BE901879A - ANALOGUE PRODUCTS OF 1ALPHA-HYDROXYVITAMIN D2, THEIR PREPARATION PROCESS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. - Google Patents
ANALOGUE PRODUCTS OF 1ALPHA-HYDROXYVITAMIN D2, THEIR PREPARATION PROCESS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.Info
- Publication number
- BE901879A BE901879A BE0/214606A BE214606A BE901879A BE 901879 A BE901879 A BE 901879A BE 0/214606 A BE0/214606 A BE 0/214606A BE 214606 A BE214606 A BE 214606A BE 901879 A BE901879 A BE 901879A
- Authority
- BE
- Belgium
- Prior art keywords
- 1alpha
- vitamin
- hydroxyvitamin
- pharmaceutical compositions
- preparation process
- Prior art date
Links
- HKXBNHCUPKIYDM-CGMHZMFXSA-N doxercalciferol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C HKXBNHCUPKIYDM-CGMHZMFXSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 229930003316 Vitamin D Natural products 0.000 abstract 3
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 abstract 3
- 235000019166 vitamin D Nutrition 0.000 abstract 3
- 239000011710 vitamin D Substances 0.000 abstract 3
- 150000003710 vitamin D derivatives Chemical class 0.000 abstract 3
- 229940046008 vitamin d Drugs 0.000 abstract 3
- 208000022458 calcium metabolism disease Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000002207 metabolite Substances 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 150000003703 vitamin D2 derivatives Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0036—Nitrogen-containing hetero ring
- C07J71/0042—Nitrogen only
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Nutrition Science (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La présente invention fournit de noveaux produits analogues des composés de la vitamine D2 qui ne comportent pas le substituant méthyle sur la position 24 et qui sont la 1-hydroxy-28-norvitamine D2 et la 1alpha,25-dihydroxy-28-norvitamine D2 de formule I. Les composés de la présente invention sont caractérisés par une forte activité inattendue, semblable à celle d'une vitamine D ainsi que par un nouveau modèle d'activité et, comme tels, sont des produits de remplacement de la vitamine D ou de dives métabolites de la vitamine D connus dans leurs applications variées pour le traitement des troubles du calcium.The present invention provides novel analog products of the vitamin D2 compounds which do not have the methyl substituent at position 24 and which are 1-hydroxy-28-norvitamin D2 and 1alpha, 25-dihydroxy-28-norvitamin D2. formula I. The compounds of the present invention are characterized by an unexpectedly strong activity, similar to that of a vitamin D as well as by a new activity model and, as such, are substitutes for vitamin D or various metabolites of vitamin D known in their various applications for the treatment of calcium disorders.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58616084A | 1984-03-05 | 1984-03-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BE901879A true BE901879A (en) | 1985-07-01 |
Family
ID=24344548
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE0/214606A BE901879A (en) | 1984-03-05 | 1985-03-05 | ANALOGUE PRODUCTS OF 1ALPHA-HYDROXYVITAMIN D2, THEIR PREPARATION PROCESS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. |
Country Status (12)
| Country | Link |
|---|---|
| JP (1) | JPH064536B2 (en) |
| AU (1) | AU584071B2 (en) |
| BE (1) | BE901879A (en) |
| CH (1) | CH667658A5 (en) |
| DE (2) | DE3590080C2 (en) |
| DK (1) | DK153145C (en) |
| FR (1) | FR2560597B1 (en) |
| GB (1) | GB2155478B (en) |
| IE (1) | IE57951B1 (en) |
| IL (1) | IL74168A (en) |
| NL (1) | NL8520021A (en) |
| WO (1) | WO1985003939A1 (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8915770D0 (en) * | 1989-07-10 | 1989-08-31 | Leo Pharm Prod Ltd | Chemical compounds |
| US5260290A (en) * | 1990-02-14 | 1993-11-09 | Wisconsin Alumni Research Foundation | Homologated vitamin D2 compounds and the corresponding 1α-hydroxylated derivatives |
| US5030772A (en) * | 1990-02-14 | 1991-07-09 | Deluca Hector F | Process for preparing vitamin D2 compounds and the corresponding 1 α-hydroxylated derivatives |
| IN171426B (en) * | 1990-02-14 | 1992-10-10 | Wisconsin Alumni Res Found |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3907843A (en) * | 1974-06-14 | 1975-09-23 | Wisconsin Alumni Res Found | 1{60 -Hydroxyergocalciferol and processes for preparing same |
| US3880894A (en) * | 1974-05-24 | 1975-04-29 | Wisconsin Alumni Res Found | 1,25-Dihydroxyergocalciferol |
| US4195027A (en) * | 1978-01-16 | 1980-03-25 | Wisconsin Alumni Research Foundation | Process for preparing 1α-hydroxylated compounds |
| US4267117A (en) * | 1978-06-19 | 1981-05-12 | The Upjohn Company | Compounds and process |
| US4206131A (en) * | 1978-06-19 | 1980-06-03 | The Upjohn Company | Compounds and process |
| US4360471A (en) * | 1981-12-11 | 1982-11-23 | Wisconsin Alumni Research Foundation | 23-Dehydro-25-hydroxyvitamin D3 |
| US4508651A (en) * | 1983-03-21 | 1985-04-02 | Hoffmann-La Roche Inc. | Synthesis of 1α,25-dihydroxyergocalciferol |
| AU587174B2 (en) * | 1984-01-30 | 1989-08-10 | Wisconsin Alumni Research Foundation | 1a, 25-dihydroxy-22z-dehydrovitamin d compound |
-
1985
- 1985-01-22 CH CH4779/85A patent/CH667658A5/en not_active IP Right Cessation
- 1985-01-22 WO PCT/US1985/000097 patent/WO1985003939A1/en not_active Ceased
- 1985-01-22 DE DE3590080A patent/DE3590080C2/de not_active Expired - Lifetime
- 1985-01-22 JP JP60500734A patent/JPH064536B2/en not_active Expired - Lifetime
- 1985-01-22 AU AU38895/85A patent/AU584071B2/en not_active Ceased
- 1985-01-22 DE DE19853590080 patent/DE3590080T/en active Pending
- 1985-01-22 NL NL8520021A patent/NL8520021A/en unknown
- 1985-01-25 IL IL74168A patent/IL74168A/en not_active IP Right Cessation
- 1985-03-01 IE IE520/85A patent/IE57951B1/en not_active IP Right Cessation
- 1985-03-04 FR FR8503135A patent/FR2560597B1/en not_active Expired
- 1985-03-04 GB GB08505486A patent/GB2155478B/en not_active Expired
- 1985-03-05 BE BE0/214606A patent/BE901879A/en not_active IP Right Cessation
- 1985-11-04 DK DK506985A patent/DK153145C/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DK506985A (en) | 1985-11-06 |
| IE850520L (en) | 1985-09-05 |
| WO1985003939A1 (en) | 1985-09-12 |
| DK153145C (en) | 1988-10-31 |
| FR2560597B1 (en) | 1987-12-04 |
| DE3590080T (en) | 1986-02-20 |
| DK153145B (en) | 1988-06-20 |
| GB8505486D0 (en) | 1985-04-03 |
| AU584071B2 (en) | 1989-05-18 |
| IE57951B1 (en) | 1993-05-19 |
| JPS61501447A (en) | 1986-07-17 |
| DE3590080C2 (en) | 1992-08-06 |
| AU3889585A (en) | 1985-09-24 |
| IL74168A0 (en) | 1985-04-30 |
| DK506985D0 (en) | 1985-11-04 |
| JPH064536B2 (en) | 1994-01-19 |
| IL74168A (en) | 1988-11-15 |
| GB2155478B (en) | 1987-12-16 |
| GB2155478A (en) | 1985-09-25 |
| NL8520021A (en) | 1986-02-03 |
| FR2560597A1 (en) | 1985-09-06 |
| CH667658A5 (en) | 1988-10-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RE | Patent lapsed |
Owner name: WISCONSIN ALUMNI RESEARCH FOUNDATION Effective date: 19990331 |