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BG64650B1 - 9а-азалиди - Google Patents

9а-азалиди Download PDF

Info

Publication number
BG64650B1
BG64650B1 BG104445A BG10444500A BG64650B1 BG 64650 B1 BG64650 B1 BG 64650B1 BG 104445 A BG104445 A BG 104445A BG 10444500 A BG10444500 A BG 10444500A BG 64650 B1 BG64650 B1 BG 64650B1
Authority
BG
Bulgaria
Prior art keywords
group
same
generally
hydrogen
methyl
Prior art date
Application number
BG104445A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG104445A (en
Inventor
Gabrijela Kobrehel
Gorjana Lazarevski
Mladen Vinkovic
Original Assignee
Pliva, Farmaceutska Industrija, Dionicko Drustvo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HR970551A external-priority patent/HRP970551B1/xx
Priority claimed from HR980497A external-priority patent/HRP980497B1/xx
Application filed by Pliva, Farmaceutska Industrija, Dionicko Drustvo filed Critical Pliva, Farmaceutska Industrija, Dionicko Drustvo
Publication of BG104445A publication Critical patent/BG104445A/xx
Publication of BG64650B1 publication Critical patent/BG64650B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
BG104445A 1997-10-16 2000-05-16 9а-азалиди BG64650B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HR970551A HRP970551B1 (en) 1997-10-16 1997-10-16 Novel o-methyl azythromycin derivatives
HR980497A HRP980497B1 (en) 1998-09-10 1998-09-10 NOVEL 3,6-HEMIKETALS FROM THE CLASS OF 9a-AZALIDES

Publications (2)

Publication Number Publication Date
BG104445A BG104445A (en) 2001-02-28
BG64650B1 true BG64650B1 (bg) 2005-10-31

Family

ID=26317108

Family Applications (1)

Application Number Title Priority Date Filing Date
BG104445A BG64650B1 (bg) 1997-10-16 2000-05-16 9а-азалиди

Country Status (25)

Country Link
US (1) US6369035B1 (xx)
EP (2) EP1036083B9 (xx)
JP (1) JP2001520234A (xx)
KR (1) KR100554549B1 (xx)
CN (1) CN1281615C (xx)
AR (1) AR018014A1 (xx)
AT (2) ATE267835T1 (xx)
AU (1) AU755315B2 (xx)
BG (1) BG64650B1 (xx)
BR (1) BR9812808A (xx)
CA (1) CA2306963C (xx)
DE (2) DE69824201T2 (xx)
DK (2) DK1437359T3 (xx)
EE (1) EE04681B1 (xx)
ES (2) ES2222610T3 (xx)
HU (1) HUP0004085A3 (xx)
IL (2) IL135648A0 (xx)
NO (1) NO20001871L (xx)
NZ (1) NZ503897A (xx)
PL (1) PL191087B1 (xx)
PT (2) PT1437359E (xx)
RU (1) RU2220148C2 (xx)
SI (2) SI1036083T1 (xx)
SK (1) SK285914B6 (xx)
WO (1) WO1999020639A2 (xx)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9914998A (pt) 1998-11-03 2001-07-10 Pfizer Prod Inc Antibióticos macrólidos
KR100361397B1 (ko) * 2000-03-15 2002-11-23 한미약품공업 주식회사 에리스로마이신 에이 9-오-트로필옥심 유도체를 이용한클라리스로마이신의 제조방법
NZ535355A (en) 2002-02-15 2007-09-28 Merckle Gmbh Antibiotic conjugates
WO2003070173A2 (en) 2002-02-15 2003-08-28 Sympore Gmbh Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
EP1483277A4 (en) 2002-02-15 2007-10-03 Merckle Gmbh CONJUGATES OF BIOLOGICALLY ACTIVE COMPOUNDS, METHODS OF PREPARATION AND USE, AND FORMULATION AND PHARMACEUTICAL APPLICATIONS
HRP20020779A2 (en) 2002-09-27 2005-02-28 Pliva-Istra�iva�ki institut d.o.o. NEW 3-DECLADINOSYL DERIVATIVES OF 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERYTHROMICIN A 9a, 11-CYCLIC CARBAMATES
ITMI20022292A1 (it) * 2002-10-29 2004-04-30 Zambon Spa 9a-azalidi ad attivita' antiinfiammatoria.
AU2003264910A1 (en) * 2003-05-30 2005-01-21 Pliva - Istrazivacki Institut D.O.O. Process for selective alkylation of macrolide and azalide derivatives
US7435805B2 (en) * 2003-05-30 2008-10-14 Glaxpsmithkline Istrazivacki O-alkyl macrolide and azalide derivatives and regioselective process for their preparation
US7276487B2 (en) 2003-09-23 2007-10-02 Enanta Pharmaceuticals, Inc. 9a, 11-3C-bicyclic 9a-azalide derivatives
US20060116336A1 (en) * 2004-03-17 2006-06-01 American Pharmaceutical Partners, Inc. Lyophilized azithromycin formulation
US7468428B2 (en) * 2004-03-17 2008-12-23 App Pharmaceuticals, Llc Lyophilized azithromycin formulation
US7402568B2 (en) 2004-09-29 2008-07-22 Enanta Pharmaceuticals, Inc. Bicyclic 9a-azalide derivatives
US7271155B2 (en) * 2005-01-07 2007-09-18 Enanta Pharmaceuticals, Inc. 9A, 11-2C-bicyclic 9a-azalide derivatives
WO2008106226A2 (en) * 2007-02-28 2008-09-04 Rib-X Pharmaceuticals, Inc. Macrolide compounds and methods of making and using the same
MX2013004013A (es) 2010-10-10 2013-09-26 Synovo Gmbh Macrolidos antiinflamatorios.
AU2013239679A1 (en) * 2012-03-27 2014-10-30 Michael W. BURNET Anti-inflammatory macrolides
JP7184520B2 (ja) * 2018-01-22 2022-12-06 旭化成株式会社 トランス型脂環式カーボネートの製造方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI8110592A8 (en) * 1981-03-06 1996-06-30 Pliva Pharm & Chem Works Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof
US4474768A (en) * 1982-07-19 1984-10-02 Pfizer Inc. N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
MX12213A (es) * 1987-07-09 1993-05-01 Pfizer Metodo de preparacion de dihidrato de azitromicina cristalino
DE3860503D1 (de) * 1987-09-03 1990-10-04 Pliva Pharm & Chem Works 10-dihydro-10-deoxo-11-azaerythronolid-a-verbindungen,verfahren und zwischenprodukte zu ihrer herstellung und ihre verwendung in arzneimitteln und in deren herstellung.
WO1989002271A1 (en) * 1987-09-10 1989-03-23 Pfizer Azithromycin and derivatives as antiprotozoal agents
SI9011409A (en) * 1990-07-18 1995-10-31 Pliva Pharm & Chem Works O-methyl azitromycin derivates, methods and intermediates for their preparation and methods for preparation of pharmaceuticals products which comprise them
JP2880338B2 (ja) * 1991-10-25 1999-04-05 株式会社森組 圧搾気体による被移送物の圧送方式
FR2691464B1 (fr) * 1992-05-21 1995-06-02 Roussel Uclaf Nouveaux dérivés de la 1-oxa 6-azacyclopentadécane 13,15-dione, leur procédé de préparation et leur application comme médicaments.
WO1999000124A1 (en) * 1997-06-26 1999-01-07 Merck & Co., Inc. 9a-azalides, compositions containing such compounds and methods of treatment

Also Published As

Publication number Publication date
ES2222610T3 (es) 2005-02-01
ATE348836T1 (de) 2007-01-15
DK1036083T5 (da) 2005-04-04
CA2306963A1 (en) 1999-04-29
BG104445A (en) 2001-02-28
JP2001520234A (ja) 2001-10-30
EE200000226A (et) 2001-06-15
PT1437359E (pt) 2007-04-30
EP1437359B1 (en) 2006-12-20
EP1036083B1 (en) 2004-05-26
DK1437359T3 (da) 2007-04-30
DE69824201D1 (de) 2004-07-01
IL135648A0 (en) 2001-05-20
KR100554549B1 (ko) 2006-03-03
SI1437359T1 (sl) 2007-06-30
DE69836697T2 (de) 2007-10-04
AU755315B2 (en) 2002-12-12
HUP0004085A3 (en) 2003-05-28
PT1036083E (pt) 2004-10-29
ES2279242T3 (es) 2007-08-16
AR018014A1 (es) 2001-10-31
CN1280585A (zh) 2001-01-17
PL191087B1 (pl) 2006-03-31
WO1999020639A3 (en) 1999-07-08
PL340372A1 (en) 2001-01-29
ATE267835T1 (de) 2004-06-15
AU9362298A (en) 1999-05-10
EP1437359A2 (en) 2004-07-14
HK1032785A1 (en) 2001-08-03
DK1036083T3 (da) 2004-09-27
NO20001871D0 (no) 2000-04-11
EP1437359A3 (en) 2005-03-30
WO1999020639A2 (en) 1999-04-29
KR20010031160A (ko) 2001-04-16
EE04681B1 (et) 2006-08-15
SK5522000A3 (en) 2000-11-07
CA2306963C (en) 2007-05-01
SI1036083T1 (en) 2004-10-31
NO20001871L (no) 2000-04-17
NZ503897A (en) 2002-10-25
US6369035B1 (en) 2002-04-09
CN1281615C (zh) 2006-10-25
HUP0004085A2 (hu) 2001-04-28
DE69824201T2 (de) 2005-09-22
SK285914B6 (sk) 2007-11-02
IL135648A (en) 2007-03-08
RU2220148C2 (ru) 2003-12-27
EP1036083B9 (en) 2005-01-12
EP1036083A2 (en) 2000-09-20
DE69836697D1 (de) 2007-02-01
BR9812808A (pt) 2005-04-12

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