[go: up one dir, main page]

BE2022C541I2 - - Google Patents

Download PDF

Info

Publication number
BE2022C541I2
BE2022C541I2 BE2022C541C BE2022C541C BE2022C541I2 BE 2022C541 I2 BE2022C541 I2 BE 2022C541I2 BE 2022C541 C BE2022C541 C BE 2022C541C BE 2022C541 C BE2022C541 C BE 2022C541C BE 2022C541 I2 BE2022C541 I2 BE 2022C541I2
Authority
BE
Belgium
Application number
BE2022C541C
Other languages
French (fr)
Original Assignee
Nektar Therapeutics
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32927670&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BE2022C541(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Nektar Therapeutics filed Critical Nektar Therapeutics
Publication of BE2022C541I2 publication Critical patent/BE2022C541I2/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/37—Factors VIII
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/38—Albumins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
BE2022C541C 2003-02-26 2022-09-05 BE2022C541I2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45057803P 2003-02-26 2003-02-26
PCT/US2004/006034 WO2004075923A2 (en) 2003-02-26 2004-02-26 Polymer-factor viii moiety conjugates

Publications (1)

Publication Number Publication Date
BE2022C541I2 true BE2022C541I2 (en) 2023-08-09

Family

ID=32927670

Family Applications (1)

Application Number Title Priority Date Filing Date
BE2022C541C BE2022C541I2 (en) 2003-02-26 2022-09-05

Country Status (21)

Country Link
US (13) US7199223B2 (en)
EP (4) EP2338523B1 (en)
JP (2) JP5539607B2 (en)
KR (1) KR101085375B1 (en)
CN (2) CN1767857A (en)
AU (2) AU2004215912B2 (en)
BE (1) BE2022C541I2 (en)
BR (1) BRPI0407882B1 (en)
CA (2) CA2788505C (en)
CY (1) CY1125235T1 (en)
DK (1) DK1596887T3 (en)
ES (1) ES2911435T3 (en)
FR (1) FR22C1043I2 (en)
HU (1) HUE058897T2 (en)
IL (1) IL170424A (en)
LT (1) LT1596887T (en)
MX (1) MXPA05009169A (en)
NL (1) NL301184I2 (en)
PT (1) PT1596887T (en)
SI (1) SI1596887T1 (en)
WO (1) WO2004075923A2 (en)

Families Citing this family (151)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8008252B2 (en) * 2001-10-10 2011-08-30 Novo Nordisk A/S Factor VII: remodeling and glycoconjugation of Factor VII
US7214660B2 (en) * 2001-10-10 2007-05-08 Neose Technologies, Inc. Erythropoietin: remodeling and glycoconjugation of erythropoietin
US7157277B2 (en) 2001-11-28 2007-01-02 Neose Technologies, Inc. Factor VIII remodeling and glycoconjugation of Factor VIII
US7173003B2 (en) 2001-10-10 2007-02-06 Neose Technologies, Inc. Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
EP1465933B1 (en) 2002-01-16 2007-08-29 Biocompatibles UK Limited Polymer conjugates
DE60336555D1 (en) * 2002-06-21 2011-05-12 Novo Nordisk Healthcare Ag PEGYLATED GLYCO FORMS OF FACTOR VII
GB0301014D0 (en) * 2003-01-16 2003-02-19 Biocompatibles Ltd Conjugation reactions
DK1596887T3 (en) 2003-02-26 2022-06-20 Nektar Therapeutics Polymer-Factor VIII conjugate
US20070026485A1 (en) 2003-04-09 2007-02-01 Neose Technologies, Inc. Glycopegylation methods and proteins/peptides produced by the methods
US8791070B2 (en) 2003-04-09 2014-07-29 Novo Nordisk A/S Glycopegylated factor IX
US7947261B2 (en) 2003-05-23 2011-05-24 Nektar Therapeutics Conjugates formed from polymer derivatives having particular atom arrangements
HUE043911T2 (en) * 2003-05-23 2019-09-30 Nektar Therapeutics PEG derivatives containing two PEG chains
WO2005012484A2 (en) 2003-07-25 2005-02-10 Neose Technologies, Inc. Antibody-toxin conjugates
US7786213B2 (en) * 2003-10-15 2010-08-31 The Regents Of The University Of California Biomacromolecule polymer conjugates
US20080305992A1 (en) 2003-11-24 2008-12-11 Neose Technologies, Inc. Glycopegylated erythropoietin
US20060040856A1 (en) 2003-12-03 2006-02-23 Neose Technologies, Inc. Glycopegylated factor IX
US6887952B1 (en) * 2004-02-12 2005-05-03 Biosite, Inc. N-aryl-carbamic acid ester-derived and valeric acid ester-derived cross-linkers and conjugates, and methods for their synthesis and use
AU2005222641B2 (en) * 2004-03-15 2011-04-07 Nektar Therapeutics Polymer-based compositions and conjugates of HIV entry inhibitors
WO2005115477A2 (en) 2004-04-13 2005-12-08 Quintessence Biosciences, Inc. Non-natural ribonuclease conjugates as cytotoxic agents
WO2006010143A2 (en) 2004-07-13 2006-01-26 Neose Technologies, Inc. Branched peg remodeling and glycosylation of glucagon-like peptide-1 [glp-1]
ES2566670T3 (en) 2004-10-29 2016-04-14 Ratiopharm Gmbh Remodeling and glucopegilation of fibroblast growth factor (FGF)
AU2013203348B2 (en) * 2004-11-12 2016-03-03 Bayer Healthcare Llc Site-directed modification of FVIII
AU2012203813B2 (en) * 2004-11-12 2013-10-24 Bayer Healthcare Llc Site-directed modification of FVIII
HRP20070268B1 (en) 2004-11-12 2018-04-20 Bayer Healthcare Llc Site-directed modification of fviii
AU2016203693B2 (en) * 2004-11-12 2018-08-23 Bayer Healthcare Llc Site-directed modification of FVIII
BRPI0519562A2 (en) * 2004-12-27 2009-01-27 Baxter Int proteinaceous construct, complex, method for prolonging the in vivo half-life of factor viii (fviii) or a biologically active derivative of the same pharmaceutical composition, and method for forming a proteinaceous construct
JP4951527B2 (en) 2005-01-10 2012-06-13 バイオジェネリックス アーゲー GlycoPEGylated granulocyte colony stimulating factor
US7714114B2 (en) 2005-02-16 2010-05-11 Nektar Therapeutics Conjugates of an EPO moiety and a polymer
EP1861125A2 (en) * 2005-03-23 2007-12-05 Nektar Therapeutics Al, Corporation Conjugates of an hgh moiety and peg derivatives
US20080227691A1 (en) * 2005-04-01 2008-09-18 Novo Nordisk Health Care Ag Blood Coagulation FVIII Analogues
US20070154992A1 (en) * 2005-04-08 2007-07-05 Neose Technologies, Inc. Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants
WO2006110776A2 (en) 2005-04-12 2006-10-19 Nektar Therapeutics Al, Corporation Polyethylene glycol cojugates of antimicrobial agents
EP2975135A1 (en) 2005-05-25 2016-01-20 Novo Nordisk A/S Glycopegylated factor IX
EP1893632B1 (en) * 2005-06-17 2015-08-12 Novo Nordisk Health Care AG Selective reduction and derivatization of engineered factor vii proteins comprising at least one non-native cysteine
WO2007019331A2 (en) * 2005-08-04 2007-02-15 Nektar Therapeutics Al, Corporation Conjugates of a g-csf moiety and a polymer
US20070105755A1 (en) 2005-10-26 2007-05-10 Neose Technologies, Inc. One pot desialylation and glycopegylation of therapeutic peptides
US20090048440A1 (en) 2005-11-03 2009-02-19 Neose Technologies, Inc. Nucleotide Sugar Purification Using Membranes
WO2007078820A2 (en) * 2005-12-19 2007-07-12 Sun Bio, Inc. Methylmaleimidyl polymer derivatives
US7795221B2 (en) * 2006-03-30 2010-09-14 Palatin Technologies, Inc. Linear natriuretic peptide constructs
US8580746B2 (en) * 2006-03-30 2013-11-12 Palatin Technologies, Inc. Amide linkage cyclic natriuretic peptide constructs
AU2007233116B2 (en) 2006-03-30 2013-05-09 Palatin Technologies, Inc. Cyclic natriuretic peptide constructs
US7982010B2 (en) 2006-03-31 2011-07-19 Baxter International Inc. Factor VIII polymer conjugates
US7985839B2 (en) 2006-03-31 2011-07-26 Baxter International Inc. Factor VIII polymer conjugates
NZ572050A (en) 2006-03-31 2011-09-30 Baxter Int Factor VIII conjugated to polyethylene glycol
US7645860B2 (en) 2006-03-31 2010-01-12 Baxter Healthcare S.A. Factor VIII polymer conjugates
RU2008145084A (en) * 2006-05-24 2010-06-27 Ново Нордиск Хелс Кеа Аг (Ch) ANALOGUES OF FACTOR IX HAVING A LONG-TERM HALF-TIME IN VIVO
WO2007149594A2 (en) 2006-06-23 2007-12-27 Quintessence Biosciences, Inc. Modified ribonucleases
US8298801B2 (en) * 2006-07-17 2012-10-30 Quintessence Biosciences, Inc. Methods and compositions for the treatment of cancer
US20080248959A1 (en) 2006-07-21 2008-10-09 Neose Technologies, Inc. Glycosylation of peptides via o-linked glycosylation sequences
EP2054521A4 (en) 2006-10-03 2012-12-19 Novo Nordisk As METHODS OF PURIFYING CONJUGATES OF POLYPEPTIDES
AU2007333049B2 (en) * 2006-12-15 2014-02-20 Takeda Pharmaceutical Company Limited Factor VIIa-(poly)sialic acid conjugate having prolonged in vivo half-life
WO2008082669A2 (en) * 2006-12-27 2008-07-10 Nektar Therapeutics Al, Corporation Von willebrand factor- and factor viii-polymer conjugates having a releasable linkage
US8507653B2 (en) * 2006-12-27 2013-08-13 Nektar Therapeutics Factor IX moiety-polymer conjugates having a releasable linkage
PL2144923T3 (en) 2007-04-03 2013-12-31 Biogenerix Ag Methods of treatment using glycopegylated g-csf
EP2170919B8 (en) 2007-06-12 2016-01-20 ratiopharm GmbH Improved process for the production of nucleotide sugars
WO2009045539A2 (en) * 2007-10-05 2009-04-09 Nektar Therapeutics Al, Corporation Oligomer-corticosteroid conjugates
CA2702043A1 (en) 2007-10-08 2009-04-16 Quintessence Biosciences, Inc. Compositions and methods for ribonuclease-based therapies
GB2467700A (en) * 2007-11-09 2010-08-11 Baxter Int Modified recombinant Factor VIII and von Willebrand Factor and methods of use
ES2515365T3 (en) 2007-12-27 2014-10-29 Baxter International Inc. Method and compositions for specifically detecting physiologically acceptable polymer molecules
EP2626079A3 (en) 2008-02-27 2014-03-05 Novo Nordisk A/S Conjungated factor VIII molecules
TWI395593B (en) 2008-03-06 2013-05-11 Halozyme Inc In vivo temporal control of activatable matrix-degrading enzymes
WO2009128917A2 (en) 2008-04-14 2009-10-22 Halozyme, Inc. Modified hyaluronidases and uses in treating hyaluronan-associated diseases and conditions
TWI394580B (en) 2008-04-28 2013-05-01 Halozyme Inc Super fast-acting insulin compositions
CA2726942A1 (en) 2008-06-04 2009-12-10 Bayer Healthcare Llc Fviii muteins for treatment of von willebrand disease
KR101648734B1 (en) 2008-06-24 2016-08-18 체에스엘 베링 게엠베하 Factor VIII, von Willebrand factor or complexes thereof with prolonged in vivo half-life
WO2010014258A2 (en) * 2008-08-01 2010-02-04 Nektar Therapeutics Al, Corporation Conjugates having a releasable linkage
AU2009282747B2 (en) * 2008-08-22 2015-04-02 Takeda Pharmaceutical Company Limited Polymeric benzyl carbonate-derivatives
WO2010039985A1 (en) 2008-10-01 2010-04-08 Quintessence Biosciences, Inc. Therapeutic Ribonucleases
PL2349341T3 (en) 2008-10-15 2014-03-31 Baxalta Inc Pegylation of recombinant blood coagulation factors in the presence of bound antibodies
KR20110071012A (en) * 2008-10-17 2011-06-27 백스터 인터내셔널 인코포레이티드 Modified blood factors that include low levels of water soluble polymers
JP5281358B2 (en) * 2008-10-27 2013-09-04 学校法人常翔学園 Polymer, transepithelial absorption promoter, and pharmaceutical preparation
WO2010062768A1 (en) * 2008-11-03 2010-06-03 Bayer Healthcare Llc Method for the treatment of hemophilia
CN103205407B (en) 2008-12-09 2016-03-16 哈洛齐梅公司 Soluble PH 20 polypeptides extended and uses thereof
EP2387413A4 (en) * 2009-01-19 2015-12-23 Bayer Healthcare Llc Protein conjugate having an endopeptidase-cleavable bioprotective moiety
US8716448B2 (en) 2009-02-03 2014-05-06 Amunix Operating Inc. Coagulation factor VII compositions and methods of making and using same
EA020843B1 (en) 2009-02-03 2015-02-27 Амуникс Оперейтинг Инк. Extended recombinant polypeptides and compositions comprising same
WO2010102886A1 (en) * 2009-02-19 2010-09-16 Novo Nordisk A/S Modification of factor viii
WO2010140148A1 (en) 2009-06-01 2010-12-09 Yeda Research And Development Co . Ltd Prodrugs containing albumin binding probe
KR101832937B1 (en) 2009-07-27 2018-02-28 박스알타 인코퍼레이티드 Blood coagulation protein conjugates
HUE028056T2 (en) 2009-07-27 2016-11-28 Baxalta GmbH Blood coagulation protein conjugates
US9795683B2 (en) 2009-07-27 2017-10-24 Lipoxen Technologies Limited Glycopolysialylation of non-blood coagulation proteins
US8642737B2 (en) 2010-07-26 2014-02-04 Baxter International Inc. Nucleophilic catalysts for oxime linkage
US8809501B2 (en) 2009-07-27 2014-08-19 Baxter International Inc. Nucleophilic catalysts for oxime linkage
PL2477603T3 (en) 2009-09-17 2016-10-31 Stable co-formulation of hyaluronidase and immunoglobulin, and methods of use thereof
ES2545893T3 (en) * 2010-04-20 2015-09-16 Octapharma Ag New stabilizing agent for pharmaceutical proteins
GB201007357D0 (en) * 2010-04-30 2010-06-16 Leverton Licence Holdings Ltd Conjugated factor VIII
GB201007356D0 (en) 2010-04-30 2010-06-16 Leverton Licence Holdings Ltd Conjugated factor VIIa
WO2012006623A1 (en) 2010-07-09 2012-01-12 Biogen Idec Hemophilia Inc. Systems for factor viii processing and methods thereof
MX348420B (en) 2010-07-20 2017-06-12 Halozyme Inc Treatment of the adverse side-effects associated with administration of an anti-hyaluronan agent.
TWI557135B (en) 2010-11-03 2016-11-11 介控生化科技公司 Modified ninth factor multi-peptide and use thereof
HUE049352T2 (en) 2010-12-22 2020-09-28 Baxalta GmbH Materials and methods for conjugating a water soluble fatty acid derivative to a protein
JP2014510045A (en) 2011-02-08 2014-04-24 ハロザイム インコーポレイテッド Hyaluronan degrading enzyme composition and lipid preparation and its use for the treatment of benign prostatic hypertrophy
EP2696897A2 (en) 2011-04-11 2014-02-19 Yeda Research and Development Co. Ltd. Albumin binding probes and drug conjugates thereof
WO2012140650A2 (en) * 2011-04-12 2012-10-18 Hepacore Ltd. Conjugates of carboxy polysaccharides with fibroblast growth factors and variants thereof
US9993529B2 (en) 2011-06-17 2018-06-12 Halozyme, Inc. Stable formulations of a hyaluronan-degrading enzyme
EA201400030A1 (en) 2011-06-17 2014-07-30 Галозим, Инк. METHOD OF CONTINUOUS SUBDITIONAL INSULIN INJECTION WITH USE OF ENZYME DESTRUCTING HYALURONANE
WO2012174478A2 (en) 2011-06-17 2012-12-20 Halozyme, Inc. Stable formulations of a hyaluronan-degrading enzyme
US20130071394A1 (en) 2011-09-16 2013-03-21 John K. Troyer Compositions and combinations of organophosphorus bioscavengers and hyaluronan-degrading enzymes, and methods of use
SG11201401797TA (en) 2011-10-24 2014-09-26 Halozyme Inc Companion diagnostic for anti-hyaluronan agent therapy and methods of use thereof
IL317266A (en) 2011-12-30 2025-01-01 Halozyme Inc Ph20 polypeptide variants, formulations and uses thereof
US11370827B2 (en) 2012-01-12 2022-06-28 Bioverativ Therapeutics Inc. Chimeric factor VIII polypeptides and uses thereof
DK2814502T3 (en) 2012-02-15 2017-12-18 Csl Behring Gmbh Von Willebrand Factor variants with improved Factor VIII binding affinity
PT3564260T (en) 2012-02-15 2023-01-18 Bioverativ Therapeutics Inc Factor viii compositions and methods of making and using same
EP2822577B1 (en) 2012-02-15 2019-02-06 Bioverativ Therapeutics Inc. Recombinant factor viii proteins
US9913822B2 (en) 2012-04-04 2018-03-13 Halozyme, Inc. Combination therapy with an anti-hyaluronan agent and therapeutic agent
BR112014025737A2 (en) * 2012-04-16 2017-07-04 Cantab Biopharmaceuticals Patents Ltd method for administering a therapeutic agent, method for preventing entry of a therapeutic agent, method for modulating the rate of release of a therapeutic agent, therapeutic agent, dosage forms, method of treating a disease and parts kit
AU2013270682A1 (en) 2012-06-08 2014-12-11 Biogen Ma Inc. Procoagulant compounds
CA2875247A1 (en) 2012-06-08 2013-12-12 Biogen Idec Ma Inc. Chimeric clotting factors
WO2014008375A1 (en) * 2012-07-05 2014-01-09 Mersana Therapeutics, Inc. Terminally modified polymers and conjugates thereof
CN110054699A (en) 2012-07-11 2019-07-26 比奥贝拉蒂治疗公司 Factor IX compound with XTEN and vWF ELISA albumen, and application thereof
EP2882457A1 (en) * 2012-08-13 2015-06-17 Novo Nordisk A/S Liquid factor viii formulations
US9278124B2 (en) 2012-10-16 2016-03-08 Halozyme, Inc. Hypoxia and hyaluronan and markers thereof for diagnosis and monitoring of diseases and conditions and related methods
US10391152B2 (en) 2012-10-18 2019-08-27 Bioverativ Therapeutics Inc. Methods of using a fixed dose of a clotting factor
US10660940B2 (en) 2013-03-05 2020-05-26 Hanmi Pharm. Co., Ltd Preparation method for high-yield production of physiologically active polypeptide conjugate
EP2970431A4 (en) * 2013-03-13 2016-08-24 Univ Emory TARGETED ELIMINATION OF FUME VIII IMMUNE CELLS
US10588949B2 (en) 2013-03-15 2020-03-17 Bioverativ Therapeutics Inc. Factor IX polypeptide formulations
US20200157159A1 (en) 2013-04-16 2020-05-21 The Board Of Regents Of The University Of Oklahoma Peptide compounds and compositions thereof
EP2796145B1 (en) 2013-04-22 2017-11-01 CSL Ltd. A covalent complex of von willebrand factor and faktor viii linked by a disulphide bridge
CN105392495A (en) 2013-06-28 2016-03-09 比奥根Ma公司 Thrombin cleavable linkers with XTEN and uses thereof
TW201534726A (en) 2013-07-03 2015-09-16 Halozyme Inc Thermally stable PH20 hyaluronidase variants and uses thereof
EP4108254A1 (en) 2013-08-14 2022-12-28 Bioverativ Therapeutics Inc. Recombinant factor viii proteins
TW202003554A (en) 2013-08-14 2020-01-16 美商百歐維拉提夫治療公司 Factor VIII-XTEN fusions and uses thereof
DK3091997T5 (en) 2014-01-10 2024-10-14 Bioverativ Therapeutics Inc CHIMERIC FACTOR VIII PROTEINS AND USES THEREOF
WO2015132724A1 (en) 2014-03-05 2015-09-11 Pfizer Inc. Improved muteins of clotting factor viii
AU2015283822B2 (en) 2014-07-02 2019-10-03 CSL Behring Lengnau AG Modified von willebrand factor
PL3186281T3 (en) 2014-08-28 2019-10-31 Halozyme Inc Combination therapy with a hyaluronan-degrading enzyme and an immune checkpoint inhibitor
EA201700181A1 (en) 2014-10-14 2017-09-29 Галозим, Инк. COMPOSITIONS OF ADENOSINDEMINASE-2 (ADA-2), THEIR OPTIONS AND METHODS OF USE
MA40835A (en) 2014-10-23 2017-08-29 Biogen Ma Inc ANTI-GPIIB / IIIA ANTIBODIES AND THEIR USES
MA40861A (en) 2014-10-31 2017-09-05 Biogen Ma Inc ANTI-GLYCOPROTEIN IIB / IIIA ANTIBODIES
CN107406493B (en) 2015-03-06 2021-08-13 康诺贝林伦瑙有限公司 Modified von Willebrand factor with improved half-life
SG10201910896UA (en) 2015-05-22 2020-01-30 CSL Behring Lengnau AG Truncated von willebrand factor polypeptides for treating hemophilia
SG11201708754XA (en) 2015-05-22 2017-12-28 Csl Behring Recombinant Facility Ag Methods for preparing modified von willebrand factor
BR112018002150A2 (en) 2015-08-03 2018-09-18 Bioverativ Therapeutics Inc factor ix fusion proteins and methods of manufacturing and using them
CA3010720A1 (en) 2016-01-07 2017-07-13 Csl Behring Recombinant Facility Ag Mutated truncated von willebrand factor
KR20180098404A (en) 2016-01-07 2018-09-03 체에스엘 베링 리컴비넌트 퍼실리티 아게 Mutated von Willebrand factor
EP3476860A4 (en) * 2016-06-24 2020-01-22 Mogam Institute for Biomedical Research SINGLE RECOMBINANT CHAIN FVIII AND ITS CHEMICAL CONJUGATE
US11628205B2 (en) 2016-07-22 2023-04-18 Nektar Therapeutics Conjugates of a factor VIII moiety having an oxime-containing linkage
JP7252890B2 (en) 2016-11-11 2023-04-05 ツェー・エス・エル・ベーリング・レングナウ・アクチエンゲゼルシャフト Truncated von Willebrand factor polypeptides for treating hemophilia
US11890327B2 (en) 2016-11-11 2024-02-06 CSL Behring Lengnau AG Truncated von Willebrand factor polypeptides for extravascular administration in the treatment or prophylaxis of a blood coagulation disorder
US12257288B2 (en) 2016-12-02 2025-03-25 Bioverativ Therapeutics Inc. Methods of inducing immune tolerance to clotting factors
IL308416B2 (en) 2016-12-02 2025-08-01 Bioverativ Therapeutics Inc Methods for treating hemophilic arthritis using chimeric blood clotting factors
SG10202110500TA (en) 2017-06-22 2021-11-29 Catalyst Biosciences Inc Modified membrane type serine protease 1 (mtsp-1) polypeptides and methods of use
US11491212B1 (en) 2017-09-27 2022-11-08 Catalyst Biosciences, Inc. Subcutaneous administration of modified factor IX polypeptides and treatment of hemophilia B
WO2019222435A1 (en) 2018-05-16 2019-11-21 Halozyme, Inc. Methods of selecting subjects for combination cancer therapy with a polymer-conjugated soluble ph20
BR112020022164A2 (en) 2018-05-18 2021-02-02 Bioverativ Therapeutics Inc. methods of treating hemophilia a
US20210261814A1 (en) * 2018-07-20 2021-08-26 Hercules Llc Water soluble or dispersible composition
US11613744B2 (en) 2018-12-28 2023-03-28 Vertex Pharmaceuticals Incorporated Modified urokinase-type plasminogen activator polypeptides and methods of use
MX2021007843A (en) 2018-12-28 2021-08-11 Vertex Pharma Modified urokinase-type plasminogen activator polypeptides and methods of use.
WO2021154414A2 (en) 2020-01-29 2021-08-05 Catalyst Biosciences, Inc. Gene therapy for hemophilia b with a chimeric aav capsid vector encoding modified factor ix polypeptides
US12232007B2 (en) * 2021-06-03 2025-02-18 Apple Inc. Systems and methods for emergency service access by reduced capability radio frequency devices
WO2025227129A2 (en) 2024-04-25 2025-10-30 Starrock Pharma Llc Delivery vehicles comprising proglucagon derived polypeptides and anabolic polypeptides and uses thereof

Family Cites Families (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
JPS59172425A (en) 1983-03-18 1984-09-29 Nippon Chemiphar Co Ltd Novel blood coagulation factor derivative, its preparation and blood coagulation promoting agent containing the same
WO1984003628A1 (en) 1983-05-09 1984-09-27 Nordisk Insulinlab A concentrate of the antihemophilic factor viii and a process for producing it
US4757006A (en) 1983-10-28 1988-07-12 Genetics Institute, Inc. Human factor VIII:C gene and recombinant methods for production
US4965199A (en) 1984-04-20 1990-10-23 Genentech, Inc. Preparation of functional human factor VIII in mammalian cells using methotrexate based selection
DK525384D0 (en) 1984-11-05 1984-11-05 Nordisk Insulinlab FACTOR PREPARATION VIII FOR THE TREATMENT OF HAEMOFILI A INHIBITOR PATIENTS AND PROCEDURE FOR THE PREPARATION OF SUCH A PREPARATION
US4970300A (en) 1985-02-01 1990-11-13 New York University Modified factor VIII
MX9203440A (en) 1985-04-12 1992-07-01 Genetics Inst NOVEL PROCOAGULANT PROTEINS.
AT387234B (en) 1987-03-05 1988-12-27 Vogelbusch Gmbh DEVICE FOR BREEDING PERMANENT SHAPES, IN PARTICULAR FILAMENTOUS MICROORGANISMS
US4994439A (en) * 1989-01-19 1991-02-19 California Biotechnology Inc. Transmembrane formulations for drug administration
SE465222C5 (en) * 1989-12-15 1998-02-10 Pharmacia & Upjohn Ab A recombinant human factor VIII derivative and process for its preparation
US5397771A (en) 1990-05-10 1995-03-14 Bechgaard International Research And Development A/S Pharmaceutical preparation
IT1248723B (en) 1990-06-12 1995-01-26 Scalvo S P A PROCESS FOR THE PURIFICATION OF FACTOR VIII AND FACTOR VIII OBTAINED WITH SUCH PROCESS
US5766897A (en) 1990-06-21 1998-06-16 Incyte Pharmaceuticals, Inc. Cysteine-pegylated proteins
AU1676992A (en) * 1991-03-18 1992-10-21 Enzon, Inc. Hydrazine containing conjugates of polypeptides and glycopolypeptides with polymers
DE4111393A1 (en) 1991-04-09 1992-10-15 Behringwerke Ag STABILIZED FACTOR VIII PREPARATIONS
US6376463B1 (en) 1992-04-07 2002-04-23 Emory University Modified factor VIII
US6037452A (en) 1992-04-10 2000-03-14 Alpha Therapeutic Corporation Poly(alkylene oxide)-Factor VIII or Factor IX conjugate
AU5006993A (en) * 1992-08-21 1994-03-15 Enzon, Inc. Novel attachment of polyalkylene oxides to bio-effecting substances
US5298643A (en) 1992-12-22 1994-03-29 Enzon, Inc. Aryl imidate activated polyalkylene oxides
WO1994015625A1 (en) 1993-01-15 1994-07-21 Enzon, Inc. Factor viii - polymeric conjugates
US5321095A (en) 1993-02-02 1994-06-14 Enzon, Inc. Azlactone activated polyalkylene oxides
US5621039A (en) 1993-06-08 1997-04-15 Hallahan; Terrence W. Factor IX- polymeric conjugates
SE504074C2 (en) 1993-07-05 1996-11-04 Pharmacia Ab Protein preparation for subcutaneous, intramuscular or intradermal administration
US5446090A (en) 1993-11-12 1995-08-29 Shearwater Polymers, Inc. Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules
US5612039A (en) * 1994-03-14 1997-03-18 Nini E. Policappelli Dietary supplement
EP0788375A2 (en) * 1994-11-09 1997-08-13 Robin Ewart Offord Functionalized polymers for site-specific attachment
US5569596A (en) * 1995-01-04 1996-10-29 The Board Of Regents Of The University Of Oklahoma Method for bacterial reduction of chromium (VI)
US5932462A (en) 1995-01-10 1999-08-03 Shearwater Polymers, Inc. Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
SE9503380D0 (en) 1995-09-29 1995-09-29 Pharmacia Ab Protein derivatives
US6158888A (en) 1996-09-05 2000-12-12 University Of Florida Materials and methods for improved radiography
US5804420A (en) 1997-04-18 1998-09-08 Bayer Corporation Preparation of recombinant Factor VIII in a protein free medium
AU7485398A (en) 1997-05-14 1998-12-08 Emory University Antigen-mpeg conjugates suppress humoral and cell mediated immune responses
DE69811200T2 (en) 1997-07-22 2003-10-09 Nippon Steel Corp., Tokio/Tokyo TEMPERED STEEL WITH EXCELLENT PREVENTION OF SECONDARY RECRISTALIZATION DURING CARBONING, METHOD FOR THE PRODUCTION THEREOF, SEMI-PRODUCT FOR PARTS TO BE CARBONED
US5985263A (en) 1997-12-19 1999-11-16 Enzon, Inc. Substantially pure histidine-linked protein polymer conjugates
US6358703B1 (en) 1998-12-10 2002-03-19 Bayer Corporation Expression system for factor VIII
EP1144613B2 (en) 1999-01-14 2020-05-06 Bolder Biotechnology, Inc. Methods for making proteins containing free cysteine residues
US6309633B1 (en) 1999-06-19 2001-10-30 Nobex Corporation Amphiphilic drug-oligomer conjugates with hydroyzable lipophile components and methods for making and using the same
WO2001062827A2 (en) 2000-02-22 2001-08-30 Shearwater Corporation N-maleimidyl polymer derivatives
AU2001274853B2 (en) 2000-05-16 2007-03-22 Bolder Biotechnology, Inc. Methods for refolding proteins containing free cysteine residues
KR100396983B1 (en) 2000-07-29 2003-09-02 이강춘 Highly reactive branched polymer and proteins or peptides conjugated with the polymer
TW593427B (en) * 2000-12-18 2004-06-21 Nektar Therapeutics Al Corp Synthesis of high molecular weight non-peptidic polymer derivatives
BR0209896A (en) * 2001-05-21 2004-08-17 Nektar Therapeutics Insulin composition for pulmonary administration, and methods for supplying insulin to a mammalian subject, to provide a non-immunogenic insulin composition and a long-acting insulin composition for administration to an individual's lung.
US6546159B1 (en) 2001-08-22 2003-04-08 Avanex Corporation Method and apparatus for compensating differential group delay
US20030161791A1 (en) * 2001-10-30 2003-08-28 Bentley Michael David Water-soluble polymer conjugates of retinoic acid
AP2005003249A0 (en) 2002-09-09 2005-03-31 Nektar Therapeutics Al Corp Water-soluble polymer alkanals.
CA2497980C (en) 2002-09-09 2011-06-21 Nektar Therapeutics Al, Corporation Method for preparing water-soluble polymer derivatives bearing a terminal carboxylic acid
CA2509248A1 (en) 2002-12-31 2004-07-22 Nektar Therapeutics Al, Corporation Polymeric reagents comprising a ketone or a related functional group
EP1578843B1 (en) * 2002-12-31 2008-07-09 Nektar Therapeutics Al, Corporation Methods for the formation of hydrogels using thiosulfonate compositions and uses thereof
KR101177340B1 (en) * 2003-01-06 2012-08-30 넥타르 테라퓨틱스 Thiol-selective water-soluble polymer derivatives
DK1596887T3 (en) * 2003-02-26 2022-06-20 Nektar Therapeutics Polymer-Factor VIII conjugate
JP2006521372A (en) 2003-03-28 2006-09-21 バイオポリメド インコーポレーテッド 1: 1 conjugate of biologically active substance and biocompatible polymer, method for producing the same, and pharmaceutical composition containing the same
US20070026485A1 (en) 2003-04-09 2007-02-01 Neose Technologies, Inc. Glycopegylation methods and proteins/peptides produced by the methods
EP1613261A4 (en) 2003-04-09 2011-01-26 Novo Nordisk As INTRACELLULAR FORMATION OF PEPTIDE CONJUGATES
HUE043911T2 (en) 2003-05-23 2019-09-30 Nektar Therapeutics PEG derivatives containing two PEG chains
KR102612902B1 (en) 2016-04-22 2023-12-18 삼성디스플레이 주식회사 Transparent conductive film and electronic device including the same

Also Published As

Publication number Publication date
CY1125235T1 (en) 2024-09-20
BRPI0407882A (en) 2006-03-01
ES2911435T3 (en) 2022-05-19
JP2006519238A (en) 2006-08-24
US11141465B2 (en) 2021-10-12
CA2517369A1 (en) 2004-09-10
US20120244597A1 (en) 2012-09-27
US20150038422A1 (en) 2015-02-05
AU2004215912B2 (en) 2009-03-26
CN102139114A (en) 2011-08-03
AU2009201308B2 (en) 2011-06-02
US8247536B2 (en) 2012-08-21
US9999657B2 (en) 2018-06-19
FR22C1043I1 (en) 2022-09-30
PT1596887T (en) 2022-04-14
LT1596887T (en) 2022-04-25
IL170424A (en) 2010-02-17
MXPA05009169A (en) 2005-11-17
EP2338523A1 (en) 2011-06-29
EP1596887B1 (en) 2022-03-23
CA2788505C (en) 2018-09-04
CN1767857A (en) 2006-05-03
AU2009201308A1 (en) 2009-04-23
NL301184I2 (en) 2022-07-21
US7199223B2 (en) 2007-04-03
US7858749B2 (en) 2010-12-28
EP1596887A2 (en) 2005-11-23
EP2572732A1 (en) 2013-03-27
US20160175402A1 (en) 2016-06-23
WO2004075923A3 (en) 2005-02-24
US20090041714A1 (en) 2009-02-12
US7863421B2 (en) 2011-01-04
US20180250367A1 (en) 2018-09-06
US8519102B2 (en) 2013-08-27
US20100125049A1 (en) 2010-05-20
SI1596887T1 (en) 2022-05-31
JP2012025747A (en) 2012-02-09
US20120245289A1 (en) 2012-09-27
BRPI0407882B1 (en) 2021-07-27
US20210401948A1 (en) 2021-12-30
CA2788505A1 (en) 2004-09-10
CA2517369C (en) 2013-06-04
US8143378B2 (en) 2012-03-27
KR20050105497A (en) 2005-11-04
US8889831B2 (en) 2014-11-18
US20040235734A1 (en) 2004-11-25
EP2338523B1 (en) 2024-01-17
KR101085375B1 (en) 2011-11-21
US20100120689A1 (en) 2010-05-13
WO2004075923A2 (en) 2004-09-10
US20100130427A1 (en) 2010-05-27
FR22C1043I2 (en) 2023-12-15
US20120178692A1 (en) 2012-07-12
AU2004215912A1 (en) 2004-09-10
JP5539607B2 (en) 2014-07-02
EP2572733A1 (en) 2013-03-27
US8618259B2 (en) 2013-12-31
DK1596887T3 (en) 2022-06-20
US20080058504A1 (en) 2008-03-06
US8133977B2 (en) 2012-03-13
HUE058897T2 (en) 2022-09-28

Similar Documents

Publication Publication Date Title
BE2022C541I2 (en)
BE2013C069I2 (en)
JP2004152265A5 (en)
JP2004220870A5 (en)
JP2004184969A5 (en)
JP2003341100A5 (en)
JP2003318894A5 (en)
JP2004069689A5 (en)
JP2004221992A5 (en)
JP2003319792A5 (en)
JP2003347945A5 (en)
JP2004144092A5 (en)
JP2004035264A5 (en)
JP2004024857A5 (en)
JP2004030635A5 (en)
JP2004004018A5 (en)
AU2002322913A1 (en)
AU2002339901A1 (en)
AU2002327042A1 (en)
AU2002324323A1 (en)
AU2002340206A1 (en)
AU2002321535A1 (en)
AU2002318342A1 (en)
AU2002341898A1 (en)
AU2002355123A1 (en)