BG104321A - Sweetener salts of n-[n-(3,3-dimethylbutyl)-l-alpha-aspartyl]-l-phenylalanine 1 methyl ester - Google Patents

Sweetener salts of n-[n-(3,3-dimethylbutyl)-l-alpha-aspartyl]-l-phenylalanine 1 methyl ester

Info

Publication number: BG104321A
Authority: BG; Bulgaria
Prior art keywords: aspartyl; dimethylbutyl; phenylalanine; alpha; methyl ester
Prior art date: 1997-09-11

Application number

BG104321A

Other languages

Bulgarian (bg)

English (en)

Inventor

Indra Prakash

Zhi Guo

Original Assignee

The Nutrasweet Company

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-09-11

Filing date

2000-04-10

Publication date

2001-02-28

2000-04-10 Application filed by The Nutrasweet Company filed Critical The Nutrasweet Company

2001-02-28 Publication of BG104321A publication Critical patent/BG104321A/xx

Links

235000003599 food sweetener Nutrition 0.000 title abstract 4
239000003765 sweetening agent Substances 0.000 title abstract 4
150000003839 salts Chemical class 0.000 title abstract 3
HLIAVLHNDJUHFG-HOTGVXAUSA-N neotame Chemical class CC(C)(C)CCN[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 HLIAVLHNDJUHFG-HOTGVXAUSA-N 0.000 title abstract 2
108010016626 Dipeptides Proteins 0.000 abstract 1
VTAJIXDZFCRWBR-UHFFFAOYSA-N Licoricesaponin B2 Natural products C1C(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2)C(O)=O)C)(C)CC2)(C)C2C(C)(C)CC1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O VTAJIXDZFCRWBR-UHFFFAOYSA-N 0.000 abstract 1
YGCFIWIQZPHFLU-UHFFFAOYSA-N acesulfame Chemical compound CC1=CC(=O)NS(=O)(=O)O1 YGCFIWIQZPHFLU-UHFFFAOYSA-N 0.000 abstract 1
229960005164 acesulfame Drugs 0.000 abstract 1
230000002378 acidificating effect Effects 0.000 abstract 1
239000000625 cyclamic acid and its Na and Ca salt Substances 0.000 abstract 1
HCAJEUSONLESMK-UHFFFAOYSA-N cyclohexylsulfamic acid Chemical compound OS(=O)(=O)NC1CCCCC1 HCAJEUSONLESMK-UHFFFAOYSA-N 0.000 abstract 1
230000005595 deprotonation Effects 0.000 abstract 1
238000010537 deprotonation reaction Methods 0.000 abstract 1
LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 abstract 1
229960004949 glycyrrhizic acid Drugs 0.000 abstract 1
UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 abstract 1
239000001685 glycyrrhizic acid Substances 0.000 abstract 1
235000019410 glycyrrhizin Nutrition 0.000 abstract 1
LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 abstract 1
239000007788 liquid Substances 0.000 abstract 1
235000013615 non-nutritive sweetener Nutrition 0.000 abstract 1
235000019204 saccharin Nutrition 0.000 abstract 1
CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 abstract 1
229940081974 saccharin Drugs 0.000 abstract 1
239000000901 saccharin and its Na,K and Ca salt Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C07K5/06113—Asp- or Asn-amino acid
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/30—Artificial sweetening agents
- A23L27/31—Artificial sweetening agents containing amino acids, nucleotides, peptides or derivatives
- A23L27/32—Artificial sweetening agents containing amino acids, nucleotides, peptides or derivatives containing dipeptides or derivatives

Landscapes

Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Nutrition Science (AREA)
Engineering & Computer Science (AREA)
Food Science & Technology (AREA)
Polymers & Plastics (AREA)
Seasonings (AREA)
Peptides Or Proteins (AREA)

BG104321A 1997-09-11 2000-04-10 Sweetener salts of n-[n-(3,3-dimethylbutyl)-l-alpha-aspartyl]-l-phenylalanine 1 methyl ester BG104321A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US5850797P	1997-09-11	1997-09-11
PCT/US1998/018900 WO1999012954A1 (en)	1997-09-11	1998-09-11	SWEETENER SALTS OF N-[N-(3,3-DIMETHYLBUTYL) -L-α-ASPARTYL]-L-PHENYLALANINE 1-METHYL ESTER

Publications (1)

Publication Number	Publication Date
BG104321A true BG104321A (en)	2001-02-28

Family

ID=22017236

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG104321A BG104321A (en)	1997-09-11	2000-04-10	Sweetener salts of n-[n-(3,3-dimethylbutyl)-l-alpha-aspartyl]-l-phenylalanine 1 methyl ester

Country Status (16)

Country	Link
US (1)	US6129942A (xx)
EP (1)	EP1012169A1 (xx)
CN (1)	CN1278828A (xx)
AU (1)	AU753089B2 (xx)
BG (1)	BG104321A (xx)
BR (1)	BR9812639A (xx)
CA (1)	CA2303434A1 (xx)
EE (1)	EE200000114A (xx)
HU (1)	HUP0003734A2 (xx)
IL (1)	IL134916A0 (xx)
LT (1)	LT2000027A (xx)
NO (1)	NO20001271L (xx)
PL (1)	PL339189A1 (xx)
SI (1)	SI20328A (xx)
SK (1)	SK3262000A3 (xx)
WO (1)	WO1999012954A1 (xx)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP3643922B2 (ja) *	1998-05-08	2005-04-27	味の素株式会社	甘味料組成物
US6692778B2 (en)	1998-06-05	2004-02-17	Wm. Wrigley Jr. Company	Method of controlling release of N-substituted derivatives of aspartame in chewing gum
IL139657A0 (en) *	1998-06-26	2002-02-10	Ajinomoto Kk	Novel aspartyl dipeptide ester derivatives and sweeteners
AU4028300A (en) *	1999-03-26	2000-10-16	Nutrasweet Company, The	Particles of n-(n-(3,3-dimethylbutyl)-l-alpha-aspartyl)-l-phenylalanine 1-methylester
US6368651B1 (en) *	1999-05-13	2002-04-09	The Nutrasweet Company	Use of additives to modify the taste characteristics of N-neohexyl-α-aspartyl-L-phenylalanine methyl ester
AU4994700A (en) *	1999-05-13	2000-12-05	Nutrasweet Company, The	Modification of the taste and physicochemical properties of neotame using hydrophobic acid additives
CN1407991A (zh)	1999-10-05	2003-04-02	味之素株式会社	固体状甜味料组合物、液体状甜味料组合物及其用途
US7326430B2 (en) *	2000-07-18	2008-02-05	The Nutrasweet Company	Method of preparing liquid compositions for delivery of N-[N- (3,3-dimethylbutyl-L-α-aspartyl]-L-phenylalanine 1-methyl ester in food and beverage systems
DE10120413A1 (de) *	2001-04-26	2002-10-31	Nutrinova Gmbh	Acesulfamsalz, Verfahren zu seiner Herstellung und seine Verwendung
DE10330025A1 (de) *	2003-07-03	2005-01-20	Nutrinova Nutrition Specialties & Food Ingredients Gmbh	Verfahren zur Herstellung eines Süßstoffsalzes basierend auf Aspartam und Acesulfam
US20080038411A1 (en) *	2006-06-30	2008-02-14	Michael Jensen	Seasoning and method for enhancing and potentiating food flavor
US20110097449A1 (en) *	2006-06-30	2011-04-28	Conagra Foods Rdm, Inc.	Seasoning and method for seasoning a food product while reducing dietary sodium intake
US20080008790A1 (en) *	2006-06-30	2008-01-10	Michael Jensen	Seasoned food, seasoning, and method for seasoning a food product
US7923047B2 (en) *	2006-06-30	2011-04-12	Conagra Foods Rdm, Inc.	Seasoning and method for seasoning a food product while reducing dietary sodium intake
WO2008039533A2 (en) *	2006-09-27	2008-04-03	Conagra Foods, Inc.	Seasoning and method for enhancing and potentiating food flavor utilizing microencapsulation
CN112321676B (zh) *	2020-12-12	2022-06-14	山东诚汇双达药业有限公司	一种纽甜的成盐方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4029701A (en) *	1972-03-30	1977-06-14	General Foods Corporation	Sweetening with hydrohalide salts of dipeptide sweeteners
US4031258A (en) *	1972-03-30	1977-06-21	General Foods Corporation	Inorganic salts of dipeptide sweeteners
CA1028197A (en) *	1973-04-02	1978-03-21	Jeffrey H. Berg	Concentrated liquid low calorie sweetener
US4448716A (en) *	1982-03-04	1984-05-15	G. D. Searle & Co.	Dipeptide sweetener-metal complexes
ES8604766A1 (es) *	1985-09-20	1986-03-16	Palomo Coll Alberto	Procedimiento para la preparacion de nuevas sales fisiologi-camente activas o aceptables de sabor dulce
FR2697844B1 (fr) *	1992-11-12	1995-01-27	Claude Nofre	Nouveaux composés dérivés de dipeptides ou d'analogues dipeptidiques utiles comme agents édulcorants, leur procédé de préparation.
FR2719590B1 (fr) *	1994-05-09	1996-07-26	Claude Nofre	Procédé perfectionné de préparation d'un composé dérivé de l'aspartame utile comme agent édulcorant.
BE1009660A3 (nl) *	1995-10-11	1997-06-03	Holland Sweetener Co	Zoetstofzouten.
US5728862A (en) *	1997-01-29	1998-03-17	The Nutrasweet Company	Method for preparing and purifying an N-alkylated aspartame derivative

1998
- 1998-09-04 US US09/148,134 patent/US6129942A/en not_active Expired - Fee Related
- 1998-09-11 SI SI9820060A patent/SI20328A/sl unknown
- 1998-09-11 BR BR9812639-3A patent/BR9812639A/pt not_active Application Discontinuation
- 1998-09-11 HU HU0003734A patent/HUP0003734A2/hu unknown
- 1998-09-11 IL IL13491698A patent/IL134916A0/xx unknown
- 1998-09-11 EP EP98949334A patent/EP1012169A1/en not_active Ceased
- 1998-09-11 WO PCT/US1998/018900 patent/WO1999012954A1/en not_active Ceased
- 1998-09-11 SK SK326-2000A patent/SK3262000A3/sk unknown
- 1998-09-11 PL PL98339189A patent/PL339189A1/xx unknown
- 1998-09-11 CN CN98811058A patent/CN1278828A/zh active Pending
- 1998-09-11 AU AU95678/98A patent/AU753089B2/en not_active Ceased
- 1998-09-11 CA CA002303434A patent/CA2303434A1/en not_active Abandoned
- 1998-09-11 EE EEP200000114A patent/EE200000114A/xx unknown
2000
- 2000-03-10 NO NO20001271A patent/NO20001271L/no not_active Application Discontinuation
- 2000-04-06 LT LT2000027A patent/LT2000027A/lt unknown
- 2000-04-10 BG BG104321A patent/BG104321A/xx unknown

Also Published As

Publication number	Publication date
EP1012169A1 (en)	2000-06-28
SK3262000A3 (en)	2000-10-09
AU753089B2 (en)	2002-10-10
PL339189A1 (en)	2000-12-04
HUP0003734A2 (en)	2001-03-28
CN1278828A (zh)	2001-01-03
LT2000027A (lt)	2000-12-27
CA2303434A1 (en)	1999-03-18
IL134916A0 (en)	2001-05-20
SI20328A (sl)	2001-02-28
EE200000114A (et)	2000-12-15
AU9567898A (en)	1999-03-29
NO20001271L (no)	2000-05-10
NO20001271D0 (no)	2000-03-10
WO1999012954A1 (en)	1999-03-18
US6129942A (en)	2000-10-10
BR9812639A (pt)	2000-08-22

Publication	Publication Date	Title
BG104321A (en)	2001-02-28	Sweetener salts of n-[n-(3,3-dimethylbutyl)-l-alpha-aspartyl]-l-phenylalanine 1 methyl ester
US4996358A (en)	1991-02-26	Hydroxylamine bearing amino acid derivatives as collagenase inhibitors
BR9714881B1 (pt)	2013-11-12	Composição adoçante, e, bebida
WO2001090138A3 (en)	2002-03-21	SYNTHESIS OF N-[N-(3,3-DIMETHYLBUTYL)-L-α-ASPARTYL]-L-PHENYLALANINE 1-METHYL ESTER USING OXAZOLIDINONE DERIVATIVES
ATE248526T1 (de)	2003-09-15	Co-kristallisation von zucker und n-(n-(3,3- dimethylbutyl)-l-alpha-aspartyl)-l-phenylalanin 1-methyl ester
BG104322A (en)	2001-02-28	Basic salts of n-[n-(3,3-dimethylbutyl)-l-alpha-aspartyl]-l-phenylalanine 1-methyl ester
MD1175F1 (en)	1999-03-31	Method for the preparation of an aspartame-derived compound useful as a sweetener
AR015498A1 (es)	2001-05-02	Composiciones de edulcorante de mesa.
TR200002929T2 (tr)	2001-03-21	Aspartil dipeptid ester türevleri ve tatlandırıcıları
BG104323A (en)	2001-02-28	Acid salts of n-[n-(3,3-dimethylbutyl)-l-alpha-aspartyl]-l-phenylalanine 1-methyl ester
EE200000115A (et)	2000-12-15	N-[N-(3,3-dimetüülbutüül)-L-a-aspartüül]-L-fenüülalaniini 1-metüülestri metallikompleksid ja madala kalorsusega vedel magusti
TR200003750T2 (tr)	2001-06-21	Yeni aspartil dipeptid ester türevleri ve tatlandırıcıları
US5968581A (en)	1999-10-19	Dipeptide derivatives and sweetening agents
TR200000731T2 (tr)	2001-06-21	N-[N-(3,3-Dimetilbutil)-L-alfa-aspartil]-L-fenilalanin 1-metil esterin tatlandırıcı tuzları.
DE3782880D1 (de)	1993-01-14	Hemmende peptide.
DK0759030T3 (da)	1999-06-07	N-[N-(3,3-dimethylbutyl)-L-alfa-aspartyl]-L-hexahydrophenylalanin-1-methylester, som er anvendelig som sødemiddel, samt en
WO2000052019A3 (en)	2001-01-11	Crystallization products of neotame and methods for producing same
AR017092A1 (es)	2001-08-22	Sales y complejos de n-[n-(3,3-dimetilbutil)-l-alfa-aspartil]-l-fenilalanina 1-metil ester.
CA2310760A1 (en)	1999-06-24	Mixed crystals comprising aspartame and aspartame derivative and process for producing the same
Yasutake et al.	1979	Hydrolysis of cyclic depsidipeptides by trypsin or chymotrypsin
Pavlova et al.	1981	Aspartame and its analogues
ATE238344T1 (de)	2003-05-15	Synthese und gewinnung von aspartam, unter anwendung eines enzymatischen deformylationsschrittes
ECSP982666A (es)	1999-04-21	Sales y complejos de n-[n-(3,3- dimetilbutilo)-l alfa-aspartil)-l- fenilalanina-1- ester de metilo
TH41179A (th)	2000-11-15	ส่วนประกอบทำความหวานที่มีรสดีขึ้น