BG103574A - Производни на аминофосфоновата киселина с фармацевтична активност - Google Patents

Производни на аминофосфоновата киселина с фармацевтична активност Download PDF

Info

Publication number: BG103574A
Authority: BG; Bulgaria
Prior art keywords: hydroxy; formula; aminomethylphosphonate; compound; dimethylpyridyl
Prior art date: 1996-12-20

Application number

BG103574A

Other languages

Bulgarian (bg)

English (en)

Inventor

Raymond Azoulay

Craig Bentzen

Simon Floret

Robert IFE

Lan Nguyen

Eric Niesor

Hieu Phan

Diep Vinh Van

Original Assignee

Symphar S.A.

Smithkline Beecham P.L.C.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-12-20

Filing date

1999-07-13

Publication date

2000-11-30

1999-07-13 Application filed by Symphar S.A., Smithkline Beecham P.L.C. filed Critical Symphar S.A.

2000-11-30 Publication of BG103574A publication Critical patent/BG103574A/bg

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/58—Pyridine rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

BG103574A 1996-12-20 1999-07-13 Производни на аминофосфоновата киселина с фармацевтична активност BG103574A (bg)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9626615.0A GB9626615D0 (en)	1996-12-20	1996-12-20	Novel compounds
PCT/EP1997/007161 WO1998028310A1 (en)	1996-12-20	1997-12-17	Pharmaceutical aminophosphonic acid derivatives

Publications (1)

Publication Number	Publication Date
BG103574A true BG103574A (bg)	2000-11-30

Family

ID=10804837

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG103574A BG103574A (bg)	1996-12-20	1999-07-13	Производни на аминофосфоновата киселина с фармацевтична активност

Country Status (31)

Country	Link
US (2)	US6303784B1 (xx)
EP (1)	EP0946572B1 (xx)
JP (1)	JP2001506667A (xx)
KR (1)	KR20000069609A (xx)
CN (1)	CN1105117C (xx)
AP (1)	AP9901546A0 (xx)
AR (1)	AR008541A1 (xx)
AT (1)	ATE255117T1 (xx)
AU (1)	AU5858898A (xx)
BG (1)	BG103574A (xx)
BR (1)	BR9714650A (xx)
CA (1)	CA2275696A1 (xx)
CO (1)	CO4930276A1 (xx)
DE (1)	DE69726449T2 (xx)
DZ (1)	DZ2377A1 (xx)
EA (1)	EA199900580A1 (xx)
GB (1)	GB9626615D0 (xx)
HU (1)	HUP0002171A3 (xx)
ID (1)	ID22053A (xx)
IL (1)	IL130334A0 (xx)
MA (1)	MA24427A1 (xx)
NO (1)	NO993001L (xx)
NZ (1)	NZ335884A (xx)
OA (1)	OA11068A (xx)
PE (1)	PE46799A1 (xx)
PL (1)	PL334189A1 (xx)
SK (1)	SK81099A3 (xx)
TR (1)	TR199901423T2 (xx)
TW (1)	TW434221B (xx)
WO (1)	WO1998028310A1 (xx)
ZA (1)	ZA9711431B (xx)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2001060805A1 (en)	2000-02-16	2001-08-23	Smithkline Beecham P.L.C.	Pyrimidine-4-one derivatives as ldl-pla2 inhibitors
US7442689B2 (en)	2000-02-29	2008-10-28	Medicure International Inc.	Cardioprotective phosphonates and malonates
PT1268498E (pt)	2000-02-29	2005-07-29	Medicure Int Inc	Fosfonatos cardioprotectores
EP1531157B1 (en) *	2000-02-29	2008-03-19	Medicure International Inc.	Cardioprotective phosphonates
US6897228B2 (en)	2000-07-07	2005-05-24	Medicure International Inc.	Pyridoxine and pyridoxal analogues: new uses
JP2004513891A (ja) *	2000-09-27	2004-05-13	アイレックス　オンコロジー　リサーチ　エス．エイ．	α−置換β−アミノエチルホスホネート
US20030114421A1 (en) *	2000-09-27	2003-06-19	Phan Hieu Trung	Alpha-substituted beta-aminoethyl phosphonate derivatives
GB0024808D0 (en)	2000-10-10	2000-11-22	Smithkline Beecham Plc	Novel compounds
GB0025849D0 (en) *	2000-10-23	2000-12-06	Smithkline Beecham Plc	Novel compounds
WO2003068240A1 (en) *	2002-02-11	2003-08-21	Ilex Products, Inc.	Alpha-substituted heteroarylalkyl phosphonate derivattives
US7208481B2 (en) *	2002-02-19	2007-04-24	Ilex Products, Inc.	Aminodiphosphonate apolipoprotein E modulators
US7459468B2 (en)	2004-10-28	2008-12-02	Medicure International, Inc.	Aryl sulfonic pyridoxines as antiplatelet agents
JP4824968B2 (ja) *	2005-08-18	2011-11-30	株式会社クレハ	ホスホン酸誘導体及びその酸付加塩、並びにそれを用いた農園芸用病害防除剤
MX2013006342A (es)	2010-12-06	2013-08-26	Glaxo Group Ltd	Compuestos de pirimidinona para usarse en el tratamiento de enfermedades o afecciones mediadas por fosfolipasa asociada con lipoproteinas a2 (lp-pla2).
KR20140059203A (ko)	2011-07-27	2014-05-15	글락소 그룹 리미티드	2,3-디히드로이미다조[1,2-c]피리미딘-5(1h)-온 화합물의 lp-pla2 억제제로서의 용도
AU2012288865B2 (en)	2011-07-27	2015-10-01	Glaxo Group Limited	Bicyclic pyrimidone compounds
JP6199291B2 (ja)	2011-09-01	2017-09-20	グラクソグループリミテッドＧｌａｘｏＧｒｏｕｐＬｉｍｉｔｅｄ	新規な結晶形態
AU2014209949B2 (en)	2013-01-25	2016-09-08	Glaxosmithkline Intellectual Property Development Limited	2,3-dihydroimidazol(1,2-c)pyrimidin-5(1h)-one based lipoprotein-associated phospholipase a2 (Lp-PLA2) inhibitors
JP2016505053A (ja)	2013-01-25	2016-02-18	グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅＩｎｔｅｌｌｅｃｔｕａｌＰｒｏｐｅｒｔｙＤｅｖｅｌｏｐｍｅｎｔＬｉｍｉｔｅｄ	Ｌｐ‐ＰＬＡ２の阻害剤としての二環式ピリミドン化合物
CA2899124A1 (en)	2013-01-25	2014-07-31	Glaxosmithkline Intellectual Property Development Limited	Compounds
WO2016012916A1 (en)	2014-07-22	2016-01-28	Glaxosmithkline Intellectual Property Development Limited	1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidine derivatives useful in the treatment of diseases and disorders mediated by lp-pla2
WO2016012917A1 (en)	2014-07-22	2016-01-28	Glaxosmithkline Intellectual Property Development Limited	1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidine derivatives useful in the treatment of diseases and disorders mediated by lp-pla2
BR112022008786A2 (pt)	2019-11-09	2022-07-26	Shanghai Simr Biotechnology Co Ltd	Composto, composição, uso do composto ou da composição, e, método para tratar ou prevenir uma complicação diabética, doença relacionada à neuroinflamação ou aterosclerose
CN115304620A (zh)	2021-05-07	2022-11-08	上海赛默罗生物科技有限公司	嘧啶酮衍生物、其制备方法、药物组合物和用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH683996A5 (fr)	1992-03-05	1994-06-30	Symphar Sa	Dérivés aminophosphonates substitués, leur procédé de préparation et compositions pharmaceutiques les contenant.
DE4433244A1 (de)	1994-09-19	1996-03-28	Hoechst Ag	Aminomethylphosphon- und Aminomethylphosphinsäure-Derivate und deren Verwendung zur Behandlung von degenerativen Gelenkserkrankungen
CH690264A5 (fr)	1995-06-30	2000-06-30	Symphar Sa	Dérivés aminophosphonates substitués, leur procédé de préparation et leur utilisation pour la préparation de compositions pharmaceutiques.
GB9626536D0 (en)	1996-12-20	1997-02-05	Symphar Sa	Novel compounds

1996
- 1996-12-20 GB GBGB9626615.0A patent/GB9626615D0/en active Pending
1997
- 1997-12-17 NZ NZ335884A patent/NZ335884A/xx unknown
- 1997-12-17 CN CN97180724A patent/CN1105117C/zh not_active Expired - Fee Related
- 1997-12-17 EP EP97954436A patent/EP0946572B1/en not_active Expired - Lifetime
- 1997-12-17 JP JP52836498A patent/JP2001506667A/ja active Pending
- 1997-12-17 PL PL97334189A patent/PL334189A1/xx unknown
- 1997-12-17 WO PCT/EP1997/007161 patent/WO1998028310A1/en not_active Ceased
- 1997-12-17 EA EA199900580A patent/EA199900580A1/ru unknown
- 1997-12-17 SK SK810-99A patent/SK81099A3/sk unknown
- 1997-12-17 DZ DZ970227A patent/DZ2377A1/xx active
- 1997-12-17 TR TR1999/01423T patent/TR199901423T2/xx unknown
- 1997-12-17 CA CA002275696A patent/CA2275696A1/en not_active Abandoned
- 1997-12-17 IL IL13033497A patent/IL130334A0/xx unknown
- 1997-12-17 ID IDW990550A patent/ID22053A/id unknown
- 1997-12-17 KR KR1019997005605A patent/KR20000069609A/ko not_active Ceased
- 1997-12-17 AT AT97954436T patent/ATE255117T1/de not_active IP Right Cessation
- 1997-12-17 US US09/331,385 patent/US6303784B1/en not_active Expired - Fee Related
- 1997-12-17 AP APAP/P/1999/001546A patent/AP9901546A0/en unknown
- 1997-12-17 DE DE69726449T patent/DE69726449T2/de not_active Expired - Fee Related
- 1997-12-17 HU HU0002171A patent/HUP0002171A3/hu unknown
- 1997-12-17 BR BR9714650-1A patent/BR9714650A/pt not_active Application Discontinuation
- 1997-12-17 AU AU58588/98A patent/AU5858898A/en not_active Abandoned
- 1997-12-18 PE PE1997001130A patent/PE46799A1/es not_active Application Discontinuation
- 1997-12-18 MA MA24903A patent/MA24427A1/fr unknown
- 1997-12-18 AR ARP970105997A patent/AR008541A1/es unknown
- 1997-12-18 CO CO97073902A patent/CO4930276A1/es unknown
- 1997-12-19 ZA ZA9711431A patent/ZA9711431B/xx unknown
- 1997-12-20 TW TW086119555A patent/TW434221B/zh active
1999
- 1999-06-18 OA OA9900136A patent/OA11068A/en unknown
- 1999-06-18 NO NO993001A patent/NO993001L/no not_active Application Discontinuation
- 1999-07-13 BG BG103574A patent/BG103574A/bg unknown
2001
- 2001-09-04 US US09/946,737 patent/US20020082423A1/en not_active Abandoned

Also Published As

Publication number	Publication date
PL334189A1 (en)	2000-02-14
PE46799A1 (es)	1999-06-24
AU5858898A (en)	1998-07-17
CN1240451A (zh)	2000-01-05
DE69726449D1 (en)	2004-01-08
US6303784B1 (en)	2001-10-16
EA199900580A1 (ru)	1999-12-29
ATE255117T1 (de)	2003-12-15
NO993001D0 (no)	1999-06-18
WO1998028310A1 (en)	1998-07-02
IL130334A0 (en)	2000-06-01
CN1105117C (zh)	2003-04-09
KR20000069609A (ko)	2000-11-25
TW434221B (en)	2001-05-16
ZA9711431B (en)	1999-06-21
EP0946572B1 (en)	2003-11-26
EP0946572A1 (en)	1999-10-06
AR008541A1 (es)	2000-01-19
DE69726449T2 (de)	2004-08-26
NO993001L (no)	1999-06-18
US20020082423A1 (en)	2002-06-27
OA11068A (en)	2003-03-10
NZ335884A (en)	2000-11-24
HUP0002171A3 (en)	2002-12-28
HUP0002171A2 (hu)	2001-05-28
MA24427A1 (fr)	1998-07-01
BR9714650A (pt)	2000-10-03
AP9901546A0 (en)	1999-06-30
DZ2377A1 (fr)	2002-12-28
CO4930276A1 (es)	2000-06-27
JP2001506667A (ja)	2001-05-22
CA2275696A1 (en)	1998-07-02
ID22053A (id)	1999-08-26
TR199901423T2 (xx)	1999-10-21
GB9626615D0 (en)	1997-02-05
SK81099A3 (en)	1999-11-08

Publication	Publication Date	Title
BG103574A (bg)	2000-11-30	Производни на аминофосфоновата киселина с фармацевтична активност
AU705206B2 (en)	1999-05-20	Compounds and pharmaceutical compositions containing them
MXPA98000189A (en)	1998-04-01	Compounds and pharmaceutical compositions that contains them
WO1998028311A1 (en)	1998-07-02	Pharmaceutical aminophosphonic acid derivatives
WO1998028312A1 (en)	1998-07-02	Pharmaceutical aminophosphonic acid derivatives
AU2001294792B2 (en)	2006-12-14	Alpha-substituted beta-aminoethyl phosphonates
CZ219699A3 (cs)	2000-02-16	Farmaceutické deriváty kyseliny aminofosfonové
US20030114421A1 (en)	2003-06-19	Alpha-substituted beta-aminoethyl phosphonate derivatives
US20020111488A1 (en)	2002-08-15	Beta-substitued beta-aminoethyl phosphonate derivatives
US20050124586A1 (en)	2005-06-09	Alpha-substituted arylalkyl phosphonate derivatives
JP2005529071A (ja)	2005-09-29	α−置換ヘテロアリールアルキルホスホン酸エステル誘導体