AU9624398A - Pyrrolopyrrolidine derivatives and their use as serine protease inhibitors - Google Patents

Pyrrolopyrrolidine derivatives and their use as serine protease inhibitors

Info

Publication number: AU9624398A
Authority: AU; Australia
Prior art keywords: pyrrolopyrrolidine; derivatives; protease inhibitors; serine protease; serine
Prior art date: 1997-09-09
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

AU96243/98A

Inventor

Steven John Coote

Michael Dennis Dowle

Harry Finch

Michael Menteith Hann

Henry Anderson Kelly

Simon John Fawcett Macdonald

Neil Anthony Pegg

Nigel Grahame Ramsden

Nigel Stephen Watson

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Glaxo Group Ltd

Original Assignee

Glaxo Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-09-09

Filing date

1998-09-07

Publication date

1999-03-29

1998-09-07 Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd

1999-03-29 Publication of AU9624398A publication Critical patent/AU9624398A/en

Status Abandoned legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Pulmonology (AREA)
Hematology (AREA)
Diabetes (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AU96243/98A 1997-09-09 1998-09-07 Pyrrolopyrrolidine derivatives and their use as serine protease inhibitors Abandoned AU9624398A (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GBGB9719161.3A GB9719161D0 (en)	1997-09-09	1997-09-09	New therapeutic method
GB9719161		1997-09-09
PCT/EP1998/005744 WO1999012935A1 (en)	1997-09-09	1998-09-07	Pyrrolopyrrolidine derivatives and their use as serine protease inhibitors

Publications (1)

Publication Number	Publication Date
AU9624398A true AU9624398A (en)	1999-03-29

Family

ID=10818801

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AU96243/98A Abandoned AU9624398A (en)	1997-09-09	1998-09-07	Pyrrolopyrrolidine derivatives and their use as serine protease inhibitors

Country Status (5)

Country	Link
EP (1)	EP1015456A1 (en)
JP (1)	JP2001515906A (en)
AU (1)	AU9624398A (en)
GB (1)	GB9719161D0 (en)
WO (1)	WO1999012935A1 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6221914B1 (en)	1997-11-10	2001-04-24	Array Biopharma Inc.	Sulfonamide bridging compounds that inhibit tryptase activity
US6335324B1 (en)	1998-06-25	2002-01-01	Bristol-Myers Squibb Co.	Beta lactam compounds and their use as inhibitors of tryptase
GB9821199D0 (en) *	1998-09-30	1998-11-25	Glaxo Group Ltd	Chemical compounds
WO2002057273A1 (en) *	2001-01-20	2002-07-25	Trigen Limited	Serine protease inhibitors comprising a hydrogen-bond acceptor
EP1325962A1 (en) *	2001-12-17	2003-07-09	Gentium S.p.A.	A method for determining the biological activity of defibrotide
DK1569912T3 (en)	2002-12-03	2015-06-29	Pharmacyclics Inc	2- (2-hydroxybiphenyl-3-yl) -1h-benzoimidazole-5-carboxamidine derivatives as factor VIIa inhibitors.
US7138412B2 (en)	2003-03-11	2006-11-21	Bristol-Myers Squibb Company	Tetrahydroquinoline derivatives useful as serine protease inhibitors
US7129264B2 (en) *	2003-04-16	2006-10-31	Bristol-Myers Squibb Company	Biarylmethyl indolines and indoles as antithromboembolic agents
US7417063B2 (en)	2004-04-13	2008-08-26	Bristol-Myers Squibb Company	Bicyclic heterocycles useful as serine protease inhibitors
EP2637672B1 (en)	2010-11-12	2018-08-22	Gentium S.r.l.	Defibrotide for use in prophylaxis and/or treatment of graft versus host disease (gvhd).
CA2874960C (en)	2012-06-22	2021-05-18	Gentium S.P.A.	Euglobulin-based method for determining the biological activity of defibrotide
EP3026122A1 (en)	2014-11-27	2016-06-01	Gentium S.p.A.	Cellular-based method for determining the potency of defibrotide

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1995003278A1 (en) *	1993-07-26	1995-02-02	Zaidan Hojin Biseibutsu Kagaku Kenkyukai	Pyrrolidine derivative or pharmaceutically acceptable salt thereof
WO1995024186A1 (en) *	1994-03-11	1995-09-14	Pharmacopeia, Inc.	Sulfonamide derivatives and their use
WO1997048706A1 (en) *	1996-06-18	1997-12-24	Warner-Lambert Company	Pyrrolo[1,2-a]pyrazine-1,4-dione serine protease inhibitors
WO1998043975A1 (en) *	1997-04-02	1998-10-08	Glaxo Group Limited	Pyrolopyrrolone derivatives

1997
- 1997-09-09 GB GBGB9719161.3A patent/GB9719161D0/en not_active Ceased
1998
- 1998-09-07 EP EP98950011A patent/EP1015456A1/en not_active Withdrawn
- 1998-09-07 WO PCT/EP1998/005744 patent/WO1999012935A1/en not_active Ceased
- 1998-09-07 JP JP2000510742A patent/JP2001515906A/en active Pending
- 1998-09-07 AU AU96243/98A patent/AU9624398A/en not_active Abandoned

Also Published As

Publication number	Publication date
GB9719161D0 (en)	1997-11-12
WO1999012935A1 (en)	1999-03-18
JP2001515906A (en)	2001-09-25
EP1015456A1 (en)	2000-07-05

Publication	Publication Date	Title
AU8875398A (en)	1999-03-22	1-amino-7-isoquinoline derivatives as serine protease inhibitors
AU7127298A (en)	1998-11-11	Serine protease inhibitors
AU5481498A (en)	1998-06-22	Benzamidoaldehydes and their use as cysteine protease inhibitors
AU4236796A (en)	1996-05-31	Cysteine protease and serine protease inhibitors
AU3972697A (en)	1998-02-25	Inhibitors of cysteine protease
AU4135697A (en)	1998-03-26	Novel acetamide derivatives and protease inhibitors
AU8140898A (en)	1998-12-30	Inhibitors of beta-lactamases and uses therefor
ZA983629B (en)	1998-11-04	Serine protease inhibitors
HUP9901187A3 (en)	1999-11-29	Serine protease inhibitors
AU1795697A (en)	1997-09-16	Serine protease inhibitors
AU4723799A (en)	2000-01-10	Protease inhibitors
AU1877597A (en)	1997-09-16	Serine protease inhibitors
AU7139598A (en)	1998-11-24	Protease inhibitors
AU7179598A (en)	1998-06-03	Benzothiazo and related heterocyclic group-containing cysteine and serine protease inhibitors
AU6536200A (en)	2001-03-05	Proteases and protease inhibitors
AU4092799A (en)	1999-12-06	Protease inhibitors
AU9624398A (en)	1999-03-29	Pyrrolopyrrolidine derivatives and their use as serine protease inhibitors
AU1393900A (en)	2000-06-05	Morpholino-ethoxybenzofuran protease inhibitors
AU9110298A (en)	1999-12-06	Protease inhibitors
AU1588901A (en)	2001-06-06	Protease inhibitors
AU9300298A (en)	1999-03-22	Protease inhibitors
AU4672996A (en)	1996-09-04	Serine protease inhibitors
AU2713100A (en)	2000-07-31	Protease inhibitors
AU4564499A (en)	1999-12-30	Protease inhibitors
AU1474801A (en)	2001-06-06	Protease inhibitors

Legal Events

Date	Code	Title	Description
2000-06-01	MK6	Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase