BG104507A - Комбинирана терапия за лечение на спин - Google Patents

Комбинирана терапия за лечение на спин Download PDF

Info

Publication number: BG104507A
Authority: BG; Bulgaria
Prior art keywords: compound; indinavir; pharmaceutically acceptable; acceptable salt; ester
Prior art date: 1997-11-13

Application number

BG104507A

Other languages

Bulgarian (bg)

English (en)

Inventor

Joseph P. Vacca

Jiunn H. Lin

Kuang C. Yen

Jeffrey A. Chodakewitz

Paul J. Deutsch

William D. Ju

Original Assignee

Merck & Co.,Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-11-13

Filing date

2000-06-05

Publication date

2001-03-30

1998-04-15 Priority claimed from GBGB9807938.7A external-priority patent/GB9807938D0/en

1998-09-08 Priority claimed from GBGB9819590.2A external-priority patent/GB9819590D0/en

2000-06-05 Application filed by Merck & Co.,Inc. filed Critical Merck & Co.,Inc.

2001-03-30 Publication of BG104507A publication Critical patent/BG104507A/bg

Links

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235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
230000001323 posttranslational effect Effects 0.000 description 1
159000000001 potassium salts Chemical class 0.000 description 1
235000012015 potatoes Nutrition 0.000 description 1
239000002243 precursor Substances 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
230000000750 progressive effect Effects 0.000 description 1
230000002035 prolonged effect Effects 0.000 description 1
TVDSBUOJIPERQY-UHFFFAOYSA-N prop-2-yn-1-ol Chemical compound OCC#C TVDSBUOJIPERQY-UHFFFAOYSA-N 0.000 description 1
150000003242 quaternary ammonium salts Chemical class 0.000 description 1
230000002829 reductive effect Effects 0.000 description 1
238000006894 reductive elimination reaction Methods 0.000 description 1
230000010076 replication Effects 0.000 description 1
238000011160 research Methods 0.000 description 1
238000007363 ring formation reaction Methods 0.000 description 1
229960003542 saquinavir mesylate Drugs 0.000 description 1
235000020183 skimmed milk Nutrition 0.000 description 1
AWUCVROLDVIAJX-GSVOUGTGSA-N sn-glycerol 3-phosphate Chemical compound OC[C@@H](O)COP(O)(O)=O AWUCVROLDVIAJX-GSVOUGTGSA-N 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
235000010413 sodium alginate Nutrition 0.000 description 1
239000000661 sodium alginate Substances 0.000 description 1
229940005550 sodium alginate Drugs 0.000 description 1
239000012279 sodium borohydride Substances 0.000 description 1
229910000033 sodium borohydride Inorganic materials 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
235000009518 sodium iodide Nutrition 0.000 description 1
239000012321 sodium triacetoxyborohydride Substances 0.000 description 1
HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
230000003381 solubilizing effect Effects 0.000 description 1
238000009331 sowing Methods 0.000 description 1
239000007921 spray Substances 0.000 description 1
229940032147 starch Drugs 0.000 description 1
239000007929 subcutaneous injection Substances 0.000 description 1
238000010254 subcutaneous injection Methods 0.000 description 1
235000000346 sugar Nutrition 0.000 description 1
150000008163 sugars Chemical class 0.000 description 1
238000001356 surgical procedure Methods 0.000 description 1
229940054565 sustiva Drugs 0.000 description 1
239000003765 sweetening agent Substances 0.000 description 1
208000024891 symptom Diseases 0.000 description 1
230000002195 synergetic effect Effects 0.000 description 1
230000001839 systemic circulation Effects 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
235000012222 talc Nutrition 0.000 description 1
238000012360 testing method Methods 0.000 description 1
JRMUNVKIHCOMHV-UHFFFAOYSA-M tetrabutylammonium bromide Chemical compound [Br-].CCCC[N+](CCCC)(CCCC)CCCC JRMUNVKIHCOMHV-UHFFFAOYSA-M 0.000 description 1
238000000003 thermogravimetry coupled to Fourier transform infrared spectroscopy Methods 0.000 description 1
238000004809 thin layer chromatography Methods 0.000 description 1
239000004408 titanium dioxide Substances 0.000 description 1
235000010215 titanium dioxide Nutrition 0.000 description 1
238000004448 titration Methods 0.000 description 1
230000001988 toxicity Effects 0.000 description 1
231100000419 toxicity Toxicity 0.000 description 1
238000012546 transfer Methods 0.000 description 1
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
ZDPHROOEEOARMN-UHFFFAOYSA-N undecanoic acid Chemical compound CCCCCCCCCCC(O)=O ZDPHROOEEOARMN-UHFFFAOYSA-N 0.000 description 1
229940023080 viracept Drugs 0.000 description 1
239000001993 wax Substances 0.000 description 1
239000000080 wetting agent Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Immunology (AREA)
Molecular Biology (AREA)
Bioinformatics & Cheminformatics (AREA)
Virology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Tropical Medicine & Parasitology (AREA)
AIDS & HIV (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

BG104507A 1997-11-13 2000-06-05 Комбинирана терапия за лечение на спин BG104507A (bg)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US6542197P	1997-11-13	1997-11-13
GBGB9807938.7A GB9807938D0 (en)	1998-04-15	1998-04-15	Combination therapy for the treatment of AIDS
US9094098P	1998-06-26	1998-06-26
GBGB9819590.2A GB9819590D0 (en)	1998-09-08	1998-09-08	Combination therapy for the treatment of aids
PCT/US1998/024097 WO1999025352A1 (en)	1997-11-13	1998-11-12	Combination therapy for the treatment of aids

Publications (1)

Publication Number	Publication Date
BG104507A true BG104507A (bg)	2001-03-30

Family

ID=27451773

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG104507A BG104507A (bg)	1997-11-13	2000-06-05	Комбинирана терапия за лечение на спин

Country Status (24)

Country	Link
EP (1)	EP1044000B1 (es)
JP (1)	JP2001522889A (es)
KR (1)	KR20010032055A (es)
CN (1)	CN1285747A (es)
AR (1)	AR013758A1 (es)
AT (1)	ATE218866T1 (es)
AU (1)	AU749795B2 (es)
BG (1)	BG104507A (es)
BR (1)	BR9814146A (es)
CA (1)	CA2309164A1 (es)
CO (1)	CO4970782A1 (es)
DE (1)	DE69806062T2 (es)
EA (1)	EA200000513A1 (es)
ES (1)	ES2177103T3 (es)
HU (1)	HUP0100365A3 (es)
ID (1)	ID24922A (es)
IL (1)	IL135994A0 (es)
IS (1)	IS5481A (es)
NO (1)	NO20002481L (es)
PE (1)	PE20000020A1 (es)
PL (1)	PL340430A1 (es)
SK (1)	SK6842000A3 (es)
TR (1)	TR200001938T2 (es)
WO (1)	WO1999025352A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9820417D0 (en) *	1998-09-18	1998-11-11	Glaxo Group Ltd	Antiviral combinations
AU2002355739A1 (en)	2001-07-30	2003-02-17	University Of Southern California	Preparation and use of alpha-keto phosphonates
WO2004064845A1 (en)	2003-01-14	2004-08-05	Gilead Sciences, Inc.	Compositions and methods for combination antiviral therapy
GB2400553A (en) *	2003-04-14	2004-10-20	Cipla Ltd	Antiviral pharmaceutical combination of lamivudine, stavudine and efavirenz, or derivatives thereof
TWI375560B (en)	2005-06-13	2012-11-01	Gilead Sciences Inc	Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
TWI471145B (zh)	2005-06-13	2015-02-01	Bristol Myers Squibb & Gilead Sciences Llc	單一式藥學劑量型

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PL314984A1 (en) *	1993-12-15	1996-09-30	Merck & Co Inc	Hiv protease inhibitors

1998
- 1998-11-11 CO CO98066470A patent/CO4970782A1/es unknown
- 1998-11-12 KR KR1020007005176A patent/KR20010032055A/ko not_active Withdrawn
- 1998-11-12 WO PCT/US1998/024097 patent/WO1999025352A1/en not_active Ceased
- 1998-11-12 HU HU0100365A patent/HUP0100365A3/hu unknown
- 1998-11-12 EP EP98959424A patent/EP1044000B1/en not_active Expired - Lifetime
- 1998-11-12 SK SK684-2000A patent/SK6842000A3/sk unknown
- 1998-11-12 AU AU15225/99A patent/AU749795B2/en not_active Ceased
- 1998-11-12 CN CN98813077A patent/CN1285747A/zh active Pending
- 1998-11-12 CA CA002309164A patent/CA2309164A1/en not_active Abandoned
- 1998-11-12 TR TR2000/01938T patent/TR200001938T2/xx unknown
- 1998-11-12 BR BR9814146-5A patent/BR9814146A/pt not_active Application Discontinuation
- 1998-11-12 EA EA200000513A patent/EA200000513A1/ru unknown
- 1998-11-12 ID IDW20000895A patent/ID24922A/id unknown
- 1998-11-12 ES ES98959424T patent/ES2177103T3/es not_active Expired - Lifetime
- 1998-11-12 AR ARP980105720A patent/AR013758A1/es unknown
- 1998-11-12 PL PL98340430A patent/PL340430A1/xx unknown
- 1998-11-12 AT AT98959424T patent/ATE218866T1/de not_active IP Right Cessation
- 1998-11-12 DE DE69806062T patent/DE69806062T2/de not_active Expired - Fee Related
- 1998-11-12 JP JP2000520785A patent/JP2001522889A/ja not_active Withdrawn
- 1998-11-12 IL IL13599498A patent/IL135994A0/xx unknown
- 1998-11-12 PE PE1998001094A patent/PE20000020A1/es not_active Application Discontinuation
2000
- 2000-05-09 IS IS5481A patent/IS5481A/is unknown
- 2000-05-12 NO NO20002481A patent/NO20002481L/no not_active Application Discontinuation
- 2000-06-05 BG BG104507A patent/BG104507A/bg unknown

Also Published As

Publication number	Publication date
ATE218866T1 (de)	2002-06-15
JP2001522889A (ja)	2001-11-20
TR200001938T2 (tr)	2001-07-23
EP1044000A1 (en)	2000-10-18
SK6842000A3 (en)	2000-12-11
PE20000020A1 (es)	2000-01-27
WO1999025352A1 (en)	1999-05-27
KR20010032055A (ko)	2001-04-16
CA2309164A1 (en)	1999-05-27
DE69806062T2 (de)	2003-03-20
IS5481A (is)	2000-05-09
PL340430A1 (en)	2001-02-12
BR9814146A (pt)	2000-10-03
ID24922A (id)	2000-08-31
NO20002481L (no)	2000-07-12
CO4970782A1 (es)	2000-11-07
HUP0100365A3 (en)	2002-06-28
HUP0100365A2 (hu)	2002-05-29
AU749795B2 (en)	2002-07-04
EP1044000B1 (en)	2002-06-12
IL135994A0 (en)	2001-05-20
AU1522599A (en)	1999-06-07
ES2177103T3 (es)	2002-12-01
NO20002481D0 (no)	2000-05-12
AR013758A1 (es)	2001-01-10
DE69806062D1 (de)	2002-07-18
EA200000513A1 (ru)	2000-10-30
CN1285747A (zh)	2001-02-28

Publication	Publication Date	Title
DE69534549T2 (de)	2006-07-20	Kombination von retroviralen Proteasehemmern
KR101524165B1 (ko)	2015-06-01	Ｈｉｖ 인테그라제 억제제의 약동학을 개선하기 위한 방법
US6180634B1 (en)	2001-01-30	Combination therapy for the treatment of AIDS
EP0806957B1 (en)	2003-06-25	Combination therapy for hiv infection using the hiv protease inhibitor indinavir adn the reverse transcriptase inhibitor 3tc together with azt.
EP1044000B1 (en)	2002-06-12	Combination therapy for the treatment of aids
AU2863895A (en)	1996-01-19	Combination therapy for hiv infection
CA2197207C (en)	2006-10-17	Hiv protease inhibitor combination
CZ20001752A3 (cs)	2000-10-11	Farmaceutické prostředky obsahující kombinaci pro léčbu AIDS
HK1004659B (en)	2003-10-10	Combination therapy for hiv infection using the hiv protease inhibitor indinavir and the reverse transcriptase inhibitor 3tc together with azt
JPH05301816A (ja)	1993-11-16	抗エイズ剤
NZ732033B2 (en)	2024-01-30	Compositions comprising 2-((1-(2(4-fluorophenyl)-2-oxoethyl)piperidin-4-yl)methyl)isoindolin-1-one for treating schizophrenia