[go: up one dir, main page]

BG29287A3 - Метод за получаване на субституирани 6-фенил-1,2,4-триазоло(4,3-в)- пиридазини - Google Patents

Метод за получаване на субституирани 6-фенил-1,2,4-триазоло(4,3-в)- пиридазини

Info

Publication number
BG29287A3
BG29287A3 BG037371A BG3737177A BG29287A3 BG 29287 A3 BG29287 A3 BG 29287A3 BG 037371 A BG037371 A BG 037371A BG 3737177 A BG3737177 A BG 3737177A BG 29287 A3 BG29287 A3 BG 29287A3
Authority
BG
Bulgaria
Prior art keywords
pyridazines
triazolo
phenyl
preparation
substituted
Prior art date
Application number
BG037371A
Other languages
English (en)
Inventor
George Allen
John Hanifin
Daniel Moran
Jay Albrighn
Original Assignee
American Cyanamid Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/725,597 external-priority patent/US4230705A/en
Application filed by American Cyanamid Company filed Critical American Cyanamid Company
Publication of BG29287A3 publication Critical patent/BG29287A3/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/08—Preparation of carboxylic acids or their salts, halides or anhydrides from nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/08—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/12—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/14—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/20—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Метод за получаване на охарактеризирани и доказани в описанието субституирани -6-фенил-1,2,4 -триазоло-(4,3-в)-пиридазини с формула........... Патентните претенции са формулирани в 5 точки
BG037371A 1976-09-22 1977-09-20 Метод за получаване на субституирани 6-фенил-1,2,4-триазоло(4,3-в)- пиридазини BG29287A3 (bg)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US05/725,597 US4230705A (en) 1976-09-22 1976-09-22 6-Phenyl-1,2,4-triazolo[4,3-b]pyridazines and their uses in treating anxiety
US73039576A 1976-10-07 1976-10-07
US73547576A 1976-10-26 1976-10-26

Publications (1)

Publication Number Publication Date
BG29287A3 true BG29287A3 (bg) 1980-10-15

Family

ID=27419081

Family Applications (1)

Application Number Title Priority Date Filing Date
BG037371A BG29287A3 (bg) 1976-09-22 1977-09-20 Метод за получаване на субституирани 6-фенил-1,2,4-триазоло(4,3-в)- пиридазини

Country Status (19)

Country Link
JP (1) JPS5340798A (bg)
AR (2) AR218036A1 (bg)
AT (1) AT360034B (bg)
AU (1) AU513760B2 (bg)
BG (1) BG29287A3 (bg)
CA (1) CA1080712A (bg)
DD (1) DD132586A5 (bg)
DE (1) DE2741763A1 (bg)
DK (1) DK417377A (bg)
ES (3) ES462543A1 (bg)
FI (1) FI772802A7 (bg)
FR (1) FR2442848A1 (bg)
GB (1) GB1589237A (bg)
GR (1) GR71699B (bg)
LU (1) LU78150A1 (bg)
NL (1) NL7710389A (bg)
NO (1) NO773245L (bg)
PT (1) PT67067B (bg)
RO (1) RO72226A (bg)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR70309B (bg) * 1979-10-29 1982-09-08 Dow Chemical Co
FR2473522A1 (fr) * 1980-01-16 1981-07-17 Synthelabo Nouveaux derives substitues de dihydro-2,3 imidazo(1,2-b)pyridazines et les medicaments, utiles notamment comme antidepresseurs, qui en contiennent
EP0036711B1 (en) * 1980-03-22 1985-12-04 Fbc Limited Pesticidal heterocyclic compounds, processes for preparing them, compositions containing them, and their use
DE3217325A1 (de) * 1982-05-08 1983-11-10 Hoechst Ag, 6230 Frankfurt 3-amino-6-aryl-1,2,4-triazolo(4,3-b)-pyridazine, ihre herstellung und ihre verwendung
US4487930A (en) * 1982-09-07 1984-12-11 The Dow Chemical Company 6-[(Cyclic amino)alkylamino]-tetrahydrotriazolo[3,4-a]phthalazines
FR2562071B1 (fr) * 1984-03-30 1986-12-19 Sanofi Sa Triazolo(4,3-b)pyridazines, procede pour leur preparation et compositions pharmaceutiques les contenant
US4654343A (en) * 1985-10-31 1987-03-31 American Cyanamid Company N-substituted-N[3-(1,2,4-triazolo[4,3-b]pyridazin-6-yl)phenyl]alkanamides, carbamates and ureas
US4767765A (en) * 1985-10-31 1988-08-30 American Cyanamid Company N-substituted-N-[3-(1,2,4-triazolo-[4,3-b]pyridazin-6-yl)phenyl]alkanamides, carbamates and ureas
WO1998004559A2 (en) * 1996-07-25 1998-02-05 Merck Sharp & Dohme Limited Substituted triazolo-pyridazine derivatives as ligands for gaba receptors
EP1047697A1 (en) * 1998-01-14 2000-11-02 MERCK SHARP & DOHME LTD. Triazolo-pyridazine derivatives as ligands for gaba receptors
GB9801234D0 (en) 1998-01-21 1998-03-18 Merck Sharp & Dohme Therapeutic agents
GB9801202D0 (en) 1998-01-21 1998-03-18 Merck Sharp & Dohme Therapeutic agents
GB9801208D0 (en) 1998-01-21 1998-03-18 Merck Sharp & Dohme Therapeutic agents
PL341652A1 (en) * 1998-01-21 2001-04-23 Merck Sharp & Dohme Derivatives of triazolopyridazine as ligands for gaba receptors
GB9801210D0 (en) 1998-01-21 1998-03-18 Merck Sharp & Dohme Therapeutic agents
GB9801397D0 (en) * 1998-01-22 1998-03-18 Merck Sharp & Dohme Therapeutic agents
GB9801538D0 (en) 1998-01-23 1998-03-25 Merck Sharp & Dohme Pharmaceutical product
US7645756B2 (en) * 2004-02-18 2010-01-12 Banyu Pharmaceutical Co. Ltd. Nitrogenous fused heteroaromatic ring derivative
EP3548033B1 (en) * 2016-11-28 2024-04-10 Praxis Precision Medicines, Inc. Compounds and their methods of use
AU2019278814B2 (en) 2018-05-30 2025-12-18 Praxis Precision Medicines, Inc. Ion channel modulators
EA202092908A1 (ru) 2018-09-28 2021-05-14 Праксис Пресижн Медсинз, Инк. Модуляторы ионных каналов
US11773099B2 (en) 2019-05-28 2023-10-03 Praxis Precision Medicines, Inc. Compounds and their methods of use
US11505554B2 (en) 2019-05-31 2022-11-22 Praxis Precision Medicines, Inc. Substituted pyridines as ion channel modulators
JP7712932B2 (ja) * 2019-12-18 2025-07-24 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア Ｌｉｎ２８の阻害剤及びその使用方法

Also Published As

Publication number Publication date
PT67067B (en) 1979-02-19
AU2899577A (en) 1979-03-29
AU513760B2 (en) 1980-12-18
JPS5340798A (en) 1978-04-13
DE2741763A1 (de) 1978-03-23
DK417377A (da) 1978-03-23
AR217886A1 (es) 1980-04-30
NO773245L (no) 1978-03-28
ES477800A1 (es) 1979-10-16
FI772802A7 (fi) 1978-03-23
DD132586A5 (de) 1978-10-11
ATA677577A (de) 1980-05-15
FR2442848A1 (fr) 1980-06-27
ES462543A1 (es) 1979-06-16
AT360034B (de) 1980-12-10
LU78150A1 (bg) 1978-01-23
RO72226A (ro) 1982-09-09
PT67067A (en) 1977-10-01
GR71699B (bg) 1983-06-21
ES477799A1 (es) 1980-04-01
AR218036A1 (es) 1980-05-15
NL7710389A (nl) 1978-03-28
GB1589237A (en) 1981-05-07
CA1080712A (en) 1980-07-01

Similar Documents

Publication Publication Date Title
BG29287A3 (bg) Метод за получаване на субституирани 6-фенил-1,2,4-триазоло(4,3-в)- пиридазини
BG36199A3 (bg) Метод за получаване на производни на 3-/1-пиперидинилалкил/ -4н-пиридо 1,2-а]пиримидин-4-он
BG40654A3 (bg) Метод за получаване на циклоалкилтриазоли
BG34340A3 (bg) Метод за получаване на съединения с- 076 и техни производни
BG28712A3 (bg) Метод за получаване на заместени в 11-а позиция,5,11-дихидро-6н-пиридо (2,3-в)(1,4)бензодиазепин-6-они
BG32851A3 (bg) Метод за получаване на 3,4,5,6-тетрахидро-2н- -1-бензоксецини
BG29722A3 (bg) Метод за получаване на 2,5-дисубституирани пиримидин-4-они
BG28711A3 (bg) Метод за получаване на заместени в 11-а позиция 5,11-дихидро-6н-пиридо (2,3-в)(1,4)бензодиазепин-6-они
BG28713A3 (bg) Метод за получаване на 5,11-дихидро-6н-пиридо (2,3-в)(1,4) бензодиазепин-6-они
BG35042A3 (bg) Метод за получаване на бензодиазепинови съединения
BG28072A4 (bg) Метод за получаване на 1 n заместени канамицинови производни
BG28573A3 (bg) Метод за получаване на аминоалкоксифенилови производни
FR2327785A1 (fr) 1,2,4-triazolo(4,3-b)pyridazin-3-ones
BG35464A3 (bg) Метод за получаване на флуоренови производни
BG34038A3 (bg) Метод за получаване на 7-заместени амино-ацетамидо оксадетиа-цефалоспорини
PL206903A1 (pl) Sposob wytwarzania nowych podstawionych w pozycji 2-4a,9b-trans-5-arylo-2,3,4,4a,5a,9b-szesciowodoro-1h-pirydo(4,3-b)indoli
BG31073A3 (bg) Метод за получаване на 1,5-заместени-2-пиролидони
BG28064A3 (bg) Метод за получаване на 26-метан-2н-1-бензоксозини
BG36935A3 (bg) Метод за получаване на бензодиазепинови съединения
BG30773A3 (bg) Метод за получаване на окислени производни на 3-(1',1'-диметилхептил) -6,6а,7,8,10,10а-хексахидро-1-хидрокси-6,6-диметил-9н-дибензо(в,d)- пирани
BG28845A3 (bg) Метод за получаване на n-алкилдифениламини
BG35032A3 (bg) Метод за получаване на 1, 1, 2- трифенилпропенови производни
BG28066A3 (bg) Метод за получаване на пиридобензодиазепинони
BG33284A3 (bg) Метод за получаване на пиридазинилхидразони
BG28062A3 (bg) Метод за получаване на 6а,10а-цис-хексахидродибензопираноли