BR0012351A - Pós consistindo de partìculas com uma superfìcie perfeitamente macia, para uso como veìculos para a preparação de misturas de inalação com medicamentos micronizados e o método para sua preparação - Google Patents
Pós consistindo de partìculas com uma superfìcie perfeitamente macia, para uso como veìculos para a preparação de misturas de inalação com medicamentos micronizados e o método para sua preparaçãoInfo
- Publication number
- BR0012351A BR0012351A BR0012351-0A BR0012351A BR0012351A BR 0012351 A BR0012351 A BR 0012351A BR 0012351 A BR0012351 A BR 0012351A BR 0012351 A BR0012351 A BR 0012351A
- Authority
- BR
- Brazil
- Prior art keywords
- preparation
- vehicles
- particles
- smooth surface
- perfectly smooth
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 3
- 229940079593 drug Drugs 0.000 title abstract 2
- 239000002245 particle Substances 0.000 title abstract 2
- 239000000843 powder Substances 0.000 title abstract 2
- 229940112141 dry powder inhaler Drugs 0.000 abstract 1
- 230000002685 pulmonary effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2991—Coated
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2991—Coated
- Y10T428/2998—Coated including synthetic resin or polymer
Landscapes
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Otolaryngology (AREA)
- Pulmonology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Detergent Compositions (AREA)
Abstract
"PóS CONSISTINDO DE PARTìCULAS COM UMA SUPERFìCIE PERFEITAMENTE MACIA, PARA USO COMO VEìCULOS PARA A PREPARAçãO DE MISTURAS DE INALAçãO COM MEDICAMENTOS MICRONIZADOS E O MéTODO PARA SUA PREPARAçãO". Estão descritos os veículos para uso na preparação de misturas para pós de inalação visados para administração pulmonar de medicamentos micronizados por meio de um inalador de pó seco e o método de sua preparação.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT1999MI001582A ITMI991582A1 (it) | 1999-07-16 | 1999-07-16 | Polveri costituite da particelle aventi la superficie perfettamente levigata da utilizzare come veicoli per la preparazione di miscele inala |
| PCT/EP2000/006690 WO2001005429A2 (en) | 1999-07-16 | 2000-07-13 | Powder particles with smooth surface for use in inhalation therapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0012351A true BR0012351A (pt) | 2002-06-11 |
Family
ID=11383357
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0012351-0A BR0012351A (pt) | 1999-07-16 | 2000-07-13 | Pós consistindo de partìculas com uma superfìcie perfeitamente macia, para uso como veìculos para a preparação de misturas de inalação com medicamentos micronizados e o método para sua preparação |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US6780508B1 (pt) |
| EP (1) | EP1196146B1 (pt) |
| AT (1) | ATE339191T1 (pt) |
| AU (1) | AU6823200A (pt) |
| BR (1) | BR0012351A (pt) |
| CY (1) | CY1106269T1 (pt) |
| DE (1) | DE60030721T2 (pt) |
| DK (1) | DK1196146T3 (pt) |
| ES (1) | ES2272313T3 (pt) |
| IT (1) | ITMI991582A1 (pt) |
| PT (1) | PT1196146E (pt) |
| SI (1) | SI1196146T1 (pt) |
| WO (1) | WO2001005429A2 (pt) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9006175B2 (en) | 1999-06-29 | 2015-04-14 | Mannkind Corporation | Potentiation of glucose elimination |
| PT1337239E (pt) | 2000-11-30 | 2010-01-26 | Vectura Ltd | Partículas servindo à preparação de uma composição farmacêutica |
| ES2708961T3 (es) | 2000-11-30 | 2019-04-12 | Vectura Ltd | Composiciones farmacéuticas para inhalación |
| US8337816B2 (en) | 2001-09-17 | 2012-12-25 | Glaxo Group Limited | Dry powder medicament formulations |
| ES2425392T3 (es) | 2002-03-20 | 2013-10-15 | Mannkind Corporation | Cartucho para un aparato de inhalación |
| GB0210527D0 (en) * | 2002-05-08 | 2002-06-19 | Univ Bath | Process for the treatment of particles for use in pharmaceutical formulations |
| GB0327723D0 (en) * | 2003-09-15 | 2003-12-31 | Vectura Ltd | Pharmaceutical compositions |
| KR101725225B1 (ko) | 2004-04-23 | 2017-04-12 | 사이덱스 파마슈티칼스, 인크. | 술포알킬 에테르 시클로덱스트린 함유 dpi 제형 |
| ITMI20040795A1 (it) * | 2004-04-23 | 2004-07-23 | Eratech S R L | Composizione farmaceutica solida secca suo processo di preparazione e sospensione acquosa stabile ottenuta dalla stessa |
| GB0409197D0 (en) | 2004-04-24 | 2004-05-26 | Innovata Biomed Ltd | Device |
| ES2385934T3 (es) | 2004-08-20 | 2012-08-03 | Mannkind Corporation | Catálisis de la síntesis de dicetopiperazina. |
| HUE025151T2 (en) | 2004-08-23 | 2016-01-28 | Mannkind Corp | Diceto-piperazine salts for drug delivery |
| EP3199164B1 (en) | 2005-02-10 | 2020-03-18 | Glaxo Group Limited | Processes for making lactose utilizing pre-classification techniques and pharmaceutical formulations formed therefrom |
| EP1863451A2 (en) * | 2005-03-31 | 2007-12-12 | Rafael-Armament Development Authority Ltd. | Spherically shaped substances |
| US7799344B2 (en) | 2005-09-14 | 2010-09-21 | Mannkind Corporation | Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents |
| US7629331B2 (en) | 2005-10-26 | 2009-12-08 | Cydex Pharmaceuticals, Inc. | Sulfoalkyl ether cyclodextrin compositions and methods of preparation thereof |
| US8039431B2 (en) | 2006-02-22 | 2011-10-18 | Mannkind Corporation | Method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent |
| WO2007127163A2 (en) * | 2006-04-24 | 2007-11-08 | Geron Corporation | Cns-tumor treatment method and composition |
| EP1944018A1 (en) | 2007-01-10 | 2008-07-16 | CHIESI FARMACEUTICI S.p.A. | Micronised particles of low-dosage strength active agents for powder formulations for inhalation |
| DE102008014237A1 (de) * | 2008-03-14 | 2009-09-17 | J. Rettenmaier & Söhne Gmbh + Co. Kg | Direktverpressbares Tablettierhilfsmittel |
| DK2293833T3 (en) * | 2008-06-13 | 2016-05-23 | Mannkind Corp | DRY POWDER INHALER AND MEDICINAL ADMINISTRATION SYSTEM |
| US8485180B2 (en) | 2008-06-13 | 2013-07-16 | Mannkind Corporation | Dry powder drug delivery system |
| JP5479465B2 (ja) | 2008-06-20 | 2014-04-23 | マンカインド コーポレイション | 吸入努力をリアルタイムにプロファイルする対話式機器および方法 |
| TWI494123B (zh) | 2008-08-11 | 2015-08-01 | Mannkind Corp | 超快起作用胰島素之用途 |
| EP2191821A1 (en) | 2008-11-26 | 2010-06-02 | CHIESI FARMACEUTICI S.p.A. | Microparticles comprising a salt of 8-hydroxy-2-[[(1R)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]-2(1H)-quinolinone having improved adhesion properties for dry powder inhalation |
| US8314106B2 (en) | 2008-12-29 | 2012-11-20 | Mannkind Corporation | Substituted diketopiperazine analogs for use as drug delivery agents |
| EP2221048A1 (en) * | 2009-02-18 | 2010-08-25 | Siegfried Generics International AG | Pharmaceutical composition for inhalation |
| WO2010097188A1 (en) | 2009-02-25 | 2010-09-02 | Chiesi Farmaceutici S.P.A. | Inhalation particles comprising a salt of carmoterol and a corticosteroid |
| AU2010221254B2 (en) | 2009-03-04 | 2014-04-03 | Mannkind Corporation | An improved dry powder drug delivery system |
| CA2754595C (en) | 2009-03-11 | 2017-06-27 | Mannkind Corporation | Apparatus, system and method for measuring resistance of an inhaler |
| US8551528B2 (en) | 2009-06-12 | 2013-10-08 | Mannkind Corporation | Diketopiperazine microparticles with defined specific surface areas |
| CA2770714A1 (en) * | 2009-08-27 | 2011-03-17 | Stc.Unm | Methods and systems for dosing and coating inhalation powders onto carrier particles |
| US9016147B2 (en) | 2009-11-03 | 2015-04-28 | Mannkind Corporation | Apparatus and method for simulating inhalation efforts |
| US9492625B2 (en) | 2009-11-12 | 2016-11-15 | Stc.Unm | Dry powder inhaler with flutter dispersion member |
| EP2360147A1 (en) | 2010-02-22 | 2011-08-24 | CHIESI FARMACEUTICI S.p.A. | Process for preparing crystalline particles of a salt of 8-hydroxy-5-[(1R)-1-hydroxy-2-[[(1R)-2-(4-methoxyphenyl)-1-methylethyl]amino] ethyl]-2(1H)-quinolinone (carmoterol) |
| WO2011120779A1 (en) * | 2010-04-01 | 2011-10-06 | Chiesi Farmaceutici S.P.A. | Process for preparing carrier particles for dry powders for inhalation |
| IL223742A (en) | 2010-06-21 | 2016-06-30 | Mannkind Corp | A dry powder inhaler and preparation for it |
| EP2648788B1 (en) | 2010-12-07 | 2017-08-09 | Respira Therapeutics, Inc. | Dry powder inhaler |
| MY180552A (en) | 2011-04-01 | 2020-12-02 | Mannkind Corp | Blister package for pharmaceutical cartridges |
| WO2012174472A1 (en) | 2011-06-17 | 2012-12-20 | Mannkind Corporation | High capacity diketopiperazine microparticles |
| EP2776053A1 (en) | 2011-10-24 | 2014-09-17 | MannKind Corporation | Methods and compositions for treating pain |
| US9603906B2 (en) | 2012-02-01 | 2017-03-28 | Protalix Ltd. | Inhalable liquid formulations of DNase I |
| US10463815B2 (en) | 2012-02-21 | 2019-11-05 | Respira Therapeutics, Inc. | Inhaler to deliver substances for prophylaxis or prevention of disease or injury caused by the inhalation of biological or chemical agents |
| DK3421042T3 (da) | 2012-03-07 | 2024-07-22 | Beyond Air Ltd | Indånding af nitrogenoxid til behandling af luftvejssygdomme |
| SG11201500218VA (en) | 2012-07-12 | 2015-03-30 | Mannkind Corp | Dry powder drug delivery systems and methods |
| US10159644B2 (en) | 2012-10-26 | 2018-12-25 | Mannkind Corporation | Inhalable vaccine compositions and methods |
| AU2014228415B2 (en) | 2013-03-15 | 2018-08-09 | Mannkind Corporation | Microcrystalline diketopiperazine compositions and methods |
| MX394255B (es) | 2013-07-18 | 2025-03-24 | Mannkind Corp | Composiciones farmaceuticas en polvo seco estables al calor y metodos |
| EP3030294B1 (en) | 2013-08-05 | 2020-10-07 | MannKind Corporation | Insufflation apparatus |
| US10307464B2 (en) | 2014-03-28 | 2019-06-04 | Mannkind Corporation | Use of ultrarapid acting insulin |
| US10561806B2 (en) | 2014-10-02 | 2020-02-18 | Mannkind Corporation | Mouthpiece cover for an inhaler |
| WO2016057693A1 (en) | 2014-10-10 | 2016-04-14 | Alnylam Pharmaceuticals, Inc. | Methods and compositions for inhalation delivery of conjugated oligonucleotide |
| EP3244952A4 (en) | 2015-01-14 | 2018-11-14 | Respira Therapeutics, Inc. | Powder dispersion methods and devices |
| KR20220002600A (ko) | 2019-04-29 | 2022-01-06 | 인스메드 인코포레이티드 | 트레프로스티닐 전구약물의 건조 분말 조성물 및 이의 사용 방법 |
| WO2023150747A1 (en) | 2022-02-07 | 2023-08-10 | Insmed Incorporated | Dry powder compositions of bedaquiline and salts and methods of use thereof |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1242211A (en) | 1967-08-08 | 1971-08-11 | Fisons Pharmaceuticals Ltd | Pharmaceutical composition |
| GB1381872A (en) | 1971-06-22 | 1975-01-29 | Fisons Ltd | Pharmaceutical compositions for inhalation |
| GB1520247A (en) | 1974-08-10 | 1978-08-02 | Fisons Ltd | Pelletised medicament formulations |
| GB1571629A (en) | 1977-11-30 | 1980-07-16 | Fisons Ltd | Pharmaceutical compositions containing beclomethasone dipropionate |
| US4349542A (en) * | 1979-06-08 | 1982-09-14 | National Research Development Corporation | Mixture containing active ingredient and dendritic crystalline sugar for tableting |
| IT1204826B (it) | 1986-03-04 | 1989-03-10 | Chiesi Farma Spa | Composizioni farmaceutiche per inalazione |
| GB9001635D0 (en) * | 1990-01-24 | 1990-03-21 | Ganderton David | Aerosol carriers |
| US5376386A (en) * | 1990-01-24 | 1994-12-27 | British Technology Group Limited | Aerosol carriers |
| IE67345B1 (en) * | 1991-03-12 | 1996-03-20 | Akzo Nv | Low dose dry pharmaceutical preparations |
| DE4140689B4 (de) | 1991-12-10 | 2007-11-22 | Boehringer Ingelheim Kg | Inhalationspulver und Verfahren zu ihrer Herstellung |
| CA2115444C (en) | 1992-06-12 | 2000-10-03 | Yuji Makino | Preparation for intratracheobronchial administration |
| US5603960A (en) * | 1993-05-25 | 1997-02-18 | O'hagan; Derek T. | Preparation of microparticles and method of immunization |
| GB9322014D0 (en) | 1993-10-26 | 1993-12-15 | Co Ordinated Drug Dev | Improvements in and relating to carrier particles for use in dry powder inhalers |
| US6051256A (en) * | 1994-03-07 | 2000-04-18 | Inhale Therapeutic Systems | Dispersible macromolecule compositions and methods for their preparation and use |
| GB9404945D0 (en) | 1994-03-15 | 1994-04-27 | Glaxo Group Ltd | Pharmaceutical composition |
| DE4425255A1 (de) * | 1994-07-16 | 1996-01-18 | Asta Medica Ag | Formulierung zur inhalativen Applikation |
| SE9700136D0 (sv) | 1997-01-20 | 1997-01-20 | Astra Ab | New formulation |
| SE9700134D0 (sv) | 1997-01-20 | 1997-01-20 | Astra Ab | New formulation |
| GB9423419D0 (en) * | 1994-11-19 | 1995-01-11 | Andaris Ltd | Preparation of hollow microcapsules |
| GB9501841D0 (en) | 1995-01-31 | 1995-03-22 | Co Ordinated Drug Dev | Improvements in and relating to carrier particles for use in dry powder inhalers |
| JP4090529B2 (ja) | 1996-01-24 | 2008-05-28 | フロイント産業株式会社 | 乳糖の球形粒及びその製造方法 |
| US5985309A (en) * | 1996-05-24 | 1999-11-16 | Massachusetts Institute Of Technology | Preparation of particles for inhalation |
| DE59806609D1 (de) * | 1997-09-22 | 2003-01-23 | Osram Opto Semiconductors Gmbh | Laserbauelement mit einem Laserarray und Verfahren zu dessen Herstellung |
| ES2192866T3 (es) | 1998-11-13 | 2003-10-16 | Jago Res Ag | Polvo seco para inhalacion. |
| GB9826783D0 (en) | 1998-12-04 | 1999-01-27 | Scherer Ltd R P | Inhalation powders |
| IT1309592B1 (it) * | 1999-03-05 | 2002-01-24 | Chiesi Farma Spa | Particelle veicolo modificate da utilizzarsi nella preparazione diformulazioni farmaceutiche sotto forma di polimeri per inalazione e |
| AU3409399A (en) * | 1999-03-05 | 2000-09-28 | Chiesi Farmaceutici S.P.A. | Improved powdery pharmaceutical compositions for inhalation |
-
1999
- 1999-07-16 IT IT1999MI001582A patent/ITMI991582A1/it unknown
-
2000
- 2000-07-13 PT PT00956180T patent/PT1196146E/pt unknown
- 2000-07-13 DK DK00956180T patent/DK1196146T3/da active
- 2000-07-13 SI SI200030911T patent/SI1196146T1/sl unknown
- 2000-07-13 ES ES00956180T patent/ES2272313T3/es not_active Expired - Lifetime
- 2000-07-13 AT AT00956180T patent/ATE339191T1/de active
- 2000-07-13 DE DE60030721T patent/DE60030721T2/de not_active Expired - Lifetime
- 2000-07-13 WO PCT/EP2000/006690 patent/WO2001005429A2/en not_active Ceased
- 2000-07-13 US US10/030,686 patent/US6780508B1/en not_active Expired - Lifetime
- 2000-07-13 BR BR0012351-0A patent/BR0012351A/pt not_active Application Discontinuation
- 2000-07-13 EP EP00956180A patent/EP1196146B1/en not_active Revoked
- 2000-07-13 AU AU68232/00A patent/AU6823200A/en not_active Abandoned
-
2004
- 2004-03-23 US US10/806,240 patent/US7399528B2/en not_active Expired - Lifetime
-
2006
- 2006-11-28 CY CY20061101710T patent/CY1106269T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US7399528B2 (en) | 2008-07-15 |
| WO2001005429A3 (en) | 2001-10-04 |
| US6780508B1 (en) | 2004-08-24 |
| ITMI991582A1 (it) | 2001-01-16 |
| EP1196146A2 (en) | 2002-04-17 |
| ES2272313T3 (es) | 2007-05-01 |
| WO2001005429A2 (en) | 2001-01-25 |
| SI1196146T1 (sl) | 2007-06-30 |
| DE60030721T2 (de) | 2007-09-13 |
| DE60030721D1 (de) | 2006-10-26 |
| AU6823200A (en) | 2001-02-05 |
| ITMI991582A0 (it) | 1999-07-16 |
| ATE339191T1 (de) | 2006-10-15 |
| DK1196146T3 (da) | 2007-01-29 |
| EP1196146B1 (en) | 2006-09-13 |
| CY1106269T1 (el) | 2011-10-12 |
| US20050118113A1 (en) | 2005-06-02 |
| PT1196146E (pt) | 2007-01-31 |
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| WO2002043693A3 (en) | Pharmaceutical compositions for inhalation | |
| TNSN05048A1 (en) | Inhalation compositions with high drug ratios |
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