AU6044496A - Compounds having bradykinin antagonistic activity and mu-opi oid agonistic activity - Google Patents
Compounds having bradykinin antagonistic activity and mu-opi oid agonistic activityInfo
- Publication number
- AU6044496A AU6044496A AU60444/96A AU6044496A AU6044496A AU 6044496 A AU6044496 A AU 6044496A AU 60444/96 A AU60444/96 A AU 60444/96A AU 6044496 A AU6044496 A AU 6044496A AU 6044496 A AU6044496 A AU 6044496A
- Authority
- AU
- Australia
- Prior art keywords
- activity
- oid
- opi
- compounds
- agonistic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 101800004538 Bradykinin Proteins 0.000 title 1
- QXZGBUJJYSLZLT-UHFFFAOYSA-N H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH Natural products NC(N)=NCCCC(N)C(=O)N1CCCC1C(=O)N1C(C(=O)NCC(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CO)C(=O)N2C(CCC2)C(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CCCN=C(N)N)C(O)=O)CCC1 QXZGBUJJYSLZLT-UHFFFAOYSA-N 0.000 title 1
- 102100035792 Kininogen-1 Human genes 0.000 title 1
- 230000001270 agonistic effect Effects 0.000 title 1
- 230000003042 antagnostic effect Effects 0.000 title 1
- QXZGBUJJYSLZLT-FDISYFBBSA-N bradykinin Chemical compound NC(=N)NCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1[C@H](C(=O)NCC(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CO)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)CCC1 QXZGBUJJYSLZLT-FDISYFBBSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/18—Kallidins; Bradykinins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US465672 | 1995-06-05 | ||
| US08/465,672 US5843900A (en) | 1991-04-01 | 1995-06-05 | Bradykinin antagonists |
| US64716096A | 1996-05-21 | 1996-05-21 | |
| US647160 | 1996-05-21 | ||
| PCT/US1996/008923 WO1996039425A2 (fr) | 1995-06-05 | 1996-06-04 | Composes ayant une activite antagoniste de la bradykinine et une activite agoniste mu-opioïde |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU6044496A true AU6044496A (en) | 1996-12-24 |
Family
ID=27041368
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU60444/96A Abandoned AU6044496A (en) | 1995-06-05 | 1996-06-04 | Compounds having bradykinin antagonistic activity and mu-opi oid agonistic activity |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP0832106A2 (fr) |
| AU (1) | AU6044496A (fr) |
| TW (1) | TW407159B (fr) |
| WO (1) | WO1996039425A2 (fr) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6262265B1 (en) * | 1999-06-18 | 2001-07-17 | Microgenics Corporation | Non-hydrolyzable analogs of heroin metabolites suitable for use in immunoassay |
| EP1312923B1 (fr) * | 2001-11-16 | 2007-03-28 | Randox Laboratories Ltd. | Méthode et trousse pour détecter, ou quantifier, des métabolites de fentanyl et des métabolites de fentanyl analogues |
| ATE358275T1 (de) | 2001-11-16 | 2007-04-15 | Randox Lab Ltd | Verfahren und kit zum nachweis, oder zum quantifizieren von, metaboliten von fentanyl und metaboliten von fentanyl analoga |
| EP1812391A2 (fr) * | 2004-11-10 | 2007-08-01 | Boehringer Ingelheim Chemicals, Inc. | Procede de fabrication de produits intermediaires de fentanyle |
| US7238791B1 (en) * | 2005-12-16 | 2007-07-03 | Roche Diagnostics Operations, Inc. | 6-monoacetylmorphine derivatives useful in immunoassay |
| WO2011011543A1 (fr) * | 2009-07-21 | 2011-01-27 | Nektar Therapeutics | Conjugués oligomères-agonistes opioïdes |
| US10512644B2 (en) | 2007-03-12 | 2019-12-24 | Inheris Pharmaceuticals, Inc. | Oligomer-opioid agonist conjugates |
| US8173666B2 (en) | 2007-03-12 | 2012-05-08 | Nektar Therapeutics | Oligomer-opioid agonist conjugates |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE63490B1 (en) * | 1988-11-24 | 1995-05-03 | Hoechst Ag | Peptides having bradykinin antagonist action |
| CA2106677A1 (fr) * | 1991-04-01 | 1992-10-02 | John C. Cheronis | Antagonistes de la bradykinine |
| AU1873992A (en) * | 1991-04-19 | 1992-11-17 | Nova Technology Limited Partnership | Bradykinin antagonist peptides |
| IL107400A0 (en) * | 1992-11-10 | 1994-01-25 | Cortech Inc | Bradykinin antagonists |
| JPH09511500A (ja) * | 1994-03-09 | 1997-11-18 | コーテック，インコーポレイティド | Ｎ−置換化グリシンを含むブラジキニン拮抗薬ペプチド |
| US5648336A (en) * | 1994-11-18 | 1997-07-15 | University Of Colorado | Bradykinin antagonist peptides containing indane-substituted amino acids |
-
1996
- 1996-06-04 WO PCT/US1996/008923 patent/WO1996039425A2/fr not_active Ceased
- 1996-06-04 EP EP96918098A patent/EP0832106A2/fr not_active Withdrawn
- 1996-06-04 AU AU60444/96A patent/AU6044496A/en not_active Abandoned
- 1996-06-05 TW TW85106740A patent/TW407159B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| WO1996039425A2 (fr) | 1996-12-12 |
| WO1996039425A3 (fr) | 1997-01-30 |
| EP0832106A2 (fr) | 1998-04-01 |
| TW407159B (en) | 2000-10-01 |
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