BG111357A - COSMETIC COMPOSITION - Google Patents

Abstract

The cosmetic composition according to the invention contains a lyophilized extract of snail mucus and lyophilized snail spawn extract, the amount of components being the following in weight. %: lyophilized snail mucus extract from 0.001 to 0.5, lyophilized snail cavity extract from 0.001 to 7, argan oil from 0.10 to 10, anti-inflammatory agent from 0.01 to 0.50, humectants from 1 to 10, alpha-hydroxy acid from 0.01 to 1, retinyl palmitate from 0.01 to 0.5 tocopheril acetate 0.1-2.0, D-panthenol 0.1-5.0, preservatives from 0.05 to 1.20, chelate compound from 0.05 to 0.2, perfume composition 0.0 to 0.7, thickeners from 2 to 5, antioxidants from 0.01 to 1.00 and deionized water to 100 and optionally further comprising surfactants or a regenerating additive and / or aqueous / oil stabilizing composition and / or oil component solvents. The composition of the invention provides an unexpectedly rapid effect. The effect of its use depending on its intended use is between the 5th and 10th day of the treatment of the skin areas. The cosmetic composition has an extremely rapid and positive effect on acne and traces of acne, rosacea, aging spots and freckles, wrinkles and mimic lines, including legs, scars, stretch marks, dead skin cells in need of exfoliation. The cosmetic composition preserves the biological activity of the active substance over a long period of time. The enzymes contained in the cosmetic composition retain their conformational integrity, respectively activity. This activity is controllable depending on the intended use of the composition according to the invention. The shelf life of the composition and its storage options, which do not require special conditions, are significantly extended.

Description

COSMETIC COMPOSITION

I. FIELD OF THE INVENTION

The cosmetic composition according to the invention will find application in the cosmetic industry for the production of cosmetic products with natural ingredients.

II. FIELD OF ENGINEERING

In recent years, the efforts of cosmetic companies have focused on creating products derived from nature. Snail extract has been shown to contain natural ingredients that have a positive effect on human skin. Cosmetic companies such as Babaria and Diet Esthetic Spain, Unifarmed Italy, Gutto Cosmetic Turkey and the Bulgarian companies Synaps & Eski, Natural Garden ltd. and Goton, have developed and offered cosmetics containing snail extract and excipients.

A cosmetic composition / Snail Secretion Filtrate / containing snail secretion is known and additionally contains proteoglycans, glucosamine glycans, glycoprotein enzymes, hyaluronic acid, peptides (containing copper), antimicrobial peptides and inorganic elements such as Cu, Zn, Ca + 2 and Fe.

A disadvantage of the known cosmetic compositions is the use in their composition of snail extract, an aqueous solution of serum, which has a small percentage of active substance, which leads to a delay in their action and reduce their effect in the treatment of facial and body skin.

III. SUMMARY OF THE INVENTION

The objective of the invention is to provide a cosmetic composition containing active ingredients - extracts of mucus and snail caviar, as in the active ingredients no water content and in combination with excipients to have a rapid effect in treating the skin of the face and body.

The problem according to the invention is solved with a composition containing in wt. %: lyophilized snail mucus extract and lyophilized snail caviar extract, the amount of components being as follows: lyophilized snail mucus extract from 0.001 to 0.5, lyophilized snail caviar extract from 0.001 to 7, argan oil from 0.10 to 10, anti-inflammatory agent from 0.01 to 0.50, humectants from 1 to 10, alpha-hydroxy acid from 0.01 to 1, retinyl palmitate from 0.01 0.5, tocopheryl acetate 0.1- 2.0, D-panthenol - 0.1-5.0, preservatives from 0.05 to 1.20, chelating compound from 0.05 to 0.2, perfume composition from 0.0 to 0.7, thickeners from 2 to 5, antioxidants from 0.01 to 1.00 and deionized water up to 100 and optionally further comprising surfactants or a regenerating additive and / or a water / oil stabilizing composition and / or solvents of oil components.

According to the invention, the surfactants used are in an amount (in% by weight) from 10 to 70 and they are: sodium lauryl sulfate, disodium laureth sulfosuccinate, diethanolamine cocoamide, cocamidopropyl betaine, disodium polyethanol glycol-8-pallamate glyphosate . The cosmetic composition according to the invention optionally further comprises a skin regenerating additive in (wt%), which is a mixture of palmitoyl oligopeptide and palmitoyl tetrapeptide - 7 in an amount of 3 to 8 or a mixture of hydrolyzed rice protein, soy protein and superoxide dismutase in an amount from 2 to 5.

According to an embodiment of the invention, the cosmetic composition further comprises an oil stabilizing composition which comprises / in wt. % / emulsifiers from 2 to 15 and emollients from 1 to 30. The emulsifiers are glycerin monostearate, polyethanol glycol-100 stearate, glycerin monostearate, polyglyceryl 3-stearate, and the emollients are caprylic / capric triglyceride, decyl oleate and vegetable oils such as almond oil, olive oil, apricot kernel oil.

The cosmetic composition of the invention optionally further comprises solvents of oily components are / wt. % / alcohol from 0.1 to 40 and a solubilizer from 0.01 to 5.00, the alcohol being ethyl and the solubilizer being polyethanol glycol-40, hydrogenated castor oil or polysorbate 20.

The anti-inflammatory substances of the invention are alpha-bisabolol, or extracts of herbs such as calendula, chamomile, St. John's wort.

Sodium hyaluronate, glycerin, propylene glycol are used as humectants according to the invention. Preservatives are phenoxyethanol, ethylhexyl glycerol, 2-bromo-2-nitropropane-1,3-diol, sodium benzoate, potassium sorbate and benzyl alcohol. Antioxidants are coenzyme Q10, butylhydroxytoluene, tocopherol. Alpha-hydroxy acid is lactic acid or glycolic acid. The chelated compound is the disodium salt of ethylenediamine tetraacetic acid or the tetrasodium salt of ethylenediamine tetraacetic acid.

To prove the effectiveness and usefulness of the cosmetic composition according to the invention, clinical medico-biological studies have been performed, one of which we apply:

the method used, with exposure exceeding the expected conditions ...... shows the absence of objective skin reactions (erythema.

desquamash, edema) and subjective complaints of irritation, burning or itching.

2. Uncontrolled, home use test

The test was performed on 50 healthy women aged 30 to 65 years.

Preliminarily, the probants are given instructions on how to. use of the cream and the indicators contained in a slip made for the study, in order to better assess the appearance and impact on the body. It is recommended to apply in the morning, before applying makeup and in the evening, after cleaning. At the end of the 20-day period of use, the conclusions of the linden probants are presented as follows in

1. ablipa 3

Indicators Nature of consumer opinions excellent very good and good missing Consistency 50 _: - Aroma · 50 - s ~; - Color 50 . - and i Application: 50 '- ί - - Takeover - from the skin · 50 '' - Residual ί and film _; - 50 Softened; : on the skin 50 ... i Elasticity; 50 ..... ' irritation: - · skin - -; -; 50 !! - eyes' - ; -: - ί 50

The data in the table show the full approval by the probants of the organoleptic properties of Cream.

The qualities such as easy application, absorption by the skin, lack of residual film, improvement of elasticity are highly appreciated. Effectively and quickly improves the relief of sensitive skin around the eyes. Helps increase its elasticity. to prevent the appearance of wrinkles, dark circles and puffiness, to eliminate the signs of fatigue. No skin or eye reactions, in the sense of irritation of the skin, have been reported.

1. Clinical methods:

A, One-time open epicutaneous test

The skin compatibility of the cream was tested in 20 volunteers. Fields with a size of 2/4 cm on the inner surface of the forearm were marked. In the test field was applied cream in pure form, undiluted. as when used under cream conditions.

A 5% solution of sodium lauryl sulfate was used as a control.

A single application of cream in the test field and control lasted 60 minutes. The reading was after washing the samples every 24 hours; 48 hours. referring to four degrees: redness (0 to 4). sneezing (from 3 to 3), swelling (+ or-), itching (0 to 3), burning (0 to 3).

B. Single closed epicutaneous test with complete occlusion

The test was performed on 20 volunteers aged 30 to 60 years. Reference cosmetic products were used for comparison. The tested cosmetic product is applied undiluted on the back for 48 hours by a closed method. The results were reported on the 1st, 24th and 48th hour after downloading the closed test. The obtained results are reported visually by scoring system, when determining the average score and are presented in

1 йи.ИЩй ί Medium 5al ί Number of persons with skin reactions; 0 and 20 - 1 : 0 ^! A · '0; 3 U! 4 and 0 {

The data show excellent compatibility of the cosmetic product Eye Cream "JUVENIS" at exposures exceeding the expected conditions of use.

C. Repeated closed epicutaneous test under occlusion

20 women were examined, using liquid paraffin for control. The product is applied under back occlusion for 24 hours for the first time and for 6 hours daily for the next 4 days (Frosch & Kligman, 1979). Reporting was performed daily, after removal of the closed epicutaneous sample and before application of the next application, until the 8th day. The evaluation of the data of each indicator was carried out taking into account the average values in points reported after the applications and on the eighth day the results were presented in

Table 2

1 Average score Number of persons with skin reactions; is it : и 20 4 yes! about 1. j 2 about L !! with ........ 0 ........... .......... Ί ................... ....... i ..... —........ — .......... !! 4 0 and

^; * - · В.

• · · ...... 6

The advantages of the composition compared to the known ones used for the same purpose are:

The cosmetic composition of the invention has a proven unexpectedly rapid effect.

The effect of its use, depending on the purpose, is between 5 and 10 days from the treatment of the skin areas.

The cosmetic composition of the invention has an extremely rapid and positive effect on acne and traces of acne, rosacea, age spots and freckles, wrinkles and facial lines, including "crow's feet", scars, stretch marks, dead skin cells in need of exfoliation.

The cosmetic composition preserves the biological activity of the active substance for a long time.

The enzymes contained in the cosmetic composition retain their conformational integrity, respectively activity. This activity is controllable depending on the purpose of the composition of the invention.

The shelf life of the composition according to the invention and the possibilities for its storage, which does not require special conditions, is significantly extended.

EXAMPLE EMPLOYMENT OF THE INVENTION

Example 1

Composition in kilograms:

Lyophilized snail mucus extract - 0.20

Lyophilized snail caviar extract -1.0

Argan oil - 0.50

Alpha-bisabolol - 0.30

D-panthenol - 1.00

Tocopheryl acetate - 0.05

Retinyl palmitate - 0.05

Palmitoyl oligopeptide, palmitoyl tetrapeptide - 7 - 3

Glycerin -1.00

Lactic acid - 0.20

2-Bromo-2-nitropropane-1,3-diol - 0.05

Disodium salt of ethylenediamine tetraacetic acid - 0.10

Perfume composition - 0.40

Surfactant - a mixture of sodium lauryl sulfate, disodium laureth sulfosuccinate, diethanolamine cocoamide, cocamidopropyl betaine, disodium polyethanol glycol-8 palm glyceride sulfosuccinate, polyethanol glycol-7-glyceryl

Xanthan - 2.00

Butylhydroxytoluene -0.01

-40 hydrogenated castor oil - 2.00

Salt - 1.00

Deionized water up to 100

To the previously beaten xanthan in water, slowly add the surfactant solution and the other components, stirring constantly at low speed until the mixture is completely homogenized.

Example 2

Composition in kilograms:

Lyophilized snail mucus extract - 0.2

Lyophilized snail caviar extract - 1.0

Argan oil -7.0

Alpha-bisabolol - 0.5

D-panthenol - 1.00

Tocopheryl acetate - 0.05

Retinyl palmitate - 0.05

Palmitoyl oligopeptide, palmitoyl tetrapeptide - 7 - 5.0

Glycerin - 7.00

Sodium hyaluronate - 1.00

Lactic acid -0.2

Phenoxyethanol (90%), ethylhexyl glycerol (10%) / - 0.8

Disodium salt of ethylenediamine tetraacetic acid - 0.2

Perfume composition - 0.5

Carbopol-0.50

Butylhydroxytoluene - 0.05

A mixture of glycerin monostearate and polyethylene glycol-100 stearate / - 9.00

Decyl oleate -4.00

Olive oil - 3.00 • · ·· ....... ....... 8

Sunflower oil - 4.00

Cetyl alcohol - 2.00

Triethanolamine - 0.50

Deionized water up to 100

Preparation of the aqueous phase: Break up the carbopol in water to obtain a homogeneous solution and add to it the glycerol, the disodium salt of ethylediamine tetraacetic acid. In another vessel, prepare the oil phase: glycerol monostearate and polyethylene glycol-100 stearate, argan oil, decyl oleate, olive oil, sunflower oil, cetyl alcohol and butylhydroxytoluene.

The two phases are heated on a water bath to a temperature of 70 ° C. Stir with constant stirring by adding the oil phase to the aqueous phase. Homogenize the finished emulsion for 5-10 minutes. Then, with constant stirring, the emulsion is cooled to 40-45 ° C, when added: lyophilized extracts of snail mucus and caviar, alpha-bisabolol, sodium hyaluronate, lactic acid, phenoxyethanol and ethylhexylglycerol, perfume composition. Finally, a solution of triethanolamine is added. Homogenize the emulsion for 2-3 minutes and continue cooling to room temperature.

Example 3:

Composition in kilograms:

Lyophilized snail mucus extract - 0.2

Lyophilized snail caviar extract - 1.0

Argan oil -3.0

Alpha-bisabolol -0.2

Glycerin - 5.00

Sodium hyaluronate - 0.5

Lactic acid - 0.2

D-panthenol - 1.00

Tocopheryl acetate - 1.00

Retinyl palmitate - 0.2

Coenzyme Q10 - 0.05

Phenoxyethanol (90%), ethylhexyl glycerol (10%) / - 0.8

Disodium salt of ethylenediamine tetraacetic acid - 0.2

Perfume composition - 0.5

Carbopol-0.50

A mixture of glycerin monostearate and polyethylene glycol-100 stearate / - 5.00

Capricillin / capric triglyceride -4.00

Olive oil - 3.00

Almond oil - 4.00

Cetyl alcohol - 2.00

Hydrolyzed rice protein, soy protein, superoxide dismutase - 3 Triethanolamine - 0.50

Deionized water up to 100

Preparation of the aqueous phase: Break up the carbopol in water to obtain a homogeneous solution and add to it the glycerol, the disodium salt of ethylediamine tetraacetic acid. In another vessel, prepare the oil phase: glycerol monostearate and polyethylene glycol-100 stearate, argan oil, caprylic / capric triglyceride, olive oil, almond oil, cetyl alcohol and butylhydroxytoluene.

The two phases are heated on a water bath to a temperature of 70 ° C. Stir with constant stirring by adding the oil phase to the aqueous phase. Homogenize the finished emulsion for 5-10 minutes. Then, with constant stirring, cool the emulsion to 40-45 ° C, when added: lyophilized extracts of snail mucus and caviar, D-panthenol, tocopheryl acetate, retinyl palmitate, coenzyme Q 10, hydrolyzed rice protein, soy protein, superoxide dismutase, alpha-bisabolol, sodium hyaluronate, lactic acid, phenoxyethanol and ethylhexylglycerol, perfume composition. Finally, a solution of triethanolamine is added. Homogenize the emulsion for 2-3 minutes and continue cooling to room temperature.

Example 4:

Composition in kilograms:

Lyophilized snail mucus extract - 0.50

Lyophilized snail caviar extract - 5.00

Argan oil - 0.20

Alpha-bisabolol -0.10

D-panthenol - 1.00

Tocopheryl acetate - 0.05

Retinyl palmitate - 0.05

Palmitoyl oligopeptide, palmitoyl tetrapeptide - 7 - 3,0 * · · · · “* ·» ·· · * »« · .. ·· 10

Glycerin - 4.00

Sodium hyaluronate - 1.00

Glycolic acid -0.50

A mixture of potassium sorbate, sodium benzoate, benzyl alcohol -1.0

Disodium salt of ethylenediamine tetraacetic acid - 0.10

Perfume composition - 0.50

Carbopol - 0.20

Butylhydroxytoluene - 0.02

Ethyl alcohol -15.00 polyethylene glycol -40 hydrogenated castor oil - 2.00

Triethanoylamine - 0.20

Deionized water up to 100

To the ethyl alcohol are added the oil-soluble components - perfume composition, alpha bisabolol, argan oil and butylhydroxytoluene. Carbopol is added to the deionized water and stirred until a clear solution is obtained, after which the following components are added: glycerin, sodium hyaluronate, lyophilized extracts of snail mucus and caviar, glycolic acid, benzyl alcohol, potassium sorbate, sodium benzoate, sodium benzoate ethylenediamine tetraacetic acid, polyethylene glycol-40 hydrogenated castor oil. Mix the two solutions and neutralize the finished mass with a solution of triethanolamine.

Although the present invention has been described in connection with preferred embodiments, it should be noted that various changes and modifications will be apparent to those skilled in the art. These changes and modifications are to be construed as falling within the scope of the present invention as defined by the appended claims, without going beyond that scope.

Other embodiments of the present invention are possible that will achieve the desired effects by the disclosure of the essential features in this specification and in the claims, thus also being within the scope of the present invention as defined by the claims.

Claims (11)

A cosmetic composition comprising snail extract, characterized in that the snail extract is a lyophilized snail mucus extract and a lyophilized snail caviar extract, the amount of components (by weight) being as follows: lyophilized snail mucus extract snails from 0.001 to 0.5, lyophilized snail caviar extract from 0.001 to 7, argan oil from 0.10 to 10, anti-inflammatory agent from 0.01 to 0.50, humectants from 1 to 10, alpha-hydroxy acid from 0.01 to 1, preservatives from 0.05 to 1.2, chelating compound from 0.05 to 0.2, perfume composition from 0.0 to 0.7, thickeners from 2 to 5, antioxidants from 0.01 to 1, 00 and deionized water up to 100 and in a case additionally further contains surfactants or a regenerating additive and / or an oil stabilizing composition and / or solvents for the oil components. Cosmetic composition comprising snail extract according to Claim 1, characterized in that the surfactants are present in an amount (in% by weight) of from 10 to 70 and the surfactants are: sodium lauryl sulfate, disodium laureth sulfosuccinate, cocoamide of diethanolamine, cocamidopropyl betaine, disodium polyethanol glycol-8 palm glyceride sulfosuccinate, polyethanol glycol-7 glyceryl cocoate. Cosmetic composition comprising snail extract according to Claim 1, characterized in that the regenerating additive is a mixture of palmitoyl oligopeptide, palmitoyl tetrapeptide - 7 in an amount of 30% by weight or a mixture of hydrolyzed rice protein, soy protein and superoxide dismutase in an amount of from 2 to 5% Cosmetic composition comprising snail extract according to Claim 1, characterized in that the oil-stabilizing composition contains by weight. % emulsifiers from 2 to 15 and emollients from 1 to 30, emulsifiers are glycerol monostearate, polyethanol glycol-100 stearate, glycerin monostearate, polyglyceryl 3-stearate, and emollients are caprylic / capric triglyceride, decyl oleate and vegetable oils, such as almond oil butter. '*' · · _F ^: _f * · - * · • · ·· ... ».... 12 Cosmetic composition comprising snail extract according to claim 1, characterized in that the solvents of the oil components are / in wt. % / alcohol from 0.1 to 40 and a solubilizer from 0.01 to 5.00, the alcohol is ethyl and the solubilizer is polyethanol glycol-40, hydrogenated castor oil or polysorbate 20. Cosmetic composition comprising snail extract according to claim 1, characterized in that the anti-inflammatory substances are alpha-bisabolol or extracts of herbs such as calendula, chamomile, St. John's wort. Cosmetic composition comprising snail extract according to claim 1, characterized in that the humectants are sodium hyaluronate, glycerin, propylene glycol. Cosmetic composition comprising snail extract according to Claim 1, characterized in that the preservatives are phenoxyethanol, ethylhexyl glycerol, 2-bromo-2-nitropropane-1,3-diol, sodium benzoate, potassium sorbate and benzyl alcohol. Cosmetic composition comprising snail extract according to claim 1, characterized in that the antioxidants are coenzyme Q10, butylhydroxytoluene, tocopherol. Cosmetic composition comprising snail extract according to claim 1, characterized in that the alpha-hydroxy acid is lactic acid or glycolic acid. Cosmetic composition comprising snail extract according to claim 1, characterized in that the chelated compound is the disodium salt of ethylenediamine tetraacetic acid or the tetrasodium salt of ethylenediamine tetraacetic acid.