[go: up one dir, main page]

BE900241A - PROCESS FOR THE PREPARATION OF A-ACETOXYETHYL ESTER OF CEFUROXIME. - Google Patents

PROCESS FOR THE PREPARATION OF A-ACETOXYETHYL ESTER OF CEFUROXIME.

Info

Publication number
BE900241A
BE900241A BE0/213398A BE213398A BE900241A BE 900241 A BE900241 A BE 900241A BE 0/213398 A BE0/213398 A BE 0/213398A BE 213398 A BE213398 A BE 213398A BE 900241 A BE900241 A BE 900241A
Authority
BE
Belgium
Prior art keywords
cefuroxime
preparation
acetoxyethyl ester
cefuroxime axetil
solvents
Prior art date
Application number
BE0/213398A
Other languages
French (fr)
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of BE900241A publication Critical patent/BE900241A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Procédé pour l'obtention de céfuroxime axétil cristallin très pur. Le procédé consiste à faire cristalliser le céfuroxime axétil à partir d'une de ses solutions dans un solvant organique ou aqueux ou dans un mélange de ces deux types de solvants, puis à sècher et à isoler le produit. Les solvants préférés sont des acétates d'alkyle mélangés avec des éthers ou des hydrocarbures aliphatiques ou aromatiques.Process for obtaining very pure crystalline cefuroxime axetil. The process consists in crystallizing cefuroxime axetil from one of its solutions in an organic or aqueous solvent or in a mixture of these two types of solvents, then drying and isolating the product. The preferred solvents are alkyl acetates mixed with ethers or aliphatic or aromatic hydrocarbons.

BE0/213398A 1983-07-29 1984-07-27 PROCESS FOR THE PREPARATION OF A-ACETOXYETHYL ESTER OF CEFUROXIME. BE900241A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB838320521A GB8320521D0 (en) 1983-07-29 1983-07-29 Chemical process

Publications (1)

Publication Number Publication Date
BE900241A true BE900241A (en) 1985-01-28

Family

ID=10546505

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/213398A BE900241A (en) 1983-07-29 1984-07-27 PROCESS FOR THE PREPARATION OF A-ACETOXYETHYL ESTER OF CEFUROXIME.

Country Status (21)

Country Link
JP (1) JPH0613526B2 (en)
KR (1) KR910008377B1 (en)
AT (1) AT392470B (en)
AU (2) AU582121B2 (en)
BE (1) BE900241A (en)
CA (1) CA1265511A (en)
CH (1) CH662121A5 (en)
DE (1) DE3427828A1 (en)
DK (1) DK165505C (en)
ES (1) ES8601869A1 (en)
FI (1) FI76808C (en)
FR (1) FR2549837B1 (en)
GB (2) GB8320521D0 (en)
IE (1) IE57726B1 (en)
IL (1) IL72536A (en)
NL (1) NL8402372A (en)
NO (1) NO167292C (en)
NZ (1) NZ209046A (en)
PT (1) PT78985B (en)
SE (1) SE463263B (en)
ZA (1) ZA845830B (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8400024D0 (en) * 1984-01-03 1984-02-08 Glaxo Group Ltd Cephalosporin antibiotics
GB8524001D0 (en) * 1985-09-30 1985-11-06 Glaxo Group Ltd Pharmaceutical composition
US5063224A (en) * 1990-07-09 1991-11-05 Eli Lilly And Company R-cefuroxime axetil
IT1277426B1 (en) * 1995-08-03 1997-11-10 Acs Dobfar Spa BIOAVAILABLE CRYSTALLINE FORM OF CEFUROXIMA AXETIL
CN1111537C (en) * 1997-05-15 2003-06-18 第一制糖株式会社 The preparation method of highly pure crystalline form of cefuroxime axetil
KR100228264B1 (en) * 1997-08-02 1999-11-01 김선진 The synthetic method of crystalline cefuroxime axetil
CA2209868C (en) * 1997-08-15 2001-08-14 Bernard Charles Sherman Pharmaceutical compositions comprising cefuroxime axetil
IN186539B (en) * 1997-09-29 2001-09-29 Ranbaxy Lab Ltd
ES2171056T3 (en) * 1998-02-20 2002-08-16 Fako Ilaclari A S PROCEDURE FOR THE MANUFACTURE OF SOLUBLE CRYSTALLINE AXETIL CEFUROXIMA.
IN190849B (en) 2000-07-17 2003-08-23 Ranbaxy Lab Ltd
AT411996B (en) 2000-09-11 2004-08-26 Sandoz Ag METHOD FOR PRODUCING CEFUROXIME IN THE FORM OF ITS N-BUTYL LAMONIUM SALTS
ITMI20011763A1 (en) * 2001-08-10 2003-02-10 Antibioticos Spa HIGH-PURITY CEFUROXIME AXELITE PREPARATION PROCESS
ITMI20011925A1 (en) * 2001-09-14 2003-03-14 Antibioticos Spa METHOD APPLICABLE ON INDUSTRIAL SCALE FOR THE PREPARATION OF CEFUROXIME AXETILE CRISTALLINO
TWI328006B (en) * 2003-12-26 2010-08-01 Nissan Chemical Ind Ltd Crystal form of quinoline compound and process for its production
CN100448879C (en) * 2004-07-22 2009-01-07 北京化工大学 A kind of preparation method of amorphous cefuroxime axetil
DE102005019458A1 (en) 2005-04-25 2006-10-26 Grünenthal GmbH Composition, useful in the preparation of pellets and the multi-particular-presentation form, comprises cefuroximaxetil and carrageenan of the group of lambda carrageenan, tau carrageenan and kappa carrageenan
CN118561870A (en) * 2024-05-15 2024-08-30 广东立国制药有限公司 Method for preparing cefuroxime acid

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1571683A (en) * 1976-02-16 1980-07-16 Glaxo Operations Ltd Ester derivatives of cefuroxime
CA1094545A (en) * 1976-02-16 1981-01-27 Michael Gregson Cephalosporin antibiotics
GB1598568A (en) * 1977-04-19 1981-09-23 Glaxo Lab Ltd Esters of(6r,7r)-3-carbamoyloxymethyl-7-((z)-2-(fur-2-yl)-2-methoxyiminoacetamido)-ceph-3-em-4-carboxylic acid
JPS577485A (en) * 1980-06-13 1982-01-14 Takeda Chem Ind Ltd Cephalosporin
YU44680B (en) * 1982-07-30 1990-12-31 Glaxo Lab Ltd Process for obtaining very pure amorphous form of cephuroxim axetile
GB8400024D0 (en) * 1984-01-03 1984-02-08 Glaxo Group Ltd Cephalosporin antibiotics

Also Published As

Publication number Publication date
DK165505B (en) 1992-12-07
ES534695A0 (en) 1985-11-01
FI843011L (en) 1985-01-30
ES8601869A1 (en) 1985-11-01
CA1265511A (en) 1990-02-06
CH662121A5 (en) 1987-09-15
DE3427828A1 (en) 1985-02-14
NO167292B (en) 1991-07-15
ATA244484A (en) 1990-09-15
AT392470B (en) 1991-04-10
AU634965B2 (en) 1993-03-11
FR2549837A1 (en) 1985-02-01
GB2145409B (en) 1987-02-18
IL72536A0 (en) 1984-11-30
GB2145409A (en) 1985-03-27
IE57726B1 (en) 1993-03-24
GB8419202D0 (en) 1984-08-30
FI843011A0 (en) 1984-07-27
AU582121B2 (en) 1989-03-16
KR910008377B1 (en) 1991-10-12
SE8403897D0 (en) 1984-07-27
SE8403897L (en) 1985-01-30
NO167292C (en) 1991-10-23
DK366684A (en) 1985-01-30
JPH0613526B2 (en) 1994-02-23
KR850001221A (en) 1985-03-16
FI76808C (en) 1988-12-12
DK165505C (en) 1993-04-19
ZA845830B (en) 1986-03-26
FR2549837B1 (en) 1986-12-26
AU3660189A (en) 1989-10-05
PT78985B (en) 1986-10-23
NL8402372A (en) 1985-02-18
IE841938L (en) 1985-01-29
DK366684D0 (en) 1984-07-27
AU3125684A (en) 1985-01-31
IL72536A (en) 1988-01-31
JPS6075484A (en) 1985-04-27
PT78985A (en) 1984-08-01
NZ209046A (en) 1988-02-29
FI76808B (en) 1988-08-31
SE463263B (en) 1990-10-29
NO843055L (en) 1985-01-30
GB8320521D0 (en) 1983-09-01

Similar Documents

Publication Publication Date Title
BE900241A (en) PROCESS FOR THE PREPARATION OF A-ACETOXYETHYL ESTER OF CEFUROXIME.
BR8401744A (en) ETHANOL SEPARATION PROCESS FROM AN ETHANOL CONTAINING SOLUTION
FR2557124B1 (en) CONTINUOUS PROCESS FOR THE MANUFACTURE OF PHTALOCYANIN PIGMENT DISPERSIONS IN AN ORGANIC SOLVENT
KR930002311A (en) N-phenylthiourea derivatives and pharmaceutical uses thereof
BE855235A (en) CONTINUOUS PROCESS FOR THE PREPARATION OF ORGANIC ISOCYANATES
FR2538802B1 (en) PROCESS FOR PRODUCING CERAMIC MATERIAL, ORGANIC SOLVENT SYSTEM, AQUEOUS DISPERSION, AND ARTICLE OBTAINED BY THE PROCESS
PT71209B (en) PROCESS FOR THE PREPARATION OF NEW ORGANIC COMPOUNDS
EP0039126A3 (en) Water-based chlorinated aliphatic polymer compositions and the preparation and use thereof
DE2964324D1 (en) Process for the preparation of compounds containing hydantoin groups
FR2657539B1 (en) PROCESS FOR EXTRACTING THE CONSTITUENTS OF A PLANT MATERIAL USING SELECTIVE SOLVENTS.
BE860303A (en) PROCESS FOR THE PREPARATION OF ORGANIC TIN COMPOUNDS
FR2276270A1 (en) PROCESS FOR THE REMOVAL OF ORGANIC CHLORINATED COMPOUNDS FROM AQUEOUS LIQUIDS
KR840002241A (en) Process of making a laxative from senna
BE894530A (en) PROCESS FOR RETURNING THE INDIUM OF CERTAIN PHASES OF ORGANIC SOLVENT
JPS57203053A (en) Preparation of cyanoacetic acid ester
JPS5716852A (en) Nitrile derivative, its preparation, and fibrosis suppressing agent containing the same
SU1746665A1 (en) N-acyl derivatives of 4-phenylpyrrolidine-2-ones showing cerebroprotective (nootropic) action
FR2410660A1 (en) 16,17-PYRAZOLINO- AND 16,17-ISOPYRAZOLINO-1,4-PREGNADIENE DERIVATIVES FOR USE AS MEDICINES AND METHOD FOR PREPARING THEM
FR2517690B1 (en) COMPOSITION FOR RECOVERY OF ORGANIC MATERIALS
KR880701272A (en) r-1-cyano-1-R²-cis-4-R¹-cyclohexane compound
JPS52151184A (en) Preparation of benzo (c) cinnoline and its derivatives
JPS5721321A (en) Antihyperlipemic agent
JPS5581855A (en) Adduct of pantethine with metal salt
JPS57212189A (en) Novel cephalosporin compound
EP0289394A3 (en) Process for the purification of a barium salt

Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: *GLAXO GROUP LTD

Effective date: 20020731