[go: up one dir, main page]

BE2010C019I2 - - Google Patents

Download PDF

Info

Publication number
BE2010C019I2
BE2010C019I2 BE2010C019C BE2010C019C BE2010C019I2 BE 2010C019 I2 BE2010C019 I2 BE 2010C019I2 BE 2010C019 C BE2010C019 C BE 2010C019C BE 2010C019 C BE2010C019 C BE 2010C019C BE 2010C019 I2 BE2010C019 I2 BE 2010C019I2
Authority
BE
Belgium
Application number
BE2010C019C
Other languages
French (fr)
Original Assignee
Ucb Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9893121&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BE2010C019(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ucb Pharma Sa filed Critical Ucb Pharma Sa
Publication of BE2010C019I2 publication Critical patent/BE2010C019I2/fr

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6845Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a cytokine, e.g. growth factors, VEGF, TNF, a lymphokine or an interferon
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6875Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody being a hybrid immunoglobulin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241Tumor Necrosis Factors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Compression Of Band Width Or Redundancy In Fax (AREA)
BE2010C019C 2000-06-06 2010-04-13 BE2010C019I2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0013810.7A GB0013810D0 (en) 2000-06-06 2000-06-06 Biological products
PCT/GB2001/002477 WO2001094585A1 (en) 2000-06-06 2001-06-05 Antibody molecules having specificity for human tumor necrosis factor alpha, and use thereof

Publications (1)

Publication Number Publication Date
BE2010C019I2 true BE2010C019I2 (en) 2020-08-20

Family

ID=9893121

Family Applications (1)

Application Number Title Priority Date Filing Date
BE2010C019C BE2010C019I2 (en) 2000-06-06 2010-04-13

Country Status (42)

Country Link
US (4) US7012135B2 (en)
EP (4) EP2308975B1 (en)
JP (3) JP4064812B2 (en)
KR (1) KR20020047097A (en)
CN (1) CN1289671C (en)
AP (1) AP2092A (en)
AR (1) AR033978A1 (en)
AT (1) ATE451460T1 (en)
AU (1) AU783756B2 (en)
BE (1) BE2010C019I2 (en)
BG (1) BG66072B1 (en)
BR (2) BR0106682A (en)
CA (2) CA2707766C (en)
CY (6) CY1109889T1 (en)
CZ (1) CZ300737B6 (en)
DE (3) DE122010000027I1 (en)
DK (4) DK3059314T3 (en)
EC (1) ECSP024210A (en)
ES (5) ES2600080T3 (en)
FR (1) FR10C0015I2 (en)
GB (2) GB0013810D0 (en)
HU (4) HU230553B1 (en)
IL (3) IL147992A0 (en)
IS (2) IS2808B (en)
LT (1) LT2308975T (en)
LU (1) LU91674I2 (en)
MX (1) MXPA01013440A (en)
MY (1) MY136603A (en)
NL (1) NL300982I9 (en)
NO (4) NO334808B1 (en)
NZ (1) NZ516596A (en)
OA (1) OA12282A (en)
PE (1) PE20020292A1 (en)
PL (2) PL212738B1 (en)
PT (4) PT2230308E (en)
RU (1) RU2303604C2 (en)
SI (3) SI2230308T1 (en)
SK (1) SK288343B6 (en)
TR (1) TR201900227T4 (en)
TW (2) TWI353358B (en)
WO (1) WO2001094585A1 (en)
ZA (1) ZA200200097B (en)

Families Citing this family (111)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0013810D0 (en) 2000-06-06 2000-07-26 Celltech Chiroscience Ltd Biological products
CA2385745C (en) 2001-06-08 2015-02-17 Abbott Laboratories (Bermuda) Ltd. Methods of administering anti-tnf.alpha. antibodies
US20060073141A1 (en) * 2001-06-28 2006-04-06 Domantis Limited Compositions and methods for treating inflammatory disorders
GB0129105D0 (en) * 2001-12-05 2002-01-23 Celltech R&D Ltd Expression control using variable intergenic sequences
EP1495056B1 (en) * 2002-03-20 2011-03-02 UCB Pharma, S.A. Methods of analyzing antibody disulfide isomers
US20040009172A1 (en) * 2002-04-26 2004-01-15 Steven Fischkoff Use of anti-TNFalpha antibodies and another drug
GB0210121D0 (en) 2002-05-02 2002-06-12 Celltech R&D Ltd Biological products
ES2916174T3 (en) * 2002-05-02 2022-06-28 Wyeth Holdings Llc Calicheamicin-derived transporter conjugates
AU2003240790A1 (en) * 2002-05-28 2003-12-12 Pharmacia Corporation Antibody peg positional isomers, compositions comprising same, and use thereof
US9321832B2 (en) 2002-06-28 2016-04-26 Domantis Limited Ligand
BR0312785A (en) * 2002-07-19 2005-08-30 Abbott Biotech Ltd Treatment of Tnf-related disorders (alpha)
AU2003276844A1 (en) * 2002-08-28 2004-03-19 Pharmacia Corporation Formulations of modified antibodies and methods of making the same
WO2004019861A2 (en) * 2002-08-28 2004-03-11 Pharmacia Corporation Stable ph optimized formulation of a modified antibody
US20040105858A1 (en) * 2002-08-29 2004-06-03 Kim Joanne Young Hee Kwak Diagnosis and treatment of infertility
MY150740A (en) 2002-10-24 2014-02-28 Abbvie Biotechnology Ltd Low dose methods for treating disorders in which tnf? activity is detrimental
CA2503697A1 (en) 2002-10-29 2004-05-13 Borean Pharma A/S Trimeric binding proteins for trimeric cytokines
EP1578799B8 (en) 2002-12-02 2011-03-23 Amgen Fremont Inc. Antibodies directed to tumor necrosis factor and uses thereof
US7101978B2 (en) 2003-01-08 2006-09-05 Applied Molecular Evolution TNF-α binding molecules
US7575893B2 (en) * 2003-01-23 2009-08-18 Genentech, Inc. Methods for producing humanized antibodies and improving yield of antibodies or antigen binding fragments in cell culture
GB0303337D0 (en) * 2003-02-13 2003-03-19 Celltech R&D Ltd Biological products
WO2004074345A2 (en) * 2003-02-19 2004-09-02 Pharmacia Corporation Carbonate esters of polyethylene glycol activated by means of oxalate esters
WO2004098578A2 (en) * 2003-05-12 2004-11-18 Altana Pharma Ag Composition comprising a pde4 inhibitor and a tnf-alfa antagonist selected from infliximab, adalimumab, cdp870 and cdp517
AU2004220325B2 (en) * 2003-06-30 2011-05-12 Domantis Limited Polypeptides
WO2005014649A2 (en) * 2003-08-08 2005-02-17 Pharmacia Corporation Method for the preparation of molecules having antibody activity
SI1656455T1 (en) * 2003-08-13 2012-12-31 Sandoz Ag Process for the purification of recombinant polypeptides
US7785830B2 (en) * 2003-08-13 2010-08-31 Sandoz Ag Expression vectors, transformed host cells and fermentation process for the production of recombinant polypeptides
GB0319601D0 (en) 2003-08-20 2003-09-24 Sandoz Ag Production process
KR100570422B1 (en) * 2003-10-16 2006-04-11 한미약품 주식회사 Expression vectors for secreting and producing antibody fragments using E. coli secretion sequences and methods for mass production of antibody fragments using the same
CN100393748C (en) * 2003-11-06 2008-06-11 上海中信国健药业有限公司 Human tumour necrosin antibody, its preparation and medicinal composition
KR100772800B1 (en) * 2003-11-17 2007-11-01 주식회사유한양행 Variable regions of monoclonal antibodies that recognize human tumor necrosis factor α and genes encoding them
US7435799B2 (en) 2004-01-08 2008-10-14 Applied Molecular Evolution TNF-α binding molecules
CN100427504C (en) * 2004-06-02 2008-10-22 北京天广实生物技术有限公司 TNFα high-affinity chimeric antibody and use thereof
JP2008504356A (en) * 2004-06-30 2008-02-14 ドマンティス リミテッド Compositions and methods for treating inflammatory diseases
GB0425972D0 (en) * 2004-11-25 2004-12-29 Celltech R&D Ltd Biological products
US8022040B2 (en) * 2004-11-29 2011-09-20 The Regents Of The University Of California Hydroxyapatite-binding peptides for bone growth and inhibition
ATE499385T1 (en) * 2004-12-29 2011-03-15 Yuhan Corp TUMOR NECROSIS FACTOR-ALPHA SPECIFIC HUMANIZED ANTIBODIES
MX2007014440A (en) 2005-05-16 2008-02-11 Abbott Biotech Ltd Use of tnf inhibitor for treatment of erosive polyarthritis.
CN101189265B (en) * 2005-06-01 2012-07-04 米克罗麦特股份公司 Anti-il2 antibodies
EP3260465A1 (en) 2005-06-07 2017-12-27 ESBATech, an Alcon Biomedical Research Unit LLC Stable and soluble antibodies inhibiting tnf-alpha
GB0520169D0 (en) * 2005-10-04 2005-11-09 Celltech R&D Ltd Biological products
CA2648582C (en) 2006-04-07 2016-12-06 Nektar Therapeutics Al, Corporation Conjugates of an anti-tnf-alpha antibody
US9605064B2 (en) 2006-04-10 2017-03-28 Abbvie Biotechnology Ltd Methods and compositions for treatment of skin disorders
EP2007426A4 (en) * 2006-04-10 2010-06-16 Abbott Biotech Ltd Uses and compositions for treatment of psoriatic arthritis
EP2010214A4 (en) 2006-04-10 2010-06-16 Abbott Biotech Ltd Uses and compositions for treatment of rheumatoid arthritis
US20080131374A1 (en) * 2006-04-19 2008-06-05 Medich John R Uses and compositions for treatment of rheumatoid arthritis
CA2656347A1 (en) 2006-07-03 2008-01-10 Charles David Adair Composition for modulating the expression of cell adhesion molecules
EP1914242A1 (en) * 2006-10-19 2008-04-23 Sanofi-Aventis Novel anti-CD38 antibodies for the treatment of cancer
ES2350029T3 (en) * 2007-03-02 2011-01-17 Farnam Companies, Inc. SUSTAINED RELEASE PELLETS THAT INCLUDE A WAX TYPE MATERIAL.
US20080305115A1 (en) * 2007-06-07 2008-12-11 Tice Thomas R Reduced-mass, long-acting dosage forms
EP2171451A4 (en) 2007-06-11 2011-12-07 Abbott Biotech Ltd Methods for treating juvenile idiopathic arthritis
US8865875B2 (en) 2007-08-22 2014-10-21 Medarex, L.L.C. Site-specific attachment of drugs or other agents to engineered antibodies with C-terminal extensions
WO2015164330A1 (en) 2014-04-21 2015-10-29 Millennium Pharmaceuticals, Inc. Anti-psyk antibody molecules and use of same for syk-targeted therapy
US20110002927A1 (en) * 2008-02-05 2011-01-06 Delenex Therapeutics Ag Antigen-binding polypeptides against cartilage degeneration
EP2279207B1 (en) * 2008-05-07 2015-09-09 Argos Therapeutics, Inc. Humanized antibodies against human interferon-alpha
ES2677003T3 (en) 2008-06-25 2018-07-27 Esbatech, An Alcon Biomedical Research Unit Llc Humanization of rabbit antibodies using a universal antibody framework
ES2890405T3 (en) 2008-06-25 2022-01-19 Novartis Ag Humanization of rabbit antibodies using a universal antibody framework
CN102076716A (en) * 2008-06-25 2011-05-25 艾斯巴技术,爱尔康生物医药研究装置有限责任公司 Stable and soluble antibodies that inhibit TNFα
DK2307454T3 (en) 2008-06-25 2017-04-24 Esbatech Alcon Biomed Res Unit Stable and soluble antibodies that inhibit VEGF
CN101684156B (en) * 2008-09-27 2011-12-28 苏州工业园区晨健抗体组药物开发有限公司 Human TNF alpha monoclonal antibody, PEGylation nanoparticle and application thereof
RU2011135768A (en) * 2009-01-29 2013-03-10 Эбботт Лэборетриз PROTEINS BINDING IL-1
US20110165063A1 (en) * 2009-01-29 2011-07-07 Abbott Laboratories Il-1 binding proteins
US9150640B2 (en) 2009-07-10 2015-10-06 Ablynx N.V. Method for the production of variable domains
LT2993231T (en) 2009-09-24 2018-11-12 Ucb Biopharma Sprl BACTERIA CAMPAIGN WITH PROTEASE-PRODUCING FUEL WITH SUSPENSIONED SAPERONIC ACTIVITY AND RECOVERED TSP AND PTR GENUS
CA3031851C (en) 2009-10-23 2020-07-07 Amgen British Columbia Anti-gcc antibody molecules and related compositions and methods
GB201000591D0 (en) 2010-01-14 2010-03-03 Ucb Pharma Sa Bacterial hoist strain
GB201000590D0 (en) 2010-01-14 2010-03-03 Ucb Pharma Sa Bacterial host strain
GB201000588D0 (en) 2010-01-14 2010-03-03 Ucb Pharma Sa Bacterial host strain
GB201000587D0 (en) 2010-01-14 2010-03-03 Ucb Pharma Sa Bacterial hoist strain
GB201001791D0 (en) * 2010-02-03 2010-03-24 Ucb Pharma Sa Process for obtaining antibodies
BR112012022342A2 (en) 2010-03-04 2017-02-14 Vet Therapeutics Inc cd52 targeted monoclonal antibodies
US9616120B2 (en) 2010-03-04 2017-04-11 Vet Therapeutics, Inc. Monoclonal antibodies directed to CD20
PH12012501991A1 (en) 2010-04-07 2017-07-26 Abbvie Inc Tnf-alpha binding proteins
GB201012603D0 (en) * 2010-07-27 2010-09-08 Ucb Pharma Sa Protein purification
GB201012599D0 (en) 2010-07-27 2010-09-08 Ucb Pharma Sa Process for purifying proteins
GB201012784D0 (en) * 2010-07-29 2010-09-15 Ucb Pharma Sa Method
TWI538918B (en) 2010-10-20 2016-06-21 財團法人工業技術研究院 Humanized monoclonal antibody, nucleotide sequence thereof, and use thereof
UY33679A (en) 2010-10-22 2012-03-30 Esbatech STABLE AND SOLUBLE ANTIBODIES
WO2012164083A1 (en) 2011-06-01 2012-12-06 Actogenix N.V. Polycistronic expression system for bacteria
EP2546267A1 (en) 2011-07-13 2013-01-16 UCB Pharma S.A. Bacterial host strain expressing recombinant DsbC
EP2731973B1 (en) 2011-07-13 2017-11-15 UCB Biopharma SPRL Bacterial host strain expressing recombinant dsbc
EP2758513B1 (en) 2011-09-23 2018-05-16 Intrexon Actobiotics NV Modified gram positive bacteria and uses thereof
WO2013041672A1 (en) 2011-09-23 2013-03-28 Actogenix Nv Modified gram positive bacteria and uses thereof
WO2013087914A1 (en) 2011-12-16 2013-06-20 Synthon Biopharmaceuticals B.V. EXPRESSION OF SECRETORY IgA ANTIBODIES IN DUCKWEED
US9156915B2 (en) 2012-04-26 2015-10-13 Thomas Jefferson University Anti-GCC antibody molecules
GB201208367D0 (en) 2012-05-14 2012-06-27 Ucb Pharma Sa Biological product
KR102193080B1 (en) 2012-08-13 2020-12-18 제넨테크, 인크. Anti-jagged antibodies and methods of use
WO2016065042A1 (en) 2014-10-22 2016-04-28 Extend Biosciences, Inc. Therapeutic vitamin d conjugates
WO2016065052A1 (en) 2014-10-22 2016-04-28 Extend Biosciences, Inc. Insulin vitamin d conjugates
SI3237433T1 (en) 2014-12-22 2025-11-28 UCB Biopharma SRL Method of protein manufacture
US11091559B2 (en) 2015-08-27 2021-08-17 Celldex Therapeutics, Inc. Anti-ALK antibodies and methods for use thereof
GB201522394D0 (en) 2015-12-18 2016-02-03 Ucb Biopharma Sprl Antibodies
CN108883140A (en) 2016-01-14 2018-11-23 英特瑞克斯顿阿克图比奥帝克斯有限公司 Compositions and methods for treating type 1 diabetes
RU2680011C2 (en) * 2016-04-29 2019-02-14 Закрытое Акционерное Общество "Биокад" Trispecific il-17a, il-17f and other proinflammatory molecules antibodies
PE20190622A1 (en) * 2016-06-02 2019-04-26 Abbvie Inc GLUCOCORTICOID AND IMMUNOCONJUGATE RECEPTOR AGONIST OF THE SAME
EP3824906A1 (en) 2016-12-21 2021-05-26 Amgen Inc. Anti-tnf alpha antibody formulations
HUE054428T2 (en) 2017-12-01 2021-09-28 Abbvie Inc Glucocorticoid receptor agonist and its immunoconjugates
SG11202107995SA (en) 2019-01-31 2021-08-30 Numab Therapeutics AG Multispecific antibodies having specificity for tnfa and il-17a, antibodies targeting il-17a, and methods of use thereof
KR102323342B1 (en) 2019-04-26 2021-11-08 주식회사 와이바이오로직스 Bispecific Antibody Against IL-17A and TNF-α
CN111909268B (en) * 2019-05-07 2022-04-19 北京天成新脉生物技术有限公司 anti-TNF-alpha humanized monoclonal antibody TCX060 with low immunogenicity and low ADCC/CDC function and application thereof
TW202237639A (en) 2020-12-09 2022-10-01 日商武田藥品工業股份有限公司 Compositions of guanylyl cyclase c (gcc) antigen binding agents and methods of use thereof
TW202237638A (en) 2020-12-09 2022-10-01 日商武田藥品工業股份有限公司 Compositions of guanylyl cyclase c (gcc) antigen binding agents and methods of use thereof
MX2023009497A (en) 2021-02-15 2023-08-23 Takeda Pharmaceuticals Co COMPOSITIONS AND METHODS OF CELLULAR THERAPY TO MODULATE THE SIGNALING OF TRANSFORMING GROWTH FACTOR-BETA (TGF-BETA).
CN120463762A (en) 2021-08-26 2025-08-12 映恩生物科技(上海)有限公司 A steroid compound and its conjugate
EP4405473A1 (en) 2021-09-24 2024-07-31 Xbrane Biopharma AB Dna constructs and host cells for expressing recombinant protein
SE545694C2 (en) * 2021-09-24 2023-12-05 Xbrane Biopharma Ab Dna construct comprising nucleotide sequences encoding amino acid sequences of certolizumab and pelb signal peptides
SE545714C2 (en) * 2021-09-24 2023-12-19 Xbrane Biopharma Ab Dna contructs for producing a pelb signal peptide
WO2023154799A1 (en) 2022-02-14 2023-08-17 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Combination immunotherapy for treating cancer
AU2023353057A1 (en) 2022-09-30 2025-05-01 Extend Biosciences, Inc. Long-acting parathyroid hormone
EP4673455A1 (en) * 2023-03-01 2026-01-07 Lupin Limited Process for manufacturing antibody fragment protein
WO2025049345A1 (en) 2023-08-25 2025-03-06 Proteologix Us Inc. Anti-il-13 multispecific antibody constructs and uses thereof
WO2025099576A1 (en) 2023-11-06 2025-05-15 Momenta Pharmaceuticals, Inc. Compositions and methods for treating rheumatoid arthritis

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8422238D0 (en) 1984-09-03 1984-10-10 Neuberger M S Chimeric proteins
DK336987D0 (en) 1987-07-01 1987-07-01 Novo Industri As immobilization
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
GB8719042D0 (en) 1987-08-12 1987-09-16 Parker D Conjugate compounds
US5030570A (en) 1988-06-30 1991-07-09 The Eunice Kennedy Shriver Center For Mental Retardation DNA encoding and method of expressing human monoamine oxidase type A
IL162181A (en) 1988-12-28 2006-04-10 Pdl Biopharma Inc A method of producing humanized immunoglubulin, and polynucleotides encoding the same
PT92900A (en) * 1989-01-24 1990-07-31 EXPRESSION VECTOR SYSTEM FOR THE PRODUCTION OF QUIMERIC MONOCLONAL ANTIBODIES
GB8907617D0 (en) 1989-04-05 1989-05-17 Celltech Ltd Drug delivery system
GB8928874D0 (en) 1989-12-21 1990-02-28 Celltech Ltd Humanised antibodies
GB9109645D0 (en) * 1991-05-03 1991-06-26 Celltech Ltd Recombinant antibodies
US5919452A (en) 1991-03-18 1999-07-06 New York University Methods of treating TNFα-mediated disease using chimeric anti-TNF antibodies
GB9112536D0 (en) 1991-06-11 1991-07-31 Celltech Ltd Chemical compounds
GB9120467D0 (en) 1991-09-26 1991-11-06 Celltech Ltd Anti-hmfg antibodies and process for their production
DE69405102T2 (en) * 1993-06-03 1998-01-15 Therapeutic Antibodies, Inc., Nashville, Tenn. ANTIBODY FRAGMENTS IN THERAPY
NO309690B1 (en) 1995-01-23 2001-03-12 Western Atlas Int Inc Detonator type exploding wire for use with a perforation tool in a well
AU2365795A (en) 1995-04-20 1996-11-07 Centocor Inc. Multiple administrations of anti-tnf antibody
US6258562B1 (en) 1996-02-09 2001-07-10 Basf Aktiengesellschaft Human antibodies that bind human TNFα
US5980898A (en) 1996-11-14 1999-11-09 The United States Of America As Represented By The U.S. Army Medical Research & Material Command Adjuvant for transcutaneous immunization
GB9625640D0 (en) * 1996-12-10 1997-01-29 Celltech Therapeutics Ltd Biological products
WO1999009055A2 (en) * 1997-08-18 1999-02-25 Innogenetics N.V. Interferon-gamma-binding molecules for treating septic shock, cachexia, immune diseases and skin disorders
GB9720054D0 (en) * 1997-09-19 1997-11-19 Celltech Therapeutics Ltd Biological products
ES2222689T3 (en) 1998-03-12 2005-02-01 Nektar Therapeutics Al, Corporation DERIVATIVES OF POLYETHYLENE GLYCOL WITH PROXIMAL REACTIVE GROUPS.
GB9812545D0 (en) * 1998-06-10 1998-08-05 Celltech Therapeutics Ltd Biological products
GB0013810D0 (en) * 2000-06-06 2000-07-26 Celltech Chiroscience Ltd Biological products

Also Published As

Publication number Publication date
GB0013810D0 (en) 2000-07-26
DK2230308T3 (en) 2013-05-06
DE10192353T1 (en) 2003-05-22
HUP1600016A2 (en) 2002-10-28
NO341218B1 (en) 2017-09-11
AP2092A (en) 2010-02-28
HU230561B1 (en) 2016-12-28
GB2366800B (en) 2005-01-19
DE60140738D1 (en) 2010-01-21
TWI353358B (en) 2011-12-01
LT2308975T (en) 2016-11-10
CY1109889T1 (en) 2012-01-25
DK3059314T3 (en) 2019-02-18
CY1118220T1 (en) 2017-06-28
WO2001094585A1 (en) 2001-12-13
LU91674I2 (en) 2010-05-31
ES2403217T3 (en) 2013-05-16
EP2230308B1 (en) 2013-01-23
NO2014026I2 (en) 2018-02-14
BG66072B1 (en) 2011-01-31
PT2308975T (en) 2016-11-14
MXPA01013440A (en) 2003-09-04
HU230669B1 (en) 2017-07-28
IS2808B (en) 2012-09-15
ES2337763T3 (en) 2010-04-29
ZA200200097B (en) 2003-01-06
HUP0202346A2 (en) 2002-10-28
CY1114143T1 (en) 2016-07-27
US20060233800A1 (en) 2006-10-19
CY2019018I1 (en) 2020-05-29
SI1287140T1 (en) 2010-04-30
CA2707766C (en) 2013-05-21
CZ2002837A3 (en) 2002-05-15
IS3016B (en) 2019-10-15
HUP0202346A3 (en) 2004-11-29
BRPI0106682B1 (en) 2020-10-13
JP4476989B2 (en) 2010-06-09
EP2308975A1 (en) 2011-04-13
PL353960A1 (en) 2003-12-15
ES2707714T3 (en) 2019-04-04
DK1287140T3 (en) 2010-04-19
CN1383450A (en) 2002-12-04
AR033978A1 (en) 2004-01-21
HU230553B1 (en) 2016-11-28
PE20020292A1 (en) 2002-05-08
CA2707766A1 (en) 2001-12-13
ES2230975B2 (en) 2007-04-16
BR0106682A (en) 2002-05-14
FR10C0015I1 (en) 2010-04-16
PT3059314T (en) 2019-02-01
US7402662B2 (en) 2008-07-22
US7186820B2 (en) 2007-03-06
JP2003535591A (en) 2003-12-02
NO20020554L (en) 2002-04-08
SK3152002A3 (en) 2002-07-02
US7012135B2 (en) 2006-03-14
US20020151682A1 (en) 2002-10-17
OA12282A (en) 2006-05-11
LU91674I9 (en) 2019-01-03
HK1051385A1 (en) 2003-08-01
BRPI0106682B8 (en) 2021-05-25
NO20020554D0 (en) 2002-02-04
HK1148776A1 (en) 2011-09-16
CY2010011I1 (en) 2012-01-25
HUP1600483A2 (en) 2002-10-28
IL147992A0 (en) 2002-09-12
NZ516596A (en) 2004-07-30
TR201900227T4 (en) 2019-02-21
PL399351A1 (en) 2012-12-17
ES2600080T3 (en) 2017-02-07
NL300982I1 (en) 2019-05-01
AU6051101A (en) 2001-12-17
NO339282B1 (en) 2016-11-21
DK2308975T3 (en) 2016-10-31
CY2019018I2 (en) 2020-05-29
JP5185143B2 (en) 2013-04-17
NO20131316L (en) 2002-04-08
PL218516B1 (en) 2014-12-31
EP2308975B1 (en) 2016-08-10
MY136603A (en) 2008-10-31
ES2230975A1 (en) 2005-05-01
SK288343B6 (en) 2016-04-01
HUS1700013I1 (en) 2017-08-28
TW200817430A (en) 2008-04-16
NL300982I9 (en) 2019-05-06
JP2007105043A (en) 2007-04-26
EP2230308A1 (en) 2010-09-22
IL147992A (en) 2009-06-15
IL195085A0 (en) 2009-08-03
AU783756B2 (en) 2005-12-01
GB2366800A (en) 2002-03-20
EP3059314B1 (en) 2018-10-24
JP2009171966A (en) 2009-08-06
CA2380298C (en) 2010-09-28
CZ300737B6 (en) 2009-07-29
EP1287140A1 (en) 2003-03-05
PT2230308E (en) 2013-05-03
RU2303604C2 (en) 2007-07-27
KR20020047097A (en) 2002-06-21
CY1121173T1 (en) 2020-05-29
NO334808B1 (en) 2014-06-02
EP1287140B1 (en) 2009-12-09
NO20160694A1 (en) 2002-04-08
TWI316088B (en) 2009-10-21
EP3059314A1 (en) 2016-08-24
SI2308975T1 (en) 2016-11-30
BG106278A (en) 2002-12-29
CA2380298A1 (en) 2001-12-13
ECSP024210A (en) 2002-05-23
FR10C0015I2 (en) 2011-12-30
GB0128386D0 (en) 2002-01-16
ATE451460T1 (en) 2009-12-15
CY2010011I2 (en) 2012-01-25
CN1289671C (en) 2006-12-13
US20030026805A1 (en) 2003-02-06
US20080269465A1 (en) 2008-10-30
NO2014026I1 (en) 2014-10-23
JP4064812B2 (en) 2008-03-19
DE122010000027I1 (en) 2010-08-12
US7977464B2 (en) 2011-07-12
SI2230308T1 (en) 2013-06-28
PL212738B1 (en) 2012-11-30
IS6217A (en) 2002-01-03
PT1287140E (en) 2010-03-08
AP2002002690A0 (en) 2002-12-31

Similar Documents

Publication Publication Date Title
BE2017C009I2 (en)
BE2016C018I2 (en)
BE2014C019I2 (en)
BE2012C016I2 (en)
BE2010C019I2 (en)
BRPI0113420B8 (en)
BRPI0113085B8 (en)
JP2002169896A5 (en)
BRPI0113372A8 (en)
CH694022C1 (en)
CN3135585S (en)
CN3139848S (en)
AU2000280388A8 (en)
CL2001002979A1 (en)
CN3133951S (en)
CN3134542S (en)
CN3135469S (en)
CN3135488S (en)
CN3135489S (en)
CN3135513S (en)
CN3135563S (en)
AU2000280296A8 (en)
CN3135789S (en)
CN3136721S (en)
CN3137473S (en)