BR0016115A - Peptide derivatives of acrylamide, process for its preparation and use as tumor inhibiting agents - Google Patents
Peptide derivatives of acrylamide, process for its preparation and use as tumor inhibiting agentsInfo
- Publication number
- BR0016115A BR0016115A BR0016115-2A BR0016115A BR0016115A BR 0016115 A BR0016115 A BR 0016115A BR 0016115 A BR0016115 A BR 0016115A BR 0016115 A BR0016115 A BR 0016115A
- Authority
- BR
- Brazil
- Prior art keywords
- hydrogen
- different
- preparation
- inhibiting agents
- peptide derivatives
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 230000002401 inhibitory effect Effects 0.000 title abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
- 150000003926 acrylamides Chemical class 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 125000003647 acryloyl group Chemical group O=C([*])C([H])=C([H])[H] 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
"DERIVADOS PEPTìDICOS DE ACRILOìLA, PROCESSO PARA SUA PREPARAçãO E SEU USO COMO AGENTES INIBIDORES DE TUMOR". Compostos que são derivados peptídicos de acriloíla da fórmula (I) , onde n é 3 ou 4; m é 0, 1 ou 2; X e Y são iguais ou diferentes e são selecionados, independentemente para cada anel heterocíclico, de N ou CH; R~ 1~ e R~ 2~, iguais ou diferentes, são selecionados de hidrogênio, halogênio ou alquila C~ 1~-C~ 4~,; R~ 3~, é hidrogênio ou halogênio; B é selecionado dos grupos que consistem nas fórmulas (1) , (2) , (3) , (4) , (5), (6) e (7), onde R~ 4~/ R~ 5~, R~ 7~ e R~ 8~ são, independentemente entre si, hidrogênio ou alquila C~ 1~-C~ 4~; R~ 6~ é hidrogênio, hidróxi ou alquila C~ 1~-C~ 4~; ou um seu sal farmaceuticamente aceitável; desde que X e Y não sejam ambos átomos N para o mesmo anel-heterocíclico; quando todos de X e Y forem grupos CH e m for 0, então pelo menos um de R~ 4~, R~ 5~, ou R~ 6~ é diferente de hidrogênio; quando pelo menos um de X e Y for diferente de CH, então pelo menos um de R~ 4~ e R~ 5~, é diferente de hidrogênio; são úteis como agentes inibidores de tumor."PEPTIDIC DERIVATIVES FROM ACRYLOL, PROCESS FOR THEIR PREPARATION AND USE AS TUMOR INHIBITORS". Compounds that are acryloyl peptide derivatives of formula (I), where n is 3 or 4; m is 0, 1 or 2; X and Y are the same or different and are selected, independently for each heterocyclic ring, from N or CH; R ~ 1 ~ and R ~ 2 ~, the same or different, are selected from hydrogen, halogen or C ~ 1 ~ -C ~ 4 ~ alkyl; R ~ 3 ~, is hydrogen or halogen; B is selected from the groups consisting of formulas (1), (2), (3), (4), (5), (6) and (7), where R ~ 4 ~ / R ~ 5 ~, R ~ 7 ~ and R ~ 8 ~ are, independently of each other, hydrogen or C ~ 1 ~ -C ~ 4 ~ alkyl; R ~ 6 ~ is hydrogen, hydroxy or C ~ 1 ~ -C ~ 4 ~ alkyl; or a pharmaceutically acceptable salt thereof; provided that X and Y are not both N atoms for the same heterocyclic ring; when all of X and Y are groups CH and m is 0, then at least one of R ~ 4 ~, R ~ 5 ~, or R ~ 6 ~ is different from hydrogen; when at least one of X and Y is different from CH, then at least one of R ~ 4 ~ and R ~ 5 ~ is different from hydrogen; are useful as tumor inhibiting agents.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9928703.9A GB9928703D0 (en) | 1999-12-03 | 1999-12-03 | Acryloyl peptidic derivatives,process for their preparation and their use as antitumour agents |
| PCT/EP2000/011714 WO2001040181A1 (en) | 1999-12-03 | 2000-11-23 | Acryloyl peptidic derivatives, process for their preparation and their use as antitumor agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0016115A true BR0016115A (en) | 2002-08-20 |
Family
ID=10865724
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0016115-2A BR0016115A (en) | 1999-12-03 | 2000-11-23 | Peptide derivatives of acrylamide, process for its preparation and use as tumor inhibiting agents |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP1242374A1 (en) |
| JP (1) | JP2003515586A (en) |
| KR (1) | KR20020084069A (en) |
| AU (1) | AU781657B2 (en) |
| BR (1) | BR0016115A (en) |
| CA (1) | CA2395094A1 (en) |
| GB (1) | GB9928703D0 (en) |
| NZ (1) | NZ519581A (en) |
| WO (1) | WO2001040181A1 (en) |
| ZA (1) | ZA200204722B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0011059D0 (en) | 2000-05-08 | 2000-06-28 | Pharmacia & Upjohn Spa | Use of substituted acryloyl distamycin derivatives in the treatment of tumours associated with high levels of glutathione |
| GB0015447D0 (en) | 2000-06-23 | 2000-08-16 | Pharmacia & Upjohn Spa | Combined therapy against tumors comprising substituted acryloyl derivates and alkylating agents |
| GB0015446D0 (en) | 2000-06-23 | 2000-08-16 | Pharmacia & Upjohn Spa | Combined therapy against tumors comprising substituted acryloyl distamycin derivates,taxanes and/or antimetabolites |
| GB0016447D0 (en) | 2000-07-04 | 2000-08-23 | Pharmacia & Upjohn Spa | Process for preparing distamycin derivatives |
| US6576612B1 (en) * | 2000-10-02 | 2003-06-10 | Pharmacia Italia S.P.A. | Antitumor therapy comprising distamycin derivatives |
| US6969592B2 (en) | 2001-09-26 | 2005-11-29 | Pharmacia Italia S.P.A. | Method for predicting the sensitivity to chemotherapy |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9416005D0 (en) * | 1994-08-08 | 1994-09-28 | Erba Carlo Spa | Peptidic compounds analogous to distamycin a and process for their preparation |
| GB9610079D0 (en) * | 1996-05-14 | 1996-07-17 | Pharmacia Spa | Distamycin deriratives process for preparing them and their use as antitumor and antiviral agents |
| GB9615692D0 (en) * | 1996-07-25 | 1996-09-04 | Pharmacia Spa | Acryloyl substituted distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents |
| GB9806689D0 (en) * | 1998-03-27 | 1998-05-27 | Pharmacia & Upjohn Spa | Acryloyl derivatives analogous to distamycin,process for preparing them,and their use as antitumour and antiviral agents |
-
1999
- 1999-12-03 GB GBGB9928703.9A patent/GB9928703D0/en not_active Ceased
-
2000
- 2000-11-23 AU AU28370/01A patent/AU781657B2/en not_active Ceased
- 2000-11-23 KR KR1020027007127A patent/KR20020084069A/en not_active Withdrawn
- 2000-11-23 NZ NZ519581A patent/NZ519581A/en unknown
- 2000-11-23 JP JP2001541867A patent/JP2003515586A/en not_active Withdrawn
- 2000-11-23 CA CA002395094A patent/CA2395094A1/en not_active Abandoned
- 2000-11-23 BR BR0016115-2A patent/BR0016115A/en not_active IP Right Cessation
- 2000-11-23 EP EP00993255A patent/EP1242374A1/en not_active Withdrawn
- 2000-11-23 WO PCT/EP2000/011714 patent/WO2001040181A1/en not_active Ceased
-
2002
- 2002-06-12 ZA ZA200204722A patent/ZA200204722B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2837001A (en) | 2001-06-12 |
| WO2001040181A1 (en) | 2001-06-07 |
| ZA200204722B (en) | 2004-02-03 |
| CA2395094A1 (en) | 2001-06-07 |
| AU781657B2 (en) | 2005-06-02 |
| GB9928703D0 (en) | 2000-02-02 |
| KR20020084069A (en) | 2002-11-04 |
| NZ519581A (en) | 2004-05-28 |
| EP1242374A1 (en) | 2002-09-25 |
| JP2003515586A (en) | 2003-05-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application fees: application dismissed [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A E 8A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 2008 DE 30/06/2009. |