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AU666586B2 - Cyclopeptides - Google Patents

Cyclopeptides

Info

Publication number
AU666586B2
AU666586B2 AU50399/93A AU5039993A AU666586B2 AU 666586 B2 AU666586 B2 AU 666586B2 AU 50399/93 A AU50399/93 A AU 50399/93A AU 5039993 A AU5039993 A AU 5039993A AU 666586 B2 AU666586 B2 AU 666586B2
Authority
AU
Australia
Prior art keywords
asp
arg
ala
gly
denotes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU50399/93A
Other versions
AU5039993A (en
Inventor
Beate Diefenbach
Brunhilde Felding-Habermann
Roland Haubner
Gunter Holzemann
Alfred Jonczyk
Horst Kessler
Guido Melzer
Friedrich Ripmann
Jochen Wermuth
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of AU5039993A publication Critical patent/AU5039993A/en
Application granted granted Critical
Publication of AU666586B2 publication Critical patent/AU666586B2/en
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/52—Cyclic peptides containing at least one abnormal peptide link with only normal peptide links in the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/75—Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cardiology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The invention relates to novel cyclopeptides of the formula I Cyclo-(A-B-C-D-Arg) I in which A and B in each case independently of one another denote Ala, Asn, Asp, Arg, Cys, Gln, Glu, Gly, His, Ile, Leu, Lys, Met, Phe, Pro, Ser, Thr, Trp, Tyr or Val, C denotes Asp or Asp(O-C1-4-alkyl) and D denotes Gly or Ala, at least two of the amino acid radicals indicated being present in the D-form, and their salts. These compounds act as integrin inhibitors and can be used in particular for the prophylaxis and treatment of circulation disorders and in tumour therapy.
AU50399/93A 1992-11-06 1993-11-01 Cyclopeptides Expired AU666586B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4237456A DE4237456A1 (en) 1992-11-06 1992-11-06 cyclopeptides
DE4237456 1992-11-06

Publications (2)

Publication Number Publication Date
AU5039993A AU5039993A (en) 1994-05-19
AU666586B2 true AU666586B2 (en) 1996-02-15

Family

ID=6472232

Family Applications (1)

Application Number Title Priority Date Filing Date
AU50399/93A Expired AU666586B2 (en) 1992-11-06 1993-11-01 Cyclopeptides

Country Status (21)

Country Link
EP (1) EP0596350B1 (en)
JP (1) JP3681764B2 (en)
KR (1) KR100238894B1 (en)
CN (1) CN1038751C (en)
AT (1) ATE154037T1 (en)
AU (1) AU666586B2 (en)
CA (1) CA2102447C (en)
CZ (1) CZ286170B6 (en)
DE (2) DE4237456A1 (en)
DK (1) DK0596350T3 (en)
ES (1) ES2105041T3 (en)
GR (1) GR3024550T3 (en)
HU (1) HU215600B (en)
MX (1) MX9306885A (en)
NO (1) NO309864B1 (en)
PL (1) PL177772B1 (en)
RU (1) RU2129563C1 (en)
SK (1) SK280597B6 (en)
TW (1) TW340849B (en)
UA (1) UA43822C2 (en)
ZA (1) ZA938281B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4237456A1 (en) * 1992-11-06 1994-05-11 Merck Patent Gmbh cyclopeptides
DE4310643A1 (en) * 1993-04-01 1994-10-06 Merck Patent Gmbh Cyclic adhesion inhibitors
DE19538741A1 (en) * 1995-10-18 1997-04-24 Merck Patent Gmbh Cyclopeptide derivatives
DE19653036A1 (en) * 1996-12-19 1998-06-25 Merck Patent Gmbh Cyclopeptide derivatives
RU2255765C2 (en) * 2000-01-21 2005-07-10 Чилдренз Хоспитал Лос-Анджелес Method for inhibiting cerebral tumors growth due to selected antagonists of integrins
CZ2003584A3 (en) * 2000-08-30 2003-08-13 F. Hoffmann-La Roche Ag Selective cyclic peptides
FR2814744B1 (en) * 2000-10-04 2002-11-29 Commissariat Energie Atomique CYCLOPEPTIDES, THEIR PREPARATION PROCESS AND THEIR USE AS ANGIOGENESIS INHIBITOR OR ACTIVATOR
WO2019098811A2 (en) * 2017-11-20 2019-05-23 주식회사 노브메타파마 Composition for preventing, alleviating, or treating bone loss diseases, comprising cyclo(his-pro) (chp)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816449A (en) * 1984-08-09 1989-03-28 Immunetech Pharmaceuticals Immunotherapeutic anti-inflammatory peptide agents

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU892871A1 (en) * 1980-07-28 1983-09-15 Ордена Трудового Красного Знамени Институт Органического Синтеза Ан Латвсср Cyclic analog of bradiquinine having prolonged hypotensive effect
GB8729802D0 (en) * 1987-12-22 1988-02-03 Beecham Group Plc Novel compounds
DE4237456A1 (en) * 1992-11-06 1994-05-11 Merck Patent Gmbh cyclopeptides
US5516889A (en) * 1993-06-21 1996-05-14 University Technologies International, Inc. Synthetic thrombin receptor peptides

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816449A (en) * 1984-08-09 1989-03-28 Immunetech Pharmaceuticals Immunotherapeutic anti-inflammatory peptide agents

Also Published As

Publication number Publication date
CN1093090A (en) 1994-10-05
PL177772B1 (en) 2000-01-31
NO934003L (en) 1994-05-09
DE59306654D1 (en) 1997-07-10
DK0596350T3 (en) 1997-12-29
CZ286170B6 (en) 2000-02-16
CN1038751C (en) 1998-06-17
JPH0892282A (en) 1996-04-09
UA43822C2 (en) 2002-01-15
GR3024550T3 (en) 1997-12-31
KR940011479A (en) 1994-06-21
DE4237456A1 (en) 1994-05-11
HUT68321A (en) 1995-06-28
CZ235293A3 (en) 1994-07-13
TW340849B (en) 1998-09-21
CA2102447C (en) 2007-04-10
MX9306885A (en) 1995-01-31
ZA938281B (en) 1994-06-07
KR100238894B1 (en) 2000-01-15
ATE154037T1 (en) 1997-06-15
HU215600B (en) 1999-01-28
SK121793A3 (en) 1995-06-07
RU2129563C1 (en) 1999-04-27
PL300935A1 (en) 1994-05-16
EP0596350A1 (en) 1994-05-11
EP0596350B1 (en) 1997-06-04
AU5039993A (en) 1994-05-19
ES2105041T3 (en) 1997-10-16
JP3681764B2 (en) 2005-08-10
NO934003D0 (en) 1993-11-05
CA2102447A1 (en) 1994-05-07
SK280597B6 (en) 2000-04-10
NO309864B1 (en) 2001-04-09

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