BG102623A - Нови производни на бензоилгуанидина, методи за тяхното получаване и приложението им за производството на ле- карствени средства - Google Patents
Нови производни на бензоилгуанидина, методи за тяхното получаване и приложението им за производството на ле- карствени средстваInfo
- Publication number
- BG102623A BG102623A BG102623A BG10262398A BG102623A BG 102623 A BG102623 A BG 102623A BG 102623 A BG102623 A BG 102623A BG 10262398 A BG10262398 A BG 10262398A BG 102623 A BG102623 A BG 102623A
- Authority
- BG
- Bulgaria
- Prior art keywords
- manufacture
- methods
- derivatives
- benzoylugunidine
- farming
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Furan Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19601303A DE19601303A1 (de) | 1996-01-16 | 1996-01-16 | Neuartige Benzoylguanidin-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung bei der Herstellung von Arzneimitteln |
| PCT/EP1997/000177 WO1997026253A1 (de) | 1996-01-16 | 1997-01-16 | Neuartige benzoylguanidin-derivate, verfahren zu ihrer herstellung und ihre verwendung bei der herstellung von arzneimitteln |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BG102623A true BG102623A (bg) | 1999-03-31 |
Family
ID=7782846
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG102623A BG102623A (bg) | 1996-01-16 | 1998-07-10 | Нови производни на бензоилгуанидина, методи за тяхното получаване и приложението им за производството на ле- карствени средства |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US6114335A (xx) |
| EP (1) | EP0882031A1 (xx) |
| JP (1) | JP2000503309A (xx) |
| KR (1) | KR19990077304A (xx) |
| CN (1) | CN1072663C (xx) |
| AR (1) | AR005468A1 (xx) |
| AU (1) | AU722619B2 (xx) |
| BG (1) | BG102623A (xx) |
| BR (1) | BR9707002A (xx) |
| CA (1) | CA2240075A1 (xx) |
| CO (1) | CO4761058A1 (xx) |
| CZ (1) | CZ225398A3 (xx) |
| DE (1) | DE19601303A1 (xx) |
| EE (1) | EE9800200A (xx) |
| HU (1) | HUP9900584A3 (xx) |
| IL (1) | IL124779A0 (xx) |
| NO (1) | NO311517B1 (xx) |
| NZ (1) | NZ326347A (xx) |
| PL (1) | PL327854A1 (xx) |
| RU (1) | RU2181720C2 (xx) |
| SK (1) | SK282751B6 (xx) |
| TR (1) | TR199801328T2 (xx) |
| TW (1) | TW426673B (xx) |
| UA (1) | UA48214C2 (xx) |
| WO (1) | WO1997026253A1 (xx) |
| ZA (1) | ZA97277B (xx) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19843489B4 (de) * | 1998-09-22 | 2006-12-21 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Benzoylguanidin-Abkömmlinge mit vorteilhaften Eigenschaften, Verfahren zu ihrer Herstellung und ihre Verwendung bei der Herstellung von Arzneimitteln, sowie diese enthaltende pharmazeutische Zubereitung |
| US6323207B1 (en) * | 1998-09-22 | 2001-11-27 | Boehringer Ingelheim Pharma Kg | Benzoylguanidine derivatives |
| JP2000219674A (ja) * | 1999-01-29 | 2000-08-08 | Daiichi Radioisotope Labs Ltd | 新規アラルキルグアニジン化合物 |
| CA2430669C (en) * | 2000-11-30 | 2011-06-14 | The Children's Medical Center Corporation | Synthesis of 3-amino-thalidomide and its enantiomers |
| IL147696A0 (en) * | 2001-01-25 | 2002-08-14 | Pfizer Prod Inc | Combination therapy |
| US6730678B2 (en) * | 2001-02-15 | 2004-05-04 | Boehringer Ingelheim Pharma Kg | Benzoylguanidine salt and hydrates thereof |
| DE10106970A1 (de) * | 2001-02-15 | 2002-08-29 | Boehringer Ingelheim Pharma | Neues Benzoylguanidinsalz |
| DE10204989A1 (de) * | 2002-02-07 | 2003-08-21 | Aventis Pharma Gmbh | Dihydro-thia-phenanthren-carbonyl-guanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| US7323479B2 (en) * | 2002-05-17 | 2008-01-29 | Celgene Corporation | Methods for treatment and management of brain cancer using 1-oxo-2-(2,6-dioxopiperidin-3-yl)-4-methylisoindoline |
| UA83504C2 (xx) | 2003-09-04 | 2008-07-25 | Селджин Корпорейшн | Поліморфні форми 3-(4-аміно-1-оксо-1,3-дигідроізоіндол-2-іл)піперидин-2,6-діону$полиморфные формы 3-(4-амино-1-оксо-1,3-дигидроизоиндол-2-ил) пиперидин-2,6-диона |
| KR20070057907A (ko) * | 2004-09-03 | 2007-06-07 | 셀진 코포레이션 | 치환된 2-(2,6-디옥소피페리딘-3-일)-1-옥소이소인돌린의제조 방법 |
| BRPI0612803A2 (pt) * | 2005-06-30 | 2012-10-02 | Celgene Corp | processo para preparar um composto |
| US8642278B2 (en) * | 2005-11-22 | 2014-02-04 | University Of South Florida | Inhibition of cell proliferation |
| WO2007136640A2 (en) * | 2006-05-16 | 2007-11-29 | Celgene Corporation | Processes for the preparation of substituted 2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione |
| EP2321274A1 (en) * | 2008-07-08 | 2011-05-18 | Boehringer Ingelheim International GmbH | Pyrrolidinyl and piperidinyl compounds useful as nhe-1 inhibitors |
| US20100184851A1 (en) * | 2008-08-29 | 2010-07-22 | University Of South Florida | Inhibition of cell proliferation |
| EP2817300B1 (en) | 2012-02-21 | 2018-04-25 | Celgene Corporation | Solid forms of 3-(4-nitro-1-oxoisoindolin-2-yl)piperidine-2,6-dione |
| EP2815749A1 (en) | 2013-06-20 | 2014-12-24 | IP Gesellschaft für Management mbH | Solid form of 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione having specified X-ray diffraction pattern |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0589336B1 (de) * | 1992-09-22 | 1997-01-08 | Hoechst Aktiengesellschaft | Benzoylguanidine, Verfahren zu ihrer Herstellung, sowie ihre Verwendung als Antiarrhythmika |
| DK0600371T3 (da) * | 1992-12-02 | 1999-09-20 | Hoechst Ag | Guanidinalkyl-1,1-bisphosphonsyrederivater, fremgangsmåde til deres fremstilling samt deres anvendelse |
| TW250477B (xx) * | 1992-12-15 | 1995-07-01 | Hoechst Ag | |
| DE4337611A1 (de) * | 1993-11-04 | 1995-05-11 | Boehringer Ingelheim Kg | Neue Benzoylguanidine, ihre Herstellung und ihre Verwendung in Arzneimitteln |
| DE4404183A1 (de) * | 1994-02-10 | 1995-08-17 | Merck Patent Gmbh | 4-Amino-1-piperidylbenzoylguanidine |
| DE4430861A1 (de) * | 1994-08-31 | 1996-03-07 | Merck Patent Gmbh | Heterocyclyl-benzoylguanidine |
-
1996
- 1996-01-16 DE DE19601303A patent/DE19601303A1/de not_active Withdrawn
-
1997
- 1997-01-14 ZA ZA97277A patent/ZA97277B/xx unknown
- 1997-01-15 CO CO97001473A patent/CO4761058A1/es unknown
- 1997-01-15 TW TW086100385A patent/TW426673B/zh not_active IP Right Cessation
- 1997-01-15 AR ARP970100146A patent/AR005468A1/es not_active Application Discontinuation
- 1997-01-16 CA CA002240075A patent/CA2240075A1/en not_active Abandoned
- 1997-01-16 US US09/101,792 patent/US6114335A/en not_active Expired - Fee Related
- 1997-01-16 JP JP9525687A patent/JP2000503309A/ja active Pending
- 1997-01-16 CN CN97191727A patent/CN1072663C/zh not_active Expired - Fee Related
- 1997-01-16 BR BR9707002A patent/BR9707002A/pt not_active IP Right Cessation
- 1997-01-16 KR KR1019980705450A patent/KR19990077304A/ko not_active Ceased
- 1997-01-16 AU AU14429/97A patent/AU722619B2/en not_active Ceased
- 1997-01-16 EP EP97901043A patent/EP0882031A1/de not_active Withdrawn
- 1997-01-16 IL IL12477997A patent/IL124779A0/xx unknown
- 1997-01-16 NZ NZ326347A patent/NZ326347A/en unknown
- 1997-01-16 PL PL97327854A patent/PL327854A1/xx unknown
- 1997-01-16 EE EE9800200A patent/EE9800200A/xx unknown
- 1997-01-16 UA UA98084428A patent/UA48214C2/uk unknown
- 1997-01-16 HU HU9900584A patent/HUP9900584A3/hu unknown
- 1997-01-16 CZ CZ982253A patent/CZ225398A3/cs unknown
- 1997-01-16 WO PCT/EP1997/000177 patent/WO1997026253A1/de not_active Ceased
- 1997-01-16 SK SK957-98A patent/SK282751B6/sk unknown
- 1997-01-16 RU RU98115533/04A patent/RU2181720C2/ru not_active IP Right Cessation
- 1997-01-16 TR TR1998/01328T patent/TR199801328T2/xx unknown
-
1998
- 1998-07-10 BG BG102623A patent/BG102623A/xx unknown
- 1998-07-15 NO NO19983261A patent/NO311517B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| PL327854A1 (en) | 1999-01-04 |
| CN1072663C (zh) | 2001-10-10 |
| IL124779A0 (en) | 1999-01-26 |
| TW426673B (en) | 2001-03-21 |
| NZ326347A (en) | 2001-03-30 |
| CO4761058A1 (es) | 1999-04-27 |
| RU2181720C2 (ru) | 2002-04-27 |
| AR005468A1 (es) | 1999-06-23 |
| AU722619B2 (en) | 2000-08-10 |
| HK1016981A1 (en) | 1999-11-12 |
| SK282751B6 (sk) | 2002-12-03 |
| WO1997026253A1 (de) | 1997-07-24 |
| NO311517B1 (no) | 2001-12-03 |
| AU1442997A (en) | 1997-08-11 |
| BR9707002A (pt) | 1999-07-20 |
| CZ225398A3 (cs) | 1998-12-16 |
| JP2000503309A (ja) | 2000-03-21 |
| HUP9900584A2 (hu) | 1999-07-28 |
| EP0882031A1 (de) | 1998-12-09 |
| NO983261D0 (no) | 1998-07-15 |
| KR19990077304A (ko) | 1999-10-25 |
| HUP9900584A3 (en) | 2001-01-29 |
| EE9800200A (et) | 1998-12-15 |
| SK95798A3 (en) | 1999-01-11 |
| DE19601303A1 (de) | 1997-07-17 |
| ZA97277B (en) | 1997-07-16 |
| NO983261L (no) | 1998-07-15 |
| UA48214C2 (uk) | 2002-08-15 |
| US6114335A (en) | 2000-09-05 |
| CN1208409A (zh) | 1999-02-17 |
| TR199801328T2 (xx) | 1998-10-21 |
| CA2240075A1 (en) | 1997-07-24 |
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