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AU6724598A - 5-oxysubstituted chinolines and their use as cholesterol ester transfer proteinsinhibitors - Google Patents

5-oxysubstituted chinolines and their use as cholesterol ester transfer proteinsinhibitors

Info

Publication number
AU6724598A
AU6724598A AU67245/98A AU6724598A AU6724598A AU 6724598 A AU6724598 A AU 6724598A AU 67245/98 A AU67245/98 A AU 67245/98A AU 6724598 A AU6724598 A AU 6724598A AU 6724598 A AU6724598 A AU 6724598A
Authority
AU
Australia
Prior art keywords
proteinsinhibitors
chinolines
oxysubstituted
cholesterol ester
ester transfer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU67245/98A
Inventor
Rolf Angerbauer
Hilmar Bischoff
Arndt Brandes
Klaus-Dieter Bremm
Michael Logers
Matthias Muller-Gliemann
Carsten Schmeck
Delf Schmidt
Gunter Schmidt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of AU6724598A publication Critical patent/AU6724598A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
AU67245/98A 1997-03-06 1998-02-24 5-oxysubstituted chinolines and their use as cholesterol ester transfer proteinsinhibitors Abandoned AU6724598A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19709125 1997-03-06
DE19709125A DE19709125A1 (en) 1997-03-06 1997-03-06 Substituted quinolines
PCT/EP1998/001046 WO1998039299A1 (en) 1997-03-06 1998-02-24 5-oxysubstituted chinolines and their use as cholesterol ester transfer proteins inhibitors

Publications (1)

Publication Number Publication Date
AU6724598A true AU6724598A (en) 1998-09-22

Family

ID=7822418

Family Applications (1)

Application Number Title Priority Date Filing Date
AU67245/98A Abandoned AU6724598A (en) 1997-03-06 1998-02-24 5-oxysubstituted chinolines and their use as cholesterol ester transfer proteinsinhibitors

Country Status (5)

Country Link
EP (1) EP0970053A1 (en)
JP (1) JP2001513790A (en)
AU (1) AU6724598A (en)
DE (1) DE19709125A1 (en)
WO (1) WO1998039299A1 (en)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6262277B1 (en) 1994-09-13 2001-07-17 G.D. Searle And Company Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
US6642268B2 (en) 1994-09-13 2003-11-04 G.D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors
DE19741051A1 (en) * 1997-09-18 1999-03-25 Bayer Ag New tetrahydroquinoline derivatives useful in treatment of raised lipid levels and arteriosclerosis
DE19741399A1 (en) * 1997-09-19 1999-03-25 Bayer Ag New tetrahydroquinoline derivatives useful in treatment of elevated lipid levels and arteriosclerosis
ATE296796T1 (en) * 1998-09-25 2005-06-15 Monsanto Co (R)-CHIRAL HALOGENATED 1-SUBSTITUTED AMINO-(N+1)-ALKANOLS FOR INHIBITING CHOLESTERYL ESTER TRANSFER PROTEIN ACTIVITY
PT1140184E (en) 1998-12-23 2003-10-31 Searle Llc COMBINATIONS OF ESTER TRANSFER PROTEIN INHIBITORS OF CHOLESTEROL WITH NICOTINIC ACID DERIVATIVES FOR CARDIOVASCULAR INDICATIONS
US6683113B2 (en) 1999-09-23 2004-01-27 Pharmacia Corporation (R)-chiral halogenated substituted N,N-Bis-benzyl aminioalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity
US20010018446A1 (en) 1999-09-23 2001-08-30 G.D. Searle & Co. Substituted N-Aliphatic-N-Aromatictertiary-Heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity
US7115279B2 (en) 2000-08-03 2006-10-03 Curatolo William J Pharmaceutical compositions of cholesteryl ester transfer protein inhibitors
FR2820435B1 (en) * 2001-02-05 2004-02-27 Genfit S A METHODS OF IDENTIFYING COMPOUNDS MODULATING THE REVERSE TRANSPORT OF CHOLESTEROL
OA12625A (en) 2001-06-22 2006-06-12 Pfizer Prod Inc Pharmaceutical compositions of adsorbates of amorphous drug.
MXPA03011784A (en) 2001-06-22 2004-04-02 Pfizer Prod Inc Pharmaceutical compositions of dispersions of drugs and neutral polymers.
EP1269994A3 (en) 2001-06-22 2003-02-12 Pfizer Products Inc. Pharmaceutical compositions comprising drug and concentration-enhancing polymers
US6852753B2 (en) 2002-01-17 2005-02-08 Pharmacia Corporation Alkyl/aryl hydroxy or keto thiepine compounds as inhibitors of apical sodium co-dependent bile acid transport (ASBT) and taurocholate uptake
EP1469832B2 (en) 2002-02-01 2016-10-26 Bend Research, Inc. Pharmaceutical compositions of amorphous dispersions of drugs and lipophilic microphase-forming materials
AR038375A1 (en) 2002-02-01 2005-01-12 Pfizer Prod Inc PHARMACEUTICAL COMPOSITIONS OF INHIBITORS OF THE PROTEIN OF TRANSFER OF ESTERES DE COLESTERILO
MXPA05005813A (en) 2002-12-20 2005-12-12 Pfizer Prod Inc Dosage forms comprising a cetp inhibitor and an hmg-coa reductase inhibitor.
AU2004222436A1 (en) 2003-03-17 2004-09-30 Japan Tobacco Inc. Method for increasing the oral bioavailability of S-(2-(((1- (2-ethylbutyl) cyclohexyl)carbonyl) amino) phenyl)-2-methylpropanethioate
MXPA06001417A (en) 2003-08-04 2006-05-15 Pfizer Prod Inc Pharmaceutical compositions of adsorbates of amorphous drugs and lipophilic microphase-forming materials.
CL2004001884A1 (en) 2003-08-04 2005-06-03 Pfizer Prod Inc DRYING PROCEDURE FOR SPRAYING FOR THE FORMATION OF SOLID DISPERSIONS AMORPHES OF A PHARMACO AND POLYMERS.
CN101342162A (en) 2003-09-26 2009-01-14 日本烟草产业株式会社 Method of inhibiting remnant lipoprotein production
CN1863778A (en) 2003-10-08 2006-11-15 伊莱利利公司 Compounds and methods for treating dyslipidemia
CA2547518A1 (en) 2003-12-12 2005-06-30 Wyeth Quinolines useful in treating cardiovascular disease
WO2005097806A1 (en) 2004-03-26 2005-10-20 Eli Lilly And Company Compounds and methods for treating dyslipidemia
PT1828137E (en) 2004-12-18 2012-07-04 Bayer Pharma AG 4-cycloalkyl-substituted tetrahydrochinoline derivatives and use thereof as medicaments
WO2006082518A1 (en) 2005-02-03 2006-08-10 Pfizer Products Inc. Pharmaceutical compositions with enhanced performance
WO2006098394A1 (en) * 2005-03-14 2006-09-21 Japan Tobacco Inc. Method for inhibiting lipid absorption and lipid absorption inhibitor
US7737155B2 (en) 2005-05-17 2010-06-15 Schering Corporation Nitrogen-containing heterocyclic compounds and methods of use thereof
WO2007048027A2 (en) 2005-10-21 2007-04-26 Novartis Ag Combination of a renin-inhibitor and an anti-dyslipidemic agent and/or an antiobesity agent
DE102006012548A1 (en) 2006-03-18 2007-09-20 Bayer Healthcare Ag Substituted chromanol derivatives and their use
EP2379562A1 (en) 2008-12-16 2011-10-26 Schering Corporation Bicyclic pyranone derivatives as nicotinic acid receptor agonists
US20110245209A1 (en) 2008-12-16 2011-10-06 Schering Corporation Pyridopyrimidine derivatives and methods of use thereof
US20130156720A1 (en) 2010-08-27 2013-06-20 Ironwood Pharmaceuticals, Inc. Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1336714C (en) * 1987-08-20 1995-08-15 Yoshihiro Fujikawa Quinoline type mevalonolactone inhibitors of cholesterol biosynthesis
DE19610932A1 (en) * 1996-03-20 1997-09-25 Bayer Ag 2-aryl substituted pyridines
HRP970330B1 (en) * 1996-07-08 2004-06-30 Bayer Ag Cycloalkano pyridines

Also Published As

Publication number Publication date
JP2001513790A (en) 2001-09-04
WO1998039299A1 (en) 1998-09-11
EP0970053A1 (en) 2000-01-12
DE19709125A1 (en) 1998-09-10

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