BE1022329B1 - AQUEOUS COMPOSITIONS CONTAINING HYDROLATES - Google Patents

Abstract

The present invention relates to aqueous compositions containing hydrosols, characterized in that they comprise: - at least one hydrosol whose action is chosen from decongestant, antimicrobial, antiviral, antifungal, antispasmodic, stimulating, soothing, fluidifying actions. , antiallergic, cough suppressant and healing, - sodium chloride, - one or more trace elements, - a humectant, - one or more vitamins. The compositions according to the invention can be used in the treatment of disorders and affections of the nasopharyngeal sphere, of the bronchopulmonary system or of the skin.

Description

AQUEOUS COMPOSITIONS CONTAINING HYDROLATES

The present invention relates, in general, to aqueous compositions comprising, as active ingredient, hydrolates as well as to their process of preparation and their use.

More particularly, the invention relates to aqueous compositions containing hydrolates useful in the pharmaceutical, cosmetic or hygienic field.

Hydrolates are natural products obtained from the distillation of plants by steam distillation. They possess the same aromatic molecules as the essential oils harvested during this distillation as well as the same active ingredients but in a much reduced concentration (60 to 150 mg / l). However, during distillation, too water-soluble molecules are not found in the essential oil but in the aqueous phase of the hydrosol. In addition, the hydrolates have properties similar to those of essential oils and their use for the treatment of various disorders or physiological disorders has been known for a very long time.

Thus, US Patent Application No. 2003/0225394 discloses an aromatic composition for nasal administration comprising: from 0.1% to about 99.4% of a pharmaceutically acceptable salt solution comprising 0.5% to 1% , 9% of a salt, preferably 0.9% of this salt, from 0.02% to 0.10% of sesame oil having a lubricating, antiseptic and decongestant action; and from 0.003% to 0.040% of an essential oil chosen from the group consisting of peppermint oil and eucalyptus oil (antiseptic, cleaning, preventive action against the development of pathogenic bacteria). On the other hand, nasal, broncho-pulmonary or cutaneous administrative compositions comprising hydrolates or essential oils in very low concentrations are currently marketed. By way of examples, mention may be made of the following compositions intended for nasal administration: A. - isotonic physiological saline - extracts of propolis (2%) - extracts of thyme (2%), rosemary (2%), eucalyptus (2%) %), white nettle (2%), - oily macerate of sulfur (sulfur hydrosol)

This composition should be administered 3 to 4 times daily at a rate of 4 to 5 sprays per nostril for each administration. B. For a composition of 20 ml: - 0.9% isotonic sea salt solution, - essential oils ie eucalyptus (10 mg or 0.05%)), thyme (10 mg or 0.05%), tree tea (10 mg), niaouli (10 mg) and mint (10 mg), - trace elements namely copper gluconate (1.42 mg or 0.07%) and manganese gluconate (2.66 mg or 0.133%) - benzalkonium chloride

This composition should be administered 4 to 6 times per day with one spray in each nostril. C. - hypertonic solution with Himalayan salt - essential oil of mandravasarotra, black spruce, eucalyptus, rockrose, myrtle, geranium

The recommended dosage is 1 to 4 sprays in each nostril up to 5 times per day.

These examples show that to obtain ungQi; effective therapeutic coverage during a day, it is necessary to perform multiple administrations, at least 3 and an average of 4 administrations and this, several spraying, usually 3 to 4 sprays, in each nostril at each administration.

The present invention aims to provide aqueous compositions capable of overcoming these disadvantages in that they require only a minimum of daily administrations and a minimum of spraying in each nostril during each administration.

Accordingly, the invention relates to aqueous compositions containing hydrolats, characterized in that they comprise: at least one hydrosol chosen from hydrolates having a decongestant action, hydrolates having an antimicrobial action, hydrolates having an action antiviral, hydrolates having antifungal action, hydrolates having an antispasmodic action, hydrolates having a stimulating action, hydrolates having a soothing action, hydrolates having a fluidizing action, hydrolates having an antiallergic action, hydrolates having antitussive action and hydrolates having a cicatrizing action, - sodium chloride, - one or more trace elements, - a humectant, - one or more vitamins.

These compositions according to the invention, which will be referred to hereinafter as "formulation compositions A", can be used internally essentially for nasal administration or broncho-pulmonary administration or externally, that is, say for cutaneous administration. Cels-c: 20i3 preferably in the form of spray solutions (spray, aerosol), may find application in the nasopharyngeal sphere to treat for example colds, allergic rhinitis or bleeding from the nose, in the bronchopulmonary system especially for treat oily, dry or spasmodic coughs or in the cutaneous domain, for example to treat infected or uninfected wounds, mycoses, itching or eczema. These spray solutions are usually packaged in a nebulizing device to be delivered as a spray or aerosol in a nasal or broncho-pulmonary or cutaneous administration. A. Formulation compositions A may comprise from 1 to 10 different hydrolates which will bring a total weight, in general, from 25 mg to 130 mg of essential oil per liter of hydrolates, which is equivalent to a concentration of 25.10%. 4% to 130.10-4% in essential oil.

These hydrolates are usually natural hydrolates or reconstituted hydrolates.

By "natural hydrolates" is meant the hydrolates corresponding to the products obtained directly by distillation (steam distillation) of a fresh plant whether it be fruits, leaves, roots or flowers which, according to the species , comprise physiologically acceptable active and / or nutritive ingredients. These natural hydrolats retain in solution the hydrophilic elements but also hydrophobic elements. In addition to a minimal concentration of essential oil, these natural hydrolats also contain other heavy products such as metals, metalloids, mucilages or trace elements.

Similarly, "reconstituted hydrolates" refers to the hydrolates obtained by adding a low concentration of essential oil to an aqueous phase: generally a concentration similar to that of the natural hydrolate.

In the context of the present description and the claims, the general term "hydrosol" will be used to designate both a natural hydrolate and a reconstituted hydrosol.

The hydrolates used in the compositions of formulation A have various properties which will be exploited according to the therapeutic objective pursued and as a function of the destination reserved for these compositions, that is to say a nasal, broncho-pulmonary or cutaneous administration.

Thus, the following hydrolats will bring the benefits mentioned below: * Decongestant hydrolate: causes a contraction of the blood vessels in the nasal cavity or sinuses. * Antimicrobial Hydrolat: Kills microbes or slows their growth. * Antiviral Hydrolat: Slows down and eventually stops a viral infection. * Antispasmodic Hydrolat: Calms or neutralizes involuntary muscle contractions. * Stimulating Hydrolat: speeds up the process of healing. * Soothing Hydrolat: provides relief from the situation felt, for example brings a feeling of freshness in case of burn. * Antitussive Hydrolat: decreases the reflex of coughing. * Thinner: makes fluid nasal and / or bronchial secretions. * Antiallergic hydrolate: fight against different manifestations of allergy. * Antifungal Hydrolat: fight against infections caused by microscopic fungi and deg®i3 yeasts. * Hydrolat healing: stimulates the healing of wounds.

The plants, which give rise to the hydrolates used in the compositions according to the invention, are particularly useful in the treatment of disorders or conditions occurring in particular in the airways, broncho-pulmonary or skin. It will be, more generally, any plant, plant extract or part of plant containing active ingredients useful in this treatment. Any plant or part of a plant meeting this criterion can be used in particular fruits, roots, flowers or leaves depending on the species.

Thus, the families of hydrolates below, which are endowed with the properties indicated, can be obtained, by way of non-limiting examples, from the plants listed: * Decongesting hydrolates: mint, eucalyptus, tea tree, * Hydrolats antimicrobials: cinnamon, tea tree, rosemary, oregano, ravintsara, * antiviral hydrolates: niaouli, laurel, ravintsara, * antispasmodic hydrosols: tarragon, basil, * stimulating hydrosities: vanilla, black spruce, thyme, * soothing hydrolys: chamomile, lavender , * Hydrolats antitussifs: khella, * Hydrolats fluidifying: inule, * Hydrolats antiallergic: tarragon, tansy, * Antifungal hydrolates: cinnamon, palmarosa, * Hydrolats cicatrisants: rockrose, petit grain bigarade, geranium, balm of Peru.

Each formulation composition A may comprise hydrolates from one or more families defined above. On the other hand, the compositions of formulation A, whether they contain natural hydrolates, reconstituted hydrolates or a mixture of both, will be free of preservatives such as benzalkonium chloride, which will limit the duration of use a few days. However, the use of reconstituted hydrolates instead of natural hydrolates will extend the life of the composition until about two months before its expiration. B. - Sodium chloride in the presence of water, for example the so-called "physiological saline" solution, has in particular the property of cleaning the mucosa or the skin and, at the level of the nasopharyngeal sphere and the bronchopulmonary system, detach or loosen any mucus.

This component, sodium chloride, is present in the compositions of formulation A, preferably at a rate of from 0.01 mg / l to 15000 mg / l of composition, which equates to a concentration of 10 ~ 5% to 1, 5%. C. Humectant or moisturizing agent, such as glucose or, preferably, glycerine, has bio-adhesive properties on the mucosa and on the skin, especially on the nasal mucosa and the pharynx. He lines them and lubricates them to ensure sufficient hydration. On the other hand, it prolongs the duration of action of the compositions of formulation A, for example the duration of the antiseptic action by maintaining, on the mucous membrane or on the skin, an adhesive effect of the agents responsible for this antiseptic action .

This humectant is present in Formulation A compositions, preferably 0.01 g / l to 250 g / l, equivalent to a concentration of 10 -3% to 25%. D.- The trace elements supplement, if necessary, the spectrum of activity of the hydrolate or hydrolates and reinforce leu ^ oi; action. For example, the copper ion provides additional antiseptic properties and the zinc ion has regenerative properties of the irritated mucosa.

Depending on their end use, formulation compositions A may contain from 1 to 15 trace elements which are most often selected from silver, copper, magnesium, manganese, gold, potassium, sulfur and zinc .

These trace elements are present in the compositions of formulation A, preferably at a rate of 0.1 mg / l to 1000 mg / l, which is equivalent to a concentration of 10 -4% to 0.1%. E.- Vitamins also supplement, if necessary, the physiological effects provided by the hydrolate (s) while reinforcing these effects. For example, vitamin B5 can be used to reconstitute a healthy mucosa initially deteriorated, this vitamin contributing mainly to cell renewal and strengthening.

According to their end use, the formulations of formulation A may contain from 1 to 5 vitamins chosen, by way of non-limiting examples, from vitamins A, C, E, K and B vitamins such as vitamin B6, especially vitamin B5.

These vitamins are present in these Formulation A compositions, preferably at a level of from 0.01 g / l to 200 g / l, equivalent to a concentration of 10 -3% to 20%.

According to a first characteristic, the invention relates to a group of aqueous compositions resulting from the compositions of formula A above, the aqueous compositions of this group comprising: at least one hydrosol chosen from hydrolates having a decongestant action, hydrolates having urggi; antimicrobial action, hydrolates having an antiviral action, hydrolates having a stimulating action, hydrolates having a soothing action, hydrolates having a fluidizing action, hydrolates having an antiallergic action and hydrolates having a healing action, - sodium chloride - one or more trace elements, - a humectant, - one or more vitamins.

The compositions of this group, which will be referred to hereinafter as "Al formulation compositions", are more particularly indicated for nasal administration, for example for the treatment of colds, allergies or nosebleeds.

In this application at the level of the nasopharyngeal sphere, the hydrolates in particular have the effect of opening the way to the components of these formulation compositions Al in order to allow them an effective action.

In addition, the trace elements that come into these Al formulation compositions are generally silver, copper, magnesium, manganese, gold, potassium, sulfur and zinc while the vitamins are usually B5 vitamins, C and K.

Thus, the families of hydrolates below can be used from the plants listed as non-limiting examples: a) in the treatment of colds: * decongestant hydrolates: mint, eucalyptus, * antimicrobial hydrolates: oregano, rosemary, * antiviral hydrolates: laurel, niaouli, ravintsara, * stimulating hydrolates: spruce, thyme, vanilla, * soothing hydrolates: chamomile, lavender, * fluidizing hydrolate: inula.

These examples include, in particular, eucalyptus hydrolate, oregano hydrolyzate, mint hydrolyzate, chamomile hydrolyzate, inula hydrolyzate and vanilla hydrolate which may be included in Al formulation compositions indicated for the treatment of colds.

The trace elements generally present in the Al formulation compositions useful in this type of treatment are silver, copper, gold and zinc while the vitamins are usually vitamins B5 and C.

In these compositions indicated in the treatment of colds, copper, for example, has the effect of extending the duration of action of the components.

In addition, the presence, for example, of vitamin B5 in Al formulation formulations for the treatment of colds makes it possible to reduce the duration to a maximum of 2 days, generally 24 to 36 hours, as a result of stimulation of the blood. 'immunity. On the other hand, when administering hydrolates alone, that is to say in the absence of vitamin B5, the evacuation of symptoms takes place only after 3 to 4 days. On the other hand, Al formulation compositions, intended more particularly for the treatment of colds, are endowed with an antiseptic action and treat the nasal mucosa. They fluidify the mucus, allow to effectively eliminate them and slow down the production. b) in the treatment of allergies: * decongestant hydrolates: mint, eucalyptus, * soothing hydrolates: chamomile, lavender, * antiallergic (respiratory) hydrolate: tarragon. The trace element usually present in the Al formulation compositions used in this type of treatment is manganese while the vitamin is, in general, vitamin B5.

Formulation compositions A1 which comprise one or more decongestant hydrolates, for example those which are useful in the treatment of colds or allergies, generate a mild vasoconstriction of the nasal fossae which can be obtained after 15 to 20 seconds. Two daily administrations are already sufficient for effective action although three administrations are advised. c) in the treatment of bleeding from the nose: * soothing hydrolates: chamomile, lavender * healing hydrolates: rock rose, geranium, balm of Peru.

The vitamins used in Al formulation compositions for this type of application are generally vitamins B5, C and K.

According to a second characteristic, the invention relates to a group of aqueous compositions resulting from the compositions of formula A above, the aqueous compositions of this group comprising: at least one hydrosol chosen from hydrolates having a decongestant action, hydrolates having an antimicrobial action, hydrolates having an antiviral action, hydrolates having a stimulating action, hydrolates having a soothing action, hydrolates having a fluidizing action, hydrolates having an antiallergic action and hydrolates having an antitussive action, - chloride sodium, one or more trace elements, a humectant, one or more vitamins.

The compositions of this group, which will be referred to hereinafter as "formulation compositions A2", are more particularly indicated for bronchopulmonary administration, for example for the treatment of fatty cough, dry cough or spasmodic cough or for the treatment of respiratory allergies.

In this application at the level of the bronchopulmonary system, the hydrolates used in particular have the effect of opening the way to the components of these A2 formulation compositions in order to allow them an effective action.

In addition, the trace elements that come into these A2 formulation compositions are, in general, manganese and zinc while the vitamins are usually vitamins B5 and C.

Thus, the families of hydrolates below can be used from the plants listed as non-limiting examples: a) in the treatment of a fatty cough: * Decongestant hydrolates: eucalyptus, mint, * antimicrobial hydrolates: oregano , rosemary * antiviral hydrolates: laurel, niaouli, * stimulating hydrosols: spruce, thyme, vanilla * soothing hydrolates: chamomile, lavender, * fluidifying hydrolate: inula.

Among these examples, mention may be made in particular of mint hydrolyzate, rosemary hydrolyzate and inula hydrolyzate which can be used in A2 formulation compositions useful in the treatment of a fatty cough.

Likewise, the trace element usually present in formulation compositions A2 for this type of treatment is zinc while the vitamin is, in general, vitamin C. b) in the treatment of a dry cough: * decongestant hydrolates: eucalyptus, mint, * antimicrobial hydrolates: oregano, rosemary, * antiviral hydrolates: laurel, niaouli, * stimulating hydrosols: spruce, thyme, vanilla, * soothing hydrolates: chamomile, lavender, * anti-tussive hydrolate: khella. The trace element generally present in the A2 formulation compositions indicated in this type of treatment is zinc, the vitamin, usually used, being vitamin C. c) in the treatment of a spasmodic cough (asthma, allergies, etc.): * stimulating hydrolates: spruce, thyme, vanilla, * soothing hydrolates: chamomile, lavender, * antitussive hydrolate: khella, * antiallergic hydrolate; tarragon,

These examples include, in particular, khella hydrolyzate, chamomile hydrolyzate and tarragon hydrolyzate which may be included in A2 formulation compositions useful in the treatment of allergic asthma.

In addition, for the treatment of a spasmodic cough (asthma, allergies, etc.) the trace element usually used in A2 formulation compositions is usually manganese at very low doses while the vitamin is, in general, vitamin B5. d) in the treatment of respiratory allergies: * antiallergic hydrolate: tarragon, tansy * antitussive hydrolate: khella The trace element, usually present in the A2 formulations indicated in this type of treatment, is manganese at very low doses; the vitamin is, in general, vitamin B5.

According to a third characteristic, the invention relates to a group of aqueous compositions resulting from the compositions of formula A above, the aqueous compositions of this group comprising: at least one hydrosol selected from hydrolates having an antimicrobial action, hydrolates having antifungal action, hydrolates having a soothing action, hydrolates having an antiallergic action and hydrolates having a cicatrizing action, - sodium chloride, - one or more trace elements, - a humectant, - one or more vitamins.

The compositions of this group, which will be designated hereinafter by the terms "formulation compositions A3", are more particularly indicated for cutaneous administration, for example for the treatment of infected or uninfected wounds, mycoses, itching or other infections. 'eczema.

In these compositions of formulation A3, the trace elements, generally used, are silver, copper and zinc while the vitamins are usually vitamins A, B5, C and E.

Thus, the families of hydrolates below can be used from the plants listed as non-limiting examples: a) in the treatment of wounds (infected or not): * antimicrobial hydrolates: oregano, rosemary, * soothing hydrosols : chamomile, lavender, * hydrolate cicatrisants: rockrose, geranium, petit grain bigarade, balm of Peru.

Among these examples, mention may be made in particular of the small bitter grain hydrolyzate, the lavender hydrolyzate and the rosin hydrolyzate which may be included in A3 formulation compositions useful for promoting healing.

In addition, the trace elements present in the formulation compositions A3 useful in this type of treatment are generally silver, copper and zinc while the vitamins are usually vitamins A, B5, C and E. b) in the treatment mycoses: * antimicrobial hydrolates: oregano, rosemary, * soothing hydrolates: chamomile, lavender, * antiallergic hydrolate (cutaneous): tansy, * antifungal hydrolates: cinnamon, palmarosa, * healing hydrolates: rock rose, geranium, balm of Peru. On the other hand, the trace elements present in the formulation compositions A3 for this type of treatment are, in general, copper and zinc, the vitamins usually used being the vitamins B5 and C. c) in the treatment of itching or dandruff. eczema: soothing hydrolates: chamomile, lavender, antiallergic (cutaneous) hydrolate: tansy.

Similarly, the trace elements present in the formulation compositions A3 useful for this type of treatment are usually copper and zinc while the vitamins are, in general, vitamins B5 and C.

According to another of its objects, the invention relates to a process for the preparation of the compositions according to the invention, process according to which one or more natural or reconstituted hydrolates are mixed with the other ingredients entering into these compositions, namely sodium, at least one micronutrient, a humectant and at least one vitamin and this, at a temperature ranging from 5 ° C to 100 ° C, preferably at room temperature.

The natural hydrolates, for their part, can be obtained in known manner essentially by distillation of the plant concerned under the effect of steam distillation while the reconstituted hydrolates will also be prepared by known methods. that is, by introducing the desired amount of an essential oil into an aqueous medium. Usually, the aqueous medium, preferably distilled water, will contain a maximum of 130 mg / l of essential oil.

According to another of its features, the invention also relates to formulation compositions A used as pharmaceuticals or products for medical use, in particular in the treatment of disorders and conditions of the nasopharyngeal sphere, the bronchopulmonary system or the skin. On the other hand, the invention also relates to formulation compositions Al used as pharmaceuticals or products for medical use, in particular in the treatment of disorders and conditions of the nasopharyngeal sphere.

In addition, the invention also relates to formulation compositions A2 used as pharmaceuticals or products for medical use, eg; particularly in the treatment of disorders and conditions of the bronchopulmonary system.

In addition, the invention also relates to formulation compositions A3 used as pharmaceuticals or products for medical use, particularly in the treatment of skin disorders and conditions.

According to a further characteristic, the invention also relates to formulation compositions A packaged in a nebulization device for nasal or bronchopulmonary or cutaneous administration. On the other hand, the invention also relates to Al formulation compositions packaged in a nebulizing device for nasal administration.

In addition, the invention also relates to A2 formulation compositions packaged in a nebulization device for bronchopulmonary administration.

Similarly, the invention also relates to formulation compositions A3 packaged in a nebulization device for cutaneous administration.

The following nonlimiting examples illustrate compositions according to the invention for internal or external administration. COMPOSITIONS FOR NASAL ADMINISTRATION EXAMPLE 1

A following formulation composition is produced for nasal administration: mg per liter of composition Chamomile hydrolyzates, mint and inula total weight of 65.00

Sodium chloride 8538.00

Magnesium sulphate 0.6

Sulfur 2.00

0.08 zinc sulphate

Glycerine 1140.00

Vitamin C 3000,00

A mixture of chamomile hydrolate, mint hydrolate and inulin hydrolate is prepared at ambient temperature, and then, at room temperature, magnesium sulphate, sulfur, zinc sulphate, magnesium sulphate and glycerine and vitamin C. The resulting composition is separated into aliquots and introduced into nebulizers.

The composition thus prepared can be used in the treatment of colds. EXAMPLES 2 AND 3

In the same manner as before but starting from the appropriate components, compositions according to the following formulations are prepared: a) Example 2 mg per liter of composition

Hydrosols of oregano and vanilla total weight of 97.00

Sodium chloride 12402.00

Potassium chloride 0.25

Sulfur 2.1

Glycerine 43240.00

0.01 Vitamin A

Vitamin E 240,00

This composition can be used in the treatment of colds. b) Example 3 mg per liter of composition Hydrolats of eucalyptus, mint and jasmine total weight of 38.00

Sodium chloride 9021.00

Manganese sulphate 0.92

Sulfur 2.1

Glycerine 98400,00

Vitamin B6 24.00 Jasmine hydrosol has no therapeutic applications. Its only purpose is to perfume the composition. This can be used in the treatment of colds.

COMPOSITION FOR BRONCHO-PULMONARY ADMINISTRATION EXAMPLE 4

By applying the same method as that described in Example 1 but starting from the appropriate components, a following formulation composition is prepared for bronchopulmonary administration: mg per liter of composition

Tarragon, tansy and khella hydrosols total weight of 85.00

Sodium chloride 7000,00

Manganese sulphate 10.00

Glycerine 1100,00

Vitamin B5 2000.00

This composition can be used in the treatment of respiratory allergies.

COMPOSITION FOR SKIN DELIVERY EXAMPLE 5

By applying the same method as that described in Example 1 but starting from the appropriate components, a following formulation composition for cutaneous administration is produced: mg per liter of composition

Bigarade, lavender and cistus hydrosols weighing between 70.00 and 130.00

Sodium chloride 9000,00

Copper sulphate 3500.00

Glycerine 5000.00

Vitamin C 10000.00

This composition can be used to promote the healing of wounds.

CLINICAL TESTS

Clinical trials have been conducted with compositions according to the invention administered in the treatment of various conditions. I. Cold For this purpose, the following formulation formulation Al was used:% by weight of the composition

Oregano hydrosol 9.12% Laurel hydrosol 9.12% Chamomile hydrosol 9.12% Ravintsara hydrosol 13.67% Eucalyptus hydrosol 18.24% Mineral hydrosol 13.67% Vanilla hydrosol 9.12 % Hydrolat of Thyme Saturoides 13.68% Sodium Chloride 0.9%

Copper sulphate 0.01% Zinc sulphate 0.35% Glycerin 1.00% Vitamin B5 2.00% The test, which was spread over a period of 60 days (beginning of March to the end of April), focused on on a sample of 73 people with colds and other congestion of the nose. Each person was to administer two sprays in each nostril 2 to 3 times a day and to note, after each administration, the evolution of his affection and the symptoms felt. As a result of this test, the following results were recorded: a) 54 persons reported having been cleared of symptoms within 36 hours from the first administration, b) 14 persons reported having been cleared of symptoms in the first 24 hours after the first administration, c) 3 persons reported having cleared 3 symptoms after 2 administrations, d) 3 persons judged the composition to be ineffective. These were people with intranasal deformity. II. bedsores

In a patient of about 85 years, cicatrization of a gluteal ulcer was achieved after 5 days of treatment with an A3 formulation composition according to the invention.

The compositions according to the invention have numerous advantages compared with known compositions. They are effective at dosages particularly low in essential oil while not being aggressive to the mucous membranes, for example the nasal mucosa. On the other hand, these compositions are suitable for all ages of all ages, including pregnant women, and can be used, in particular, by cardiac people because they do not cause mimetic action to adrenaline.

Each of the components of these compositions has, individually, a physiological action. However, these interact synergistically with one another when they are associated. Compared to known compositions, this synergy entails, for the compositions according to the invention, an increased speed of action during the initiation of a treatment as well as a significant extension of the duration of this action.

Claims (26)

1. Aqueous compositions containing hydrolats, characterized in that they comprise: at least one hydrosol chosen from hydrolates having a decongestant action, hydrolates having an antimicrobial action, hydrolates having an antiviral action, hydrolates having antifungal action , hydrosols having an antispasmodic action, hydrolates having a stimulating action, hydrolates having a soothing action, hydrolates having a fluidizing action, hydrolates having an antiallergic action, hydrolates having an antitussive action and hydrolates having a cicatrizing action, - sodium chloride, - one or more trace elements, - a humectant, - one or more vitamins. 2. Compositions according to claim 1, characterized in that they comprise: at least one hydrosol chosen from hydrolates having a decongestant action, hydrolates having an antimicrobial action, hydrolates having an antiviral action, hydrolates having a stimulating action , hydrolates having a soothing action, hydrolates having a fluidizing action, hydrolates having an antiallergic action and hydrolates having a cicatrizing action, - sodium chloride, - one or more trace elements, - a humectant, - one or more vitamins. 3. Compositions according to claim 1, characterized in that they comprise: at least one hydrosol selected from hydrolates having a decongestant action, hydrolates having an antimicrobial action, hydrolates having an antiviral action, hydrolates having a stimulating action , hydrolates having a soothing action, hydrolates having a fluidizing action, hydrolates having an antiallergic action and hydrolates having an antitussive action, - sodium chloride, - one or more trace elements, - a humectant, - one or more vitamins. 4. Compositions according to claim 1, characterized in that they comprise: at least one hydrosol selected from hydrolates having an antimicrobial action, hydrolates having antifungal action, hydrolates having a soothing action, hydrolates having an antiallergic action and hydrolates having a cicatrizing action, - sodium chloride, - one or more trace elements, - a humectant, - one or more vitamins. 5. Compositions according to one of claims 1 to 4, characterized in that they contain a total weight of 25 mg to 130 mg of essential oil per liter of hydrolates. 6. Compositions according to one of claims 1 to 5, characterized in that they contain from 0.01 mg / l to 15000 mg / l of sodium chloride. 7. Compositions according to one of claims 1 to 1% characterized in that they contain from 0.01 g / l to 250 g / 1 of a humectant. 8. Compositions according to one of claims 1 to 7, characterized in that they contain from 0.1 mg / l to 1000 mg / 1 of trace elements. 9. Compositions according to one of claims 1 to 8, characterized in that they contain from 0.01 g / 1 to 200 g / 1 of vitamins. 10. Compositions according to one of claims 1 to 9, characterized in that the humectant is glycerin or glucose. 11. Compositions according to one of claims 1 or 5 to 10, characterized in that the trace elements are silver, copper, magnesium, manganese, gold, potassium, sulfur and zinc. 12. Compositions according to one of claims 1 or 5 to 10, characterized in that the vitamins are vitamins A, C, E, K and vitamins of Group B. 13. Compositions according to claim 12, characterized in that the vitamins of Group B are vitamins B5 and B6. 14. Compositions according to one of claims 2 or 5 to 10, characterized in that the trace elements are silver, copper, magnesium, manganese, gold, potassium, sulfur and zinc and vitamins are vitamins B5, C and K. 15. Compositions according to one of claims 3 or 5 201 10, characterized in that the trace elements are manganese and zinc and the vitamins are vitamins B5 and C. 16. Compositions according to one of claims 4 to 10, characterized in that the trace elements are silver, copper and zinc and the vitamins are vitamins A, B5, C and E. 17. Compositions according to one of claims 1 to 16, characterized in that they are in the form of spray solutions for nasal or broncho-pulmonary or cutaneous administration. 18. Compositions according to one of claims 1 to 16, characterized in that they are used as pharmaceuticals or products for medical use. 19. Compositions according to claim 18, characterized in that they are used in the treatment of disorders and conditions of the nasopharyngeal sphere, the bronchopulmonary system or the skin. 20. Compositions according to one of claims 2, 18 or 19, characterized in that they are used in the treatment of disorders and disorders of the nasopharyngeal sphere. 21. Compositions according to one of claims 3, 18 or 19, characterized in that they are used in the treatment of disorders and conditions of the bronchopulmonary system. 22. Compositions according to one of claims 4, 18 C20V, 19, characterized in that they are used in the treatment of skin disorders and conditions. 23. Compositions according to one of claims 1 to 22, characterized in that they are packaged in a nebulization device for nasal or broncho-pulmonary or cutaneous administration. 24. Compositions according to one of claims 2, 18, 19 or 23, characterized in that they are packaged in a nebulization device for nasal administration. 25. Compositions according to one of claims 3, 18, 19 or 23, characterized in that they are packaged in a nebulization device for bronchopulmonary administration. 26. Compositions according to one of claims 4, 18, 19 or 23, characterized in that they are packaged in a nebulization device for cutaneous administration.