[go: up one dir, main page]

BE2014C049I2 - Circovirus sequences associated with piglet weight loss disease (PWD) - Google Patents

Circovirus sequences associated with piglet weight loss disease (PWD)

Info

Publication number
BE2014C049I2
BE2014C049I2 BE2014C049C BE2014C049C BE2014C049I2 BE 2014C049 I2 BE2014C049 I2 BE 2014C049I2 BE 2014C049 C BE2014C049 C BE 2014C049C BE 2014C049 C BE2014C049 C BE 2014C049C BE 2014C049 I2 BE2014C049 I2 BE 2014C049I2
Authority
BE
Belgium
Prior art keywords
pwd
circovirus
polypeptides
vectors
weight loss
Prior art date
Application number
BE2014C049C
Other languages
French (fr)
Original Assignee
Zoetis Services Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9514225&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BE2014C049(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Zoetis Services Llc filed Critical Zoetis Services Llc
Publication of BE2014C049I2 publication Critical patent/BE2014C049I2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5252—Virus inactivated (killed)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5256—Virus expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552—Veterinary vaccine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55522—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/14011—Baculoviridae
    • C12N2710/14111—Nucleopolyhedrovirus, e.g. autographa californica nucleopolyhedrovirus
    • C12N2710/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2710/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/10011—Circoviridae
    • C12N2750/10021—Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/10011—Circoviridae
    • C12N2750/10022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/10011—Circoviridae
    • C12N2750/10034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/10011—Circoviridae
    • C12N2750/10051—Methods of production or purification of viral material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/10011—Circoviridae
    • C12N2750/10061—Methods of inactivation or attenuation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/01—DNA viruses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00—Immunoassays for the detection of microorganisms
    • G01N2469/20—Detection of antibodies in sample from host which are directed against antigens from microorganisms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/13—Hollow or container type article [e.g., tube, vase, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mycology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)

Abstract

The genome sequences and the nucleotide sequences coding for the PWD circovirus polypeptides, such as the circovirus structural and non-structural polypeptides, vectors including the sequences, and cells and animals transformed by the vectors are provided. Methods for detecting the nucleic acids or polypeptides, and kits for diagnosing infection by a PWD circovirus, also are provided. Method for selecting compounds capable of modulating the viral infection are further provided. Pharmaceutical, including vaccine, compositions for preventing and/or treating viral infections caused by PWD circovirus and the use of vectors for preventing and/or treating diseases also are provided.
BE2014C049C 1997-12-05 2014-08-14 Circovirus sequences associated with piglet weight loss disease (PWD) BE2014C049I2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9715396A FR2772047B1 (en) 1997-12-05 1997-12-05 GENOMIC SEQUENCE AND POLYPEPTIDES OF CIRCOVIRUS ASSOCIATED WITH PIGLET LOSS DISEASE (MAP), APPLICATIONS TO DIAGNOSIS AND TO PREVENTION AND / OR TREATMENT OF INFECTION
PCT/FR1998/002634 WO1999029871A2 (en) 1997-12-05 1998-12-04 Circovirus sequences related to piglet weight loss disease (pwd)

Publications (1)

Publication Number Publication Date
BE2014C049I2 true BE2014C049I2 (en) 2018-07-04

Family

ID=9514225

Family Applications (2)

Application Number Title Priority Date Filing Date
BE2014C049C BE2014C049I2 (en) 1997-12-05 2014-08-14 Circovirus sequences associated with piglet weight loss disease (PWD)
BE2014C050C BE2014C050I2 (en) 1997-12-05 2014-08-14 Circovirus sequences associated with piglet weight loss disease (PWD)

Family Applications After (1)

Application Number Title Priority Date Filing Date
BE2014C050C BE2014C050I2 (en) 1997-12-05 2014-08-14 Circovirus sequences associated with piglet weight loss disease (PWD)

Country Status (15)

Country Link
US (43) US6703023B1 (en)
EP (6) EP2330188B1 (en)
AT (1) ATE412664T1 (en)
AU (1) AU1491699A (en)
BE (2) BE2014C049I2 (en)
CY (6) CY1115405T1 (en)
DE (1) DE69840174D1 (en)
DK (5) DK2000535T3 (en)
ES (5) ES2317679T5 (en)
FR (3) FR2772047B1 (en)
HK (1) HK1222415A1 (en)
LU (2) LU92523I2 (en)
NL (2) NL300686I2 (en)
PT (5) PT2330188E (en)
WO (1) WO1999029871A2 (en)

Families Citing this family (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7211379B2 (en) 1997-10-03 2007-05-01 Merial Sas Prevention of myocarditis, abortion and intrauterine infection associated with porcine circovirus-2
AU2002302120B2 (en) * 1997-10-03 2006-01-19 Merial Porcine circoviruses, vaccines and diagnostic reagents
UA78180C2 (en) * 1997-10-03 2007-03-15 Меріаль Porcine circovirus, vaccines and diagnostic reagents
US7192594B2 (en) 1997-10-03 2007-03-20 Merial Limited Postweaning multisystemic wasting syndrome and porcine circovirus from pigs
US6517843B1 (en) * 1999-08-31 2003-02-11 Merial Reduction of porcine circovirus-2 viral load with inactivated PCV-2
AU2003248395B2 (en) * 1997-10-03 2006-03-16 Merial Porcine CircoViruses, vaccines and diagnostic reagents
US6391314B1 (en) 1997-10-03 2002-05-21 Merial Porcine circoviruses vaccines diagnostic reagents
FR2772047B1 (en) 1997-12-05 2004-04-09 Ct Nat D Etudes Veterinaires E GENOMIC SEQUENCE AND POLYPEPTIDES OF CIRCOVIRUS ASSOCIATED WITH PIGLET LOSS DISEASE (MAP), APPLICATIONS TO DIAGNOSIS AND TO PREVENTION AND / OR TREATMENT OF INFECTION
ATE364624T1 (en) * 1997-12-11 2007-07-15 Univ Saskatchewan MULTISYSTEMIC CRIME GROWTH SYNDROME CAUSED BY VIRUSES IN PIGS
EP1816200B1 (en) * 1997-12-11 2016-03-09 Merial Postweaning multisystemic wasting syndrome virus for pigs
WO1999045956A1 (en) * 1998-03-13 1999-09-16 University Of Georgia Research Foundation, Inc. Vaccines against circovirus infections
US6943152B1 (en) 1999-06-10 2005-09-13 Merial DNA vaccine-PCV
ES2170622B1 (en) * 1999-12-03 2004-05-16 Consejo Superior De Investigaciones Cientificas CLONES AND INFECTIVE VECTORS DERIVED FROM CORONAVIRUS AND ITS APPLICATIONS.
WO2001061024A2 (en) 2000-02-16 2001-08-23 Large Scale Biology Corporation Rolling circle replicon expression vectors
MXPA03008810A (en) 2001-03-27 2004-02-17 Univ Saskatchewan Methods to culture circovirus.
US7276353B2 (en) * 2001-12-12 2007-10-02 Virginia Tech Intellectual Properties, Inc. Chimeric infectious DNA clones, chimeric porcine circoviruses and uses thereof
US7279166B2 (en) 2001-12-12 2007-10-09 Virginia Tech Intellectual Properties, Inc. Chimeric infectious DNA clones, chimeric porcine circoviruses and uses thereof
AU2011253941B2 (en) * 2004-12-30 2015-01-29 Boehringer Ingelheim Animal Health USA Inc. PCV2 immunogenic compositions and methods of producing such compositions
US7700285B1 (en) 2005-12-29 2010-04-20 Boehringer Ingelheim Vetmedica, Inc. PCV2 immunogenic compositions and methods of producing such compositions
EP2460819A3 (en) 2004-12-30 2013-01-09 Boehringer Ingelheim Vetmedica, Inc. PCV2 immunogenic compositions and methods of producing such compositions
US7833707B2 (en) 2004-12-30 2010-11-16 Boehringer Ingelheim Vetmedica, Inc. Methods of overexpression and recovery of porcine circovirus type 2 ORF2
UA95602C2 (en) 2004-12-30 2011-08-25 Берингер Ингельхейм Ветмедика, Инк. Pcv2 immunogenic compositions and methods of producing such compositions
ITBO20050123A1 (en) 2005-03-07 2005-06-06 Alfa Wassermann Spa GASTRORESISTIC PHARMACEUTICAL FORMULATIONS CONTAINING RIFAXIMINA
US8834891B2 (en) 2005-03-14 2014-09-16 Boehringer Ingelheim Vetmedica, Inc. Immunogenic compositions comprising Lawsonia intracellularis
WO2006132598A1 (en) * 2005-06-07 2006-12-14 Temasek Life Sciences Laboratory Limited Porcine circovirus type 2 vaccines
DK1926496T3 (en) * 2005-09-09 2013-09-30 Intervet Int Bv PCV-2 vaccine
ES2572736T3 (en) 2005-12-29 2016-06-02 Boehringer Ingelheim Vetmedica, Inc. Use of an immunogenic composition to attenuate clinical symptoms in pigs
BR122015028489B1 (en) 2005-12-29 2021-10-13 Boehringer Ingelheim Animal Health Usa Inc MULTIVALENT COMBINATION VACCINE AGAINST PCV2 AS WELL AS THE USE OF AN ORF2 PROTEIN IN THE PREPARATION OF THE SAME
US20100136060A1 (en) * 2006-11-22 2010-06-03 Boehringer Ingelheim Vetmedica, Inc. Methods of reducing porcine circovirus-associated disease outbreaks
EP2859900A1 (en) 2006-12-11 2015-04-15 Boehringer Ingelheim Vetmedica, Inc. Effective method of treatment of porcine circovirus and lawsonia intracellularis infections
AU2007333857B2 (en) 2006-12-15 2014-05-15 Boehringer Ingelheim Animal Health USA Inc. Treatment of pigs with PCV2 antigen
EP1941903A1 (en) * 2007-01-03 2008-07-09 Boehringer Ingelheim Vetmedica Gmbh Prophylaxis and treatment of PRDC
EP1958644A1 (en) 2007-02-13 2008-08-20 Boehringer Ingelheim Vetmedica Gmbh Prevention and treatment of sub-clinical pcvd
EP2155246B1 (en) * 2007-05-11 2013-03-13 Temasek Life Sciences Laboratory Limited Production of a homogeneous cell line highly permissive to porcine circovirus type 2 (pcv2) infection
US7829274B2 (en) 2007-09-04 2010-11-09 Boehringer Ingelheim Vetmedica, Inc. Reduction of concomitant infections in pigs by the use of PCV2 antigen
CA2710247C (en) * 2007-12-21 2014-02-18 Wyeth Llc Methods and compositions for immunizing pigs against porcine circovirus
KR20100103535A (en) * 2007-12-31 2010-09-27 베링거잉겔하임베트메디카인코퍼레이티드 Pcv2 orf2 virus like particle with foreign amino acid insertion
WO2009126356A2 (en) 2008-01-23 2009-10-15 Boehringer Ingelheim Vetmedica, Inc. Pcv2 mycoplasma hyopneumoniae immunogenic compositions and methods of producing such compositions
EP2254595A4 (en) * 2008-02-15 2012-12-05 Boehringer Ingelheim Vetmed METHOD AND COMPOSITIONS FOR REDUCING THE EFFECTS OF STOMACH DISEASES
KR20130054466A (en) 2008-10-16 2013-05-24 화이자 인코포레이티드 Torque teno virus(ttv) isolates and compositions
US20100150959A1 (en) * 2008-12-15 2010-06-17 Vectogen Pty Ltd. PCV 2-Based Methods and Compositions for the Treatment of Pigs
TWI627281B (en) 2009-09-02 2018-06-21 百靈佳殷格翰家畜藥品公司 Methods of reducing viricidal activity in pcv-2 compositions and pcv-2 compositions with an improved immunogenicity
MX2012003972A (en) 2009-10-02 2012-05-08 Pionner Hi Bred International Inc Down-regulation of acc synthase for improved plant performance.
US8846388B2 (en) 2009-10-16 2014-09-30 Zoetis Llc Infectious clones of torque teno virus
MX2012004448A (en) * 2009-10-16 2012-05-08 Pfizer Infectious clones of torque teno virus.
JP2013507944A (en) * 2009-10-22 2013-03-07 ウニヴェルシテート・ライプツィヒ Identification of circovirus in calves with pancytopenia
EP2528931A4 (en) * 2010-01-25 2013-12-04 Blood Systems Inc Cyclovirus and method of use
KR20110090711A (en) * 2010-02-04 2011-08-10 녹십자수의약품(주) New Porcine Circovirus Type 2 and Uses thereof
TWI442935B (en) 2010-12-22 2014-07-01 Sbc Virbac Ltd Porcine Circovirus Type 2, immunological composition containing the same, test kit and application thereof
CA2833876A1 (en) 2011-04-29 2012-11-01 Pioneer Hi-Bred International, Inc. Down-regulation of a homeodomain-leucine zipper i-class homeobox gene for improved plant performance
HUP1100470A2 (en) 2011-08-30 2013-03-28 Mezoegazdasagi Biotechnologiai Kutatokoezpont Nanoparticle-based veterinary vaccine
EP2564869A1 (en) 2011-09-02 2013-03-06 Ceva Sante Animale Synthetic capsid proteins and uses thereof
UA113192C2 (en) 2011-12-06 2016-12-26 IMMUNOGENIC COMPOSITION AGAINST PIG TYPE 2 (PCV2) CIRCULOSIS
UA114503C2 (en) 2012-04-04 2017-06-26 Зоетіс Сервісіз Ллс PCV AND MYCOPLASMA HYOPNEUMONIA COMBINED VACCINE
US9120859B2 (en) 2012-04-04 2015-09-01 Zoetis Services Llc Mycoplasma hyopneumoniae vaccine
ES2734374T3 (en) 2013-03-01 2019-12-05 Boehringer Ingelheim Animal Health Usa Inc Quantification of vaccine compositions
KR102217387B1 (en) * 2013-03-11 2021-02-19 주식회사 중앙백신연구소 Porcine circovirus2 vaccine using recombinant yeast whole cell and manufacturing thereof
EP2789346A1 (en) 2013-04-11 2014-10-15 CEVA Santé Animale SA Fusion polypeptides and vaccines
ES2882374T3 (en) 2013-05-08 2021-12-01 Pharmgate Biologics Inc PCV2 and mycoplasma vaccine
US9987348B2 (en) 2013-09-25 2018-06-05 Zoetis Services Llc PCV2B divergent vaccine composition and methods of use
US9505808B2 (en) 2013-10-02 2016-11-29 Boehringer Ingelheim Vetmedica, Inc. PCV2 ORF2 protein variant and virus like particles composed thereof
EP3034609A1 (en) 2014-12-19 2016-06-22 Ceva Sante Animale Recombinant swinepox virus and vaccines
EP3254692A1 (en) 2016-06-10 2017-12-13 Ceva Sante Animale Multivalent recombinant spv
WO2019032830A1 (en) 2017-08-09 2019-02-14 Dreamwell, Ltd. Adjustable foundation
US20200390878A1 (en) 2017-12-08 2020-12-17 Ceva Sante Animale Recombinant swinepox virus and vaccines
CA3091982A1 (en) 2018-03-26 2019-10-03 Boehringer Ingelheim Animal Health USA Inc. Method of producing an immunogenic composition
CA3102685A1 (en) 2018-06-11 2019-12-19 Ceva Sante Animale Vaccination against porcine circoviruses
EP4225940A4 (en) * 2020-10-06 2025-01-01 Materials and Machines Corporation of America Method for detection of rna or dna from biological samples
WO2023192936A2 (en) * 2022-03-30 2023-10-05 Fred Hutchinson Cancer Center Systems and methods to produce b cells that express selected antibodies and gene products
CN114736310B (en) * 2022-06-10 2022-10-28 北京华夏兴洋生物科技有限公司 Protein and biological material for producing circovirus type 2 virus-like particles and application
AR132581A1 (en) 2023-05-03 2025-07-16 Boehringer Ingelheim Vetmedica Gmbh IMMUNOGENIC COMPOSITION USEFUL FOR SELF-ADMINISTRATION BY PIGS
WO2024228149A2 (en) 2023-05-03 2024-11-07 Boehringer Ingelheim Vetmedica Gmbh Method for inducing an immune response

Family Cites Families (112)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US69233A (en) * 1867-09-24 Joseph r
US69750A (en) * 1867-10-15 Henry bean
FR2422956A1 (en) 1978-04-13 1979-11-09 Pasteur Institut METHOD OF DETECTION AND CHARACTERIZATION OF A NUCLEIC ACID OR OF A SEQUENCE OF THE SAME, AND ENZYMATIC REAGENT FOR THE IMPLEMENTATION OF THIS PROCESS
FR2464269B1 (en) 1979-08-30 1986-04-18 Anvar NUCLEOTIDE SEQUENCE ENCODING HEPATITIS B VIRUS SURFACE ANTIGEN, PROCESS FOR OBTAINING SAME AND ANTIGEN OBTAINED
FR2518755B1 (en) 1981-12-23 1986-04-11 Pasteur Institut PROBE CONTAINING MODIFIED NUCLEIC ACID RECOGNIZABLE BY SPECIFIC ANTIBODIES AND USE OF THE SAME TO DETECT AND CHARACTERIZE A HOMOLOGATED DNA SEQUENCE
US5833975A (en) 1989-03-08 1998-11-10 Virogenetics Corporation Canarypox virus expressing cytokine and/or tumor-associated antigen DNA sequence
US4745051A (en) 1983-05-27 1988-05-17 The Texas A&M University System Method for producing a recombinant baculovirus expression vector
US4946787A (en) 1985-01-07 1990-08-07 Syntex (U.S.A.) Inc. N-(ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor
US5550289A (en) 1985-01-07 1996-08-27 Syntex (U.S.A.) Inc. N-(1,(1-1)-dialkyloxy)-and N-(1,(1-1)-dialkenyloxy alk-1-yl-N-N,N-tetrasubstituted ammonium lipids and uses therefor
US5106733A (en) 1987-06-25 1992-04-21 Immunex Corporation Bovine granulocyte-macrophage colony stimulating factor
SU1538305A1 (en) 1987-07-21 1994-12-15 Всесоюзный государственный научно-контрольный институт ветеринарных препаратов Госагропрома СССР Associated vaccine against peptospirosis and parvovirus infection of pigs
US5069901A (en) 1988-02-03 1991-12-03 Jones Elaine V Preparation of a recombinant subunit vaccine against pseudorabies infection
DK0454735T3 (en) 1989-01-23 1996-10-07 Auspharm Int Ltd Vaccine composition
US5811103A (en) 1989-03-19 1998-09-22 Akzo Nobel N.V. Hog cholera virus vaccine and diagnostic
US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
EP1026253B2 (en) 1989-03-21 2012-12-19 Vical Incorporated Expression of exogenous polynucleotide sequences in a vertebrate
US5800992A (en) 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
US5264618A (en) 1990-04-19 1993-11-23 Vical, Inc. Cationic lipids for intracellular delivery of biologically active molecules
JP3187419B2 (en) 1990-05-29 2001-07-11 アメリカン・サイアナミド・カンパニー Porcine pneumonia vaccine and production method thereof
US5565205A (en) * 1990-08-16 1996-10-15 Solvay Animal Health, Inc. Inactivated Mycoplasma hypopneumoniae bacterin and method of use thereof
WO1992005255A1 (en) 1990-09-13 1992-04-02 Commonwealth Scientific And Industrial Research Organisation Ovine cytokine genes
GB9023111D0 (en) 1990-10-24 1990-12-05 Wellcome Found Expression system
ES2150419T3 (en) 1990-11-01 2000-12-01 Univ Iowa State Res Found Inc BACTERIAL AND VACCINE ATTENUATION PROCEDURE.
EP0575491B1 (en) 1991-03-07 2003-08-13 Virogenetics Corporation Genetically engineered vaccine strain
ES2026827A6 (en) 1991-03-26 1992-05-01 Ercros Sa Method for producing a subunit vaccine against porcine parvovirus.
US5580557A (en) * 1991-10-09 1996-12-03 Iowa State University Research Foundation, Inc. Live, avirulent salmonella choleraesuis vaccine used for inducing an immune response in animals
US6033904A (en) 1992-01-13 2000-03-07 Syntro Corporation Recombinant swinepox virus
US5382425A (en) 1992-01-13 1995-01-17 Syntro Corporation Recombinant swinepox virus
US5338543A (en) 1992-02-27 1994-08-16 Ambico, Inc. Thimerosal inactivated mycoplasma hyopneumoniae vaccine
US5679356A (en) 1992-07-08 1997-10-21 Schering Corporation Use of GM-CSF as a vaccine adjuvant
JP3149116B2 (en) * 1992-10-28 2001-03-26 信越化学工業株式会社 Epitope-related peptide of human parvovirus
ATE275191T1 (en) * 1992-11-09 2004-09-15 Zonagen Inc METHODS OF IMMUNOCONTRACEPTION
DE69426228T2 (en) 1993-02-08 2001-03-01 Bayer Ag Method of propagating the swine virus causing reproductive and respiratory syndrome and using it as a vaccine.
EP0620277A1 (en) 1993-03-18 1994-10-19 Merck & Co. Inc. Nucleic acid pharmaceuticals
EP0698245A1 (en) 1993-05-14 1996-02-28 Mds Health Group Limited Electronic worksheet system for microbiology testing and reporting
WO1994027435A1 (en) 1993-06-01 1994-12-08 Life Technologies, Inc. Genetic immunization with cationic lipids
WO1994029469A2 (en) 1993-06-07 1994-12-22 Vical Incorporated Plasmids suitable for gene therapy
US6015686A (en) 1993-09-15 2000-01-18 Chiron Viagene, Inc. Eukaryotic layered vector initiation systems
FR2711670B1 (en) 1993-10-22 1996-01-12 Pasteur Institut Nucleotide vector, composition containing it and vaccine for immunization against hepatitis.
GB2285766B (en) 1994-01-21 1997-07-23 Ecc Int Ltd Ceramic casting composition
KR0121105B1 (en) * 1994-02-04 1997-11-10 문정환 Fifo memory bus appurtenance
CA2190121A1 (en) 1994-03-15 1995-09-21 Edith Mathiowitz Polymeric gene delivery system
DE69534289T2 (en) 1994-04-29 2006-04-27 Baxter Healthcare S.A. Recombinant poxviruses with foreign polynucleotides in important regions
BR9507717A (en) 1994-05-10 1997-09-23 American Home Prod Enhanced modified live brsv vaccine
DK53595A (en) 1994-05-13 1995-11-14 Iberica Cyanamid Recombinant PRRSV proteins, diagnostic kits and vaccines containing such recombinant PRRSV proteins
US5719131A (en) 1994-12-09 1998-02-17 Genzyme Corporation Cationic amphiphiles containing dialkylamine lipophilic groups for intracellular delivery of therapeutic molecules
US5840306A (en) * 1995-03-22 1998-11-24 Merck & Co., Inc. DNA encoding human papillomavirus type 18
US6043232A (en) 1997-07-23 2000-03-28 Nitromed, Inc. Nitroso esters of beta-oxo-amides and aryl propionic acid derivatives of non-steroidal antiinflammatory drugs
CA2214029A1 (en) 1995-04-25 1996-10-31 Magda Marquet Single-vial formulations of dna/lipid complexes
US5681658A (en) * 1995-05-30 1997-10-28 Aluminum Company Of America Gelation-resistant alumina
US5885823A (en) 1995-06-05 1999-03-23 Nobl Laboratories, Inc. Lawsonia intracellularis cultivation, anti-Lawsonia intracellularis vaccines and diagnostic agents
US5705385A (en) 1995-06-07 1998-01-06 Inex Pharmaceuticals Corporation Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer
US5820869A (en) 1995-06-07 1998-10-13 American Home Products Corporation Recombinant raccoon pox viruses and their use as an effective vaccine against feline immunodeficiency virus infection
NZ309172A (en) 1995-06-07 1999-11-29 Leadd B Neutralizing conformational epitopes of chicken anemia virus
US6019980A (en) 1995-06-07 2000-02-01 Connaught Laboratories Limited Nucleic acid respiratory syncytial virus vaccines
US5795872A (en) 1995-09-19 1998-08-18 Pharmadigm, Inc. DNA construct for immunization
FR2751224B1 (en) 1996-07-19 1998-11-20 Rhone Merieux POLYNUCLEOTIDE VACCINE FORMULA AGAINST BREATHING AND PIG REPRODUCTIVE CONDITIONS
DE69704011T2 (en) 1996-10-09 2001-06-07 Akzo Nobel Nv Swine Reproductive System Respiratory Syndrome Virus (PRRSV) vaccine strains
WO1998040499A1 (en) 1997-03-10 1998-09-17 Heather Lynn Davis Gene delivery to mucosal epithelium for immunization or therapeutic purposes
US6004777A (en) 1997-03-12 1999-12-21 Virogenetics Corporation Vectors having enhanced expression, and methods of making and uses thereof
US5990091A (en) 1997-03-12 1999-11-23 Virogenetics Corporation Vectors having enhanced expression, and methods of making and uses thereof
US20030215445A1 (en) * 1997-05-23 2003-11-20 Ginette Serrero Methods and compositions for inhibiting the growth of hematopoietic malignant cells
US7192594B2 (en) * 1997-10-03 2007-03-20 Merial Limited Postweaning multisystemic wasting syndrome and porcine circovirus from pigs
US6517843B1 (en) * 1999-08-31 2003-02-11 Merial Reduction of porcine circovirus-2 viral load with inactivated PCV-2
US7211379B2 (en) 1997-10-03 2007-05-01 Merial Sas Prevention of myocarditis, abortion and intrauterine infection associated with porcine circovirus-2
US6391314B1 (en) * 1997-10-03 2002-05-21 Merial Porcine circoviruses vaccines diagnostic reagents
UA78180C2 (en) 1997-10-03 2007-03-15 Меріаль Porcine circovirus, vaccines and diagnostic reagents
FR2781159B1 (en) 1998-07-06 2000-10-06 Merial Sas CIRCOVIRUS VACCINE AND PIG PARVOVIRUS
FR2769321B1 (en) 1997-10-03 2001-10-26 Merial Sas NEW PIG CIRCOVIRUSES, VACCINES AND DIAGNOSTIC REAGENTS
US6143334A (en) * 1997-10-03 2000-11-07 Sargento Foods Inc. Pasta filata method for manufacturing Swiss-type cheeses
FR2769322B1 (en) 1997-10-03 2002-03-08 Merial Sas NEW PORCINE CIRCOVIRUSES, VACCINES AND DIAGNOSTIC REAGENTS
US6165493A (en) 1997-10-22 2000-12-26 New York Blood Center, Inc. "Methods and compositions for decreasing the frequency of HIV, herpesvirus and sexually transmitted bacterial infections"
FR2772047B1 (en) 1997-12-05 2004-04-09 Ct Nat D Etudes Veterinaires E GENOMIC SEQUENCE AND POLYPEPTIDES OF CIRCOVIRUS ASSOCIATED WITH PIGLET LOSS DISEASE (MAP), APPLICATIONS TO DIAGNOSIS AND TO PREVENTION AND / OR TREATMENT OF INFECTION
US20040062775A1 (en) 1997-12-05 2004-04-01 Agence Francaise De Securite Sanitaire Des Aliments Circovirus sequences associated with piglet weight loss disease (PWD)
ATE364624T1 (en) * 1997-12-11 2007-07-15 Univ Saskatchewan MULTISYSTEMIC CRIME GROWTH SYNDROME CAUSED BY VIRUSES IN PIGS
WO1999045956A1 (en) * 1998-03-13 1999-09-16 University Of Georgia Research Foundation, Inc. Vaccines against circovirus infections
US6294176B1 (en) 1998-07-10 2001-09-25 Schering-Plough Veterinary Corp. Recombinant raccoonpox virus and uses thereof as a vaccine in mammalian and avian species
WO2000024428A2 (en) 1998-10-23 2000-05-04 Heska Corporation Cationic lipid-mediated enhancement of nucleic acid immunization of cats
US6143333A (en) 1998-11-13 2000-11-07 Purina Mills, Inc. Method of preparing a packaged fish attractant block
FR2789695B1 (en) 1999-02-11 2003-03-07 Merial Sas VIRAL VACCINES AND VACCINES BASED ON RECOMBINANT AND REPLICATIVE SWINE ADENOVIRUSES
US6497883B1 (en) * 1999-06-10 2002-12-24 Merial Porcine circovirus recombinant poxvirus vaccine
US6943152B1 (en) * 1999-06-10 2005-09-13 Merial DNA vaccine-PCV
US6179461B1 (en) 1999-09-03 2001-01-30 Davis-Standard Corporation Extruder screw
US6139179A (en) 1999-09-03 2000-10-31 Davis-Standard Corporation Extruder screw having multi-channeled barrier section
GB9921146D0 (en) 1999-09-07 1999-11-10 Smithkline Beecham Biolog Novel composition
WO2001017556A1 (en) 1999-09-07 2001-03-15 Shionogi & Co., Ltd. Vaccine preparations for mucosal administration
GB9921147D0 (en) 1999-09-07 1999-11-10 Smithkline Beecham Biolog Novel composition
EP1144416B1 (en) * 1999-11-10 2005-03-02 Rodenstock GmbH Heterocyclically anellated indenochromene derivatives
US6366601B1 (en) * 1999-11-17 2002-04-02 Motorola, Inc. Variable rate spread spectrum communication method and apparatus
US7233407B1 (en) * 2000-02-02 2007-06-19 Xerox Corporation Document production system for capturing web page content
JP3363419B2 (en) * 1999-12-24 2003-01-08 住友ゴム工業株式会社 Radial tires for heavy loads
JP2004503234A (en) 2000-06-15 2004-02-05 パーデュー・リサーチ・ファウンデーション Vaccine for congenital tremor in pigs
JP4768106B2 (en) 2000-07-31 2011-09-07 スリーエム イノベイティブ プロパティズ カンパニー Adhesive composition and adhesive structure for easy thermal peeling
DE10044646A1 (en) 2000-09-08 2002-04-04 Horsch Maschinen Gmbh Spray boom guidance
DE10044648A1 (en) * 2000-09-08 2002-03-21 Aventis Behring Gmbh Process for the propagation or removal of Cirocoviruses from biological material
DE10051562A1 (en) * 2000-10-18 2002-04-25 Emitec Emissionstechnologie Electrically heated honeycomb body used for removing hydrocarbons or nitrogen oxides from I.C. engine exhaust gases comprises two zones with different coatings arranged behind each other in the flow direction
US6572081B2 (en) * 2000-12-27 2003-06-03 Nkf Kabel B.V. Installation of guide tubes in a protective duct
MXPA03008810A (en) * 2001-03-27 2004-02-17 Univ Saskatchewan Methods to culture circovirus.
AUPR567401A0 (en) 2001-06-14 2001-07-12 University Of Melbourne, The Circovirus vaccines
US7279166B2 (en) 2001-12-12 2007-10-09 Virginia Tech Intellectual Properties, Inc. Chimeric infectious DNA clones, chimeric porcine circoviruses and uses thereof
US7276353B2 (en) 2001-12-12 2007-10-02 Virginia Tech Intellectual Properties, Inc. Chimeric infectious DNA clones, chimeric porcine circoviruses and uses thereof
US20030215455A1 (en) 2002-05-14 2003-11-20 Bailey Reynolds Vaccine stabilizer and method of use
WO2004049501A1 (en) * 2002-11-28 2004-06-10 Research In Motion Limited Multiple-band antenna with patch and slot structures
US7288529B2 (en) * 2003-04-24 2007-10-30 New York University ALK protein tyrosine kinase, cells and methods embodying and using same
SG144909A1 (en) * 2003-07-25 2008-08-28 Boehringer Ingelheim Vetmed Lawsonia intracellularis of european origin and vaccines, diagnostic agents and methods of use thereof
US20050279889A1 (en) 2004-06-08 2005-12-22 Safe Flight Instrument Corporation Variable wing spacecraft
US7833707B2 (en) * 2004-12-30 2010-11-16 Boehringer Ingelheim Vetmedica, Inc. Methods of overexpression and recovery of porcine circovirus type 2 ORF2
AU2006205852A1 (en) 2005-01-13 2006-07-20 Boehringer Ingelheim Vetmedica Gmbh Improved PRRS vaccines
US7358075B2 (en) * 2005-04-13 2008-04-15 Merial Limited Assay for porcine circovirus production
ES2572736T3 (en) 2005-12-29 2016-06-02 Boehringer Ingelheim Vetmedica, Inc. Use of an immunogenic composition to attenuate clinical symptoms in pigs
US8377070B2 (en) * 2007-05-17 2013-02-19 Michael T. Gauthier Compressor distractor tool
US8214576B2 (en) 2009-03-03 2012-07-03 Vmware, Inc. Zero copy transport for target based storage virtual appliances

Also Published As

Publication number Publication date
ATE412664T1 (en) 2008-11-15
ES2456959T3 (en) 2014-04-24
HK1125676A1 (en) 2009-08-14
US20070059325A1 (en) 2007-03-15
US8715690B2 (en) 2014-05-06
US9717784B2 (en) 2017-08-01
US20070041990A1 (en) 2007-02-22
BE2014C050I2 (en) 2018-07-04
US20090162918A1 (en) 2009-06-25
US7405075B2 (en) 2008-07-29
US20100215690A1 (en) 2010-08-26
AU1491699A (en) 1999-06-28
US20100172924A1 (en) 2010-07-08
US20100189734A1 (en) 2010-07-29
US20100221276A1 (en) 2010-09-02
FR2772047B1 (en) 2004-04-09
FR14C0062I1 (en) 2014-10-10
PT2330188E (en) 2015-10-23
EP2000535B1 (en) 2014-01-22
DK1992696T3 (en) 2014-05-19
US7148015B2 (en) 2006-12-12
ES2548146T3 (en) 2015-10-14
US20070059324A1 (en) 2007-03-15
US7722883B2 (en) 2010-05-25
DK1036180T4 (en) 2012-01-23
US20070253971A1 (en) 2007-11-01
US7323330B2 (en) 2008-01-29
EP2316925A1 (en) 2011-05-04
US9700613B2 (en) 2017-07-11
US20100189743A1 (en) 2010-07-29
US20100189732A1 (en) 2010-07-29
FR14C0061I2 (en) 2016-06-24
CY1116837T1 (en) 2017-03-15
CY1115424T1 (en) 2016-04-13
US7758865B2 (en) 2010-07-20
CY2014036I1 (en) 2016-04-13
CY2014035I2 (en) 2016-04-13
US20100166791A1 (en) 2010-07-01
US20100074919A1 (en) 2010-03-25
US7741026B2 (en) 2010-06-22
US20070041989A1 (en) 2007-02-22
LU92523I2 (en) 2014-10-20
ES2317679T5 (en) 2012-02-24
US7223594B2 (en) 2007-05-29
FR2772047A1 (en) 1999-06-11
DE69840174D1 (en) 2008-12-11
US7740865B2 (en) 2010-06-22
US20070048780A1 (en) 2007-03-01
US7297537B2 (en) 2007-11-20
DK2000535T3 (en) 2014-04-22
CY1115405T1 (en) 2017-01-04
US20110135677A1 (en) 2011-06-09
EP2000535A1 (en) 2008-12-10
US7740866B2 (en) 2010-06-22
DK1036180T3 (en) 2009-03-09
US6703023B1 (en) 2004-03-09
WO1999029871A2 (en) 1999-06-17
US20110033489A1 (en) 2011-02-10
CY2014035I1 (en) 2016-04-13
US20150182616A1 (en) 2015-07-02
EP1992696B1 (en) 2014-02-19
CY2014036I2 (en) 2016-04-13
EP1036180B1 (en) 2008-10-29
NL300685I1 (en) 2014-08-27
US20100203072A1 (en) 2010-08-12
US20070110767A1 (en) 2007-05-17
US20180000927A1 (en) 2018-01-04
US20100221283A1 (en) 2010-09-02
US20100189733A1 (en) 2010-07-29
US7425444B2 (en) 2008-09-16
US20080233147A1 (en) 2008-09-25
EP2330188B1 (en) 2015-07-15
US20040076635A1 (en) 2004-04-22
US20100189736A1 (en) 2010-07-29
US8124723B2 (en) 2012-02-28
US20040161410A1 (en) 2004-08-19
US10052375B2 (en) 2018-08-21
ES2458309T3 (en) 2014-04-30
DK2330188T3 (en) 2015-10-19
DK2316925T3 (en) 2015-10-12
NL300685I2 (en) 2022-03-22
PT2000535E (en) 2014-05-02
US20040265848A1 (en) 2004-12-30
US20100189735A1 (en) 2010-07-29
US7604808B2 (en) 2009-10-20
US20090123490A1 (en) 2009-05-14
EP1992696A1 (en) 2008-11-19
HK1158694A1 (en) 2012-07-20
ES2548145T3 (en) 2015-10-14
HK1222415A1 (en) 2017-06-30
US20120034630A1 (en) 2012-02-09
US20060083756A1 (en) 2006-04-20
EP1036180B2 (en) 2011-11-02
HK1126522A1 (en) 2009-09-04
EP1036180A2 (en) 2000-09-20
US7390494B2 (en) 2008-06-24
PT1036180E (en) 2009-02-10
US20100209453A1 (en) 2010-08-19
US20070065925A1 (en) 2007-03-22
HK1158254A1 (en) 2012-07-13
US7951907B2 (en) 2011-05-31
US7407803B2 (en) 2008-08-05
EP3002331A1 (en) 2016-04-06
US20050084497A1 (en) 2005-04-21
US20150175668A1 (en) 2015-06-25
EP2330188A1 (en) 2011-06-08
LU92524I2 (en) 2014-10-20
US20040091502A1 (en) 2004-05-13
US20100226934A1 (en) 2010-09-09
NL300686I2 (en) 2022-03-22
US8415525B2 (en) 2013-04-09
CY1116761T1 (en) 2017-03-15
US7261898B2 (en) 2007-08-28
US20060222663A1 (en) 2006-10-05
US20120005768A1 (en) 2012-01-05
FR14C0062I2 (en) 2016-06-24
US7244433B2 (en) 2007-07-17
WO1999029871A3 (en) 1999-08-19
FR14C0061I1 (en) 2014-10-10
ES2317679T3 (en) 2009-04-16
US20090092627A1 (en) 2009-04-09
US7179472B2 (en) 2007-02-20
US8916353B2 (en) 2014-12-23
NL300686I1 (en) 2014-08-27
PT2316925E (en) 2015-10-23
US20050008651A1 (en) 2005-01-13
PT1992696E (en) 2014-05-27
EP2316925B1 (en) 2015-07-08

Similar Documents

Publication Publication Date Title
BE2014C050I2 (en) Circovirus sequences associated with piglet weight loss disease (PWD)
DE69526973T3 (en) SEQUENCES OF HEPATITIS C-VIRUS GENOTYPE 7, AND THEIR USE AS PREVENTIVE, THERAPEUTIC AND DIAGNOSTIC AGENTS
Ridpath et al. Segregation of bovine viral diarrhea virus into genotypes
DE69033425T3 (en) HCV isolate J-1
WO1998050554A3 (en) Enterococcus faecalis polynucleotides and polypeptides
CA2005291A1 (en) Feline infectious peritonitis virus diagnostic tools
EP1167542A3 (en) Probe for diagnosing infectious disease arising from Enterococcus faecalis
CA2108466A1 (en) Hcv genomic sequences for diagnostics and therapeutics
ATE366314T1 (en) INFECTIOUS RNA VIRUS CLONES, VACCINES AND DERIVED DIAGNOSTIC ASSAY
EP1197568A3 (en) Detection and typing of HCV using 5'UTR and NS5 nucleic acid sequences
RU93058449A (en) HCV GENOMIC SEQUENCES FOR DIAGNOSTIC AND THERAPEUTIC PURPOSES
UA27788C2 (en) Composition comprising the causative lelystad agent, vaccine composition for animal vaccination (variants) and diagnostic kit for antibody detection
EP0984068A3 (en) Sequences of hepatitis c virus genotypes and their use as therapeutic and diagnostic agents
ATE420190T1 (en) RECOMBINANT LIVE VACCINE CONTAINING FELINE HERPES VIRUS TYPE I, ESPECIALLY FOR THE TREATMENT OF INFECTIOUS PERIMONITIS IN CATS
CA2215328A1 (en) Novel human cytomegalovirus dna sequences
US20020081574A1 (en) Methods for identifying inhibitors of helicase C virus
EP0297378A3 (en) 2,5-dihydropyrroles
BR9815285A (en) Alphaviruses for paramyxoviruses vaccine
AU5322800A (en) Cloned genone of infectious hepatitis c virus of genotype 2a and uses thereof
RU96122169A (en) NON-SPLICING OPTIONS GP350 / 220
CA2226457A1 (en) Oligonucleotides specific for human papilloma virus
CA2066998A1 (en) Recombinant varicella-zoster virus and process for constructing same
AU4136797A (en) Novel semaphorin gene: semaphorin y
WO1999004029A3 (en) A swine hepatitis e virus and uses thereof
CA2198743A1 (en) Feline infectious peritonitis vaccine