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BG61122B2 - Оптично активни производни на пиридонкарбоксилната киселина - Google Patents

Оптично активни производни на пиридонкарбоксилната киселина Download PDF

Info

Publication number
BG61122B2
BG61122B2 BG098620A BG9862094A BG61122B2 BG 61122 B2 BG61122 B2 BG 61122B2 BG 098620 A BG098620 A BG 098620A BG 9862094 A BG9862094 A BG 9862094A BG 61122 B2 BG61122 B2 BG 61122B2
Authority
BG
Bulgaria
Prior art keywords
group
amino
cis
methylpyrrolidinyl
carbon atoms
Prior art date
Application number
BG098620A
Other languages
Bulgarian (bg)
English (en)
Inventor
Youichi Kimura
Isao Hayakawa
Original Assignee
Daiichi Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Pharmaceutical Co., Ltd. filed Critical Daiichi Pharmaceutical Co., Ltd.
Publication of BG61122B2 publication Critical patent/BG61122B2/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
BG098620A 1988-04-27 1994-02-28 Оптично активни производни на пиридонкарбоксилната киселина BG61122B2 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP10462588 1988-04-27
JP29698488 1988-11-24

Publications (1)

Publication Number Publication Date
BG61122B2 true BG61122B2 (bg) 1996-11-29

Family

ID=26445063

Family Applications (1)

Application Number Title Priority Date Filing Date
BG098620A BG61122B2 (bg) 1988-04-27 1994-02-28 Оптично активни производни на пиридонкарбоксилната киселина

Country Status (25)

Country Link
US (4) US5587386A (hu)
EP (1) EP0341493B1 (hu)
JP (5) JP2714597B2 (hu)
KR (1) KR0184614B1 (hu)
CN (1) CN1033751C (hu)
AT (1) ATE182145T1 (hu)
AU (1) AU625414B2 (hu)
BG (1) BG61122B2 (hu)
CA (1) CA1340801C (hu)
DE (1) DE68929030T2 (hu)
DK (1) DK175467B1 (hu)
ES (1) ES2135372T3 (hu)
FI (1) FI96947C (hu)
GR (1) GR3031365T3 (hu)
HU (1) HU211136A9 (hu)
IL (1) IL90062A (hu)
LV (1) LV10092B (hu)
MY (1) MY105136A (hu)
NO (1) NO175939C (hu)
NZ (1) NZ228893A (hu)
PT (1) PT90377B (hu)
RU (1) RU2075475C1 (hu)
SG (1) SG48036A1 (hu)
UA (1) UA29378C2 (hu)
YU (1) YU48432B (hu)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL90062A (en) * 1988-04-27 1994-10-07 Daiichi Seiyaku Co Pyridonecarboxylic acid derivatives, their preparation and pharmaceutical compositions containing them
JPH0674261B2 (ja) * 1988-06-21 1994-09-21 塩野義製薬株式会社 キノロンカルボン酸誘導体
CA1336090C (en) * 1988-08-31 1995-06-27 Isao Hayakawa Spiro-substituted cyclic amines of quinolone derivatives
CA2036516A1 (en) * 1990-02-19 1991-08-20 Yoshikazu Asahina Optically active 8-methoxyouinolonecarboxylic acid derivatives, their preparative processes and their intermediates
MY109714A (en) * 1990-10-18 1997-04-30 Daiichi Seiyaku Co Process for preparing 8-chloroquinolone derivatives
RU2100351C1 (ru) * 1991-05-28 1997-12-27 Дайити Фармасьютикал Ко., Лтд. Производные пиридонкарбоновой кислоты и композиция на их основе
EP0641339B1 (en) * 1991-06-19 1999-09-15 Pfizer Inc. Azaspiro quinolone antibacterial agents
KR960011370B1 (ko) * 1991-12-31 1996-08-22 재단법인 한국화학연구소 스피로알킬아민 유도체와 그의 제조방법
CA2112165C (en) * 1992-12-25 2003-04-08 Makoto Takemura Bicyclic amine derivatives
ZA946853B (en) * 1993-09-10 1995-04-24 Daiichi Seiyaku Co Crystals of antimicrobial compound.
CN1152916A (zh) * 1994-07-18 1997-06-25 宇部兴产株式会社 三氟甲基喹啉羧酸衍生物
PT807630E (pt) * 1995-02-02 2003-08-29 Daiichi Seiyaku Co Compostos heterociclicos
TW466237B (en) * 1995-02-07 2001-12-01 Daiichi Seiyaku Co Heterocyclic spiro-derivative
JPH09124556A (ja) 1995-08-30 1997-05-13 Dai Ichi Seiyaku Co Ltd ハロゲン化シクロプロパン誘導体の製造方法
US6121285A (en) * 1995-11-22 2000-09-19 Daiichi Pharmaceutical Co., Ltd. Substituted aminocycloalkylpyrrolidine derivatives and cis-substituted aminocycloalkylpyrrolidine derivatives
ATE317393T1 (de) * 1995-11-22 2006-02-15 Daiichi Seiyaku Co Substituierte aminocycloalkylpyrrolidinderivate
WO1997029102A1 (en) * 1996-02-09 1997-08-14 Toyama Chemical Co., Ltd. Quinolonecarboxylic acid derivatives or salts thereof
TW425394B (en) * 1996-04-24 2001-03-11 Daiichi Seiyaku Co Antimicrobial quinolone derivatives having 3-(N-cycloalkyl) aminomethylpyrrolidine group
AU1040597A (en) * 1996-12-04 1998-06-29 Daiichi Pharmaceutical Co., Ltd. Substituted aminomethylpyrrolidine derivatives
DK1134219T3 (da) 1998-11-24 2005-10-17 Daiichi Seiyaku Co Cucloalkylsubstituerede aminomethylpyrrolidinderivater
DE60011264T2 (de) * 1999-03-10 2005-07-14 Daiichi Pharmaceutical Co., Ltd. Aminomethylpyrrolidin-derivate mit aromatischen substituenten
KR100768034B1 (ko) 1999-03-17 2007-10-17 다이이찌 세이야꾸 가부시기가이샤 의약 조성물
DK1262477T3 (da) 2000-02-09 2008-12-01 Daiichi Sankyo Co Ltd Antibakterielle midler, der er virksomme mod syrefaste bakterier og indeholder pyridoncarboxylsyrer som aktiv ingrediens
BR0111248A (pt) 2000-03-31 2003-07-08 Daiichi Seiyaku Co Derivados de ácido quinolonacarboxìlico
RU2295342C2 (ru) * 2000-04-24 2007-03-20 Дайити Фармасьютикал Ко., Лтд. Стабилизированные жидкие препаративные формы
CA2417764C (en) * 2000-08-08 2009-05-05 Katsuo Kataoka Highly absorbable solid preparations containing sitafloxacin and tartaric acid
KR101041277B1 (ko) * 2002-05-17 2011-06-14 다이이찌 세이야꾸 가부시기가이샤 퀴놀론카르복실산 유도체의 제조방법
WO2004060851A1 (ja) * 2003-01-07 2004-07-22 Daiichi Pharmaceutical Co., Ltd. 還元的脱ハロゲン化方法
US7085154B2 (en) * 2003-06-03 2006-08-01 Samsung Electronics Co., Ltd. Device and method for pulse width control in a phase change memory device
EP1757598A4 (en) 2004-05-13 2010-07-21 Daiichi Seiyaku Co SUBSTITUTED PYRROLIDINE DERIVATIVE
US7563805B2 (en) 2005-05-19 2009-07-21 Daiichi Pharmaceutical Co., Ltd. Tri-, tetra-substituted-3-aminopyrrolidine derivative
RU2420524C2 (ru) * 2005-05-19 2011-06-10 Дайити Санкио Компани, Лимитед Производные три- или тетра-замещенного-3-аминопирролидина
JP5063032B2 (ja) * 2005-05-19 2012-10-31 第一三共株式会社 トリ−、テトラ−置換−３−アミノピロリジン誘導体
WO2006123767A1 (ja) 2005-05-20 2006-11-23 Daiichi Sankyo Company, Limited 不斉四置換炭素原子含有化合物の製法
US7977346B2 (en) 2006-01-17 2011-07-12 Guoqing Paul Chen Spiro compounds and methods of use
TWI386401B (zh) * 2006-03-27 2013-02-21 Daiichi Seiyaku Co 醫藥用水合物
WO2008082009A2 (en) 2007-01-05 2008-07-10 Daiichi Sankyo Company, Limited Fused substituted aminopyrrolidine derivative
CN102089439B (zh) 2008-07-11 2013-11-13 住友化学株式会社 (1s，2r)-2-氯-2-氟环丙烷羧酸的制造方法
FR2961207B1 (fr) * 2010-06-09 2013-01-18 Oreal Utilisation d'un derive de 4- carboxy 2-pyrrolidinone comme solvant dans les compositions cosmetiques ; compositions cosmetiques les contenant ; nouveaux composes
CN103467448B (zh) * 2013-09-18 2015-04-15 浙江司太立制药股份有限公司 7-(3-氨基-4-烷氧亚胺基-1-哌啶基)-1-[(1r,2s)-2-氟环丙基]喹诺酮羧酸类化合物及其制备方法
EP2957561A1 (en) * 2014-06-18 2015-12-23 Université Paris 6 Pierre et Marie Curie UPMC Novel fluoroquinolones and use thereof to treat bacterial infections
CN105330590B (zh) * 2015-10-15 2018-09-25 广州市朗启医药科技有限责任公司 西他沙星五元环侧链中间体的制备方法
CN109912504B (zh) * 2019-04-04 2020-11-10 山东省联合农药工业有限公司 一种喹啉羧酸类化合物及其制备方法与用途

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0191185B1 (en) * 1984-12-14 1990-03-07 Daiichi Seiyaku Co., Ltd. Quinoline-carboxylic acid derivatives
HUT40639A (en) * 1985-03-08 1987-01-28 Kyorin Seiyaku Kk Process for producing quinolon-carboxylic acid derivative and pharmaceutical composition containing them
DE3509546A1 (de) * 1985-03-16 1986-09-25 Bayer Ag, 5090 Leverkusen 7-amino-1-(subst.cyclopropyl)-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
US4657913A (en) 1985-04-18 1987-04-14 Warner-Lambert Company Trifluoro- quinoline -3- carboxylic acids and their use as anti-bacterial agents
US4668680A (en) * 1985-12-12 1987-05-26 Warner-Lambert Company 5-amino-6,8-difluoroquinolones as antibacterial agents
US4735949A (en) 1986-02-18 1988-04-05 Warner-Lambert Company Disubstituted-7-pyrrolidinonaphthyridine antibacterial agents
DE3705621C2 (de) * 1986-02-25 1997-01-09 Otsuka Pharma Co Ltd Heterocyclisch substituierte Chinoloncarbonsäurederivate
DE3702393A1 (de) * 1987-01-28 1988-08-11 Bayer Ag 8-cyano-1-cyclopropyl-1,4-dihydro-4-oxo- 3-chinolincarbonsaeuren, verfahren zu ihrer herstellung und diese enthaltende antibakterielle mittel
US5290934A (en) * 1987-04-16 1994-03-01 Otsuka Pharmaceutical Company, Limited Benzoheterocyclic compounds
US4851418A (en) * 1987-08-21 1989-07-25 Warner-Lambert Company Naphthyridine antibacterial agents containing an α-amino acid in the side chain of the 7-substituent
IL90062A (en) * 1988-04-27 1994-10-07 Daiichi Seiyaku Co Pyridonecarboxylic acid derivatives, their preparation and pharmaceutical compositions containing them
FI95130C (fi) * 1988-07-20 1995-12-27 Sankyo Co Menetelmä lääkeaineena käyttökelpoisten 4-oksokinoliini-3-karboksyylihapon johdannaisten valmistamiseksi
US5286723A (en) 1988-08-31 1994-02-15 Daiichi Seiyaku Co., Ltd. Spiro compound
AU5123690A (en) * 1989-03-13 1990-09-13 Bristol-Myers Squibb Company 5-substituted-1,4-dihydro-4-oxo-nephthyridine-3-carboxylate antibacterial agents
DE3910663A1 (de) * 1989-04-03 1990-10-04 Bayer Ag 5-alkylchinoloncarbonsaeuren
BR0111248A (pt) 2000-03-31 2003-07-08 Daiichi Seiyaku Co Derivados de ácido quinolonacarboxìlico
EP1757598A4 (en) * 2004-05-13 2010-07-21 Daiichi Seiyaku Co SUBSTITUTED PYRROLIDINE DERIVATIVE

Also Published As

Publication number Publication date
EP0341493B1 (en) 1999-07-14
US6031102A (en) 2000-02-29
CN1033751C (zh) 1997-01-08
AU625414B2 (en) 1992-07-09
FI891980A0 (fi) 1989-04-26
USRE41149E1 (en) 2010-02-23
DK205789D0 (da) 1989-04-27
US5587386A (en) 1996-12-24
KR0184614B1 (ko) 1999-05-01
ATE182145T1 (de) 1999-07-15
DE68929030D1 (de) 1999-08-19
HK1002108A1 (en) 1998-07-31
SG48036A1 (en) 1998-04-17
NO891698D0 (no) 1989-04-25
EP0341493A2 (en) 1989-11-15
FI96947B (fi) 1996-06-14
LV10092B (en) 1995-02-20
PT90377A (pt) 1989-11-10
ES2135372T3 (es) 1999-11-01
PT90377B (pt) 1994-09-30
CN1037507A (zh) 1989-11-29
AU3370289A (en) 1989-11-02
NZ228893A (en) 1990-06-26
EP0341493A3 (en) 1990-12-19
JPH07300416A (ja) 1995-11-14
CA1340801C (en) 1999-10-26
JPH11124367A (ja) 1999-05-11
YU87589A (en) 1990-12-31
NO891698L (no) 1989-10-30
DE68929030T2 (de) 2000-03-23
HU211136A9 (en) 1995-10-30
NO175939C (no) 1995-01-04
NO175939B (no) 1994-09-26
JP2714597B2 (ja) 1998-02-16
RU2075475C1 (ru) 1997-03-20
US5767127A (en) 1998-06-16
JPH1067779A (ja) 1998-03-10
YU48432B (sh) 1998-07-10
JPH11124380A (ja) 1999-05-11
IL90062A0 (en) 1989-12-15
FI891980A7 (fi) 1989-10-28
MY105136A (en) 1994-08-30
GR3031365T3 (en) 2000-01-31
JP2903292B2 (ja) 1999-06-07
UA29378C2 (uk) 2000-11-15
FI96947C (fi) 1996-09-25
DK205789A (da) 1989-10-28
JPH02231475A (ja) 1990-09-13
DK175467B1 (da) 2004-11-01
JP2917010B2 (ja) 1999-07-12
KR900016205A (ko) 1990-11-12
IL90062A (en) 1994-10-07

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