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BE903069A - PROCESS FOR THE PREPARATION OF AN AMINOLACTONE - Google Patents

PROCESS FOR THE PREPARATION OF AN AMINOLACTONE

Info

Publication number
BE903069A
BE903069A BE0/215472A BE215472A BE903069A BE 903069 A BE903069 A BE 903069A BE 0/215472 A BE0/215472 A BE 0/215472A BE 215472 A BE215472 A BE 215472A BE 903069 A BE903069 A BE 903069A
Authority
BE
Belgium
Prior art keywords
aminolactone
compound
general formula
preparation
same meaning
Prior art date
Application number
BE0/215472A
Other languages
French (fr)
Original Assignee
Richter Gedeon Vegyeszet
Biogal Gyogyszergyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszet, Biogal Gyogyszergyar filed Critical Richter Gedeon Vegyeszet
Publication of BE903069A publication Critical patent/BE903069A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/12—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyrane Compounds (AREA)

Abstract

Procédé de préparation d'une aminolactone de formule (I) dans lequel : a 1) on réduit un composé de formule générale (III) où R représente un groupe alcoyle en C1 à C6, pour donner un composé de formule générale (II): où R a la meme signification que ci-dessus, on traite ce dernier composé en présence d'un acide alcanecarboxylique ayant une chaine alcoyle inférieure dans la fraction alcoyle, avec un hydrure complexe puis avec de l'acide chlorhydrique aqueux concentré et on recueille l'aminolactone; ou a 2) on traite un composé de formule générale (II) où R a la meme signification que ci-dessus, en présence d'un acide alcanecarboxylique ayant une chaine alcoyle inférieure dans la fraction alcane, avec un hydrure complexe puis avec de l'acide chlorhydrique aqueux concentré, et on recueille l'aminolactone.Process for the preparation of an aminolactone of formula (I) in which: a 1) a compound of general formula (III) is reduced where R represents a C1 to C6 alkyl group, to give a compound of general formula (II): where R has the same meaning as above, the latter compound is treated in the presence of an alkanecarboxylic acid having a lower alkyl chain in the alkyl fraction, with a complex hydride then with concentrated aqueous hydrochloric acid and the 'aminolactone; or a 2) treating a compound of general formula (II) where R has the same meaning as above, in the presence of an alkanecarboxylic acid having a lower alkyl chain in the alkane fraction, with a complex hydride then with l concentrated aqueous hydrochloric acid, and aminolactone is collected.

BE0/215472A 1984-08-15 1985-08-14 PROCESS FOR THE PREPARATION OF AN AMINOLACTONE BE903069A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU309084A HU194203B (en) 1984-08-15 1984-08-15 Process for producing amino-lactone

Publications (1)

Publication Number Publication Date
BE903069A true BE903069A (en) 1986-02-14

Family

ID=10962501

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/215472A BE903069A (en) 1984-08-15 1985-08-14 PROCESS FOR THE PREPARATION OF AN AMINOLACTONE

Country Status (10)

Country Link
JP (1) JPS61246176A (en)
BE (1) BE903069A (en)
CH (1) CH666686A5 (en)
DE (1) DE3529159A1 (en)
ES (1) ES8609297A1 (en)
FR (1) FR2569194B3 (en)
GB (1) GB2163160A (en)
HU (1) HU194203B (en)
PT (1) PT80959B (en)
SE (1) SE453193B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8531638D0 (en) * 1985-12-23 1986-02-05 Ici Plc Chemical compounds
DE60318663T2 (en) 2002-10-18 2008-06-05 Yokozawa, Tohru, Fujisawa Process for the preparation of optically active amino alcohols
WO2007086076A2 (en) * 2006-01-24 2007-08-02 Unichem Laboratories Limited An improved process for preparation of leflunomide

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4287123A (en) * 1980-01-14 1981-09-01 Merck & Co., Inc. Synthesis of thienamycin via (3SR, 4RS)-3-((RS)-1-acyloxyethyl)-2-oxo-4-azetidineacetate
US4360684A (en) * 1981-04-08 1982-11-23 Merck & Co., Inc. Process for the preparation of (2S)-tetrahydro-2α-methyl-6-oxo-4βα-carboxylic acid

Also Published As

Publication number Publication date
SE8503811L (en) 1986-02-16
HU194203B (en) 1988-01-28
PT80959B (en) 1987-02-06
SE8503811D0 (en) 1985-08-14
ES8609297A1 (en) 1986-09-01
PT80959A (en) 1985-09-01
JPS61246176A (en) 1986-11-01
ES546140A0 (en) 1986-09-01
CH666686A5 (en) 1988-08-15
GB2163160A (en) 1986-02-19
DE3529159A1 (en) 1986-02-27
SE453193B (en) 1988-01-18
FR2569194B3 (en) 1987-06-26
GB8520403D0 (en) 1985-09-18
FR2569194A1 (en) 1986-02-21
HUT37777A (en) 1986-02-28

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: RICHTER GEDEON VEGYESZETI GYAR R.T. BIOGAL GYOGYS

Effective date: 19880831