length and/or suppressing telomere shortening

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU207988B (en) * 1988-10-20 1993-07-28 Biorex Kutato Fejlesztoe Kft Process for producing halogenides of o-/3-amino-2-hydroxy-propyl/hydroximic acid and pharmaceutical compositions containing them as active components
HU9502843D0 (en) 1995-09-29 1995-11-28 Livigene Ltd Pharmaceutical composition
HU222994B1 (hu) * 1995-11-02 2004-01-28 BIOREX Kutató és Fejlesztő Rt. Hidroxilaminszármazékok és azok alkalmazása sejtek molekuláris chaperon-termelésének fokozására alkalmas gyógyszerkészítmények előállítására
HUP9900475D0 (en) * 1999-02-26 1999-04-28 Biorex Kutato Fejlesztoe Kft O-(3-piperidino-2-hydroxy-1-propyl)-hiyroximic acid-halogenid derivative, it's use for treating insulin resistance, and pharmaceutical compositions containing them as active component

Also Published As

Publication number Publication date
RU2281282C2 (ru) 2006-08-10
KR100742482B1 (ko) 2007-07-25
AU5499701A (en) 2001-10-30
BG107199A (bg) 2003-07-31
HK1055741A1 (en) 2004-01-21
WO2001079174A1 (en) 2001-10-25
EE200200591A (et) 2004-04-15
CN1434800A (zh) 2003-08-06
KR20030011309A (ko) 2003-02-07
IL152337A0 (en) 2003-05-29
EP1274685A1 (en) 2003-01-15
RS51003B (sr) 2010-10-31
HUP0001583D0 (en) 2000-06-28
US7126002B2 (en) 2006-10-24
BRPI0110184B1 (pt) 2015-12-29
WO2001079174A8 (en) 2002-12-27
DE60121431D1 (de) 2006-08-24
PL359826A1 (en) 2004-09-06
CY1107473T1 (el) 2012-12-19
CZ20023445A3 (cs) 2003-03-12
UA75353C2 (en) 2006-04-17
DK1274685T3 (da) 2006-11-06
BRPI0110184B8 (pt) 2021-05-25
SI1274685T1 (sl) 2006-10-31
US20040006232A1 (en) 2004-01-08
RU2002130710A (ru) 2004-03-20
PT1274685E (pt) 2006-09-29
DE60121431T2 (de) 2007-01-18
CA2406266C (en) 2010-07-20
MXPA02010320A (es) 2004-09-06
HUP0001583A2 (hu) 2002-11-28
JP5066638B2 (ja) 2012-11-07
ATE332894T1 (de) 2006-08-15
ES2267758T3 (es) 2007-03-16
NO20025015L (no) 2002-12-16
JP2004501080A (ja) 2004-01-15
HRP20020825A2 (en) 2004-12-31
SK287606B6 (sk) 2011-03-04
IL152337A (en) 2007-10-31
EP1274685B1 (en) 2006-07-12
EE05085B1 (et) 2008-10-15
BG65889B1 (bg) 2010-04-30
ZA200208460B (en) 2003-10-20
CN1216868C (zh) 2005-08-31
SK15082002A3 (sk) 2003-05-02
NO323535B1 (no) 2007-06-04
AU2001254997B2 (en) 2006-11-23
NO20025015D0 (no) 2002-10-18
YU78302A (sh) 2005-09-19
NZ522017A (en) 2004-06-25
CA2406266A1 (en) 2001-10-25
CZ301576B6 (cs) 2010-04-21

Similar Documents

Publication Publication Date Title
BR0110184A (pt) Derivado de piridina-1-óxido, e processo para a sua transformação em compostos farmaceuticamente eficazes
BR0213040A (pt) Composto, processo para preparar um composto, e, método de tratar doenças
BR0111116A (pt) Imitadores de trombopoietina
BR9908545A (pt) Derivado de piperidina, processo para a preparação do mesmo, composto, processo para a preparação do mesmo, e, composição farmacêutica
BR0108893A (pt) Composição farmacêutica, composto e processo de preparação de compostos
BR0114576A (pt) Composto, composição farmacêutica, uso de um composto, método de tratar um estado doentio e processo para preparar um composto
BR0116084A (pt) Amidas de ácido furanocarboxìlico e tiofenocarboxìlico ariladas com efeito bloqueador de canal de potássio
PT1414816E (pt) Polimorfo estavel da flibanserina, processo tecnico para a sua preparacao e sua utilizacao na preparacao de medicamentos
DOP2002000512A (es) Sales de acido succinato de 5,7,14-triazatetraciclo [10.3.1.0² ¹¹.04,9] hexadeca-2 (11),3,5,7,9-pentaeno y composiciones farmaceuticas de las mismas
BRPI0409498A (pt) uso de um composto, formulação farmacêutica, composto, composição farmacêutica, e, processo para preparação de um composto
AR019496A1 (es) Azalidas de 13 miembros, composiciones farmaceuticas, uso en la preparacion de medicamentos y preparacion de los mismos
PT839041E (pt) Sais de derivados de amidina e de inibidor de ciclooxigenase processo para a sua preparacao sua utilizacao como farmacos e composicoes farmaceuticas contendo os referidos sais
PT748314E (pt) Derivados tetrassubstituidos do imidazol, processo para a sua preparacao, sua utilizacao como medicamentos e composicoes farmaceuticas que os incorporam
BR9814498A (pt) Processo para o tratamento de obesidade em um humano necessitando de tal tratamento, composto, uso do mesmo, produto, e, composição farmacêutica
BR1100524A (pt) Compostos, processo para sua preparação; compostos intermediários para os mesmos, e composições farmacêuticas
PT1194415E (pt) Novos derivados da piperazinil-alquil-tiopirimidina composicoes farmaceuticas que os contem e um processo de preparacao da substancia activa
BR9705456A (pt) Compostos heterocìclicos, processo de aminometila para sua preparação e composições farmacêuticas que os contêm.
PT100415A (pt) Novas morfolinas de accao farmaceutica, e processo para a sua preparacao
BR9804485A (pt) Compostos de indanol, processo para sua preparação e composições farmacêuticas contendo os mesmos.
BR9713044A (pt) Composto, uso de um composto, processo para sua preparação,e, formulação farmacêutica.
BRPI0413101A (pt) compostos de sulfonamida derivado de benzoxazinona, sua preparação e uso como medicamentos
BR0115506A (pt) Composições farmacêuticas tendo uma ação antidiabética, e processo para sua preparação
DK0863752T3 (da) Anvendelse af alkylaminderivater såsom terbinafin ved fremstillingen af et lægemiddel til behandling af ledsagende sygdomme af en helicobacter pylori-infektion.
MXPA05009763A (es) 2-(butil-1-sulfonilamino)-n-[1 (r)-(6-metoxipiridin-3-il) propil] benzamida, su uso en forma de un farmaco y preparaciones farmaceuticas que contienen a dicho compuesto.
BR0306149A (pt) Composto, processo para a preparação do mesmo, composição farmacêutica, e, usos do composto, e de um inibidor de enzima degradadora da neurotensina

Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: CYTRX CORPORATION (US)

Free format text: TRANSFERIDO DE: BIOREX KUTATO ES FEJLESZTO RT

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B25A Requested transfer of rights approved

Owner name: ORPHAZYME APS (DK)

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: PAGAR RESTAURACAO.

B08H Application fees: decision cancelled [chapter 8.8 patent gazette]

Free format text: REFERENTE RPI 2308 DE 31/03/2014 (COD. 8.6)

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 29/12/2015, OBSERVADAS AS CONDICOES LEGAIS.

B25D Requested change of name of applicant approved
B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 17/04/2001 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF

B21A Patent or certificate of addition expired [chapter 21.1 patent gazette]

Free format text: PATENTE EXTINTA EM 17/04/2021