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AU9079198A - Indolecarboxylic compounds and their use as pharmaceutical compounds - Google Patents

Indolecarboxylic compounds and their use as pharmaceutical compounds

Info

Publication number
AU9079198A
AU9079198A AU90791/98A AU9079198A AU9079198A AU 9079198 A AU9079198 A AU 9079198A AU 90791/98 A AU90791/98 A AU 90791/98A AU 9079198 A AU9079198 A AU 9079198A AU 9079198 A AU9079198 A AU 9079198A
Authority
AU
Australia
Prior art keywords
compounds
alkyl
indolecarboxylic
pharmaceutical
chr3r4
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU90791/98A
Inventor
Bruno Bernard
Maria Dalko
Jean-Baptiste Galey
Catherine Gerst
Patrick Pichaud
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LOreal SA
Original Assignee
LOreal SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LOreal SA filed Critical LOreal SA
Publication of AU9079198A publication Critical patent/AU9079198A/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
    • A61K8/492—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid having condensed rings, e.g. indol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Birds (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Cosmetics (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

2-Indole carboxylic acid derivatives (I) are new. Indole carboxylic acid derivatives of formula (I), and their optical isomers, isomer mixtures, acylated derivatives and salts, are new. One of X, Y = H and the other =-O-CHR3R4; or X + Y form a 5- or 6- membered carbocyclic or heterocyclic ring; R3, R4 = H, phenyl (optionally substituted) or a 5- or 6- membered heterocycle; or R3 + R4 form a 5- or 6- membered ring; Z = H or OR5; R5 = 1-6C alkyl or 6-12C aralkyl; R1 = H or 1-6C alkyl or 6-12C aralkyl (optionally substituted); R2 = H, 1-6C alkyl or -CHR3R4.
AU90791/98A 1997-09-05 1998-08-26 Indolecarboxylic compounds and their use as pharmaceutical compounds Abandoned AU9079198A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9711076A FR2768146B1 (en) 1997-09-05 1997-09-05 NOVEL COMPOUNDS FROM THE INDOLE-CARBOXYLIC FAMILY AND THEIR USE
FR9711076 1997-09-05
PCT/FR1998/001853 WO1999012905A1 (en) 1997-09-05 1998-08-26 Indolecarboxylic compounds and their use as pharmaceutical compounds

Publications (1)

Publication Number Publication Date
AU9079198A true AU9079198A (en) 1999-03-29

Family

ID=9510808

Family Applications (1)

Application Number Title Priority Date Filing Date
AU90791/98A Abandoned AU9079198A (en) 1997-09-05 1998-08-26 Indolecarboxylic compounds and their use as pharmaceutical compounds

Country Status (10)

Country Link
US (2) US6448285B1 (en)
EP (2) EP0964852B1 (en)
JP (2) JP4090515B2 (en)
AT (2) ATE234283T1 (en)
AU (1) AU9079198A (en)
CA (2) CA2271085C (en)
DE (2) DE69835460T2 (en)
ES (2) ES2195382T3 (en)
FR (1) FR2768146B1 (en)
WO (1) WO1999012905A1 (en)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6495538B2 (en) * 1999-06-23 2002-12-17 Zinc Therapeutics, Canada Inc. Zinc ionophores as therapeutic agents
FR2796279B1 (en) 1999-07-16 2001-09-21 Oreal USE OF 4,6-DIMETHOXY-INDOLE 2-CARBOXYLIC ACID OR DERIVATIVES THEREOF FOR THE TREATMENT OF SEBORRHEA
FR2796274B1 (en) 1999-07-16 2001-09-21 Oreal USE OF 4,6-DIMETHOXY-INDOLE 2-CARBOXYLIC ACID OR DERIVATIVES THEREOF TO STIMULATE OR INDUCE HAIR GROWTH AND / OR STOP THE HAIR LOSS
WO2003057670A2 (en) * 2001-12-28 2003-07-17 Guilford Pharmaceuticals Inc. Indoles as naaladase inhibitors
WO2003082271A2 (en) 2002-04-03 2003-10-09 Astrazeneca Ab Indole derivatives having anti-angiogenetic activity
US7041636B1 (en) 2004-01-22 2006-05-09 Benton Melody M Composition for counteracting hair loss
UA95788C2 (en) 2005-12-15 2011-09-12 Ф. Хоффманн-Ля Рош Аг Fused pyrrole derivatives
US20080063673A1 (en) * 2006-09-13 2008-03-13 Akridge Robert E Method and kit for treatment/prevention of hair loss
US20080160509A1 (en) * 2006-09-13 2008-07-03 Pacific Bioscience Laboratories, Inc. Assays for predicting and assessing predisposition to male pattern baldness
WO2008042571A2 (en) * 2006-09-29 2008-04-10 Smithkline Beecham Corporation Substituted indole compounds
JP5079818B2 (en) 2006-12-22 2012-11-21 メルク・シャープ・アンド・ドーム・コーポレーション 4,5-cyclic indole derivatives for the treatment or prevention of HCV and related viral diseases
CN101611025A (en) 2006-12-22 2009-12-23 先灵公司 5,6-cyclized indole derivatives and methods of use thereof
CN101611002A (en) * 2006-12-22 2009-12-23 先灵公司 4, 5-cyclized indole derivatives for the treatment or prevention of HCV and related viral infections
KR20090001013A (en) * 2007-06-29 2009-01-08 주식회사 웰스킨 Acne treatment and sebum secretion inhibitor containing indole-3-alkylcarboxylic acid, and photodynamic therapy kit comprising the same
TW200924751A (en) 2007-08-29 2009-06-16 Schering Corp 2,3-substituted indole derivatives and methods of use thereof
MX2010002318A (en) 2007-08-29 2010-03-22 Schering Corp 2,3-substituted azaindole derivatives for treating viral infections.
CA2697454C (en) 2007-08-29 2015-11-03 Schering Corporation 2-carboxy substituted indole derivatives and methods of use thereof
CA2705587A1 (en) 2007-11-16 2009-05-22 Schering Corporation 3-aminosulfonyl substituted indole derivatives and methods of use thereof
US8765757B2 (en) 2007-11-16 2014-07-01 Merck Sharp & Dohme Corp. 3-heterocyclic substituted indole derivatives and methods of use thereof
MX2010013630A (en) 2008-06-13 2010-12-21 Schering Corp Tricyclic indole derivatives and methods of use thereof.
WO2010143803A2 (en) * 2009-06-08 2010-12-16 Industry Foundation Of Chonnam National University New nicotinamide derivatives with anti-androgen effects, processes of preparing, and antiandrogens comprising the same
FR2953722B1 (en) 2009-12-16 2012-03-09 Expanscience Lab COMPOSITION COMPRISING AT LEAST ONE C7 SUGAR FOR THE TREATMENT OF ALOPECIA, FOR THE COSMETIC TREATMENT OF PHANES, AND FOR THE CARE OF HAIR, CILES OR NAILS
KR101213495B1 (en) 2010-06-03 2013-01-14 삼성디스플레이 주식회사 Organic light emitting device
JP6910027B2 (en) * 2017-03-29 2021-07-28 株式会社コーセー Tyrosinase activity inhibitor, melanin production inhibitor and whitening agent

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB359876A (en) 1930-05-20 1931-10-29 British Thomson Houston Co Ltd Improvements in and relating to polyphase thermionic generators
BE794483A (en) * 1972-01-26 1973-07-24 Boehringer Mannheim Gmbh INDOL-CARBONIC ACID DERIVATIVES WITH HYPOGLYCEMATING EFFECT AND METHODS FOR THEIR PREPARATION
LU86347A1 (en) * 1986-03-06 1987-11-11 Oreal SKIN COLORING COMPOSITIONS BASED ON INDOLE DERIVATIVES
FR2686345A1 (en) * 1992-01-16 1993-07-23 Oreal COLORED MINERAL PARTICLE PRODUCT COMPRISING A MELANIC PIGMENT, PROCESS FOR PREPARING THE SAME AND USE THEREOF IN COSMETICS.
FR2689898B1 (en) * 1992-04-08 1994-06-10 Oreal PIGMENTS COMPRISING AN INORGANIC SUPPORT AND THE REACTION PRODUCT OF AN INDOLIC DERIVATIVE AND A QUINONIC DERIVATIVE, THEIR PREPARATION METHOD AND THEIR USE IN COSMETICS.
WO1994022821A1 (en) * 1993-04-05 1994-10-13 Fujisawa Pharmaceutical Co., Ltd. Indole derivatives as testosterone 5 alpha-reductase inhibitors
DE4314317A1 (en) 1993-04-30 1994-11-03 Henkel Kgaa Agent containing isatin for dyeing keratin fibers
EP1021181A4 (en) * 1996-03-28 2002-06-26 Smithkline Beecham Corp Carboxylic acid indole inhibitors of chemokines
GB9716657D0 (en) 1997-08-07 1997-10-15 Zeneca Ltd Chemical compounds

Also Published As

Publication number Publication date
ES2268169T3 (en) 2007-03-16
EP1302460B1 (en) 2006-08-02
US20030050325A1 (en) 2003-03-13
DE69812073D1 (en) 2003-04-17
ATE234283T1 (en) 2003-03-15
DE69835460D1 (en) 2006-09-14
JP2000508352A (en) 2000-07-04
JP4090515B2 (en) 2008-05-28
WO1999012905A1 (en) 1999-03-18
CA2569685A1 (en) 1999-03-18
EP0964852A1 (en) 1999-12-22
CA2271085A1 (en) 1999-03-18
US6448285B1 (en) 2002-09-10
EP0964852B1 (en) 2003-03-12
EP1302460A1 (en) 2003-04-16
ATE334962T1 (en) 2006-08-15
JP2004035566A (en) 2004-02-05
CA2271085C (en) 2007-04-17
DE69812073T2 (en) 2003-09-25
ES2195382T3 (en) 2003-12-01
DE69835460T2 (en) 2007-07-26
FR2768146B1 (en) 2000-05-05
FR2768146A1 (en) 1999-03-12
US6596753B2 (en) 2003-07-22

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase