[go: up one dir, main page]

AU7929391A - New 1,2,3,4,5,6-hexahydroazepino(4,5-b)indoles and 1,2,3,4-tetrahydro-beta-carbolines processes for preparing these and pharmaceutical compositions containing them - Google Patents

New 1,2,3,4,5,6-hexahydroazepino(4,5-b)indoles and 1,2,3,4-tetrahydro-beta-carbolines processes for preparing these and pharmaceutical compositions containing them

Info

Publication number
AU7929391A
AU7929391A AU79293/91A AU7929391A AU7929391A AU 7929391 A AU7929391 A AU 7929391A AU 79293/91 A AU79293/91 A AU 79293/91A AU 7929391 A AU7929391 A AU 7929391A AU 7929391 A AU7929391 A AU 7929391A
Authority
AU
Australia
Prior art keywords
hexahydroazepino
carbolines
indoles
tetrahydro
beta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU79293/91A
Other versions
AU636232B2 (en
Inventor
Michelle Devissaguet
Jean Yves Laronze
Jean Levy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ADIR SARL
Original Assignee
ADIR SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ADIR SARL filed Critical ADIR SARL
Publication of AU7929391A publication Critical patent/AU7929391A/en
Application granted granted Critical
Publication of AU636232B2 publication Critical patent/AU636232B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU79293/91A 1990-06-27 1991-06-26 New 1,2,3,4,5,6-hexahydroazepino(4,5-b)indoles and 1,2,3,4-tetrahydro-beta-carbolines processes for preparing these and pharmaceutical compositions containing them Ceased AU636232B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9008094A FR2663935A1 (en) 1990-06-27 1990-06-27 NOVEL 1,2,3,4,5,6-HEXAHYDROAZEPINO [4,5-B] INDOLES AND 1,2,3,4-TETRAHYDROBETHACARBOLINES, PROCESSES FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
FR9008094 1990-06-27

Publications (2)

Publication Number Publication Date
AU7929391A true AU7929391A (en) 1992-01-02
AU636232B2 AU636232B2 (en) 1993-04-22

Family

ID=9398070

Family Applications (1)

Application Number Title Priority Date Filing Date
AU79293/91A Ceased AU636232B2 (en) 1990-06-27 1991-06-26 New 1,2,3,4,5,6-hexahydroazepino(4,5-b)indoles and 1,2,3,4-tetrahydro-beta-carbolines processes for preparing these and pharmaceutical compositions containing them

Country Status (10)

Country Link
EP (1) EP0466548A1 (en)
JP (1) JPH04243879A (en)
AU (1) AU636232B2 (en)
CA (1) CA2045450A1 (en)
FR (1) FR2663935A1 (en)
IE (1) IE912225A1 (en)
NZ (1) NZ238709A (en)
OA (1) OA09374A (en)
PT (1) PT98101A (en)
ZA (1) ZA914970B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2009308708B2 (en) * 2008-10-31 2015-11-19 Medivation Technologies, Inc. Azepino [4, 5-b] indoles and methods of use

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5300645A (en) * 1993-04-14 1994-04-05 Eli Lilly And Company Tetrahydro-pyrido-indole
EP0620222A3 (en) * 1993-04-14 1995-04-12 Lilly Co Eli Tetrahydro-beta-carbolines.
US5663178A (en) * 1995-02-06 1997-09-02 Eli Lilly And Company Tetrahydro-beta carbolines
FR2724384B1 (en) * 1994-09-14 1999-04-16 Cemaf NOVEL 3,4-DIHYDRO BETA-CARBOLINE DERIVATIVES OF MELATONIN AGONISTS, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS
UA74826C2 (en) 2000-05-17 2006-02-15 Ortho Mcneil Pharm Inc ?-carboline derivatives as phosphodiesterase inhibitors
WO2002024700A2 (en) 2000-09-20 2002-03-28 Pharmacia & Upjohn Company SUBSTITUTED AZEPINO[4,5b]INDOLINE DERIVATIVES
US20020160999A1 (en) * 2001-01-08 2002-10-31 Jacobsen Susan Fox Substituted indolines
US7115621B2 (en) 2001-04-25 2006-10-03 Lilly Icos Llc Chemical compounds
US7250514B1 (en) * 2002-10-21 2007-07-31 Takeda San Diego, Inc. Histone deacetylase inhibitors
DE10252667A1 (en) 2002-11-11 2004-05-27 Grünenthal GmbH New spiro-((cyclohexane)-tetrahydropyrano-(3,4-b)-indole) derivatives, are ORL1 receptor ligands useful e.g. for treating anxiety, depression, epilepsy, senile dementia, withdrawal symptoms or especially pain
US20040248880A1 (en) * 2003-04-25 2004-12-09 Jacobsen Eric Jon 1,2,3,4,5,6-Hexahydroazepino[4,5-B]indoles containing arylsulfones at the 9-position
DE10360792A1 (en) * 2003-12-23 2005-07-28 Grünenthal GmbH Spirocyclic cyclohexane derivatives
DE10360793A1 (en) * 2003-12-23 2005-07-28 Grünenthal GmbH Spirocyclic cyclohexane derivatives
DE102004039382A1 (en) 2004-08-13 2006-02-23 Grünenthal GmbH Spirocyclic cyclohexane derivatives
WO2006122931A1 (en) * 2005-05-20 2006-11-23 Biovitrum Ab (Publ) Beta-carboline derivatives and theri use as ghsr modulators
WO2007062175A2 (en) * 2005-11-21 2007-05-31 Amgen Inc. Spiro-substituted tricyclic heterocycles cxcr3 antagonists
WO2007070796A1 (en) * 2005-12-15 2007-06-21 Exelixis, Inc. Azepinoindole derivatives as pharmaceutical agents
DE102006019597A1 (en) * 2006-04-27 2007-10-31 Grünenthal GmbH Spirocyclic cyclohexane derivatives
MY152021A (en) * 2008-04-29 2014-08-15 Novartis Ag Spiro-indole derivatives for the treatment of parasitic diseases
BRPI0919948A2 (en) 2008-10-31 2015-08-25 Madivation Technologies Inc Pyrido [4,3-b] indois containing rigid portions
AU2012219251B2 (en) 2011-02-18 2016-05-12 Medivation Technologies, Inc. Compounds and methods for treatment of hypertension

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3293254A (en) * 1964-01-31 1966-12-20 Upjohn Co 2', 3', 4', 9'-tetrahydro-6'-alkoxy spiro
GR35044B (en) * 1966-05-10 1968-07-31 The Upjohn Company METHOD OF PREPARATION OF ORGANIC COMPOUNDS.
FR1524830A (en) * 1966-05-31 1968-05-10 Geigy Ag J R New indole derivatives and their preparation
US3525750A (en) * 1966-05-31 1970-08-25 Geigy Chem Corp 1,2,3,4,5,6-hexahydro-azepino(4,5-b) indole derivatives
FR2455044A1 (en) * 1979-04-26 1980-11-21 Synthelabo PYRIDO-INDOLES AND THEIR APPLICATION IN THERAPEUTICS
DE3070467D1 (en) * 1979-11-02 1985-05-15 Sandoz Ag Azepinoindoles, process for their production and pharmaceutical compositions containing them
JPS5995286A (en) * 1982-11-19 1984-06-01 Otsuka Pharmaceut Factory Inc Imidazo(4,5-c)pyridine-6-carboxylic acid derivative
LU85894A1 (en) * 1985-05-10 1986-12-05 Omnichem Sa DERIVATIVES OF 1,2,3,4,5,6-HEXAHYDRO-AZEPINO (4,5-B) INDOLE THEIR PREPARATION, INTERMEDIATE COMPOUNDS, AND THEIR THERAPEUTIC APPLICATION
ATE136032T1 (en) * 1987-07-20 1996-04-15 Duphar Int Res 8,9-ANNELLATED 1,2,3,4-TETRAHYDRO-BETA-CARBOLINE DERIVATIVES
US5006531A (en) * 1989-07-10 1991-04-09 Hoechst-Roussel Pharmaceuticals Inc. 5,6-dihydro(1H-indolo(3,2-C)quinoline-6,4'-piperidines) and related compounds which are useful for treating pain, psychosis or convulsions

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2009308708B2 (en) * 2008-10-31 2015-11-19 Medivation Technologies, Inc. Azepino [4, 5-b] indoles and methods of use

Also Published As

Publication number Publication date
CA2045450A1 (en) 1991-12-28
FR2663935A1 (en) 1992-01-03
OA09374A (en) 1992-09-15
AU636232B2 (en) 1993-04-22
NZ238709A (en) 1992-05-26
JPH04243879A (en) 1992-08-31
PT98101A (en) 1992-03-31
IE912225A1 (en) 1992-01-01
ZA914970B (en) 1992-04-29
EP0466548A1 (en) 1992-01-15

Similar Documents

Publication Publication Date Title
AU8259691A (en) 3-amidopyrazole derivatives, process for preparing these and pharmaceutical compositions containing them
AU7929391A (en) New 1,2,3,4,5,6-hexahydroazepino(4,5-b)indoles and 1,2,3,4-tetrahydro-beta-carbolines processes for preparing these and pharmaceutical compositions containing them
AU587525B2 (en) Indolizine derivatives, process for preparing them and the compositions containing them
AU646112B2 (en) N,O-sulphated heparosans, process for preparing them and pharmaceutical compositions containing them
IL96019A0 (en) Imidazole derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
HUT64734A (en) Anthraquinone-derivativdes, process for preparing them and pharmaceutical compositions containing them
IL84446A0 (en) 3-pyrrolidinylthio-1-azabicyclo-(3.2.0)hept-2-ene-2-carboxylic acid derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
IL98873A0 (en) Benzodiazepine derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
AU2974189A (en) Pharmaceutical compositions containing lactams, new substituted lactams and processes for the preparation thereof
IL105348A0 (en) Azabicyclo derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
AU8245087A (en) New pyrrolobenzimidazoles, processes for the preparation thereof and pharmaceutical compositions containing them
IL92425A0 (en) Alpha-d-glucofuranose derivatives,pharmaceutical compositions containing the same and processes for the preparation thereof
AU8315287A (en) New alkanesulfonanilide and alkylaminosulfonanilide derivatives, processes for their preparation and pharmaceutical compositions comprising the same
IL88903A0 (en) Indolylpiperidine derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
AU6741887A (en) Indole derivatives, processes for their preparation and pharmaceutical compositions containing them
IL107358A0 (en) a-Phosphonosulfonate derivatives, processes for the preparation thereof, and pharmaceutical compositions containing the same
IL97931A0 (en) Pyridazine derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
IL87563A0 (en) Isoxazole-beta-carboline derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
AU5019690A (en) New benzoxazolinone derivatives, processes for preparing them and pharmaceutical compositions containing them
AU8917891A (en) Poly-aminopyrrolecarboxamido derivatives, processes for their preparation and pharmaceutical compositions containing them
AU8808791A (en) New benzoselenazolinone compounds, process for preparing these and pharmaceutical compositions containing them
IL82294A0 (en) 1,3-dihydropyridine derivatives,process for the preparation thereof and pharmaceutical compositions containing the same
AU7942091A (en) New oxazolopyridine compounds, process for preparing these and pharmaceutical compositions containing them
IL95210A0 (en) 14,17alpha-etheno-and-ethanoestratrienes,process for the preparation thereof and pharmaceutical compositions containing the same
IL98196A0 (en) Cephalosporin derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same