BG62612B1 - Съединения, фармацевтични състави и методи за инхибиране наhiv обратна транскриптаза и за лечение на hiv инфекции, спин илиarc и методи за получаване на съединенията - Google Patents

Съединения, фармацевтични състави и методи за инхибиране наhiv обратна транскриптаза и за лечение на hiv инфекции, спин илиarc и методи за получаване на съединенията Download PDF

Info

Publication number: BG62612B1
Authority: BG; Bulgaria
Prior art keywords: substituted; unsubstituted; chloro; hiv; aids
Prior art date: 1992-08-07

Application number

BG99383A

Other languages

Bulgarian (bg)

English (en)

Other versions

BG99383A (bg

Inventor

Steven D. Young

Susan F. Britcher

Linda S. Payne

Lekhanh O. Tran

William C. Lumma Jun.

Original Assignee

Merck & Co.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-08-07

Filing date

1995-01-30

Publication date

2000-03-31

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26733517&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BG62612(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1995-01-30 Application filed by Merck & Co. filed Critical Merck & Co.

1995-09-29 Publication of BG99383A publication Critical patent/BG99383A/bg

2000-03-31 Publication of BG62612B1 publication Critical patent/BG62612B1/bg

Links

150000001875 compounds Chemical class 0.000 title claims abstract description 67
238000000034 method Methods 0.000 title claims abstract description 24
208000031886 HIV Infections Diseases 0.000 title claims abstract description 18
239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 12
108010078851 HIV Reverse Transcriptase Proteins 0.000 title claims description 16
238000011282 treatment Methods 0.000 title abstract description 23
230000005764 inhibitory process Effects 0.000 title abstract description 10
238000002360 preparation method Methods 0.000 title description 4
208000030507 AIDS Diseases 0.000 claims abstract description 55
150000003839 salts Chemical class 0.000 claims abstract description 12
208000037357 HIV infectious disease Diseases 0.000 claims abstract description 11
208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims abstract description 11
230000000840 anti-viral effect Effects 0.000 claims abstract description 8
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239000002904 solvent Substances 0.000 claims description 21
125000000217 alkyl group Chemical group 0.000 claims description 15
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239000003112 inhibitor Substances 0.000 claims description 14
230000002401 inhibitory effect Effects 0.000 claims description 12
125000000623 heterocyclic group Chemical group 0.000 claims description 11
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XPOQHMRABVBWPR-ZDUSSCGKSA-N efavirenz Chemical compound C([C@]1(C2=CC(Cl)=CC=C2NC(=O)O1)C(F)(F)F)#CC1CC1 XPOQHMRABVBWPR-ZDUSSCGKSA-N 0.000 claims description 10
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
- C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D265/18—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
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BG99383A 1992-08-07 1995-01-30 Съединения, фармацевтични състави и методи за инхибиране наhiv обратна транскриптаза и за лечение на hiv инфекции, спин илиarc и методи за получаване на съединенията BG62612B1 (bg)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US92660792A	1992-08-07	1992-08-07
US5480593A	1993-04-27	1993-04-27
PCT/US1993/007376 WO1994003440A1 (en)	1992-08-07	1993-08-06	Benzoxazinones as inhibitors of hiv reverse transcriptase

Publications (2)

Publication Number	Publication Date
BG99383A BG99383A (bg)	1995-09-29
BG62612B1 true BG62612B1 (bg)	2000-03-31

Family

ID=26733517

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG99383A BG62612B1 (bg)	1992-08-07	1995-01-30	Съединения, фармацевтични състави и методи за инхибиране наhiv обратна транскриптаза и за лечение на hiv инфекции, спин илиarc и методи за получаване на съединенията

Country Status (36)

Country	Link
EP (1)	EP0582455B1 (nl)
JP (1)	JPH0780860B2 (nl)
KR (1)	KR100272387B1 (nl)
CN (3)	CN1051767C (nl)
AT (1)	ATE197295T1 (nl)
AU (1)	AU670300B2 (nl)
BG (1)	BG62612B1 (nl)
CA (1)	CA2101572C (nl)
CZ (1)	CZ290447B6 (nl)
DE (4)	DE10199013I1 (nl)
DK (1)	DK0582455T3 (nl)
DZ (1)	DZ1707A1 (nl)
ES (1)	ES2151897T3 (nl)
FI (2)	FI115457B (nl)
GR (1)	GR3034754T3 (nl)
HR (1)	HRP931102B1 (nl)
HU (1)	HU223076B1 (nl)
IL (1)	IL106507A (nl)
LU (2)	LU90709I2 (nl)
LV (1)	LV12719B (nl)
MX (1)	MX192812B (nl)
MY (1)	MY109834A (nl)
NL (2)	NL300032I2 (nl)
NO (3)	NO304886B1 (nl)
NZ (1)	NZ255216A (nl)
PL (2)	PL176679B1 (nl)
PT (1)	PT582455E (nl)
RO (1)	RO113641B1 (nl)
RU (1)	RU2186775C2 (nl)
SG (1)	SG52698A1 (nl)
SI (1)	SI9300419B (nl)
SK (1)	SK282276B6 (nl)
TW (2)	TWI233436B (nl)
UA (1)	UA42699C2 (nl)
WO (1)	WO1994003440A1 (nl)
YU (1)	YU49439B (nl)

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AU3736197A (en) *	1996-07-26	1998-02-20	Du Pont Pharmaceuticals Company	A practical synthesis of benzoxazinones useful as hiv reverse transcripta se inhibitors
US6147210A (en)	1996-07-26	2000-11-14	Dupont Pharmaceuticals Company	Practical synthesis of benzoxazinones useful as HIV reverse transcriptase inhibitors
ZA9711256B (en)	1996-12-16	1999-06-15	Du Pont Merck Pharma	Asymmetric synthesis of benzoxazinones
US5932726A (en) *	1996-12-16	1999-08-03	Dupont Pharmaceuticals Company	Asymmetric synthesis of benzoxazinones
KR100573192B1 (ko) *	1997-02-05	2006-04-24	머크 앤드 캄파니 인코포레이티드	역-용매를 사용한 역전사효소 억제제의 결정화 방법 및 당해 역전사효소 억제제의 결정형
US5965729A (en)	1997-02-05	1999-10-12	Merck & Co., Inc.	Process for the crystallization of a reverse transcriptase inhibitor using an anti-solvent
KR20010006074A (ko) *	1997-04-07	2001-01-15	블레어 큐. 퍼거슨	신규 중간체를 통한 벤즈옥사지논의 비대칭 합성
US6124302A (en)	1997-04-09	2000-09-26	Dupont Pharmaceuticals	4,4-disubstituted-3,4-dihydro-2(1H)-quinazolinones useful as HIV reverse transcriptase inhibitors
US5952528A (en) *	1997-09-03	1999-09-14	Merck & Co., Inc.	Process for enhancing the optical purity
ATE253548T1 (de) *	1997-09-03	2003-11-15	Merck & Co Inc	Verfahren zur verbesserung der optischen reinheit von 2r-(1-hydroxy-1-trifluormethyl-3- cyclopropylpropyn-2-yl)-4-chloranilin
US20010014352A1 (en)	1998-05-27	2001-08-16	Udit Batra	Compressed tablet formulation
US6673372B1 (en)	1998-06-11	2004-01-06	Bristol-Myers Squibb Pharma Company	Crystalline Efavirenz
HRP990182A2 (en) *	1998-06-11	2000-02-29	Du Pont Pharm Co	Crystalline efavirenz
AU4719799A (en) *	1998-06-30	2000-01-17	Du Pont Pharmaceuticals Company	Substituted quinolin-2(1h)-ones useful as hiv reverse transcriptase inhibitors
US6509334B1 (en)	1999-05-04	2003-01-21	American Home Products Corporation	Cyclocarbamate derivatives as progesterone receptor modulators
SE9904652D0 (sv) *	1999-12-17	1999-12-17	Astra Pharma Prod	Novel Compounds
UA73119C2 (en)	2000-04-19	2005-06-15	American Home Products Corpoir	Derivatives of cyclic thiocarbamates, pharmaceutical composition including noted derivatives of cyclic thiocarbamates and active ingredients of medicines as modulators of progesterone receptors
WO2002081456A1 (en)	2001-03-28	2002-10-17	Bristol-Myers Squibb Company	Cyanamide, alkoxyamino, and urea derivatives of 4, 4-disubstituted-3, 4-dihydro-2 (1h)- quinazolinones as hiv reverse transcriptase inhibitors
MXPA05010081A (es)	2003-03-24	2005-11-23	Hoffmann La Roche	Bencil-piridazinonas como inhibidores de transcriptasa inversa.
AR048650A1 (es) *	2004-05-04	2006-05-10	Tibotec Pharm Ltd	Derivados de (1,10b-dihidro-2-(aminocarbonil-fenil)-5h-pirazolo[1,5 c][1,3]benzoxazin-5-il)fenil metanona como inhibidores de la replicacion viral del vih
AR056652A1 (es) *	2005-04-11	2007-10-17	Tibotec Pharm Ltd	Derivados de (1,10-b dihidro-2-(aminoalquil-fenil) -5h-pirazolo (1,5-c) (1,3)benzoxazin-5-il) fenilmetanona y su uso en la fabricacion de un medicamento
EP2210880B1 (en) *	2007-10-05	2015-08-26	Msd K.K.	Benzoxazinone derivatives
GB0720503D0 (en)	2007-10-22	2007-11-28	Angeletti P Ist Richerche Bio	New compound
WO2011000532A2 (de)	2009-07-03	2011-01-06	Archimica Gmbh	Verfahren zur enantioselektiven addition von organometallischen kohlenstoffnukleophilen an trifluormethylketone und verwendung des verfahrens in der synthese von hiv reverse transcriptase inhibitoren
PH12012501537A1 (en)	2010-01-27	2018-02-07	Viiv Healthcare Co	Antiviral therapy
EP2471783A1 (en)	2010-12-23	2012-07-04	Esteve Química, S.A.	Novel polymorphic form of efavirenz
CN103664816B (zh) *	2011-01-06	2016-03-02	中国科学院上海有机化学研究所	Hiv逆转录酶抑制剂依法韦伦类化合物的一锅法不对称合成工艺
CN102675125B (zh) *	2011-03-15	2015-02-18	中国科学院上海有机化学研究所	一种4-氯-2-三氟乙酰基苯胺及其类似物的简便高效合成方法
WO2020164218A1 (en)	2019-02-15	2020-08-20	Fujian Yongjing Technology Co., Ltd	New process for friedel-crafts reaction, and catalyst therefore
CN110372625B (zh) *	2019-08-06	2022-11-01	常州大学	蓝光照射制备4-烷甲基-4-芳基-1,3-苯并噁嗪-2(4h)-酮的方法
CN113106473B (zh) *	2021-04-14	2022-02-18	南京工业大学	一种通过连续电化学微反应器装置制备1,3-苯并噁嗪衍生物的方法
EP4416134A4 (en) *	2021-10-15	2025-09-10	Merck Sharp & Dohme Llc	BENZOXAZINONE DERIVATIVES USED AS SELECTIVE CYTOTOXIC AGENTS

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US3526621A (en) *	1966-08-03	1970-09-01	Farmaceutical Italia Soc	Substituted 3,1-benzoxazin-2-one
US3562621A (en) *	1967-07-26	1971-02-09	Technipower Inc	Inrush current limiting circuit for rectifier circuits with capacitive load
DE3217012A1 (de) *	1982-05-06	1983-11-10	Dr. Karl Thomae Gmbh, 7950 Biberach	Benzoxazin-2-one, deren herstellung und diese verbindungen enthaltende arzneimittel
CA2032259A1 (en) *	1989-12-18	1991-06-19	Wayne J. Thompson	Hiv protease inhibitors useful for the treatment of aids
IL99843A0 (en) *	1990-11-01	1992-08-18	Merck & Co Inc	Synergistic combination of hiv reverse transcriptase inhibitors

1993
- 1993-07-28 IL IL106507A patent/IL106507A/xx not_active IP Right Cessation
- 1993-07-29 CA CA002101572A patent/CA2101572C/en not_active Expired - Lifetime
- 1993-08-03 SG SG1996008032A patent/SG52698A1/en unknown
- 1993-08-03 DE DE2001199013 patent/DE10199013I1/de active Pending
- 1993-08-03 PT PT93306114T patent/PT582455E/pt unknown
- 1993-08-03 DK DK93306114T patent/DK0582455T3/da active
- 1993-08-03 DE DE1993629608 patent/DE10199013I2/de active Active
- 1993-08-03 ES ES93306114T patent/ES2151897T3/es not_active Expired - Lifetime
- 1993-08-03 DE DE122008000034C patent/DE122008000034I1/de active Pending
- 1993-08-03 DE DE69329608T patent/DE69329608T2/de not_active Expired - Lifetime
- 1993-08-03 AT AT93306114T patent/ATE197295T1/de active
- 1993-08-03 EP EP93306114A patent/EP0582455B1/en not_active Expired - Lifetime
- 1993-08-03 MY MYPI93001523A patent/MY109834A/en unknown
- 1993-08-04 TW TW088117982A patent/TWI233436B/zh not_active IP Right Cessation
- 1993-08-04 DZ DZ930090A patent/DZ1707A1/fr active
- 1993-08-04 TW TW082106237A patent/TW382014B/zh not_active IP Right Cessation
- 1993-08-05 MX MX9304775A patent/MX192812B/es not_active IP Right Cessation
- 1993-08-05 YU YU53093A patent/YU49439B/sh unknown
- 1993-08-05 JP JP5194727A patent/JPH0780860B2/ja not_active Expired - Lifetime
- 1993-08-06 CZ CZ1995286A patent/CZ290447B6/cs not_active IP Right Cessation
- 1993-08-06 RU RU95107403/04A patent/RU2186775C2/ru active
- 1993-08-06 AU AU44496/93A patent/AU670300B2/en not_active Expired
- 1993-08-06 PL PL93325950A patent/PL176679B1/pl unknown
- 1993-08-06 SK SK161-95A patent/SK282276B6/sk active Protection Beyond IP Right Term
- 1993-08-06 NZ NZ255216A patent/NZ255216A/en not_active IP Right Cessation
- 1993-08-06 WO PCT/US1993/007376 patent/WO1994003440A1/en not_active Ceased
- 1993-08-06 CN CN93117660A patent/CN1051767C/zh not_active Expired - Lifetime
- 1993-08-06 PL PL93307348A patent/PL175615B1/pl unknown
- 1993-08-06 CN CNB991181085A patent/CN1318031C/zh not_active Expired - Lifetime
- 1993-08-06 KR KR1019950700472A patent/KR100272387B1/ko not_active Expired - Lifetime
- 1993-08-06 RO RO95-00190A patent/RO113641B1/ro unknown
- 1993-08-06 SI SI9300419A patent/SI9300419B/sl unknown
- 1993-08-06 HR HR931102A patent/HRP931102B1/xx not_active IP Right Cessation
- 1993-08-06 HU HU9500366A patent/HU223076B1/hu active Protection Beyond IP Right Term
- 1993-08-06 UA UA95028099A patent/UA42699C2/uk unknown
1995
- 1995-01-30 BG BG99383A patent/BG62612B1/bg unknown
- 1995-02-06 FI FI950508A patent/FI115457B/fi not_active IP Right Cessation
- 1995-02-06 NO NO950424A patent/NO304886B1/no active Protection Beyond IP Right Term
1998
- 1998-10-10 CN CN98121309A patent/CN1107505C/zh not_active Expired - Lifetime
2000
- 2000-06-16 NO NO2000004C patent/NO2000004I1/no unknown
- 2000-11-03 GR GR20000402341T patent/GR3034754T3/el unknown
- 2000-12-08 NL NL300032C patent/NL300032I2/nl unknown
- 2000-12-20 LU LU90709C patent/LU90709I2/fr unknown
2001
- 2001-06-01 LV LVP-01-87A patent/LV12719B/lv unknown
2004
- 2004-02-27 FI FI20040309A patent/FI20040309A7/fi unknown
2008
- 2008-05-15 NL NL300347C patent/NL300347I1/nl unknown
- 2008-05-27 LU LU91446C patent/LU91446I2/fr unknown
- 2008-06-12 NO NO2008008C patent/NO2008008I1/no unknown

Also Published As

Publication number	Publication date
NO2000004I1 (no)	2000-06-16
LV12719B (lv)	2001-12-20
SG52698A1 (en)	1998-09-28
CA2101572C (en)	2001-08-28
CN1221608A (zh)	1999-07-07
CN1107505C (zh)	2003-05-07
RU2186775C2 (ru)	2002-08-10
NO304886B1 (no)	1999-03-01
DE122008000034I1 (de)	2008-10-02
BG99383A (bg)	1995-09-29
NL300032I1 (nl)	2001-02-01
IL106507A (en)	1997-11-20
NO2008008I1 (no)	2008-06-30
NO950424L (no)	1995-04-06
DE10199013I2 (de)	2007-05-24
HRP931102A2 (en)	1997-10-31
TWI233436B (en)	2005-06-01
FI115457B (fi)	2005-05-13
UA42699C2 (uk)	2001-11-15
CN1051767C (zh)	2000-04-26
CZ290447B6 (cs)	2002-07-17
PL176679B1 (pl)	1999-07-30
RU95107403A (ru)	1996-11-20
DK0582455T3 (da)	2000-11-27
CZ28695A3 (en)	1995-09-13
EP0582455B1 (en)	2000-11-02
GR3034754T3 (en)	2001-02-28
DZ1707A1 (fr)	2002-02-17
DE69329608D1 (de)	2000-12-07
NZ255216A (en)	1996-05-28
MX9304775A (es)	1994-05-31
MY109834A (en)	1997-08-30
LU90709I2 (fr)	2002-02-04
CN1250652A (zh)	2000-04-19
YU49439B (sh)	2006-03-03
NL300032I2 (nl)	2001-04-02
DE69329608T2 (de)	2001-05-03
JPH06184124A (ja)	1994-07-05
LU91446I2 (fr)	2008-07-28
DE10199013I1 (de)	2001-05-23
RO113641B1 (ro)	1998-09-30
HK1009267A1 (en)	1999-05-28
MX192812B (es)	1999-07-30
PL307348A1 (en)	1995-05-15
KR950702970A (ko)	1995-08-23
PL175615B1 (pl)	1999-01-29
HUT71219A (en)	1995-11-28
IL106507A0 (en)	1993-11-15
FI20040309A7 (fi)	2004-02-27
CA2101572A1 (en)	1994-02-08
NO950424D0 (no)	1995-02-06
AU4449693A (en)	1994-02-10
JPH0780860B2 (ja)	1995-08-30
YU53093A (sh)	1996-10-09
FI950508L (fi)	1995-02-06
SK16195A3 (en)	1995-07-11
NL300347I1 (nl)	2008-07-01
SI9300419A (en)	1994-06-30
CN1318031C (zh)	2007-05-30
HRP931102B1 (en)	2001-06-30
PT582455E (pt)	2001-03-30
CN1090277A (zh)	1994-08-03
ATE197295T1 (de)	2000-11-15
SI9300419B (sl)	2002-10-31
SK282276B6 (sk)	2002-01-07
WO1994003440A1 (en)	1994-02-17
FI950508A0 (fi)	1995-02-06
KR100272387B1 (ko)	2000-11-15
AU670300B2 (en)	1996-07-11
EP0582455A1 (en)	1994-02-09
HU9500366D0 (en)	1995-03-28
TW382014B (en)	2000-02-11
HU223076B1 (hu)	2004-03-01
ES2151897T3 (es)	2001-01-16
LV12719A (lv)	2001-09-20

Publication	Publication Date	Title
BG62612B1 (bg)	2000-03-31	Съединения, фармацевтични състави и методи за инхибиране наhiv обратна транскриптаза и за лечение на hiv инфекции, спин илиarc и методи за получаване на съединенията
US5663169A (en)	1997-09-02	Benzoxazinones as inhibitors of HIV reverse transcriptase
WO1995020389A1 (en)	1995-08-03	Benzoxazinones as inhibitors of hiv reverse transcriptase
WO1993004047A1 (en)	1993-03-04	Quinazoline derivatives as inhibitors of hiv reverse transcriptase
SK137899A3 (en)	2000-05-16	4,4-disubstituted-3,4-dihydro-2(1h)-quinazolinones useful as hiv reverse transcriptase inhibitors
EP3452045A1 (en)	2019-03-13	Methods of treatment and combination therapies using gcase activator heterobicyclic and related compounds
IE49562B1 (en)	1985-10-30	Therapeutic agents
US5846978A (en)	1998-12-08	HIV protease inhibitors useful for the treatment of AIDS
GB2271566A (en)	1994-04-20	HIV integrase inhibitors
JP2003518098A (ja)	2003-06-03	ウイルス感染の治療に用いるキノロン化合物
GB2282808A (en)	1995-04-19	3-substituted heterocyclic indoles as inhibitors of HIV reverse transcriptase
CZ289176B6 (cs)	2001-11-14	Farmaceutický prostředek pro inhibici reverzní transkripce HIV
HK1009267B (en)	2001-05-25	Benzoxazinones as inhibitors of hiv reverse transcriptase
PL176649B1 (pl)	1999-07-30	Kombinacja związków farmakologicznie czynnych do zapobiegania infekcji HIV lub leczenia infekcji HIV lub leczenia AIDS albo ARC