BG107750A - ПИРОЛОТРИАЗИНОВИ СЪЕДИНЕНИЯ И ИЗПОЛЗВАНЕТО ИМ КАТО ИНХИБИТОРИ НА р38 КИНАЗА - Google Patents

ПИРОЛОТРИАЗИНОВИ СЪЕДИНЕНИЯ И ИЗПОЛЗВАНЕТО ИМ КАТО ИНХИБИТОРИ НА р38 КИНАЗА Download PDF

Info

Publication number: BG107750A
Authority: BG; Bulgaria
Prior art keywords: alkyl; substituted; amino; triazine; aryl
Prior art date: 2000-11-17

Application number

BG107750A

Other languages

Bulgarian (bg)

English (en)

Inventor

Katerina Leftheris

Joel Barrish

John Hynes

Stephen T. Wrobleski

Original Assignee

Bristol-Myers Squibb Company

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-11-17

Filing date

2003-04-21

Publication date

2004-01-30

2003-04-21 Application filed by Bristol-Myers Squibb Company filed Critical Bristol-Myers Squibb Company

2004-01-30 Publication of BG107750A publication Critical patent/BG107750A/bg

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Immunology (AREA)
Diabetes (AREA)
Pulmonology (AREA)
Orthopedic Medicine & Surgery (AREA)
Virology (AREA)
Dermatology (AREA)
Pain & Pain Management (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Hematology (AREA)
Emergency Medicine (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Obesity (AREA)
Hospice & Palliative Care (AREA)
Vascular Medicine (AREA)
Endocrinology (AREA)
Psychiatry (AREA)
Molecular Biology (AREA)
Toxicology (AREA)
Urology & Nephrology (AREA)
Transplantation (AREA)

BG107750A 2000-11-17 2003-04-21 ПИРОЛОТРИАЗИНОВИ СЪЕДИНЕНИЯ И ИЗПОЛЗВАНЕТО ИМ КАТО ИНХИБИТОРИ НА р38 КИНАЗА BG107750A (bg)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US24987700P	2000-11-17	2000-11-17
US31056101P	2001-08-07	2001-08-07
PCT/US2001/049982 WO2002040486A2 (en)	2000-11-17	2001-11-07	METHODS OF TREATING p38 KINASE-ASSOCIATED CONDITIONS AND PYRROLOTRIAZINE COMPOUNDS USEFUL AS KINASE INHIBITORS

Publications (1)

Publication Number	Publication Date
BG107750A true BG107750A (bg)	2004-01-30

Family

ID=26940426

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG107750A BG107750A (bg)	2000-11-17	2003-04-21	ПИРОЛОТРИАЗИНОВИ СЪЕДИНЕНИЯ И ИЗПОЛЗВАНЕТО ИМ КАТО ИНХИБИТОРИ НА р38 КИНАЗА

Country Status (31)

Country	Link
EP (1)	EP1363910B1 (xx)
JP (1)	JP2004522713A (xx)
KR (1)	KR100847605B1 (xx)
CN (1)	CN1622946A (xx)
AR (1)	AR032637A1 (xx)
AT (1)	ATE318820T1 (xx)
AU (2)	AU2002232760B2 (xx)
BG (1)	BG107750A (xx)
BR (1)	BR0115446A (xx)
CA (1)	CA2429628A1 (xx)
CY (1)	CY1105250T1 (xx)
CZ (1)	CZ20031370A3 (xx)
DE (1)	DE60117607T2 (xx)
DK (1)	DK1363910T3 (xx)
EE (1)	EE200300227A (xx)
ES (1)	ES2259051T3 (xx)
GE (1)	GEP20063915B (xx)
HR (1)	HRP20030485A2 (xx)
HU (1)	HUP0303897A2 (xx)
IL (1)	IL155570A0 (xx)
IS (1)	IS6816A (xx)
MX (1)	MXPA03004290A (xx)
MY (1)	MY127066A (xx)
NO (1)	NO20032229L (xx)
NZ (1)	NZ525334A (xx)
PE (1)	PE20020819A1 (xx)
PL (1)	PL366376A1 (xx)
PT (1)	PT1363910E (xx)
SK (1)	SK5402003A3 (xx)
WO (1)	WO2002040486A2 (xx)
YU (1)	YU37903A (xx)

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ATE343415T1 (de)	2001-06-29	2006-11-15	Ab Science	Die verwendung von c-kit hemmer zur behandlung von entzündlichen darmerkrankungen
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GB0308186D0 (en)	2003-04-09	2003-05-14	Smithkline Beecham Corp	Novel compounds
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GB0308201D0 (en)	2003-04-09	2003-05-14	Smithkline Beecham Corp	Novel compounds
CA2528438A1 (en)	2003-06-03	2005-01-06	Novartis Ag	P-38 inhibitors
PL1641764T3 (pl)	2003-06-26	2011-12-30	Novartis Ag	Inhibitory kinazy P38 na bazie 5-członowych heterocykli
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US20050288290A1 (en)	2004-06-28	2005-12-29	Borzilleri Robert M	Fused heterocyclic kinase inhibitors
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JP5180967B2 (ja) *	2006-11-03	2013-04-10	ブリストル−マイヤーズスクイブカンパニー	ピロロトリアジンキナーゼ阻害剤
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US10342786B2 (en)	2017-10-05	2019-07-09	Fulcrum Therapeutics, Inc.	P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD
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CN112094219B (zh) *	2020-09-10	2022-08-05	广东莱佛士制药技术有限公司	一种制备钾离子竞争性阻滞剂中间体的方法
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2001
- 2001-11-07 GE GE5243A patent/GEP20063915B/en unknown
- 2001-11-07 DK DK01992298T patent/DK1363910T3/da active
- 2001-11-07 HU HU0303897A patent/HUP0303897A2/hu unknown
- 2001-11-07 PT PT01992298T patent/PT1363910E/pt unknown
- 2001-11-07 HR HR20030485A patent/HRP20030485A2/hr not_active Application Discontinuation
- 2001-11-07 KR KR1020037006661A patent/KR100847605B1/ko not_active Expired - Fee Related
- 2001-11-07 SK SK540-2003A patent/SK5402003A3/sk unknown
- 2001-11-07 WO PCT/US2001/049982 patent/WO2002040486A2/en not_active Ceased
- 2001-11-07 BR BR0115446-0A patent/BR0115446A/pt not_active IP Right Cessation
- 2001-11-07 ES ES01992298T patent/ES2259051T3/es not_active Expired - Lifetime
- 2001-11-07 AT AT01992298T patent/ATE318820T1/de not_active IP Right Cessation
- 2001-11-07 AU AU2002232760A patent/AU2002232760B2/en not_active Ceased
- 2001-11-07 CZ CZ20031370A patent/CZ20031370A3/cs unknown
- 2001-11-07 MX MXPA03004290A patent/MXPA03004290A/es active IP Right Grant
- 2001-11-07 CA CA002429628A patent/CA2429628A1/en not_active Abandoned
- 2001-11-07 AU AU3276002A patent/AU3276002A/xx active Pending
- 2001-11-07 EP EP01992298A patent/EP1363910B1/en not_active Expired - Lifetime
- 2001-11-07 IL IL15557001A patent/IL155570A0/xx unknown
- 2001-11-07 DE DE60117607T patent/DE60117607T2/de not_active Expired - Lifetime
- 2001-11-07 NZ NZ525334A patent/NZ525334A/en unknown
- 2001-11-07 JP JP2002543494A patent/JP2004522713A/ja active Pending
- 2001-11-07 CN CNA018189970A patent/CN1622946A/zh active Pending
- 2001-11-07 YU YU37903A patent/YU37903A/sh unknown
- 2001-11-07 EE EEP200300227A patent/EE200300227A/xx unknown
- 2001-11-07 PL PL01366376A patent/PL366376A1/xx not_active Application Discontinuation
- 2001-11-13 MY MYPI20015207A patent/MY127066A/en unknown
- 2001-11-16 AR ARP010105381A patent/AR032637A1/es unknown
- 2001-11-16 PE PE2001001141A patent/PE20020819A1/es not_active Application Discontinuation
2003
- 2003-04-21 BG BG107750A patent/BG107750A/bg unknown
- 2003-05-14 IS IS6816A patent/IS6816A/is unknown
- 2003-05-16 NO NO20032229A patent/NO20032229L/no not_active Application Discontinuation
2006
- 2006-06-01 CY CY20061100698T patent/CY1105250T1/el unknown

Also Published As

Publication number	Publication date
BR0115446A (pt)	2005-08-09
PE20020819A1 (es)	2002-09-11
EP1363910B1 (en)	2006-03-01
KR20030045195A (ko)	2003-06-09
EP1363910A2 (en)	2003-11-26
PL366376A1 (en)	2005-01-24
WO2002040486A2 (en)	2002-05-23
HK1057555A1 (en)	2004-04-08
WO2002040486A3 (en)	2003-09-12
MXPA03004290A (es)	2004-02-12
AU3276002A (en)	2002-05-27
ES2259051T3 (es)	2006-09-16
AR032637A1 (es)	2003-11-19
GEP20063915B (en)	2006-09-11
CZ20031370A3 (cs)	2003-10-15
DK1363910T3 (da)	2006-06-26
JP2004522713A (ja)	2004-07-29
AU2002232760B2 (en)	2006-12-14
SK5402003A3 (en)	2004-06-08
EE200300227A (et)	2003-10-15
CA2429628A1 (en)	2002-05-23
DE60117607D1 (de)	2006-04-27
DE60117607T2 (de)	2007-01-25
IS6816A (is)	2003-05-14
YU37903A (sh)	2006-05-25
IL155570A0 (en)	2003-11-23
HRP20030485A2 (en)	2004-08-31
ATE318820T1 (de)	2006-03-15
CN1622946A (zh)	2005-06-01
PT1363910E (pt)	2006-05-31
MY127066A (en)	2006-11-30
HUP0303897A2 (hu)	2004-03-01
NZ525334A (en)	2005-07-29
NO20032229L (no)	2003-07-16
KR100847605B1 (ko)	2008-07-21
AU2002232760C1 (en)	2002-05-27
NO20032229D0 (no)	2003-05-16
CY1105250T1 (el)	2010-03-03

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US6670357B2 (en)	2003-12-30	Methods of treating p38 kinase-associated conditions and pyrrolotriazine compounds useful as kinase inhibitors
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US7642257B2 (en)	2010-01-05	Phenyl-aniline substituted bicyclic compounds useful as kinase inhibitors
EP1503996B1 (en)	2008-12-24	Aryl ketone pyrrolo-triazine compounds useful as kinase inhibitors
JP2009535295A (ja)	2009-10-01	キナーゼ阻害剤として有用なピロロトリアジンアニリンプロドラッグ化合物
WO2005037838A1 (en)	2005-04-28	Heteroaryl-substituted pyrrolo-triazine compounds useful as kinase inhibitors
HK1057555B (en)	2006-09-15	Methods of treating p38 kinase-associated conditions and pyrrolotriazine compounds useful as kinase inhibitors
ZA200303786B (en)	2004-08-16	Methods of treating p38 kinase-associated conditions and pyrrolotriazine compounds useful as kinase inhibitors.