AU9206798A - Pyrrolidine and piperidine modulators of chemokine receptor activity - Google Patents
Pyrrolidine and piperidine modulators of chemokine receptor activity Download PDFInfo
- Publication number
- AU9206798A AU9206798A AU92067/98A AU9206798A AU9206798A AU 9206798 A AU9206798 A AU 9206798A AU 92067/98 A AU92067/98 A AU 92067/98A AU 9206798 A AU9206798 A AU 9206798A AU 9206798 A AU9206798 A AU 9206798A
- Authority
- AU
- Australia
- Prior art keywords
- pct
- phenyl
- alkyl
- 3alkyl
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 0 O=C(c1ccc(C(F)(F)F)cc1)N(C[C@@]1CN(CC2)CCC2c2ccccc2)C[C@@]1*1ccccc1 Chemical compound O=C(c1ccc(C(F)(F)F)cc1)N(C[C@@]1CN(CC2)CCC2c2ccccc2)C[C@@]1*1ccccc1 0.000 description 2
- ZHCOEWDHXCZKHB-FLBNQQOGSA-N C(C(CN(Cc1ccccc1)C1)[C@H]1c1cccc(-c(cc2)ccc2C2=CCN(CC(CN(Cc3ccccc3)C3)[C@H]3c3ccccc3)CC2)c1)N(CC1)CCN1c1ccccc1 Chemical compound C(C(CN(Cc1ccccc1)C1)[C@H]1c1cccc(-c(cc2)ccc2C2=CCN(CC(CN(Cc3ccccc3)C3)[C@H]3c3ccccc3)CC2)c1)N(CC1)CCN1c1ccccc1 ZHCOEWDHXCZKHB-FLBNQQOGSA-N 0.000 description 1
- AAYOIQDVJMEQDT-UHFFFAOYSA-N CC(C)OC(N(CC1CCCCC1)C1CCNCC1)=O Chemical compound CC(C)OC(N(CC1CCCCC1)C1CCNCC1)=O AAYOIQDVJMEQDT-UHFFFAOYSA-N 0.000 description 1
- RHTAHFVABLDZIF-NNBQYGFHSA-N CCC(CN(Cc1ccccc1)C1)[C@H]1c1ccccc1 Chemical compound CCC(CN(Cc1ccccc1)C1)[C@H]1c1ccccc1 RHTAHFVABLDZIF-NNBQYGFHSA-N 0.000 description 1
- IKYRCNWZCWOFCS-LBNVMWSVSA-N CCOC(C1CCN(C[C@@H](CN(C2)C(c3cccc4c3cccc4)=O)[C@H]2c2ccccc2)CC1)=O Chemical compound CCOC(C1CCN(C[C@@H](CN(C2)C(c3cccc4c3cccc4)=O)[C@H]2c2ccccc2)CC1)=O IKYRCNWZCWOFCS-LBNVMWSVSA-N 0.000 description 1
- XCFIZQYBDAGEHV-SVOUTRCYSA-N O=C(C1(CC2CC3C4)C23C4C1)N(C[C@@H]1CN(CC2)CCC2c2ccccc2)C[C@@H]1c1ccccc1 Chemical compound O=C(C1(CC2CC3C4)C23C4C1)N(C[C@@H]1CN(CC2)CCC2c2ccccc2)C[C@@H]1c1ccccc1 XCFIZQYBDAGEHV-SVOUTRCYSA-N 0.000 description 1
- LAVZSFUALWGHAZ-MIXNXMPVSA-N O=C(C1c2ccccc2-c2c1cccc2)N(C[C@@H]1CN(CC2)CCC2c2ccccc2)CC1c1ccccc1 Chemical compound O=C(C1c2ccccc2-c2c1cccc2)N(C[C@@H]1CN(CC2)CCC2c2ccccc2)CC1c1ccccc1 LAVZSFUALWGHAZ-MIXNXMPVSA-N 0.000 description 1
- IPKOZQYLISCSQP-SFCXHYMASA-N O=C(c(cc1)ccc1-c1ccccc1)N(C[C@@H]1CCN(CC2)CCC2c2ccccc2)CC1c1ccccc1 Chemical compound O=C(c(cc1)ccc1-c1ccccc1)N(C[C@@H]1CCN(CC2)CCC2c2ccccc2)CC1c1ccccc1 IPKOZQYLISCSQP-SFCXHYMASA-N 0.000 description 1
- DCIFTXQVCBUFRT-XOGXXFMMSA-N O=C(c1cccc2c1-c1ccccc1C2)N(C[C@@H]1CN(CC2)CCC2C2C=CC=CC2)C[C@@H]1c1ccccc1 Chemical compound O=C(c1cccc2c1-c1ccccc1C2)N(C[C@@H]1CN(CC2)CCC2C2C=CC=CC2)C[C@@H]1c1ccccc1 DCIFTXQVCBUFRT-XOGXXFMMSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Oncology (AREA)
- AIDS & HIV (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5774397P | 1997-08-28 | 1997-08-28 | |
| US60057743 | 1997-08-28 | ||
| GB9801009 | 1998-01-16 | ||
| GBGB9801009.3A GB9801009D0 (en) | 1998-01-16 | 1998-01-16 | Pyrrolidine and piperidine modulators of chemokine receptor activity |
| PCT/US1998/017755 WO1999009984A1 (fr) | 1997-08-28 | 1998-08-27 | Modulateurs de pyrrolidine et de piperidine de l'activite du recepteur de chemokine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU9206798A true AU9206798A (en) | 1999-03-16 |
Family
ID=26312970
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU92067/98A Abandoned AU9206798A (en) | 1997-08-28 | 1998-08-27 | Pyrrolidine and piperidine modulators of chemokine receptor activity |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1009405A4 (fr) |
| JP (1) | JP2001526178A (fr) |
| AU (1) | AU9206798A (fr) |
| CA (1) | CA2298813A1 (fr) |
| WO (1) | WO1999009984A1 (fr) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6025154A (en) | 1995-06-06 | 2000-02-15 | Human Genome Sciences, Inc. | Polynucleotides encoding human G-protein chemokine receptor HDGNR10 |
| US6743594B1 (en) | 1995-06-06 | 2004-06-01 | Human Genome Sciences, Inc. | Methods of screening using human G-protein chemokine receptor HDGNR10 (CCR5) |
| WO2000035877A1 (fr) * | 1998-12-18 | 2000-06-22 | Du Pont Pharmaceuticals Company | Piperidines heterocycliques utilisees en tant que modulateurs de l'activite des recepteurs des chimiokines |
| EP1013276A1 (fr) | 1998-12-23 | 2000-06-28 | Pfizer Inc. | Aminoazacycloalcanes comme modulateurs de CCR5 |
| PE20001420A1 (es) | 1998-12-23 | 2000-12-18 | Pfizer | Moduladores de ccr5 |
| US7217714B1 (en) | 1998-12-23 | 2007-05-15 | Agouron Pharmaceuticals, Inc. | CCR5 modulators |
| WO2000051608A1 (fr) * | 1999-03-02 | 2000-09-08 | Merck & Co., Inc. | Modulateurs de l'activite recepteur des chimiokines, a base de 3-thienyle et 3-furanyle pyrrolidine |
| AU3389300A (en) * | 1999-03-02 | 2000-09-21 | Merck & Co., Inc. | Pyrrolidine modulators of chemokine receptor activity |
| AU3386400A (en) * | 1999-03-02 | 2000-09-21 | Merck & Co., Inc. | 3-alkyl substituted pyrrolidine modulators of chemokine receptor activity |
| US6498161B1 (en) | 1999-04-06 | 2002-12-24 | Merck & Co., Inc. | Pyrrolidine modulators of chemokine receptor activity |
| US6399619B1 (en) | 1999-04-06 | 2002-06-04 | Merck & Co., Inc. | Pyrrolidine modulators of chemokine receptor activity |
| US6265434B1 (en) * | 1999-04-06 | 2001-07-24 | Merck & Co., Inc. | Pyrrolidine modulators of chemokine receptor activity |
| US6248755B1 (en) * | 1999-04-06 | 2001-06-19 | Merck & Co., Inc. | Pyrrolidine modulators of chemokine receptor activity |
| GB9912701D0 (en) * | 1999-06-01 | 1999-08-04 | Smithkline Beecham Plc | Novel compounds |
| AU5600100A (en) | 1999-06-11 | 2001-01-02 | Merck & Co., Inc. | Cyclopentyl modulators of chemokine receptor activity |
| WO2000076513A1 (fr) | 1999-06-11 | 2000-12-21 | Merck & Co., Inc. | Modulateurs cyclopentyliques de l'activite du recepteur de la chimiokine |
| US6472410B1 (en) | 1999-06-11 | 2002-10-29 | Merck & Co., Inc. | N-cyclopentyl modulators of chemokine receptor activity |
| JP4688381B2 (ja) * | 1999-06-11 | 2011-05-25 | メルク・シャープ・エンド・ドーム・コーポレイション | ケモカインレセプター活性のｎ−シクロペンチルモジュレーター |
| WO2000076511A1 (fr) | 1999-06-11 | 2000-12-21 | Merck & Co., Inc. | Modulateurs cyclopentyle de l'activite des recepteurs de la chimiokine |
| US6358979B1 (en) | 1999-06-11 | 2002-03-19 | Merck & Co., Inc. | N-cyclopentyl modulators of chemokine receptor activity |
| AU5473400A (en) | 1999-06-11 | 2001-01-02 | Merck & Co., Inc. | Cyclopentyl modulators of chemokine receptor activity |
| US6455548B2 (en) * | 2000-02-28 | 2002-09-24 | Merck & Co., Inc. | 4-alkyl piperidinyl pyrrolidine modulators of chemokine receptor activity |
| BR0111878A (pt) | 2000-06-30 | 2005-05-24 | Bristol Myers Squibb Co | N-ureido-(heterociclo-alquil)-piperidinas como moduladores da atividade de receptores de quimiocinas |
| US6531484B2 (en) | 2000-10-11 | 2003-03-11 | Merck & Co., Inc. | Pyrrolidine modulators of CCR5 chemokine receptor activity |
| US7175988B2 (en) | 2001-02-09 | 2007-02-13 | Human Genome Sciences, Inc. | Human G-protein Chemokine Receptor (CCR5) HDGNR10 |
| ES2272703T3 (es) | 2001-02-28 | 2007-05-01 | MERCK & CO., INC. | Derivados de piperidina acilados como agonistas de receptor de melanocortina-4. |
| ES2283550T3 (es) | 2001-02-28 | 2007-11-01 | MERCK & CO., INC. | Derivados de piperidina acilados como antagonistas del receptor de. |
| EP1368354A1 (fr) | 2001-03-07 | 2003-12-10 | Pfizer Products Inc. | Modulateurs de l'activite du recepteur de la chimiokine |
| GB0108099D0 (en) * | 2001-03-30 | 2001-05-23 | Hoffmann La Roche | Aminopiperidine derivatives |
| ATE424385T1 (de) * | 2001-04-18 | 2009-03-15 | Euro Celtique Sa | 1-(4-piperidinyl)-1,3-dihydro-2h-benzoxazole-2- one derivate und verwandte verbindungen als nociceptin analoge und orl1 liganden zur behandlung von schmerz |
| ATE411021T1 (de) | 2001-07-18 | 2008-10-15 | Merck & Co Inc | Überbrückte piperidinderivate als melanocortin- rezeptor-agonisten |
| US7393934B2 (en) | 2001-12-21 | 2008-07-01 | Human Genome Sciences, Inc. | Human G-protein chemokine receptor (CCR5) HDGNR10 |
| EP1531822B1 (fr) | 2002-06-12 | 2009-08-05 | ChemoCentryx Inc | Derives de piperazine 1-aryl-4-substitues utilises en tant qu'antagonistes du ccr1 dans le traitement de l'inflammation et des troubles immunitaires |
| US7589199B2 (en) | 2002-06-12 | 2009-09-15 | Chemocentryx, Inc. | Substituted piperazines |
| US7842693B2 (en) | 2002-06-12 | 2010-11-30 | Chemocentryx, Inc. | Substituted piperazines |
| US7414057B2 (en) | 2002-09-11 | 2008-08-19 | Merck & Co., Inc. | Piperazine urea derivatives as melanocortin-4 receptor agonists |
| CA2527159A1 (fr) * | 2003-05-30 | 2004-12-09 | Neuromed Technologies, Inc. | 3-aminomethyle-pyrrolidines comme inhibiteurs de canaux calciques de type n |
| CA2579608A1 (fr) | 2003-09-10 | 2005-03-17 | Virochem Pharma Inc. | Composes spiro et procedes pour la modulation de l'activite de recepteur de chimiokine |
| GB0328906D0 (en) * | 2003-12-12 | 2004-01-14 | Syngenta Participations Ag | Chemical compounds |
| US7435831B2 (en) | 2004-03-03 | 2008-10-14 | Chemocentryx, Inc. | Bicyclic and bridged nitrogen heterocycles |
| AU2005219438B2 (en) | 2004-03-03 | 2011-02-17 | Chemocentryx, Inc. | Bicyclic and bridged nitrogen heterocycles |
| WO2005105841A2 (fr) | 2004-03-12 | 2005-11-10 | Human Genome Sciences, Inc. | Récepteur humain (ccr5) hdgnr10 de chimiokine de la protéine g |
| NZ553202A (en) * | 2004-08-19 | 2010-12-24 | Vertex Pharma | Modulators of muscarinic receptors |
| MX2007007428A (es) * | 2004-12-24 | 2007-07-16 | Astrazeneca Ab | Compuestos heterociclicos, antagonistas de ccr2b. |
| US7880002B2 (en) | 2004-12-29 | 2011-02-01 | Millennium Pharmaceuticals, Inc. | Substituted piperazinyl-pyrrolidine compounds useful as chemokine receptor antagonists |
| US7635698B2 (en) | 2004-12-29 | 2009-12-22 | Millennium Pharmaceuticals, Inc. | Compounds useful as chemokine receptor antagonists |
| JP2008526840A (ja) * | 2005-01-06 | 2008-07-24 | アストラゼネカ アクチボラグ | 新規化合物 |
| GB0505969D0 (en) | 2005-03-23 | 2005-04-27 | Novartis Ag | Organic compounds |
| GB0514203D0 (en) | 2005-07-11 | 2005-08-17 | Novartis Ag | Organic compounds |
| GB0525957D0 (en) | 2005-12-21 | 2006-02-01 | Astrazeneca Ab | Methods |
| JP2009521483A (ja) * | 2005-12-22 | 2009-06-04 | バーテックス ファーマシューティカルズ インコーポレイテッド | ムスカリン受容体のモジュレーター |
| PT2420491E (pt) | 2005-12-30 | 2013-10-14 | Novartis Ag | Compostos de piperidina 3,5-substituída como inibidores de renina |
| US7351706B2 (en) | 2006-01-05 | 2008-04-01 | Hoffmann-La Roche Inc. | Indol-3-yl-carbonyl-spiro-piperidine derivatives |
| RU2008137583A (ru) * | 2006-02-22 | 2010-03-27 | Вертекс Фармасьютикалз Инкорпорейшн (Us) | Спиропиперидины в качестве модуляторов мускариновых рецепторов |
| WO2007136668A2 (fr) | 2006-05-19 | 2007-11-29 | Wyeth | N-benzoyle et n-benzylpyrrolidin-3-ylamines comme antagonistes de l'histamine-3 |
| US7727978B2 (en) | 2006-08-24 | 2010-06-01 | Bristol-Myers Squibb Company | Cyclic 11-beta hydroxysteroid dehydrogenase type I inhibitors |
| CA2689109A1 (fr) | 2007-06-25 | 2008-12-31 | Novartis Ag | Composes organiques |
| US8119658B2 (en) | 2007-10-01 | 2012-02-21 | Bristol-Myers Squibb Company | Triazolopyridine 11-beta hydroxysteroid dehydrogenase type I inhibitors |
| USRE48334E1 (en) | 2008-09-19 | 2020-12-01 | Takeda Pharmaceutical Company Limited | Nitrogen-containing heterocyclic compound and use of same |
| IL295400A (en) | 2020-02-19 | 2022-10-01 | Ichilov Tech Ltd | Improved treatment for depression |
| EP4536634A1 (fr) * | 2022-07-21 | 2025-04-16 | The Regents Of The University Of California | Composés inhibiteurs de la prostaglandine e synthase 3 (ptges3) |
| CN115448864B (zh) * | 2022-08-26 | 2023-12-22 | 上海方予健康医药科技有限公司 | 3-氟-3-（1-羟乙基）吡咯烷-1-羧酸叔丁酯的制备方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5635510A (en) * | 1993-05-06 | 1997-06-03 | Merrell Pharmaceuticals Inc. | Substituted pyrrolidin-3-yl-alkyl-piperidines |
-
1998
- 1998-08-27 JP JP2000507374A patent/JP2001526178A/ja active Pending
- 1998-08-27 EP EP98944548A patent/EP1009405A4/fr not_active Withdrawn
- 1998-08-27 WO PCT/US1998/017755 patent/WO1999009984A1/fr not_active Ceased
- 1998-08-27 CA CA002298813A patent/CA2298813A1/fr not_active Abandoned
- 1998-08-27 AU AU92067/98A patent/AU9206798A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2001526178A (ja) | 2001-12-18 |
| EP1009405A1 (fr) | 2000-06-21 |
| EP1009405A4 (fr) | 2001-05-09 |
| WO1999009984A1 (fr) | 1999-03-04 |
| CA2298813A1 (fr) | 1999-03-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US6166037A (en) | Pyrrolidine and piperidine modulators of chemokine receptor activity | |
| AU9206798A (en) | Pyrrolidine and piperidine modulators of chemokine receptor activity | |
| US6303593B1 (en) | 3-thienyl and 3-furanyl pyrrolidine modulators of chemokine receptor activity | |
| US6140349A (en) | Cyclic amine modulators of chemokine receptor activity | |
| US6362201B1 (en) | 3-cyclopropyl and 3-cyclobutyl pyrrolidine modulators of chemokine receptor activity | |
| US6489354B1 (en) | 3-alkyl substituted pyrrolidine modulators of chemokine receptor activity | |
| US5962462A (en) | Spiro-substituted azacycles as modulators of chemokine receptor activity | |
| US6136827A (en) | Cyclic amine modulations of chemokine receptor activity | |
| US6265434B1 (en) | Pyrrolidine modulators of chemokine receptor activity | |
| CA2319781A1 (fr) | Amines cycliques utilisees en tant que modulateurs de l'activite du recepteur de chemokine | |
| US6372764B1 (en) | Pyrrolidine modulators of chemokine receptor activity | |
| EP1003514A1 (fr) | Amines cycliques modulant l'activite des recepteurs de chimiokines | |
| US6511994B2 (en) | Modulators of CCR5 chemokine receptor activity | |
| WO1998025605A1 (fr) | Azacycles spiro-substitues utilises comme modulateurs de l'activite des recepteurs de la chemokine | |
| WO2000076514A1 (fr) | Modulateurs de cyclopentyle de l'activite du recepteur de chimiokine | |
| WO2000059498A1 (fr) | Modulateurs de pyrrolidine de l'activite du recepteur des chimiokines | |
| WO2000076512A1 (fr) | Modulateurs cyclopentyliques de l'activite du recepteur de la chimiokine | |
| US6538002B1 (en) | Cyclopentyl modulators of chemokine receptor activity | |
| EP1192133B1 (fr) | Modulateurs n-cyclopentyliques de l'activite du recepteur de la chimiokine | |
| US6593346B2 (en) | N-cyclopentyl modulators of chemokine receptor activity | |
| US6455548B2 (en) | 4-alkyl piperidinyl pyrrolidine modulators of chemokine receptor activity |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK5 | Application lapsed section 142(2)(e) - patent request and compl. specification not accepted |