BG107668A - Метод за изолиране на фармацевтично приложим динатриев етидронат - Google Patents
Метод за изолиране на фармацевтично приложим динатриев етидронат Download PDFInfo
- Publication number
- BG107668A BG107668A BG107668A BG10766803A BG107668A BG 107668 A BG107668 A BG 107668A BG 107668 A BG107668 A BG 107668A BG 10766803 A BG10766803 A BG 10766803A BG 107668 A BG107668 A BG 107668A
- Authority
- BG
- Bulgaria
- Prior art keywords
- liquid
- disodium
- etidronate
- dispersion
- water
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 31
- GWBBVOVXJZATQQ-UHFFFAOYSA-L etidronate disodium Chemical compound [Na+].[Na+].OP(=O)([O-])C(O)(C)P(O)([O-])=O GWBBVOVXJZATQQ-UHFFFAOYSA-L 0.000 title claims abstract description 28
- 229940083571 etidronate disodium Drugs 0.000 title abstract 3
- 239000007787 solid Substances 0.000 claims abstract description 11
- 239000008346 aqueous phase Substances 0.000 claims abstract description 6
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 32
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 26
- 239000007788 liquid Substances 0.000 claims description 21
- 239000006185 dispersion Substances 0.000 claims description 18
- 238000001035 drying Methods 0.000 claims description 11
- 239000012074 organic phase Substances 0.000 claims description 11
- 239000012071 phase Substances 0.000 claims description 8
- 239000011362 coarse particle Substances 0.000 claims description 7
- 239000010419 fine particle Substances 0.000 claims description 7
- 239000002244 precipitate Substances 0.000 claims description 7
- 239000007864 aqueous solution Substances 0.000 claims description 6
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 4
- 238000002329 infrared spectrum Methods 0.000 claims description 3
- 238000002955 isolation Methods 0.000 claims description 3
- 238000000634 powder X-ray diffraction Methods 0.000 claims description 3
- 239000002245 particle Substances 0.000 abstract description 7
- 238000004519 manufacturing process Methods 0.000 abstract description 2
- 230000003111 delayed effect Effects 0.000 abstract 1
- 239000007791 liquid phase Substances 0.000 abstract 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 21
- DBVJJBKOTRCVKF-UHFFFAOYSA-N Etidronic acid Chemical compound OP(=O)(O)C(O)(C)P(O)(O)=O DBVJJBKOTRCVKF-UHFFFAOYSA-N 0.000 description 9
- 239000000047 product Substances 0.000 description 8
- 150000003839 salts Chemical class 0.000 description 7
- 239000000243 solution Substances 0.000 description 7
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 6
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 6
- 239000012467 final product Substances 0.000 description 6
- 238000002425 crystallisation Methods 0.000 description 5
- 230000008025 crystallization Effects 0.000 description 5
- 235000011007 phosphoric acid Nutrition 0.000 description 5
- 238000001556 precipitation Methods 0.000 description 5
- 159000000000 sodium salts Chemical class 0.000 description 5
- 239000000203 mixture Substances 0.000 description 4
- 239000012452 mother liquor Substances 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 3
- 238000011049 filling Methods 0.000 description 3
- 239000012535 impurity Substances 0.000 description 3
- 239000003960 organic solvent Substances 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 238000004062 sedimentation Methods 0.000 description 3
- 239000002002 slurry Substances 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 239000013543 active substance Substances 0.000 description 2
- 238000001739 density measurement Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000004821 distillation Methods 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 238000004817 gas chromatography Methods 0.000 description 2
- 238000000227 grinding Methods 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- AQSJGOWTSHOLKH-UHFFFAOYSA-N phosphite(3-) Chemical class [O-]P([O-])[O-] AQSJGOWTSHOLKH-UHFFFAOYSA-N 0.000 description 2
- 150000003016 phosphoric acids Chemical class 0.000 description 2
- OJMIONKXNSYLSR-UHFFFAOYSA-N phosphorous acid Chemical compound OP(O)O OJMIONKXNSYLSR-UHFFFAOYSA-N 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 238000004566 IR spectroscopy Methods 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000001447 alkali salts Chemical class 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 238000002050 diffraction method Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 229940009626 etidronate Drugs 0.000 description 1
- 229960004585 etidronic acid Drugs 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 238000005755 formation reaction Methods 0.000 description 1
- 238000013467 fragmentation Methods 0.000 description 1
- 238000006062 fragmentation reaction Methods 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 238000003921 particle size analysis Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000004064 recycling Methods 0.000 description 1
- 239000013049 sediment Substances 0.000 description 1
- 238000005029 sieve analysis Methods 0.000 description 1
- 239000010802 sludge Substances 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
- 239000012453 solvate Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 239000003039 volatile agent Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/386—Polyphosphonic acids containing hydroxy substituents in the hydrocarbon radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10049735A DE10049735A1 (de) | 2000-09-28 | 2000-09-28 | Verfahren zur Isolierung von pharmazeutisch verwertbarem Etidronat-Dinatrium |
| PCT/DE2001/003766 WO2002026751A1 (de) | 2000-09-28 | 2001-09-28 | Verfahren zur isolierung von pharmazeutisch verwertbarem etidronat-dinatrium |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BG107668A true BG107668A (bg) | 2003-09-30 |
Family
ID=7659017
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG107668A BG107668A (bg) | 2000-09-28 | 2003-03-25 | Метод за изолиране на фармацевтично приложим динатриев етидронат |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US6974885B2 (xx) |
| EP (1) | EP1320535B1 (xx) |
| JP (1) | JP3759927B2 (xx) |
| KR (1) | KR100562822B1 (xx) |
| CN (1) | CN1244586C (xx) |
| AT (1) | ATE273314T1 (xx) |
| AU (2) | AU2344902A (xx) |
| BG (1) | BG107668A (xx) |
| BR (1) | BR0114281A (xx) |
| CA (1) | CA2434790C (xx) |
| CZ (1) | CZ2003880A3 (xx) |
| DE (2) | DE10049735A1 (xx) |
| DK (1) | DK1320535T3 (xx) |
| EA (1) | EA004688B1 (xx) |
| EE (1) | EE200300122A (xx) |
| ES (1) | ES2227308T3 (xx) |
| HR (1) | HRP20030335B1 (xx) |
| HU (1) | HUP0301226A3 (xx) |
| IL (2) | IL155081A0 (xx) |
| MX (1) | MXPA03002666A (xx) |
| NO (1) | NO20031399L (xx) |
| NZ (1) | NZ525142A (xx) |
| PL (1) | PL361060A1 (xx) |
| PT (1) | PT1320535E (xx) |
| SK (1) | SK3912003A3 (xx) |
| UA (1) | UA73612C2 (xx) |
| WO (1) | WO2002026751A1 (xx) |
| YU (1) | YU22703A (xx) |
| ZA (1) | ZA200303212B (xx) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112016019545B1 (pt) * | 2014-02-27 | 2018-09-25 | Unilever N.V. | cápsula multicompartimentada de detergente para lavagem de roupa solúvel em água e método de preparação de uma cápsula |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL280424A (xx) * | 1961-07-03 | |||
| US3855284A (en) * | 1963-11-02 | 1974-12-17 | Henkel & Cie Gmbh | Process for the manufacture of phosphonic acids and phosphonates having at least two phosphorus atoms |
| DE1261850B (de) * | 1965-03-30 | 1968-02-29 | Procter & Gamble | Verfahren zur Herstellung von AEthan-1-hydroxy-1,1-diphosphonsaeure |
| NL149701C (nl) * | 1965-12-08 | 1981-05-15 | Procter & Gamble | Werkwijze voor het bereiden van een tegen tandsteen werkzaam tandverzorgingsmiddel, dat als werkzaam bestanddeel een fosfonzuurderivaat bevat, alsmede gevormd tandverzorgingsmiddel. |
| US3497313A (en) * | 1966-12-29 | 1970-02-24 | Procter & Gamble | Carbonyldiphosphonates |
| US3527795A (en) * | 1967-11-20 | 1970-09-08 | Monsanto Co | Process for preparing water-soluble salts of organic phosphorus acids |
| NL175882C (nl) * | 1977-03-28 | Procter & Gamble | Farmaceutisch preparaat, dat een verbinding met ontstekingtegengaande werking bevat. | |
| GB2095694B (en) * | 1981-03-31 | 1984-08-01 | Hollaway E R Ltd | Tooth cleaning compositions |
| US4504463A (en) * | 1982-06-10 | 1985-03-12 | Mallinckrodt, Inc. | Process for making a lyophilized product for use in skeletal imaging |
| US6143923A (en) * | 1996-10-02 | 2000-11-07 | Lonza Inc. | Process for manufacturing 1-hydroxyalkylidene-1,1-diphosphonic acid (HADP) |
-
2000
- 2000-09-28 DE DE10049735A patent/DE10049735A1/de not_active Withdrawn
-
2001
- 2001-09-28 CA CA002434790A patent/CA2434790C/en not_active Expired - Fee Related
- 2001-09-28 WO PCT/DE2001/003766 patent/WO2002026751A1/de not_active Ceased
- 2001-09-28 PL PL01361060A patent/PL361060A1/xx unknown
- 2001-09-28 KR KR1020037004495A patent/KR100562822B1/ko not_active Expired - Fee Related
- 2001-09-28 NZ NZ525142A patent/NZ525142A/en unknown
- 2001-09-28 DK DK01985659T patent/DK1320535T3/da active
- 2001-09-28 IL IL15508101A patent/IL155081A0/xx active IP Right Grant
- 2001-09-28 AU AU2344902A patent/AU2344902A/xx active Pending
- 2001-09-28 YU YU22703A patent/YU22703A/sh unknown
- 2001-09-28 UA UA2003043905A patent/UA73612C2/uk unknown
- 2001-09-28 PT PT01985659T patent/PT1320535E/pt unknown
- 2001-09-28 EP EP01985659A patent/EP1320535B1/de not_active Expired - Lifetime
- 2001-09-28 EA EA200300396A patent/EA004688B1/ru not_active IP Right Cessation
- 2001-09-28 JP JP2002531135A patent/JP3759927B2/ja not_active Expired - Fee Related
- 2001-09-28 EE EEP200300122A patent/EE200300122A/xx unknown
- 2001-09-28 BR BR0114281-0A patent/BR0114281A/pt not_active IP Right Cessation
- 2001-09-28 AU AU2002223449A patent/AU2002223449B2/en not_active Ceased
- 2001-09-28 CN CNB018165478A patent/CN1244586C/zh not_active Expired - Fee Related
- 2001-09-28 CZ CZ2003880A patent/CZ2003880A3/cs unknown
- 2001-09-28 DE DE50103250T patent/DE50103250D1/de not_active Expired - Fee Related
- 2001-09-28 MX MXPA03002666A patent/MXPA03002666A/es active IP Right Grant
- 2001-09-28 ES ES01985659T patent/ES2227308T3/es not_active Expired - Lifetime
- 2001-09-28 SK SK391-2003A patent/SK3912003A3/sk not_active Application Discontinuation
- 2001-09-28 AT AT01985659T patent/ATE273314T1/de not_active IP Right Cessation
- 2001-09-28 HR HR20030335A patent/HRP20030335B1/xx not_active IP Right Cessation
- 2001-09-28 HU HU0301226A patent/HUP0301226A3/hu unknown
- 2001-09-28 US US10/381,535 patent/US6974885B2/en not_active Expired - Fee Related
-
2003
- 2003-03-25 BG BG107668A patent/BG107668A/bg unknown
- 2003-03-25 IL IL155081A patent/IL155081A/en not_active IP Right Cessation
- 2003-03-27 NO NO20031399A patent/NO20031399L/no not_active Application Discontinuation
- 2003-04-24 ZA ZA200303212A patent/ZA200303212B/en unknown
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