BR0016129A - Molécula de ácido nucléico, vetor recombinante, polipeptìdeo, racemase de aminoácido eucariótica, anticorpos, célula hospedeira, métodos para produzir polipeptìdeo, para detectar um parasita e uma proteìna eucariótica, para triar moléculas ativas, para detectar e quantificar a presença ou a ausência de uma sequência, para inibir uma proteìna eucariótica, para produzir uma racemase de aminoácido recombinante eucariótica e d-aminoácio e para prevenir ou inibir infecção, plasmìdeo, complexo imunológico, kit para detectar um parasita, fragmento de um polinucleotìdeo, proteìna eucariótica, processos para preparar uma proteìna eucariótica purificada, para detectar uma infecção e para infecção e para triar uma molécula, composição imunizadora, composição de vacina, qualquer modificação molecular do gene ou de um fragmento do gene, uso de qualquer modificação molecular ou bioquìmica da atividade enzimática da racemase, e, qualquer molécula ou composto - Google Patents
Molécula de ácido nucléico, vetor recombinante, polipeptìdeo, racemase de aminoácido eucariótica, anticorpos, célula hospedeira, métodos para produzir polipeptìdeo, para detectar um parasita e uma proteìna eucariótica, para triar moléculas ativas, para detectar e quantificar a presença ou a ausência de uma sequência, para inibir uma proteìna eucariótica, para produzir uma racemase de aminoácido recombinante eucariótica e d-aminoácio e para prevenir ou inibir infecção, plasmìdeo, complexo imunológico, kit para detectar um parasita, fragmento de um polinucleotìdeo, proteìna eucariótica, processos para preparar uma proteìna eucariótica purificada, para detectar uma infecção e para infecção e para triar uma molécula, composição imunizadora, composição de vacina, qualquer modificação molecular do gene ou de um fragmento do gene, uso de qualquer modificação molecular ou bioquìmica da atividade enzimática da racemase, e, qualquer molécula ou compostoInfo
- Publication number
- BR0016129A BR0016129A BR0016129-2A BR0016129A BR0016129A BR 0016129 A BR0016129 A BR 0016129A BR 0016129 A BR0016129 A BR 0016129A BR 0016129 A BR0016129 A BR 0016129A
- Authority
- BR
- Brazil
- Prior art keywords
- detect
- eukaryotic
- infection
- molecule
- eukaryotic protein
- Prior art date
Links
- 108090000623 proteins and genes Proteins 0.000 title abstract 10
- 208000015181 infectious disease Diseases 0.000 title abstract 6
- 102000004169 proteins and genes Human genes 0.000 title abstract 6
- 244000045947 parasite Species 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 4
- 230000004048 modification Effects 0.000 title abstract 4
- 238000012986 modification Methods 0.000 title abstract 4
- 102000006534 Amino Acid Isomerases Human genes 0.000 title abstract 3
- 108010008830 Amino Acid Isomerases Proteins 0.000 title abstract 3
- 239000012634 fragment Substances 0.000 title abstract 3
- 229920001184 polypeptide Polymers 0.000 title abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
- 102000004879 Racemases and epimerases Human genes 0.000 title abstract 2
- 108090001066 Racemases and epimerases Proteins 0.000 title abstract 2
- 230000003053 immunization Effects 0.000 title abstract 2
- 102000039446 nucleic acids Human genes 0.000 title abstract 2
- 108020004707 nucleic acids Proteins 0.000 title abstract 2
- 150000007523 nucleic acids Chemical class 0.000 title abstract 2
- 229960005486 vaccine Drugs 0.000 title abstract 2
- 230000002255 enzymatic effect Effects 0.000 title 1
- 239000013612 plasmid Substances 0.000 title 1
- 102000040430 polynucleotide Human genes 0.000 title 1
- 108091033319 polynucleotide Proteins 0.000 title 1
- 239000002157 polynucleotide Substances 0.000 title 1
- 241000700605 Viruses Species 0.000 abstract 3
- 230000001225 therapeutic effect Effects 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000001900 immune effect Effects 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000003226 mitogen Substances 0.000 abstract 1
- 230000001681 protective effect Effects 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
- C12Q1/701—Specific hybridization probes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/44—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/90—Isomerases (5.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
- C12Q1/6893—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for protozoa
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56905—Protozoa
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Cell Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Toxicology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16863199P | 1999-12-03 | 1999-12-03 | |
| US22020700P | 2000-07-24 | 2000-07-24 | |
| US22111700P | 2000-07-27 | 2000-07-27 | |
| PCT/IB2000/002008 WO2001040449A2 (en) | 1999-12-03 | 2000-12-04 | Cloning of a gene encoding an amino acid racemase from trypanosoma cruzi, and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR0016129A true BR0016129A (pt) | 2002-08-20 |
| BRPI0016129B1 BRPI0016129B1 (pt) | 2016-07-05 |
Family
ID=27389546
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0016129A BRPI0016129B1 (pt) | 1999-12-03 | 2000-12-04 | microorganismo transgênico, plasmídeo, kits para detectar um parasita, composição de vacina contra infecção por t. cruzi, métodos para produzir polipeptídeo prolina racemase de t. cruzi (tc45) e para detectar um parasita em uma amostra biológica, e, processos para preparar uma proteína eucariótica purificada com atividade de racemase e para detectar uma infecção por t. cruzi. |
Country Status (6)
| Country | Link |
|---|---|
| US (6) | US6713617B2 (pt) |
| EP (1) | EP1240315B1 (pt) |
| AU (1) | AU2212701A (pt) |
| BR (1) | BRPI0016129B1 (pt) |
| MX (1) | MXPA02005506A (pt) |
| WO (1) | WO2001040449A2 (pt) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2768747B1 (fr) * | 1997-09-19 | 2000-12-01 | Pasteur Institut | Acides nucleiques, cellules recombinantes, et procede de preparation de compositions immunogenes |
| US6713617B2 (en) * | 1999-12-03 | 2004-03-30 | Institut Pasteur | Cloning, sequencing and expression of a gene encoding an eukaryotic amino acid racemase, and diagnostic, therapeutic, and vaccination applications of parasite and viral mitogens |
| US7585656B2 (en) | 2003-02-11 | 2009-09-08 | Institute Pasteur | Crystallographic structure of TcPRACA and uses therefor |
| EP1592788A2 (en) | 2003-02-11 | 2005-11-09 | Institut Pasteur | Identification and characterization of racemases, definition of protein signatures, and a test for detecting d-amino acid and for screening molecules capable of inhibiting the activity of racemase, especially proline racemase |
| US20050119725A1 (en) * | 2003-04-08 | 2005-06-02 | Xingwu Wang | Energetically controlled delivery of biologically active material from an implanted medical device |
| US20050155779A1 (en) * | 2003-04-08 | 2005-07-21 | Xingwu Wang | Coated substrate assembly |
| EP1629092B1 (en) * | 2003-05-30 | 2010-12-01 | Institut Pasteur | CRYSTALLOGRAPHIC STRUCTURE OF TRYPANOSOMA CRUZI PROLINE RACEMASE (TcPRACA) AND USES THEREOF |
| US20060118758A1 (en) * | 2004-09-15 | 2006-06-08 | Xingwu Wang | Material to enable magnetic resonance imaging of implantable medical devices |
| US7468182B2 (en) * | 2004-10-27 | 2008-12-23 | North Carolina State University | Lactobacillus acidophilus nucleic acids and uses thereof |
| US20090156431A1 (en) * | 2007-12-12 | 2009-06-18 | Si Lok | Methods for Nucleic Acid Mapping and Identification of Fine Structural Variations in Nucleic Acids |
| BRPI0915371A2 (pt) * | 2008-07-04 | 2016-10-18 | Inst Rech Developpement Ird | um método para avaliação de proteínas secretadas conservadas |
| RU2490634C1 (ru) * | 2012-01-27 | 2013-08-20 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Тюменская государственная сельскохозяйственная академия" (ФГБОУ ВПО ТГСХА) | Способ диагностики хламидийной инфекции у хряков-производителей |
| CN114854728B (zh) * | 2022-05-12 | 2023-11-24 | 云南师范大学 | 一种脯氨酸消旋酶及其制备和应用 |
| CN118252943B (zh) * | 2023-10-25 | 2024-09-20 | 常州市智态生创科技有限公司 | 一种短肽偶联药物及其制备方法和应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994025606A2 (de) * | 1993-04-23 | 1994-11-10 | Sandoz Ltd. | Rekombinante alanin racemase und gapdh aus tolypocladium niveum |
| JP3473985B2 (ja) * | 1994-04-26 | 2003-12-08 | 協和醗酵工業株式会社 | D−プロリンの製造法 |
| US6713617B2 (en) | 1999-12-03 | 2004-03-30 | Institut Pasteur | Cloning, sequencing and expression of a gene encoding an eukaryotic amino acid racemase, and diagnostic, therapeutic, and vaccination applications of parasite and viral mitogens |
| JP2005117918A (ja) | 2003-10-14 | 2005-05-12 | Glycomedics Inc | 新規糖鎖プライマー |
-
2000
- 2000-11-30 US US09/725,945 patent/US6713617B2/en not_active Expired - Lifetime
- 2000-12-04 WO PCT/IB2000/002008 patent/WO2001040449A2/en not_active Ceased
- 2000-12-04 BR BRPI0016129A patent/BRPI0016129B1/pt not_active IP Right Cessation
- 2000-12-04 EP EP00985729A patent/EP1240315B1/en not_active Expired - Lifetime
- 2000-12-04 AU AU22127/01A patent/AU2212701A/en not_active Abandoned
-
2002
- 2002-06-03 MX MXPA02005506A patent/MXPA02005506A/es active IP Right Grant
-
2003
- 2003-09-16 US US10/662,425 patent/US20050130166A1/en not_active Abandoned
- 2003-09-16 US US10/662,437 patent/US20050090656A1/en not_active Abandoned
-
2006
- 2006-03-17 US US11/384,144 patent/US7851603B2/en not_active Expired - Fee Related
- 2006-03-17 US US11/378,706 patent/US8168770B2/en not_active Expired - Fee Related
- 2006-03-24 US US11/388,474 patent/US7732563B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU2212701A (en) | 2001-06-12 |
| WO2001040449A9 (en) | 2002-11-07 |
| US20060252921A1 (en) | 2006-11-09 |
| US20050090656A1 (en) | 2005-04-28 |
| US6713617B2 (en) | 2004-03-30 |
| US20050130166A1 (en) | 2005-06-16 |
| BRPI0016129B1 (pt) | 2016-07-05 |
| EP1240315A2 (en) | 2002-09-18 |
| US7851603B2 (en) | 2010-12-14 |
| MXPA02005506A (es) | 2004-09-10 |
| WO2001040449A3 (en) | 2002-01-10 |
| US8168770B2 (en) | 2012-05-01 |
| US20060292596A1 (en) | 2006-12-28 |
| WO2001040449A2 (en) | 2001-06-07 |
| EP1240315B1 (en) | 2012-06-20 |
| US20060292598A1 (en) | 2006-12-28 |
| US20040018206A1 (en) | 2004-01-29 |
| US7732563B2 (en) | 2010-06-08 |
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