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BG100829A - Бензотиофен, бензофуран и индолтиазепинони, оксазепинони и диазепинони като инхибитори на клетъчна адхезия и на нiv - Google Patents

Бензотиофен, бензофуран и индолтиазепинони, оксазепинони и диазепинони като инхибитори на клетъчна адхезия и на нiv

Info

Publication number
BG100829A
BG100829A BG100829A BG10082996A BG100829A BG 100829 A BG100829 A BG 100829A BG 100829 A BG100829 A BG 100829A BG 10082996 A BG10082996 A BG 10082996A BG 100829 A BG100829 A BG 100829A
Authority
BG
Bulgaria
Prior art keywords
oxazepinones
indoltizepepinons
diapepinons
benzotiofen
benzofurane
Prior art date
Application number
BG100829A
Other languages
English (en)
Other versions
BG62698B1 (bg
Inventor
Diane Boschelli
David Connor
James KRAMER
Paul Unangst
Original Assignee
Warner-Lambert Company Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner-Lambert Company Llc filed Critical Warner-Lambert Company Llc
Publication of BG100829A publication Critical patent/BG100829A/bg
Publication of BG62698B1 publication Critical patent/BG62698B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Изобретението се отнася до бензотиофен, бензофуран и индолтиазепинони, оксазепинони и диазепинони сформула, в която заместителите са с посочените в описанието значения и до методи затяхното получаване. Съединенията се прилагат като агенти, потискащи прилепването на левкоцитите към васкуларния ендотел, и като ефективни терапевтични агенти за лечение на възпалителни заболявания. Освен това потискат активността на вируса на човешката имунна недостатъчност /HIV/. </P>
BG100829A 1994-03-07 1996-09-05 Бензотиофен, бензофуран и индолтиазепинони, оксазепинони и диазепинони като инхибитори на клетъчна адхезия и на нiv BG62698B1 (bg)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US20733094A 1994-03-07 1994-03-07
US08/351,611 US5489586A (en) 1994-03-07 1994-12-12 Method for treating inflammatory disease in humans
PCT/US1995/001275 WO1995024408A1 (en) 1994-03-07 1995-01-30 Benzothiophene, benzofuran and indolethiazepinones, oxazepinones and diazepinones as inhibitors of cell adhesion and as inhibitors of hiv

Publications (2)

Publication Number Publication Date
BG100829A true BG100829A (bg) 1997-10-31
BG62698B1 BG62698B1 (bg) 2000-05-31

Family

ID=22770077

Family Applications (1)

Application Number Title Priority Date Filing Date
BG100829A BG62698B1 (bg) 1994-03-07 1996-09-05 Бензотиофен, бензофуран и индолтиазепинони, оксазепинони и диазепинони като инхибитори на клетъчна адхезия и на нiv

Country Status (28)

Country Link
US (2) US5489586A (bg)
EP (1) EP0749434B1 (bg)
JP (1) JPH09509961A (bg)
KR (2) KR100338017B1 (bg)
AT (1) ATE187728T1 (bg)
AU (1) AU688466B2 (bg)
BG (1) BG62698B1 (bg)
CA (1) CA2181354A1 (bg)
CZ (1) CZ292009B6 (bg)
DE (1) DE69513961T2 (bg)
DK (1) DK0749434T3 (bg)
ES (1) ES2141922T3 (bg)
FI (1) FI963462A7 (bg)
GE (1) GEP19991835B (bg)
GR (1) GR3032861T3 (bg)
HU (1) HUT77403A (bg)
MD (1) MD1688G2 (bg)
NO (1) NO313384B1 (bg)
NZ (1) NZ279737A (bg)
PH (1) PH31163A (bg)
PL (1) PL180457B1 (bg)
RO (1) RO117919B1 (bg)
RU (1) RU2144033C1 (bg)
SK (1) SK282962B6 (bg)
TJ (1) TJ252B (bg)
UA (1) UA45967C2 (bg)
WO (1) WO1995024408A1 (bg)
ZA (1) ZA951844B (bg)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5612330A (en) * 1994-03-07 1997-03-18 Warner-Lambert Company Methods for inhibiting and controlling viral growth
TR200003130T2 (tr) * 1998-04-28 2001-01-22 Arzneimittelwerk Dresden Gmbh Yeni hidroksiindoller, bunların fosfodiesteraz 4 inhibitörleri olarak kullanımları ve hazırlanmaları için işlemler
DE19818964A1 (de) * 1998-04-28 1999-11-04 Dresden Arzneimittel Neue Hydroxyindole, deren Verwendung als Inhibitoren der Phospodiesterase 4 und Verfahren zu deren Herstellung
US7015212B1 (en) 1999-05-12 2006-03-21 The United States Of America As Represented By The Department Of Health And Human Services Thiazepine inhibitors of HIV-1 integrase
DE19944829A1 (de) * 1999-09-18 2001-06-13 Kundo Systemtechnik Gmbh Ultraschall-Durchflußmesser
AU2001281142A1 (en) * 2000-08-16 2002-02-25 Japan Tobacco Inc. Diazepinones as antiviral agents
JP2005089298A (ja) * 2001-09-18 2005-04-07 Japan Tobacco Inc ナフタレン化合物及びその医薬用途
AU2003239150A1 (en) * 2002-04-23 2003-11-10 Aventis Pharmaceuticals Inc. 3-substituted amino-1h-indole-2-carboxylic acid and 3-substituted amino-benzo
GB0217920D0 (en) 2002-04-23 2002-09-11 Aventis Pharm Prod Inc Interleukin-4 Gene Expression inhibitors
US7045552B2 (en) * 2002-09-27 2006-05-16 Trimeris, Inc. Pharmaceutical composition for improved administration of HIV gp41-derived peptides, and its use in therapy
WO2004092132A1 (en) * 2003-04-15 2004-10-28 Warner-Lambert Company Llc [b]-fused bicyclic proline derivatives and their use for treating arthritic conditions
CN1238357C (zh) * 2003-10-22 2006-01-25 中国科学院昆明植物研究所 炭球菌素及其制备方法和应用
US20050203081A1 (en) * 2004-02-25 2005-09-15 Jinbo Lee Inhibitors of protein tyrosine phosphatase 1B
ATE479693T1 (de) * 2004-09-17 2010-09-15 Idenix Pharmaceuticals Inc Phosphoindole als hiv-inhibitoren
US7674822B2 (en) 2004-11-24 2010-03-09 Wyeth PTP1b inhibitors
JP2009062278A (ja) * 2005-12-29 2009-03-26 Nippon Chemiphar Co Ltd Ｐ２ｘ４受容体拮抗剤
CN102731451B (zh) 2006-06-27 2015-07-29 武田药品工业株式会社 稠环化合物
US7960428B2 (en) 2006-09-29 2011-06-14 Idenix Pharmaceuticals, Inc. Enantiomerically pure phosphoindoles as HIV inhibitors
CA2817896A1 (en) * 2010-11-15 2012-05-24 Viiv Healthcare Uk Limited Inhibitors of hiv replication
RU2506082C2 (ru) * 2011-05-24 2014-02-10 Государственное учебно-научное учреждение Химический факультет Московского государственного университета им. М.В. Ломоносова Антигипотоническое средство
US10870663B2 (en) 2018-11-30 2020-12-22 Glaxosmithkline Intellectual Property Development Limited Compounds useful in HIV therapy
CA3251670A1 (en) * 2022-02-07 2023-08-10 Riparian Pharmaceuticals, Inc. KLF2 INDUCERS AND THEIR METHODS OF USE

Family Cites Families (2)

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US4013641A (en) * 1975-10-08 1977-03-22 Xerox Corporation Indolobenzoxazepines
AU5883794A (en) * 1993-01-20 1994-08-15 A. Menarini Industrie Farmaceutiche Riunite S.R.L. Diazepin derivatives and antiviral compositions

Also Published As

Publication number Publication date
GEP19991835B (en) 1999-11-05
US5565446A (en) 1996-10-15
RU2144033C1 (ru) 2000-01-10
PL316197A1 (en) 1996-12-23
EP0749434A1 (en) 1996-12-27
ZA951844B (en) 1995-12-12
AU688466B2 (en) 1998-03-12
FI963462A0 (fi) 1996-09-04
PH31163A (en) 1998-03-20
CZ259796A3 (en) 1997-06-11
SK114196A3 (en) 1997-03-05
CA2181354A1 (en) 1995-09-14
EP0749434B1 (en) 1999-12-15
MD1688F2 (en) 2001-06-30
DE69513961T2 (de) 2000-06-29
NO963744D0 (no) 1996-09-06
WO1995024408A1 (en) 1995-09-14
JPH09509961A (ja) 1997-10-07
KR100338017B1 (ko) 2002-11-23
NZ279737A (en) 1997-07-27
FI963462L (fi) 1996-09-04
MD1688G2 (ro) 2002-01-31
DE69513961D1 (de) 2000-01-20
FI963462A7 (fi) 1996-09-04
HUT77403A (hu) 1998-04-28
AU1697395A (en) 1995-09-25
SK282962B6 (sk) 2003-01-09
PL180457B1 (pl) 2001-02-28
TJ252B (en) 1999-12-23
DK0749434T3 (da) 2000-05-29
ATE187728T1 (de) 2000-01-15
MD960230A (ro) 1997-10-31
GR3032861T3 (en) 2000-07-31
HU9602451D0 (en) 1996-11-28
NO313384B1 (no) 2002-09-23
UA45967C2 (uk) 2002-05-15
US5489586A (en) 1996-02-06
KR100325881B1 (ko) 2002-03-20
CZ292009B6 (cs) 2003-07-16
NO963744L (no) 1996-09-06
RO117919B1 (ro) 2002-09-30
BG62698B1 (bg) 2000-05-31
ES2141922T3 (es) 2000-04-01

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