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BE901218A - CHLOROCEFADROXIL MONOHYDRATE. - Google Patents

CHLOROCEFADROXIL MONOHYDRATE.

Info

Publication number
BE901218A
BE901218A BE0/214120A BE214120A BE901218A BE 901218 A BE901218 A BE 901218A BE 0/214120 A BE0/214120 A BE 0/214120A BE 214120 A BE214120 A BE 214120A BE 901218 A BE901218 A BE 901218A
Authority
BE
Belgium
Prior art keywords
monohydrate
gram
alpha
dimethylformamide
acetonitrile
Prior art date
Application number
BE0/214120A
Other languages
French (fr)
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of BE901218A publication Critical patent/BE901218A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Un nouveau monohydrate cristallin de l'acide 7-(D-alpha-amino-alpha-(3-chloro-4-hydroxyphnyl)acétamido)-3-méthyl-3-céphème-4-carboxylique (I) qui est une forme stable spécialement utile pour les compositions pharmaceutiques est obtenu, notamment, par ajustement du pH d'une solution contenant le composé en question en présence d'un excès de diméthylformamide ou d'acétonitrile pour la formation du solvate diméthylformamidique ou acétonitrilique correspondant, qui est dissout dans de l'eau acidifiée et reprécipité sous forme de monohydrate. La composition pharmaceutique comprenand le dérivé (I) est destinée au traitement des mammifères atteints de maladies provoquées par des bactéries Gram-positives ou Gram-négatives.A new crystalline monohydrate of 7- (D-alpha-amino-alpha- (3-chloro-4-hydroxyphnyl) acetamido) -3-methyl-3-cephem-4-carboxylic acid (I) which is a stable form especially useful for pharmaceutical compositions is obtained, in particular, by adjusting the pH of a solution containing the compound in question in the presence of an excess of dimethylformamide or acetonitrile for the formation of the corresponding dimethylformamide or acetonitrile solvate, which is dissolved in acidified water and reprecipitated as monohydrate. The pharmaceutical composition comprising the derivative (I) is intended for the treatment of mammals suffering from diseases caused by Gram-positive or Gram-negative bacteria.

BE0/214120A 1983-12-06 1984-12-05 CHLOROCEFADROXIL MONOHYDRATE. BE901218A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8319463A FR2555989B1 (en) 1983-12-06 1983-12-06 CHLOROCEPHADROXYL MONOHYDRATE

Publications (1)

Publication Number Publication Date
BE901218A true BE901218A (en) 1985-06-05

Family

ID=9294877

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/214120A BE901218A (en) 1983-12-06 1984-12-05 CHLOROCEFADROXIL MONOHYDRATE.

Country Status (25)

Country Link
JP (1) JPH0794461B2 (en)
KR (1) KR920001769B1 (en)
AT (1) AT386411B (en)
AU (1) AU567780B2 (en)
BE (1) BE901218A (en)
CA (1) CA1246545A (en)
CH (1) CH662569A5 (en)
CY (1) CY1559A (en)
DE (1) DE3444367A1 (en)
DK (1) DK579984A (en)
ES (1) ES8605279A1 (en)
FI (1) FI81104C (en)
FR (1) FR2555989B1 (en)
GB (1) GB2150931B (en)
GR (1) GR81159B (en)
HK (1) HK72590A (en)
IE (1) IE57832B1 (en)
IT (1) IT1177370B (en)
LU (1) LU85670A1 (en)
MY (1) MY102192A (en)
NL (1) NL8403670A (en)
SE (1) SE8406171L (en)
SG (1) SG48890G (en)
YU (1) YU45221B (en)
ZA (1) ZA849415B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2505697A1 (en) * 1981-05-12 1982-11-19 Humblot Bernard IMPROVED ELECTRIC WELDING UNIT

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US516047A (en) * 1894-03-06 Wire bed-bottom
CY773A (en) * 1967-09-05 1975-03-01 Bristol Myers Co Antibacterial agents and a process for the preparation thereof
US3781282A (en) * 1971-01-20 1973-12-25 W Garbrecht Cephalosporin process and product
US3985741A (en) * 1972-09-15 1976-10-12 Bristol-Myers Company Production of p-hydroxycephalexin
YU39709B (en) * 1972-09-15 1985-04-30 Bristol Myers Co Process for producing cephalosporin
DE2317179C2 (en) * 1973-04-05 1982-11-25 Bristol-Myers Co., 10154 New York, N.Y. Process for the preparation of the relatively water-insoluble crystalline form of cefalexin monohydrate
GB1532682A (en) * 1976-04-27 1978-11-22 Bristol Myers Co Process for the preparation of cephadroxil
JPS5356311A (en) * 1976-10-28 1978-05-22 Toyama Chem Co Ltd Cefalexin monohydrate having novel crystal form and process for preparationof the same
US4160863A (en) * 1977-04-07 1979-07-10 Bristol-Myers Company Process for the preparation of the crystalline monohydrate of 7-[D-α-aα-(p-hydroxyphenyl)acetamido]-3-methyl-3-cephem-4-carboxylic acid
US4600773A (en) * 1983-12-01 1986-07-15 Eli Lilly And Company Crystalline cephalexin hydrochloride monohydrate

Also Published As

Publication number Publication date
JPS60139695A (en) 1985-07-24
IE57832B1 (en) 1993-04-21
SE8406171L (en) 1985-06-07
GB2150931B (en) 1987-07-29
AU567780B2 (en) 1987-12-03
CA1246545A (en) 1988-12-13
GB8430753D0 (en) 1985-01-16
FI81104B (en) 1990-05-31
YU45221B (en) 1992-05-28
IT1177370B (en) 1987-08-26
CH662569A5 (en) 1987-10-15
FR2555989A1 (en) 1985-06-07
ATA386384A (en) 1988-01-15
LU85670A1 (en) 1985-09-12
DK579984A (en) 1985-06-07
NL8403670A (en) 1985-07-01
AU3632184A (en) 1985-06-13
ZA849415B (en) 1985-07-31
FR2555989B1 (en) 1987-02-20
KR850004494A (en) 1985-07-15
GB2150931A (en) 1985-07-10
DE3444367C2 (en) 1993-04-29
HK72590A (en) 1990-09-21
FI81104C (en) 1990-09-10
SE8406171D0 (en) 1984-12-05
SG48890G (en) 1990-08-17
YU207384A (en) 1987-12-31
CY1559A (en) 1991-03-22
DE3444367A1 (en) 1985-06-20
ES538235A0 (en) 1986-03-16
MY102192A (en) 1992-04-30
ES8605279A1 (en) 1986-03-16
KR920001769B1 (en) 1992-03-02
JPH0794461B2 (en) 1995-10-11
AT386411B (en) 1988-08-25
GR81159B (en) 1985-04-08
IE843117L (en) 1985-06-06
FI844756A0 (en) 1984-12-03
IT8423909A0 (en) 1984-12-05
IT8423909A1 (en) 1986-06-05
DK579984D0 (en) 1984-12-05
FI844756L (en) 1985-06-07

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: BRISTOL-MYERS CY

Effective date: 19951231