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BG50501A3 - METHOD FOR OBTAINING 1,5-BENZTHIAZEPINE DERIVATIVES - Google Patents

METHOD FOR OBTAINING 1,5-BENZTHIAZEPINE DERIVATIVES

Info

Publication number
BG50501A3
BG50501A3 BG085116A BG8511688A BG50501A3 BG 50501 A3 BG50501 A3 BG 50501A3 BG 085116 A BG085116 A BG 085116A BG 8511688 A BG8511688 A BG 8511688A BG 50501 A3 BG50501 A3 BG 50501A3
Authority
BG
Bulgaria
Prior art keywords
radical
benzthiazepine
derivatives
obtaining
hydrogen
Prior art date
Application number
BG085116A
Other languages
Bulgarian (bg)
Inventor
Hirozumi Inoue
Tsunehiro Harada
Masaaki Nagasawa
Original Assignee
Tanabe Seiyaku Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co., Ltd. filed Critical Tanabe Seiyaku Co., Ltd.
Publication of BG50501A3 publication Critical patent/BG50501A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Получените по метода съединения намират приложение в лекарствената химия. 1,5-бензтиазепиновите произвоодни с обща формулав която r1 е метилов или метоксирадикал, r2 водород или нисш алканоилов радикал, единият r3 или r4 е метилов радикал, флуорен или хлорен атом, а другият водород, r5 и r6 нисш алкилов радикал, и техните фармацевтично приемливи кисели адитивни соли се получават при взаимодействие на съединение с обща формулав която r1, r2, r3 и r4 имат посочените значения, а х1 е реактивоспособен остатък, с амин с формула в която r5 и r6 имат посочените значения. 4 претенцииThe compounds obtained by the method are used in medicinal chemistry. 1,5-Benzthiazepine derivatives of general formula in which r1 is methyl or methoxy radical, r2 hydrogen or lower alkanoyl radical, one r3 or r4 is methyl radical, fluorine or chlorine atom and the other hydrogen, r5 and r6 lower alkyl radical, and their pharmaceutical acceptable acid addition salts are obtained by reacting a compound of the general formula wherein r 1 , r 2 , r 3 , and r 4 are as defined, and x 1 is a reactive radical, with an amine of the formula wherein r 5 and r 6 are as defined. 4 claims

BG085116A 1987-08-12 1988-08-02 METHOD FOR OBTAINING 1,5-BENZTHIAZEPINE DERIVATIVES BG50501A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP62202027A JPS6445376A (en) 1987-08-12 1987-08-12 Production of 1,5-benzothiazepine derivative

Publications (1)

Publication Number Publication Date
BG50501A3 true BG50501A3 (en) 1992-08-14

Family

ID=16450708

Family Applications (1)

Application Number Title Priority Date Filing Date
BG085116A BG50501A3 (en) 1987-08-12 1988-08-02 METHOD FOR OBTAINING 1,5-BENZTHIAZEPINE DERIVATIVES

Country Status (14)

Country Link
JP (1) JPS6445376A (en)
KR (1) KR890003722A (en)
CN (1) CN1030570C (en)
AT (1) AT395010B (en)
BG (1) BG50501A3 (en)
CA (1) CA1337346C (en)
ES (1) ES2007990A6 (en)
FI (1) FI883115A7 (en)
GR (1) GR1000385B (en)
IE (1) IE61168B1 (en)
IL (1) IL86978A0 (en)
NO (1) NO170017C (en)
PT (1) PT88250B (en)
SU (1) SU1709908A3 (en)

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1236467A (en) * 1967-10-28 1971-06-23 Tanabe Seiyaku Co Benzothiazepine derivatives
US3895006A (en) * 1974-04-19 1975-07-15 Squibb & Sons Inc 5-(Substituted amino)alkyl)-2-aryl-3-halo-1,5-benzothiazepin-4(5H)-ones
SE449611B (en) * 1982-07-09 1987-05-11 Tanabe Seiyaku Co SET TO MAKE 1,5-BENZOTIAZEPINE DERIVATIVES
GB8315364D0 (en) * 1983-06-03 1983-07-06 Tanabe Seiyaku Co 8-chloro-1 5-benzothiazepine derivatives
US4567175A (en) * 1983-06-03 1986-01-28 Tanabe Seiyaku Co., Ltd. 8-Chloro-1,5-benzothiazepine derivatives
GB8406318D0 (en) * 1984-03-10 1984-04-11 Tanabe Seiyaku Co 1 5-benzothiazepine derivatives
JPS60204776A (en) * 1984-03-30 1985-10-16 Roller Japan Kk 1,5-benzothiazepine derivative
JPS61103877A (en) * 1984-10-24 1986-05-22 Tanabe Seiyaku Co Ltd Benzothiazepine derivative and its preparation

Also Published As

Publication number Publication date
CN1030570C (en) 1995-12-27
SU1709908A3 (en) 1992-01-30
NO170017C (en) 1992-09-02
IE881949L (en) 1989-02-12
AT395010B (en) 1992-08-25
FI883115A0 (en) 1988-06-29
ATA202388A (en) 1992-01-15
IL86978A0 (en) 1988-12-30
GR1000385B (en) 1992-06-30
GR880100515A (en) 1989-05-25
CN1031229A (en) 1989-02-22
NO170017B (en) 1992-05-25
PT88250B (en) 1995-03-01
IE61168B1 (en) 1994-10-05
CA1337346C (en) 1995-10-17
FI883115A7 (en) 1989-02-13
JPS6445376A (en) 1989-02-17
NO883525D0 (en) 1988-08-09
KR890003722A (en) 1989-04-17
PT88250A (en) 1989-06-30
ES2007990A6 (en) 1989-07-01
NO883525L (en) 1989-02-13

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